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Markku Varjosalo

Program Director

  • PL 65 (Viikinkaari 1)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

Accepting PhD Students

20062019
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Publications 2006 2019

  • 70 Article
  • 3 Review Article
  • 2 Doctoral Thesis
  • 1 Meeting Abstract
2019

Anagrelide for Gastrointestinal Stromal Tumor

Pulkka, O-P., Gebreyohannes, Y. K., Wozniak, A., Mpindi, J-P., Tynninen, O., Icay, K., Cervera, A., Keskitalo, S., Murumägi, A., Kulesskiy, E., Laaksonen, M., Wennerberg, K., Varjosalo, M., Laakkonen, P., Lehtonen, R., Hautaniemi, S., Kallioniemi, O., Schöffski, P., Sihto, H. & Joensuu, H., 1 Mar 2019, In : Clinical Cancer Research. 25, 5, p. 1676-1687 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease

Keskitalo, S., Haapaniemi, E. M., Glumoff, V., Liu, X., Lehtinen, V., Fogarty, C., Rajala, H., Chiang, S. C., Mustjoki, S., Kovanen, P., Lohi, J., Bryceson, Y. T., Seppänen, M., Kere, J., Heiskanen, K. & Varjosalo, M., 27 Jul 2019, In : Npj genomic medicine. 4, 1

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases

Anwar, T., Liu, X., Suntio, T., Marjamäki, A., Biazik, J., Chan, E. Y. W., Varjosalo, M. & Eskelinen, E-L., 17 May 2019, In : Cells. 8, 5, 24 p., 475.

Research output: Contribution to journalArticleScientificpeer-review

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Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing

Viita, T., Kyheroinen, S., Prajapati, B., Virtanen, J., Frilander, M. J., Varjosalo, M. & Vartiainen, M. K., Apr 2019, In : Journal of Cell Science. 132, 8, 16 p., 226852.

Research output: Contribution to journalArticleScientificpeer-review

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Pool-seq driven proteogenomic database for Group G Streptococcus

Weldatsadik, R. G., Datta, N., Kolmeder, C., Vuopio, J., Kere, J., Wilkman, S. V., Flatt, J. W., Vuento, R., Haapasalo, K. J., Keskitalo, S., Varjosalo, M. & Jokiranta, T. S., 15 Jun 2019, In : Journal of Proteomics. 201, p. 84-92 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival

Cortes, E., Lachowski, D., Robinson, B., Sarper, M., Teppo, J. S., Thorpe, S. D., Lieberthal, T. J., Iwamoto, K., Lee, D. A., Okada‐Hatakeyama, M., Varjosalo, M. T. & del Río Hernández, A. E., 2019, In : EMBO Reports. 20, 1, 22 p., e46557.

Research output: Contribution to journalArticleScientificpeer-review

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The human long non-coding RNA gene RMRP has pleiotropic effects and regulates cell-cycle progression at G2

Vakkilainen, S., Skoog, T., Einarsdottir, E., Middleton, A., Pekkinen, M., Öhman, T., Katayama, S., Krjutškov, K., Kovanen, P. E., Varjosalo, M., Lindqvist, A., Kere, J. & Mäkitie, O., 24 Sep 2019, In : Scientific Reports. 9, 1

Research output: Contribution to journalArticleScientificpeer-review

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2018

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations

Liu, X., Salokas, K., Tamene, F., Jiu, Y., Weldatsadik, R. G., öhman, T. & Varjosalo, M., 22 Mar 2018, In : Nature Communications. 9, 16 p., 1188.

Research output: Contribution to journalArticleScientificpeer-review

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Biallelic mutations in human NHLRC2 enhance myofibroblast differentiation in FINCA disease

Paakkola, T., Salokas, K., Miinalainen, I., Lehtonen, S., Manninen, A., Kaakinen, M., Ruddock, L. W., Varjosalo, M., Kaarteenaho, R., Uusimaa, J. & Hinttala, R., 15 Dec 2018, In : Human Molecular Genetics. 27, 24, p. 4288-4302 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Combined transcriptomics, proteomics and metabolomics analysis identifies metabolic pathways associated with the loss of cardiac regeneration

Talman, V., Teppo, J., Poho, P., Movahedi, P., Vaikkinen, A., Pahikkala, T., Kotiaho, T., Kostiainen, R., Varjosalo, M. & Ruskoaho, H., Apr 2018, In : Cardiovascular Research. 114, p. S22-S23 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

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Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer

Kondelin, J., Salokas, K., Saarinen, L., Ovaska, K., Rauanheimo, H., Plaketti, R-M., Hamberg, J., Liu, X., Yadav, L., Gylfe, A. E., Cajuso, T., Hänninen, U. A., Palin, K., Ristolainen, H., Katainen, R., Kaasinen, E., Tanskanen, T., Aavikko, M., Taipale, M., Taipale, J. & 17 othersRenkonen-Sinisalo, L., Lepistö, A., Koskensalo, S., Böhm, J., Mecklin, J-P., Ongen, H., Dermitzakis, E. T., Kilpivaara, O., Vahteristo, P., Turunen, M., Hautaniemi, S., Tuupanen, S., Karhu, A., Välimäki, N., Varjosalo, M., Pitkänen, E. & Aaltonen, L. A., 2018, In : EMBO molecular medicine. 10, 9, 20 p., e8552.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Haploinsufficiency of A20 impairs protein–protein interactome and leads into caspase-8-dependent enhancement of NLRP3 inflammasome activation

