Maria Lindahl

Publications

Research output per year 1997 2010 2017 2018 2019 2020 2021 2022 2023 2024 2024

• 42 Article
• 3 Meeting Abstract
• 2 Review Article
• 1 Comment/debate
• 2 More
  • 1 Conference article
  • 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2024

  Aivoinfarktin jälkeen aivojen mikrogliat tai makrofagit alkavat ilmentää MANF-proteiinia, joka systeemisesti annettuna estää tulehdusta = MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects

  Translated title of the contribution: MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti‑inflammatory effectsAnttila, J. E., Mattila, O. S., Liew, H.-K., Mätlik, K., Mervaala, E., Lindholm, P., Lindahl, M., Lindsberg, P. J., Tseng, K.-Y. & Airavaara, M., 2024, In: Duodecim. 140, 4, p. 309-309 1 p.

  Research output: Contribution to journal › Comment/debate › Professional

  Open Access

  File

• MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects

  Anttila, J. E., Mattila, O. S., Liew, H.-K., Mätlik, K., Mervaala, E., Lindholm, P., Lindahl, M., Lindsberg, P. J., Tseng, K.-Y. & Airavaara, M., 16 Jan 2024, In: Acta Neuropathologica Communications. 12, 24 p., 10.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Stereocilia fusion pathology in the cochlear outer hair cells at the nanoscale level

  Ikäheimo, K., Leinonen, S. M., Lankinen, T. S., Lindahl, M., Saarma, M. & Pirvola, U., 22 Jul 2024, In: Journal of Physiology. 602, 16

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2023

  Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage

  Tseng, K.-Y., Stratoulias, V., Hu, W.-F., Wu, J.-S., Wang, V., Chen, Y.-H., Seelbach, A., Huttunen, H. J., Kulesskaya, N., Pang, C.-Y., Chou, J.-L., Lindahl, M., Saarma, M., Huang, L.-C., Airavaara, M. & Liew, H.-K., 15 Feb 2023, In: Cell Death and Disease. 14, 2, 20 p., 128.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice

  Kim, Y., Li, C., Gu, C., Fang, Y., Tycksen, E., Puri, A., Pietka, T. A., Sivapackiam, J., Kidd, K., Park, S.-J., Johnson, B. G., Kmoch, S., Duffield, J. S., Bleyer, A. J., Jackrel, M. E., Urano, F., Sharma, V., Lindahl, M. & Chen, Y. M., 14 Oct 2023, In: Nature Communications. 14, 22 p., 6493.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Mesencephalic Astrocyte Derived Neurotrophic Factor (MANF) Stimulates Autophagy and Restores Mitochondrial Homeostasis to Treat Uromodulin Associated Nephropathy

  Li, C., Kim, Y., Gu, C., Fang, Y., Tycksen, E., Puri, A., Pietka, T. A., Sivapackiam, J., Kidd, K., Park, S.-J., Johnson, B. G., Kmoch, S., Duffield, J. S., Bleyer, A. J., Jackrel, M. E., Urano, F., Sharma, V. K., Lindahl, M. S. & Chen, Y. M., 2023, In: Journal of the American Society of Nephrology. 34, 11S, p. 19-19 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review
• 2022

  CDNF and MANF regulate ER stress in a tissue-specific manner

  Pakarinen, E., Lindholm, P., Saarma, M. & Lindahl, M., Feb 2022, In: Cellular and Molecular Life Sciences. 79, 2, 18 p., 124.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival

  Eesmaa, A., Yu, L.-Y., Göös, H., Danilova, T., Nöges, K., Pakarinen, E., Varjosalo, M., Lindahl, M., Lindholm, P. & Saarma, M., Aug 2022, In: International Journal of Molecular Sciences. 23, 16, 27 p., 9489.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea

  Ikäheimo, K., Herranen, A., Iivanainen, V., Lankinen, T., Aarnisalo, A. A., Sivonen, V., Patel, K. A., Demir, K., Saarma, M., Lindahl, M. & Pirvola, U., Feb 2022, In: Life Science Alliance. 5, 2, 20 p., 202101068.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2021

  Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress

  Montaser, H., Patel, K. A., Balboa, D., Ibrahim, H., Lithovius, V., Näätänen, A., Chandra, V., Demir, K., Acar, S., Ben-Omran, T., Colclough, K., Locke, J. M., Wakeling, M., Lindahl, M., Hattersley, A. T., Saarimaki-Vire, J. & Otonkoski, T., Apr 2021, In: Diabetes. 70, 4, p. 1006-1018 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Parkinsonin taudin tutkimus johti kasvutekijän jäljille - suojaako MANF diabetekselta?

