• PL 56 (Viikinkaari 5)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

19972018
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Publications 1997 2018

2018

FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

Minh Binh Nguyen, Cohen, I., Kumar, V., Xu, Z., Bar, C., Dauber-Decker, K. L., Tsai, P-C., Marangoni, P., Klein, O. D., Hsu, Y-C., Chen, T., Mikkola, M. L. & Ezhkova, E., 13 Jun 2018, In : Nature Communications. 9, 10 p., 2333.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation

Biggs, L. C., Mäkelä, O. J. M., Myllymäki, S-M., Das Roy, R., Närhi, K., Pispa, J., Mustonen, T. & Mikkola, M. L., 31 Jul 2018, In : eLife. 7, 33 p., 36468.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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In Utero Protein Therapy for an Inherited Developmental Disorder

Mikkola, M. L., 26 Apr 2018, In : New England Journal of Medicine. 378, 17, p. 1637-1638 2 p.

Research output: Contribution to journalEditorialScientific

2017

Anti-EDAR Agonist Antibody Therapy Resolves Palate Defects in Pax9 -/- Mice

Jia, S., Zhou, J., Wee, Y., Mikkola, M. L., Schneider, P. & D'Souza, R. N., Oct 2017, In : Journal of Dental Research. 96, 11, p. 1282-1289 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Ectodysplasin A in Biological Fluids and Diagnosis of Ectodermal Dysplasia

Podzus, J., Kowalczyk-Quintas, C., Schuepbach-Mallepell, S., Willen, L., Staehlin, G., Vigolo, M., Tardivel, A., Headon, D., Kirby, N., Mikkola, M., Schneider, H. & Schneider, P., Feb 2017, In : Journal of Dental Research. 96, 2, p. 217-224 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty

Elo, T., Lindfors, P. H., Lan, Q., Voutilainen, M., Trela, E., Ohlsson, C., Huh, S-H., Ornitz, D. M., Poutanen, M., Howard, B. A. & Mikkola, M. L., 11 Jul 2017, In : Scientific Reports. 7, 13 p., 5049.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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New insights into fetal mammary gland morphogenesis: differential effects of natural and environmental estrogens

Speroni, L., Voutilainen, M., Mikkola, M. L., Klager, S. A., Schaeberle, C. M., Sonnenschein, C. & Soto, A. M., 19 Jan 2017, In : Scientific Reports. 7, 7 p., 40806.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Early epithelial signaling center governs tooth budding morphogenesis

Ahtiainen, L., Uski, I., Thesleff, I. & Mikkola, M. L., 12 Sep 2016, In : Journal of Cell Biology. 214, 6, p. 753-767 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation

Shirokova, V., Biggs, L. C., Jussila, M., Ohyama, T., Groves, A. K. & Mikkola, M. L., Jul 2016, In : Stem Cells. 34, 7, p. 1896-1908 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2015

Ectodysplasin/NF-kappa B Promotes Mammary Cell Fate via Wnt/beta-catenin Pathway

Voutilainen, M., Lindfors, P., Trela, E., Lönnblad, D., Shirokova, V., Elo, T., Rysti, E., Schmidt-Ullrich, R., Schneider, P. & Mikkola, M. L., Nov 2015, In : PLoS Genetics. 11, 11, 26 p., 1005676.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Hairless Streaks in Cattle Implicate TSR2 in Early Hair Follicle Formation

Murgiano, L., Shirokova, V., Welle, M. M., Jagannathan, V., Plattet, P., Oevermann, A., Pienkowska-Schelling, A., Gallo, D., Gentile, A., Mikkola, M. & Drögemüller, C., Jul 2015, In : PLoS Genetics. 11, 7, 22 p., 1005427.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning

Jussila, M., Aalto, A. J., Sanz Navarro, M., Shirokova, V., Balic, A., Kallonen, A., Ohyama, T., Groves, A. K., Mikkola, M. L. & Thesleff, I., 15 Nov 2015, In : Development. 142, 22, p. 3954-3963 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Development of ectodermal organs

Thesleff, I. & Mikkola, M. L., 2014, In : Seminars in Cell and Developmental Biology. 25-26, p. 1-2 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Directional Cell Migration, but Not Proliferation, Drives Hair Placode Morphogenesis

Ahtiainen, L., Lefebvre, S., Lindfors, P. H., Renvoise, E., Shirokova, V., Vartiainen, M. K., Thesleff, I. & Mikkola, M. L., 10 Mar 2014, In : Developmental Cell. 28, 5, p. 588-602 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Early inductive events in ectodermal appendage morphogenesis

Biggs, L. C. & Mikkola, M. L., 2014, In : Seminars in Cell and Developmental Biology. 25-26, p. 11-21 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Ectodysplasin research-Where to next?