Rajamäki, K., Keskitalo, S., Seppänen, M., Kuismin, O., Vähäsalo, P., Trotta, L., Väänänen, A., Glumoff, V., Keskitalo, P., Kaarteenaho, R., Jartti, A., Hautala, N., Jackson, P., Nordström, D. C., Saarela, J., Hautala, T., Eklund, K. K. & Varjosalo, M., 1 Oct 2018, In : RMD open. 4, 2, e000740.

Research output: Contribution to journalArticleScientificpeer-review

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Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells - A possible sign of endogenous neuroprotection failure

Smedowski, A., Liu, X., Podracka, L., Akhtar, S., Trzeciecka, A., Pietrucha-Dutczak, M., Lewin-Kowalik, J., Urtti, A., Ruponen, M., Kaarniranta, K., Varjosalo, M. & Amadio, M., Jan 2018, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1864, 1, p. 296-306 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecular Atlas of Postnatal Mouse Heart Development

Talman, V., Teppo, J. S., Pöhö, P. A., Movahedi, P., Vaikkinen, A., Karhu, S. T., Trošt, K., Suvitaival, T., Heikkonen, J., Pahikkala, T., Kotiaho, A. A. T., Kostiainen, R. K., Varjosalo, M. T. & Ruskoaho, H. J., 16 Oct 2018, In : Journal of the American Heart Association. 7, 20, 46 p., 010378.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Myosin-18B Promotes the Assembly of Myosin II Stacks for Maturation of Contractile Actomyosin Bundles

Jiu, Y., Kumari, R., Fenix, A. M., Schaible, N., Liu, X., Varjosalo, M., Krishnan, R., Burnette, D. T. & Lappalainen, P., 20 Dec 2018, In : Current Biology. 29, 1, p. 81-92 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants

Korpela, K., Salonen, A., Vepsäläinen, O., Suomalainen, M., Kolmeder, C., Varjosalo, M., Miettinen, S., Kukkonen, K., Savilahti, E., Kuitunen, M. & de Vos, W. M., 16 Oct 2018, In : Microbiome. 6, 11 p., 182.

Research output: Contribution to journalArticleScientificpeer-review

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Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone

Konovalova, S., Liu, X., Manjunath, P., Baral, S., Neupane, N., Hilander, T., Yang, Y., Balboa, D., Terzioglu, M., Euro, L., Varjosalo, M. & Tyynismaa, H., Oct 2018, In : Redox biology. 19, p. 37-45 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Systems pathology analysis identifies neurodegenerative nature of age-related vitreoretinal interface diseases

Öhman, T., Tamene, F., Göös, H., Loukovaara, S. & Varjosalo, M., Oct 2018, In : Aging Cell. 17, 5, 16 p., 12809.

Research output: Contribution to journalArticleScientificpeer-review

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2017

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping

Lempiäinen, J. K., Niskanen, E. A., Vuoti, K-M., Lampinen, R. E., Göös, H., Varjosalo, M. & Palvimo, J. J., Aug 2017, In : Molecular & Cellular Proteomics. 16, 8, p. 1462-1474 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

Saarimaki-Vire, J., Balboa, D., Russell, M. A., Saarikettu, J., Kinnunen, M., Keskitalo, S., Malhi, A., Valensisi, C., Andrus, C., Eurola, S., Grym, H., Ustinov, J., Wartiovaara, K., Hawkins, R. D., Silvennoinen, O., Varjosalo, M., Morgan, N. G. & Otonkoski, T., 11 Apr 2017, In : Cell Reports. 19, 2, p. 281-294 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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A proteomics view on integrin-mediated adhesions

Manninen, A. & Varjosalo, M., Feb 2017, In : Proteomics (Weinheim). 17, 3-4, 16 p., 1600022.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access

Candidate proteins from predegenerated nerve exert time-specific protection of retinal ganglion cells in glaucoma

Pietrucha-Dutczak, M., Smedowski, A., Liu, X., Matuszek, I., Varjosalo, M. & Lewin-Kowalik, J., 6 Nov 2017, In : Scientific Reports. 7, 14 p., 14540.

Research output: Contribution to journalArticleScientificpeer-review

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Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes

Kaustio, M., Haapaniemi, E., Göös, H., Hautala, T., Park, G., Syrjänen, J., Einarsdottir, E., Sahu, B., Kilpinen, S., Rounioja, S., Fogarty, C. L., Glumoff, V., Kulmala, P., Katayama, S., Tamene, F., Trotta, L., Morgunova, E., Krjutskov, K., Nurmi, K., Eklund, K. & 9 othersLagerstedt, A., Helminen, M., Martelius, T., Mustjoki, S., Taipale, J., Saarela, J., Kere, J., Varjosalo, M. & Seppanen, M., Sep 2017, In : Journal of Allergy and Clinical Immunology. 140, 3, p. 782-796 15 p.

