Photo of Marikki Laiho
  • Viikinkaari 5

    HELSINKI

    Finland

  • PL 56 (Viikinkaari 5)

    00014

    Finland

1985 …2020

Research output per year

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Publications

2020

Reply to: Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos

Hämäläinen, R. H., Landoni, J. C., Ahlqvist, K. J., Goffart, S., Ryytty, S., Rahman, M. O., Brilhante, V., Icay, K., Hautaniemi, S., Wang, L., Laiho, M. & Suomalainen, A., Aug 2020, In : Nature metabolism. 2, 8, p. 676-677 2 p.

Research output: Contribution to journalArticleScientificpeer-review

2019

Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias

Hämäläinen, R. H., Landoni, J. C., Ahlqvist, K. J., Goffart, S., Ryytty, S., Rahman, M. O., Brilhante, V., Icay, K., Hautaniemi, S., Wang, L., Laiho, M. & Suomalainen, A., Oct 2019, In : Nature metabolism. 1, 10, p. 958-+ 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Equity and diversity in academic medicine: a perspective from the JCI editors

Resar, L. M. S., Jaffee, E. M., Armanios, M., Jackson, S., Azad, N. S., Horton, M. R., Kaplan, M. J., Laiho, M., Maus, M. V., Sumner, C. J., Wheelan, S. J. & Wills-Karp, M., 1 Oct 2019, In : Journal of Clinical Investigation. 129, 10, p. 3974-3977 4 p.

Research output: Contribution to journalEditorialScientific

2018

Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint

Wei, T., Najmi, S. M., Liu, H., Peltonen, K., Kucerova, A., Schneider, D. A. & Laiho, M., 10 Apr 2018, In : Cell Reports. 23, 2, p. 404-414 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2017

Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A

Kara, B., Koroglu, C., Peltonen, K., Steinberg, R. C., Genc, H. M., Holtta-Vuori, M., Guven, A., Kanerva, K., Kotil, T., Solakoglu, S., Zhou, Y., Olkkonen, V. M., Ikonen, E., Laiho, M. & Tolun, A., Feb 2017, In : European Journal of Human Genetics. 25, 3, p. 315-323 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2016

Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication

Balistreri, G., Viiliainen, J., Turunen, M., Diaz, R., Lyly, L., Pekkonen, P., Rantala, J., Ojala, K., Sarek, G., Teesalu, M., Denisova, O., Peltonen, K., Julkunen, I., Varjosalo, M., Kainov, D., Kallioniemi, O., Laiho, M., Taipale, J., Hautaniemi, S. & Ojala, P. M., Feb 2016, In : PLoS Pathogens. 12, 2, 26 p., 1005424.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2014

A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity

Peltonen, K., Colis, L., Liu, H., Trivedi, R., Moubarek, M. S., Moore, H. M., Bai, B., Rudek, M. A., Bieberich, C. J. & Laiho, M., 13 Jan 2014, In : Cancer Cell. 25, 1, p. 77-90 14 p.

Research output: Contribution to journalArticleScientificpeer-review

A Tissue Graft Model of DNA Damage Response in the Normal and Malignant Human Prostate

af Hallstrom, T. M., Zhao, H., Tian, J., Rantanen, V., Reese, S. W., Nolley, R., Laiho, M. & Peehl, D. M., Mar 2014, In : Journal of Urology. 191, 3, p. 842-849 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Design, Synthesis, and Structure-Activity Relationships of Pyridoquinazolinecarboxamides as RNA Polymerase I Inhibitors

Colis, L., Ernst, G., Sanders, S., Liu, H., Sirajuddin, P., Peltonen, K., DePasquale, M., Barrow, J. C. & Laiho, M., 12 Jun 2014, In : Journal of Medicinal Chemistry. 57, 11, p. 4950-4961 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells

Laos, M., Anttonen, T., Kirjavainen, A., af Hallstrom, T., Laiho, M. & Pirvola, U., Jun 2014, In : Aging Clinical and Experimental Research. 6, 6, p. 496-510 15 p.