  Lindahl, M., 2021, In: Diabetes ja lääkäri. 50, 3, p. 14-16 3 p.

  Research output: Contribution to journal › Article › Professional

  Open Access

  File

• The overexpression of GDNF in nucleus accumbens suppresses alcohol-seeking behavior in group-housed C57Bl/6J female mice

  Koskela, M., Piepponen, T. P., Lindahl, M., Harvey, B. K., Andressoo, J.-O., Voikar, V. & Airavaara, M., 20 Dec 2021, In: Journal of Biomedical Science. 28, 1, 17 p., 87.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2020

  Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice

  Lindahl, M., Chalazonitis, A., Palm, E., Pakarinen, E., Danilova, T., Pham, T. D., Setlik, W., Rao, M., Voikar, V., Huotari, J., Kopra, J., Andressoo, J.-O., Piepponen, P. T., Airavaara, M., Panhelainen, A., Gershon, M. D. & Saarma, M., Feb 2020, In: Neurobiology of Disease. 134, 18 p., 104696.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Cerebral Dopamine Neurotrophic Factor Is Essential for Enteric Neuronal Development, Maintenance and Regulation of Gastrointestinal Transit

  Chalazonitis, A., Li, Z., Pham, T. D., Chen, J., Rao, M., Lindholm, P., Saarma, M., Lindahl, M. & Gershon, M. D., Oct 2020, In: Journal of Comparative Neurology. 528, 14, p. 2420-2444 25 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss

  Herranen, A., Ikäheimo, K., Lankinen, T., Pakarinen, E., Fritzsch, B., Saarma, M., Lindahl, M. & Pirvola, U., 6 Feb 2020, In: Cell Death and Disease. 11, 2, 12 p., 100.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• MANF ablation causes prolonged activation of the UPR without neurodegeneration in the mouse midbrain dopamine system

  Pakarinen, E., Danilova, T., Voikar, V., Chmielarz, P., Piepponen, P., Airavaara, M., Saarma, M. & Lindahl, M., 2020, In: eNeuro. 7, 1, 20 p., ARTN 0477-19.2019.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Neuroplastin Modulates Anti-inflammatory Effects of MANF

  Yagi, T., Asada, R., Kanekura, K., Eesmaa, A., Lindahl, M., Saarma, M. & Urano, F., 18 Dec 2020, In: iScience. 23, 12, 23 p., 101810.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2019

  Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome

  Park, S.-J., Kim, Y., Yang, S.-M., Henderson, M. J., Yan, W., Lindahl, M., Urano, F. & Chen, Y. M., 9 Jul 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 28, p. 14154-14163 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Gfra1 Underexpression Causes Hirschsprung's Disease and Associated Enterocolitis in Mice

  Porokuokka, L. L., Virtanen, H. T., Linden, J., Sidorova, Y., Danilova, T., Lindahl, M., Saarma, M. & Andressoo, J.-O., 2019, In: Cellular and Molecular Gastroenterology and Hepatology. 7, 3, p. 655-678 24 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• MANF is Required for the Postnatal Expansion and Maintenance of the Pancreatic β-Cell Mass in Mice

  Danilova, T., Belevich, I., Li, H., Palm, E., Jokitalo, E., Otonkoski, T. & Lindahl, M., Jan 2019, In: Diabetes. 68, 1, p. 66-80 15 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function

  Danilova, T., Galli, E., Pakarinen, E., Palm, E., Lindholm, P. K., Saarma, M. & Lindahl, M., Nov 2019, In: Frontiers in Endocrinology. 10, 19 p., 765.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2018

  Emerging Roles for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) in Pancreatic Beta Cells and Diabetes

  Danilova, T. & Lindahl, M., 16 Oct 2018, In: Frontiers in Physiology. 9, 21 p., 1457.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File

• MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke

  Tseng, K.-Y., Anttila, J. E., Khodosevich, K., Tuominen, R. K., Lindahl, M., Domanskyi, A. & Airavaara, M., 3 Jan 2018, In: Molecular therapy. 26, 1, p. 238-255 18 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• MANF protects human pancreatic beta cells against stress-induced cell death

  Hakonen, E., Chandra, V., Fogarty, C. L., Yu, N.Y.-L., Ustinov, J., Katayama, S., Galli, E., Danilova, T., Lindholm, P., Vartiainen, A., Einarsdottir, E., Krjutskov, K., Kere, J., Saarma, M., Lindahl, M. & Otonkoski, T., Oct 2018, In: Diabetologia. 61, 10, p. 2202-2214 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Poststroke delivery of MANF promotes functional recovery in rats