Lefebvre, S. & Mikkola, M. L., Jun 2014, In : Seminars in immunology. 26, 3, p. 220-228 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Replaying evolutionary transitions from the dental fossil record

Harjunmaa, E., Seidel, K., Hakkinen, T., Renvoise, E., Corfe, I. J., Kallonen, A., Zhang, Z-Q., Evans, A. R., Mikkola, M. L., Salazar Ciudad, I., Klein, O. D. & Jernvall, J., 7 Aug 2014, In : Nature. 512, 7512, p. 44- 16 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Ectodysplasin/NF-κB signaling in embryonic mammary gland development

Lindfors, P., Voutilainen, M. & Mikkola, M., 2013, In : Journal of Mammary Gland Biology and Neoplasia. 18, 2, p. 165-169 5 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes

Shirokova, V., Jussila, M., Hytönen, M. K., Perälä, N., Droegemueller, C., Leeb, T., Lohi, H., Sainio, K., Thesleff, I. & Mikkola, M. L., Jun 2013, In : Developmental Dynamics. 242, 6, p. 593-603 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles

Huh, S-H., Närhi, K., Lindfors, P., Häärä, O., Yang, L., Ornitz, D. M. & Mikkola, M. L., 2013, In : Genes & Development. 27, 4, p. 450-458 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Protocol: Ex Vivo Culture of Mouse Embryonic Mammary Buds

Voutilainen, M., Lindfors, P. & Mikkola, M. L., Jun 2013, In : Journal of Mammary Gland Biology and Neoplasia. 18, 2, p. 239-245 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling

Häärä, O., Harjunmaa, E., Lindfors (o.s. Hiltunen), P., Huh, S-H., Fliniaux, I. J. J., Åberg, T., Jernvall, J., Ornitz, D. M., Mikkola, M. & Thesleff, I., 25 Jul 2012, In : Development. 139, 17, p. 3189-3199 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-κB

Voutilainen, M., Lindfors, P., Lefebvre, S., Ahtiainen, L., Fliniaux, I., Rysti, E., Murtoniemi, M., Schneider, P., Schmidt-Ullrich, R. & Mikkola, M. L., 10 Apr 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 15, p. 5744-5749 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development

Lefebvre, S., Fliniaux, I., Schneider, P. & Mikkola, M. L., Apr 2012, In : Journal of Investigative Dermatology. 132, 4, p. 1094-1102 9 p.

Research output: Contribution to journalArticleScientificpeer-review

On the difficulty of increasing dental complexity

Harjunmaa, E., Kallonen, A., Voutilainen, M., Hämäläinen, K., Mikkola, M. L. & Jernvall, J., 2012, In : Nature. 483, 7389, p. 324-328 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Sostdc1 defines the size and number of skin appendage placodes

Närhi, K., Tummers, M., Ahtiainen, L., Itoh, N., Thesleff, I. & Mikkola, M. L., 15 Apr 2012, In : Developmental Biology. 364, 2, p. 149-161 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis

Häärä, O., Fujimori, S., Schmidt-Ullrich, R., Hartmann, C., Thesleff, I. & Mikkola, M. L., 2011, In : Child Development. 138, 13, p. 2681-2691 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Inactivation of IL11 Signaling Causes Craniosynostosis, Delayed Tooth Eruption, and Supernumerary Teeth

Nieminen, P. T., Morgan, N. V., Fenwick, A. L., Parmanen, S., Veistinen, L., Mikkola, M. L., van der Spek, P. J., Giraud, A., Judd, L., Arte, S., Brueton, L. A., Wall, S. A., Mathijssen, I. M. J., Maher, E. R., Wilkie, A. O. M., Kreiborg, S. & Thesleff, I., 2011, In : American Journal of Human Genetics. 89, p. 67-81 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

Lippens, S., Lefebvre, S., Gilbert, S., Sze, M., Devos, M., Verhelst, K., Vereecke, L., Guire, CM., Guérin, C., Vandenabeele, P., Paspariks, M., Mikkola, M., Beyaert, R., Declercq, W. & van Loo, G., 2011, In : Cell Death and Differentiation. 18, p. 1845-1853 9 p.

Research output: Contribution to journalArticleScientificpeer-review

TAp63 Is Important for Cardiac Differentiation of Embryonic Stem Cells and Heart Development

Rouleau, M., Medawar, A., Hamon, L., Shivtiel, S., Wolchinsky, Z., Zhou, H., De Rosa, L., Candi, E., de la Forest Divonne, S., Mikkola, M. L., van Bokhoven, H., Missero, C., Melino, G., Puceat, M. & Aberdam, D., 2011, In : International Journal of Stem Cells . 29, 11, p. 1672-1683 12 p.

Research output: Contribution to journalArticleScientificpeer-review

The Edar Subfamily in Hair and Exocrine Gland Development

Mikkola, M. L., 2011, Advances in tnf family research. Wallach, D., Kovalenko, A. & Feldmann, M. (eds.). Berlin: Springer-Verlag, p. 23-33 11 p. (Advances in Experimental Medicine and Biology; vol. 691).