Research output: Contribution to journalArticleScientificpeer-review

DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response

Colis, L., Peltonen, K., Sirajuddin, P., Liu, H., Sanders, S., Ernst, G., Barrow, J. C. & Laiho, M., Jun 2014, In : Oncotarget. 5, 12, p. 4361-4369 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Small Molecule BMH-Compounds That Inhibit RNA Polymerase I and Cause Nucleolar Stress

Peltonen, K., Colis, L., Liu, H., Jaamaa, S., Zhang, Z., af Hallstrom, T., Moore, H. M., Sirajuddin, P. & Laiho, M., Nov 2014, In : Molecular Cancer Therapeutics. 13, 11, p. 2537-2546 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

CRM1 and its ribosome export adaptor NMD3 localize to the nucleolus and affect rRNA synthesis

Bai, B., Moore, H. M. & Laiho, M., 2013, In : Nucleus. 4, 4, p. 315-325 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Proteasome Activity Influences UV-Mediated Subnuclear Localization Changes of NPM

Moore, H. M., Bai, B., Matilainen, O., Colis, L., Peltonen, K. & Laiho, M., 12 Mar 2013, In : PLoS One. 8, 3, p. Article Number: e59096 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

PSA forms complexes with alpha(1)-antichymotrypsin in prostate

Zhu, L., Jäämaa, S. S., af Hällström, T. M., Laiho, M., Sankila, A., Nordling, F. S. A., Stenman, U. H. & Koistinen, H., 1 Jan 2013, In : Prostate. 73, 2, p. 219-226 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Contrasting DNA damage checkpoint responses in epithelium of the human seminal vesicle and prostate

Jäämaa, S. S., Sankila, A. M., Rantanen, V., Peltonen, K. D., Järvinen, P., af Hällström, T. M., Ruutu, M. L., Taari, K., Andersson, L. C. & Laiho, M., 2012, In : Prostate. 72, 10, p. 1060-1070 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Cysteine-rich protein 1 is regulated by transforming growth factor-ss 1 and expressed in lung fibrosis

Jarvinen, P. M., Myllärniemi, L. M., Liu, H., Moore, H. M., Lepparanta, O., Salmenkivi, K., Koli, K., Latonen, L., Band, A. M. & Laiho, M., 2012, In : Journal of Cellular Physiology. 227, 6, p. 2605-2612 8 p.

Research output: Contribution to journalArticleScientificpeer-review

LIM-domain proteins in transforming growth factor beta-induced epithelial-to-mesenchymal transition and myofibroblast differentiation

Järvinen, P. & Laiho, M., Apr 2012, In : Cellular Signalling. 24, 4, p. 819-825 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

LIM-domain proteins in transforming growth factor β-induced epithelial-to-mesenchymal transition and myofibroblast differentiation

Järvinen, P. & Laiho, M., 2012, In : Cellular Signalling. 24, 4, p. 819-825 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Maintenance of genomic integrity after DNA double strand breaks in the human prostate and seminal vesicle epithelium: The best and the worst

Jäämaa, S. S. & Laiho, M., 1 Oct 2012, In : Molecular oncology. 6, 5, p. 473-483 11 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

SnoN oncoprotein enhances estrogen receptor-alpha transcriptional activity

Band, A. M. & Laiho, M., 2012, In : Cellular Signalling. 24, 4, p. 922-930 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Crosstalk of TGF-beta and Estrogen Receptor Signaling in Breast Cancer

Band, A. M. & Laiho, M., 2011, In : Journal of Mammary Gland Biology and Neoplasia. 16, 2, p. 109-115 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Differential epithelium DNA damage response to ATM and DNA-PK pathway inhibition in human prostate tissue culture

Zhang, Z., Yang, Z., Jäämaa, S. S., Liu, H., Pellakuru, L. G., Iwata, T., af Hällström, T. M., De Marzo, A. M. & Laiho, M., 2011, In : Cell Cycle. 10, 20, p. 3545-3553 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecular Determinants of Radiation Response

DeWeese, T. L. & Laiho, M., 2011, 1 ed. Springer. 350 p.