  Mätlik, K., Anttila, J. E., Kuan-Yin, T., Smolander, O.-P., Pakarinen, E., Lehtonen, L., Abo-Ramadan, U., Lindholm, P., Zheng, C., Harvey, B., Arumäe, U., Lindahl, M. & Airavaara, M., 23 May 2018, In: Science Advances. 4, 5, 8 p., 8957.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2017

  Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra

  Mätlik, K., Vihinen, A. H., Bienemann, A., Palgi, J., Voutilainen, M. H., Booms, S., Lindahl, M. S., Jokitalo, E. S., Saarma, M., Huttunen, H. J., Airavaara, M. T. & Arumäe, U., 20 Feb 2017, In: eNeuro. 4, 1, 15 p., e0128-16.2017.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex

  Tseng, K.-Y., Danilova, T., Domanskyi, A., Saarma, M., Lindahl, M. S. & Airavaara, M. T., 29 Sept 2017, In: eNeuro. 4, 5, 21 p., e0214-17.2017.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Pancreatic beta-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)

  Cunha, D. A., Cito, M., Grieco, F. A., Cosentino, C., Danilova, T., Ladriere, L., Lindahl, M., Domanskyi, A., Bugliani, M., Marchetti, P., Eizirik, D. L. & Cnop, M., 8 Sept 2017, In: Journal of Biological Chemistry. 292, 36, p. 14977-14988 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential

  Lindahl, M., Saarma, M. & Lindholm, P., Jan 2017, In: Neurobiology of Disease. 97, part B, p. 90-102 13 p.

  Research output: Contribution to journal › Review Article › peer-review
• 2016

  Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes

  Galli, E., Harkonen, T., Sainio, M., Ustav, M., Toots, U., Urtti, A., Yliperttula, M., Lindahl, M., Knip, M., Saarma, M. & Lindholm, P., 30 Jun 2016, In: Scientific Reports. 6, 11 p., 29058.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Mesencephalic Astrocyte-Derived Neurotrophic Factor as a Urine Biomarker for Endoplasmic Reticulum Stress-Related Kidney Diseases

  Kim, Y., Lee, H., Manson, S. R., Lindahl, M., Evans, B., Miner, J. H., Urano, F. & Chen, Y. M., 1 Oct 2016, In: Journal of the American Society of Nephrology. 27, 10, p. 2974-2982 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2015

  GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function

  Kumar, A., Kopra, J. J., Varendi, K., Porokuokka, L. L., Panhelainen, A. E., Kuure, S. H., Marshall, P. O. L., Karalija, N., Härma, M.-A., Vilenius, C. L., Lilleväli, K., Tekko, T., Mijatovic, J., Pulkkinen, N., Jakobson, M., Jakobson, M., Ola, R., Palm, E., Lindahl, M. S. & Strömberg, I. & 4 others, Võikar, V., Piepponen, T. P., Saarma, M. & Andressoo, J.-O., 2015, In: PLoS Genetics. 11, 12, 24 p., e1005710.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2014

  MANF is indispensable for the proliferation and survival of pancreatic beta-cells

  Lindahl, M., Danilova, T., Palm, E., Lindholm, P., Voikar, V., Hakonen, E., Ustinov, J., Andressoo, J.-O., Harvey, B. K., Otonkoski, T., Rossi, J. & Saarma, M., Apr 2014, In: Cell Reports. 7, 2, p. 366-375 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2012

  CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery After MPTP Treatment in Mice

  Airavaara, M., Harvey, B. K., Voutilainen, M. H., Shen, H., Chou, J., Lindholm, P., Lindahl, M., Tuominen, R. K., Saarma, M., Hoffer, B. & Wang, Y., 2012, In: Cell Transplantation. 21, 6, p. 1213-1223 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2011

  CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery After MPTP Treatment n Mice

  Airavaara, M., Harvey, B. K., Voutilainen, M. H., Chou, J., Lindholm, P., Lindahl, M., Tuominen, R. K., Saarma, M., Wang, Y. & Hoffer, B., 2011, In: Cell Transplantation. 20, Supplement 1, p. 544-545 2 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• 2010

  New Mouse Models for Studying Postnatal Role of GDNF In Vivo

  Andressoo, J.-O., Mijatovic, J., Kuman, A., Amberg, C., Grealish, S., Lindahl, M., Bjorklund, A., Lindholm, J., Casten, E., Kulesskaya, N., Rauvala, H., Piepponen, P. & Saarma, M., 2010, In: Cell Transplantation. 19, p. 331-331 1 p.

  Research output: Contribution to journal › Conference article › Scientific

• Novel Neurotrophic Factor CDNF: Biology and Therapeutic Potential

  Saarma, M., Lindholm, P., Andressoo, J.-O., Perlinen, J. & Lindahl, M., 2010, In: Cell Transplantation. 19, 3, p. 359-360 2 p.