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

2010

Role of Sostdc1 in hair follicle and mammary gland development

Närhi, K. M., Tummers, M., Thesleff, I. & Mikkola, M. L., 2010, In : Journal of investigative dermatology symposium proceedings.. 130, p. S107-S107 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

Treasure or artifact: a decade of p63 research speaks for itself

Mikkola, M. L., Costanzo, A., Thesleff, I., Roop, D. R. & Koster, M. I., 2010, In : Cell Death and Differentiation. 17, 1, p. 180-183 4 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Biological activity of ectodysplasin A is conditioned by Its collagen and heparan sulfate proteoglycan-binding domains

Swee, L. K., Ingold-Salamin, K., Tardivel, A., Willen, L., Gaide, O., Favre, M., Demotz, S., Mikkola, M. & Schneider, P., 2009, In : Journal of Biological Chemistry. 284, 40, p. 27567-27576 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Classifying ectodermal dysplasias: incorporating the molecular basis and pathways (workshop II)

Wright, T. J., Morris, C., Clements, S. E., D'Souza, R., Gaide, O., Mikkola, M. L. & Zonana, J., 2009, In : American Journal of Medical Genetics. Part A. 149A, 9, p. 2062-2067 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Controlling the number of tooth rows

Mikkola, M. L., 2009, In : Science signaling. 2, 85, p. pe53 5 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Molecular aspects of hypohidrotic ectodermal dysplasia

Mikkola, M. L., 2009, In : American Journal of Medical Genetics. Part A. 149A, 9, p. 2031-2036 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Reciprocal requirements for EDA/EDAR/NF-B and Wnt/ß-catenin signaling pthways in hair follicle induction

Zhang, Y., Tomann, P., Andl, T., Gallant, N. M., Huelsken, J., Jerchow, B., Birchmeier, W., Paus, R., Piccolo, S., Mikkola, M. L., Morrisey, E. E., Overbeek, P. A., Scheidereit, C., Millar, S. E. & Schmidt-Ullrich, R., 2009, In : Developmental Cell. 17, 1, p. 49-61 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Reciprocal Requirements for EDA/EDAR/NF-kappa B and Wnt/beta-Catenin Signaling Pathways in Hair Follicle Induction

Zhang, Y., Tomann, P., Andl, T., Gallant, N. M., Huelsken, J., Jerchow, B., Birchmeier, W., Paus, R., Piccolo, S., Mikkola, M. L., Morrisey, E. E., Overbeek, P. A., Scheidereit, C., Millar, S. E. & Schmidt-Ullrich, R., 21 Jul 2009, In : Developmental Cell. 17, 1, p. 49-61 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development

Pispa, J., Pummila, M., Barker, P. A., Thesleff, I. & Mikkola, M. L., 2008, In : Human Molecular Genetics. 17, 21, p. 3380-3391 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes

Fliniaux, I., Mikkola, M. L., Lefebvre, S. & Thesleff, I., 2008, In : Developmental Biology. 320, 1, p. 60-71 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation

Narhi, K., Järvinen, E., Birchmeier, W., Taketo, M. M., Mikkola, M. L. & Thesleff, I., 15 Mar 2008, In : Development. 135, 6, p. 1019-1028 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Sustained epithelial ß-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation

Närhi, K., Järvinen, E., Birchmeier, W., Taketo, M. M., Mikkola, M. L. & Thesleff, I., 2008, In : Development. 135, 6, p. 1019-1028 10 p.

Research output: Contribution to journalArticleScientificpeer-review

TNF superfamily in skin appendage development

Mikkola, M. L., 2008, In : Cytokine & Growth Factor Reviews. 19, 3-4, p. 219-230 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2007

Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression

Pummila, M., Fliniaux, I., Jaatinen, R., James, M. J., Laurikkala, J., Schneider, P., Thesleff, I. & Mikkola, M. L., 2007, In : Development. 134, p. 117-125 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic basis of skin appendage development

Mikkola, M. L., 2007, In : Seminars in Cell and Developmental Biology. 18, p. 225-236 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

p63 in skin appendage development

Mikkola, M. L., 2007, In : Cell Cycle. 6, 3, p. 285-290 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2006

p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation

Laurikkala, J., Mikkola, M. L., James, M., Tummers, M., Mills, A. A. & Thesleff, I., 2006, In : Development. 133, p. 1553-1563 11 p.

Research output: Contribution to journalArticleScientificpeer-review

The mammary bud as a skin appendage: unique and shared aspects of development

Mikkola, M. L. & Millar, S. E., 2006, In : Journal of Mammary Gland Biology and Neoplasia. 11, p. 187-203 17 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2002

Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar.

Laurikkala, J., Pispa, J. M., Jung, H. S., Nieminen, P. T., Mikkola, M., Wang, X-P., Saarialho-Kere, U., Galceran, J., Grosschedl, R. & Thesleff, I., 2002, In : Development. 129, p. 2541-2553 13 p.

Research output: Contribution to journalArticleScientificpeer-review