Research output: Book/ReportAnthology or special issueScientificpeer-review

Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts

Ni, X., Zhang, Y., Ribas, J., Chowdhury, W. H., Castanares, M., Zhang, Z., Laiho, M., DeWeese, T. L. & Lupold, S. E., 2011, In : Journal of Clinical Investigation. 121, p. 2383-2390 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability

Latonen, L., Moore, H. M., Bai, B., Jaamaa, S. & Laiho, M., 2011, In : Oncogene. 30, p. 790-805 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Quantitative Proteomics and Dynamic Imaging of the Nucleolus Reveal Distinct Responses to UV and Ionizing Radiation

Moore, H. M., Bai, B., Boisvert, F-M., Latonen, L., Rantanen, V., Simpson, J. C., Pepperkok, R., Lamond, A. I. & Laiho, M., 2011, In : Molecular & Cellular Proteomics. 10, 10, p. - 15 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction

Sulg, M., Kirjavainen, A., Pajusola, K., Bueler, H., Ylikoski, J., Laiho, M. & Pirvola, U., 2010, In : Journal of Neurochemistry. 112, 6, p. 1513-1526 14 p.

Research output: Contribution to journalArticleScientificpeer-review

DNA Damage Recognition via Activated ATM and p53 Pathway in Nonproliferating Human Prostate Tissue

Jäämaa, S. S., af Hällström, T. M., Sankila, A., Rantanen, V., Koistinen, H., Stenman, U. H., Zhang, Z., Yang, Z., De Marzo, A. M., Taari, K., Ruutu, M., Andersson, L. C. & Laiho, M., 2010, In : Cancer Research. 70, 21, p. 8630-8641 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of Novel p53 Pathway Activating Small-Molecule Compounds Reveals Unexpected Similarities with Known Therapeutic Agents

Peltonen, K., Colis, L., Liu, H., Jaamaa, S., Moore, H. M., Enback, J., Laakkonen, P., Vaahtokari, A., Jones, R. J., af Hallstrom, T. M. & Laiho, M., 2010, In : PLoS One. 5, 9, p. Article Number: e12996 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways

Bjorklund, M. A., Vaahtomeri, K., Peltonen, K., Viollet, B., Makela, T. P., Band, A. M. & Laiho, M., 2010, In : Experimental Cell Research. 316, 5, p. 762-774 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency

Sarek, G., Järviluoma, A., Moore, H. M., Tojkander, S., Vartia, S., Biberfeld, P., Laiho, M. & Ojala, P. M., 2010, In : PLoS Pathogens. 6, 3, p. Article Number: e1000818 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes

Latonen, L., Järvinen, P., Suomela, S., Moore, H. M., Saarialho-Kere, U. & Laiho, M., 2010, In : Photodermatology, Photoimmunology & Photomedicine. 26, p. 70-77 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Uusi kudosleikemalli paljasti eroja eturauhassolujen perimän vauriontunnistuksessa

Jäämaa, S. S., af Hällström, T. M., Sankila, A. M., Rantanen, V., Koistinen, H. K., Stenman, U. H., Zhang, Z., Yang, Z., De Marzo, A. M., Taari, K., Ruutu, M. L., Andersson, L. C. & Laiho, M., 2010, In : Duodecim. 126, 21, p. 2529–30 2 p.

Research output: Contribution to journalArticleProfessional

2009

The phosphatidylinositol 3-kinase/Akt pathway regulates transforming growth factor-{beta} signaling by destabilizing ski and inducing Smad7.

Band, A., Björklund, M. & Laiho, M., 2009, In : Journal of Biological Chemistry. 2009, 284, p. 35441-35449 9 p.