  Research output: Contribution to journal › Meeting Abstract

• Persephin signaling through GFR alpha 1: The potential for the treatment of Parkinson's disease

  Sidorova, Y., Mätlik, K., Paveliev, M., Lindahl, M., Piranen, E., Milbrandt, J., Arumäe, U., Saarma, M. & Bespalov, M., 2010, In: Molecular and Cellular Neuroscience. 44, 3, p. 223-232 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2008

  New screening system demonstrates persephin potential in Parkinson's disease treatment

  Sidorova, Y. A., Bespalov, M. M., Lindahl, M., Paveliev, M. & Saarma, M., Jun 2008, In: The FEBS Journal. 275, p. 465-465 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• 2007

  Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

  Lindholm, P., Voutilainen, M., Lauren, J., Peränen, J., Leppänen, V.-M., Andressoo, J.-O., Lindahl, M., Janhunen, S., Kalkkinen, N., Timmusk, T., Tuominen, R. K. & Saarma, M., 2007, In: Nature. 448, 7147, p. 73-78 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2006

  Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor 4 impairs thyroid calcitonin production in young mice

  Lindfors, P. H., Lindahl, M., Rossi, J., Saarma, M., Airaksinen, M. S. & Airaksinen, M. S., 2006, In: Endocrinology. 147, 5, p. 2237-2244 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Neurotensin polyplex as an efficient carrier for delivering the human GDNF gene into nigral dopamine neurons of hemiparkinsonian rats

  Gonzalez-Barrios, J. A., Lindahl, M. S., Bannon , M. J., Anaya-Martinez, V., Flores, G., Navarro-Quiroga, I., Trudeau, L. E., Aceves, J., Martinez-Arguelles, D. B., Garcia-Villegas, R., Jimenez, I., Segovia, J. & Martinez-Fong, D., 2006, In: Gene Therapy & Molecular Biology. 14, p. 857-865 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2004

  Non-neuronal roles for GDNF and novel GDNF family receptors

  Lindahl, M. S., 2004

  Research output: Thesis › Doctoral Thesis › Monograph

• PSPN/GFRalpha4 has a significantly weaker capacity than GDNF/GFRalpha1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth.

  Yang, J., Lindahl, M. S., Lindholm, P. K., Virtanen, H., Coffey, E., Runeberg-Roos, P. & Saarma, M., 2004, In: FEBS Letters. 2004, 569, p. 267-271

  Research output: Contribution to journal › Article › Scientific › peer-review

• 2001

  Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells

  Lindahl, M., Poteryaev, D., Yu, L. Y., Arumae, U., Timmusk, T., Bongarzone, I., Aiello, A., Pierotti, M. A., Airaksinen, M. S. & Saarma, M., 2001, In: Journal of Biological Chemistry. 276, p. 9344-9351 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• 2000

  Expression and alternative splicing of mouse GFRA4 suggests roles in endocrine cell development

  Airaksinen, M. S., Lindahl, M., Timmusk, T., Rossi, J. & Saarma, M., 2000, In: Molecular and Cellular Neuroscience. 12, p. 328-328 1 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Regulation of cell fate decision of undifferentiated spermatogonia by GDNF

  Meng, X. J., Lindahl, M., Hyvönen, M. E., Parvinen, M., de Rooij, D. G., Hess, M. W., Raatikainen-Ahokas, A., Sainio, K., Rauvala, H., Lakso, M., Pichel, J. G., Westphal, H., Saarma, M. & Sariola, H., 2000, In: Science. 287, p. 1489-1493 5 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• 1999

  GDNF triggers a novel Ret-independent Src kinase family-coupled signaling via a GPI-linked GDNF receptor 1

  9. Poteryaev, D., Titievsky, A., Sun, Y.F, Thomas-Crusells, J., Lindahl, M., Billaud, M., Arumäe, U. and Saarma, M., 1999, In: FEBS Letters. 463, p. 63-66 3 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• 1997

  Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha

  Suvanto, P., Wartiovaara, K., Lindahl, M., Arumäe, U., Moshnyakov, M., Horelli-Kuitunen, N., Airaksinen, M., Palotie, A., Sariola, H. and Saarma, M, 1997, In: Human Molecular Genetics. 6, p. 1267-1279

  Research output: Contribution to journal › Article › Scientific › peer-review

• Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium

  Sainio, K., Suvanto, P., Davies, J., Wartiovaara, J., Wartiovaara, K., Saarma, M., Arumae, U., Meng, X. J., Lindahl, M., Pachnis, V. & Sariola, H., 1997, In: Development. 124, p. 4077-4087 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review