Research output: Contribution to journalArticleScientificpeer-review

The Phosphatidylinositol 3-Kinase/Akt Pathway Regulates Transforming Growth Factor-beta Signaling by Destabilizing Ski and Inducing Smad7

Band, A. M., Bjorklund, M. & Laiho, M., 2009, In : Journal of Biological Chemistry. 284, p. 35441-35449 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Cytoskeleton-interacting LIM-domain protein CRP1 suppresses cell proliferation and protects from stress-induced cell death

Latonen, L., Järvinen, P. M. & Laiho, M., 2008, In : Experimental Cell Research. 314, 4, p. 738-747 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic changes and DNA damage responses in the prostate

Kiviharju-af Hällström, T. M. & Laiho, M., 2008, In : Prostate. 68, 8, p. 902-918 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Proteasome in the control of TGF-ß signaling during development and cancer

Band, A. & Laiho, M., 2008, Transforming Growth Factor-Beta in Cancer Therapy, Volume I. Jakowlew, S. B. (ed.). Humana press, p. 243-257

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

Välkettä syvyyksistä: kemian Nobelin palkinto vihreän fluorisoivan proteiinin keksijöille

Syrjäkari, H. & Laiho, M., 2008, In : Duodecim. 124, 22, p. 2599-22601 20003 p.

Research output: Contribution to journalArticleScientific

Välkettä syvyyksistä - kemian Nobelin palkinto vihreän fluoresoivan proteiinin keksijöille

Moore, H. M. & Laiho, M., 2008, Duodecim. Duodecim

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

2007

Eturauhassyöpäalttiuden taustalla DNA-vauriovasteen puuttuminen: [Proc Natl Acad Sci USA in press]

Kiviharju-af Hällström, T. M., Jäämaa, S., Mönkkönen, M., Peltonen, K., Andersson, L. C., Medema, R. H., Peehl, D. M. & Laiho, M., 2007, In : Duodecim. 123, 9, p. 1019-1020 2 p.

Research output: Contribution to journalArticleScientific

Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement

Kiviharju-af Hällström, T. M., Jäämaa, S., Mönkkönen, M., Peltonen, K., Andersson, L. C., Medema, R. H., Peehl, D. M. & Laiho, M., 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 17, p. 7211-7216 6 p.

Research output: Contribution to journalArticleScientificpeer-review

p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis

Laine, H., Doetzlhofer, A., Mantela, J., Ylikoski, J., Laiho, M., Roussel, M. F., Segil, N. & Pirvola, U., 2007, In : Journal of Neuroscience. 27, 6, p. 1434-1444 11 p.

Research output: Contribution to journalArticleScientificpeer-review

p19[sup Ink4d] and p21[sup Cip1] collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis

Laine, H., Doetzlhofer, A., Mantela, J., Ylikoski, J., Laiho, M., Roussel, M. F., Segil, N. & Pirvola, U., 2007, In : Journal of Neuroscience. 27, 6, p. 1434-1444 11 p.

Research output: Contribution to journalArticleScientificpeer-review

p53-kasvurajoitereitin aktivaatio - uusi mahdollisuus virusperäisen lymfooman hoitoon: [J Clin Invest in press]

Sarek, G., Kurki, S., Enbäck, J., Iotzova, G., Haas, J., Laakkonen, P. M., Laiho, M. & Ojala, P. M., 2007, In : Duodecim. 123, 8, p. 869-870 2 p.

Research output: Contribution to journalArticleScientific

Perimän vauriot, vanheneminen ja syöpä - erottamaton kolmikko: [pääkirjoitus]

Laiho, M. & Saksela, E., 2007, In : Duodecim. 123, 13, p. 1535-1536 2 p.

Research output: Contribution to journalArticleScientific

Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas

Sarek, G., Kurki, S., Enbäck, J., Iotzova, G., Haas, J., Laakkonen, P. M., Laiho, M. & Ojala, P., 2007, In : Journal of Clinical Investigation. 117, 4, p. 1019-1028 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis

Koopal, S., Furuhjelm, J., Järviluoma, A., Jäämaa, S., Pyakurel, P., Pussinen, C. E., Wirzenius, M., Biberfeld, P., Alitalo, K., Laiho, M. & Ojala, P., 2007, In : PLoS Pathogens. 3, 9, p. 1348-1360 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Cellular UV damage responses: functions of tumor suppressor p53

Latonen, L. & Laiho, M., 2005, In : Biochimica et Biophysica Acta. Reviews on Cancer. 1775, 2, p. 71-89 19 p.

Research output: Contribution to journalArticleScientificpeer-review