Research output: Contribution to journalArticleScientificpeer-review

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PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression

Liu, Y., Mattila, J., Ventela, S., Yadav, L., Zhang, W., Lamichane, N., Sundstrom, J., Kauko, O., Grenman, R., Varjosalo, M., Westermarck, J. & Hietakangas, V., 23 Oct 2017, In : Developmental Cell. 43, 2, p. 240-+ 18 p.

Research output: Contribution to journalArticleScientificpeer-review

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Several Hfq-dependent alterations in physiology of Yersinia enterocolitica O: 3 are mediated by derepression of the transcriptional regulator RovM

Leskinen, K., Pajunen, M. I., Varjosalo, M., Fernandez-Carrasco, H., Bengoechea, J. A. & Skurnik, M., Mar 2017, In : Molecular Microbiology. 103, 6, p. 1065-1091 27 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry

Heikkinen, T., Kämpjärvi, K., Keskitalo, S., von Nandelstadh, P., Liu, X., Rantanen, V., Pitkänen, E., Kinnunen, M., Kuusanmäki, H., Kontro, M., Turunen, M., Mäkinen, N., Taipale, J., Heckman, C., Lehti, K., Mustjoki, S., Varjosalo, M. & Vahteristo, P., Mar 2017, In : Human Mutation. 38, 3, p. 269-274 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics

Yadav, L., Tamene, F., Goos, H., van Drogen, A., Katainen, R., Aebersold, R., Gstaiger, M. & Varjosalo, M., 26 Apr 2017, In : Cell Systems. 4, 4, p. 430-+ 20 p.

Research output: Contribution to journalArticleScientificpeer-review

Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis

Tommiska, J., Känsäkoski, J., Skibsbye, L., Vaaralahti, K., Liu, X., Lodge, E. J., Tang, C., Yuan, L., Fagerholm, R., Kanters, J. K., Lahermo, P., Kaunisto, M., Keski-Filppula, R., Vuoristo, S., Pulli, K., Ebeling, T., Valanne, L., Sankila, E-M., Kivirikko, S., Lääperi, M. & 15 othersCasoni, F., Giacobini, P., Phan-Hug, F., Buki, T., Tena-Sempere, M., Pitteloud, N., Veijola, R., Lipsanen-Nyman, M., Kaunisto, K., Mollard, P., Andoniadou, C. L., Hirsch, J. A., Varjosalo, M., Jespersen, T. & Raivio, T., 3 Nov 2017, In : Nature Communications. 8, 11 p., 1289.

Research output: Contribution to journalArticleScientificpeer-review

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UNC-45a promotes myosin folding and stress fiber assembly

Lehtimaki, J. I., Fenix, A. M., Kotila, T. M., Balistreri, G., Paavolainen, L., Varjosalo, M., Burnette, D. T. & Lappalainen, P., 20 Oct 2017, In : Journal of Cell Biology. 216, 12, p. 4053-4072 20 p.

Research output: Contribution to journalArticleScientificpeer-review

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2016

Activating STAT3 mutation leads to pancreatic hypoplasia through premature differentiation

Saarimaki-Vire, J., Balboa, D., Russell, M., Morgan, N., Eurola, S., Grym, H., Ustinov, J., Valensisi, C., Andrus, C., Saarikettu, J., Silvennoinen, O., Hawkins, D., Varjosalo, M. & Otonkoski, T., Nov 2016, In : Human Gene Therapy. 27, 11, p. A142-A142 1 p.

Research output: Contribution to journalArticleScientificpeer-review

HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix

Paveliev, M., Fenrich, K. K., Kislin, M., Kuja-Panula, J., Kulesskiy, E., Varjosalo, M., Kajander, T., Mugantseva, E., Ahonen-Bishopp, A., Khirug, L., Kulesskaya, N., Rougon, G. & Rauvala, H., 27 Sep 2016, In : Scientific Reports. 6, 17 p., 33916.

Research output: Contribution to journalArticleScientificpeer-review

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Molecular insights into the function of the viral RNA silencing suppressor HCPro

Ivanov, K., Eskelin, K. J., Bašić, M., De, S., Lohmus, A., Varjosalo, M. T. & Mäkinen, K. M., 2016, In : Plant Journal. 85, 1, p. 30-45 16 p.

Research output: Contribution to journalArticleScientificpeer-review

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Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication

Balistreri, G., Viiliainen, J., Turunen, M., Diaz, R., Lyly, L., Pekkonen, P., Rantala, J., Ojala, K., Sarek, G., Teesalu, M., Denisova, O., Peltonen, K., Julkunen, I., Varjosalo, M., Kainov, D., Kallioniemi, O., Laiho, M., Taipale, J., Hautaniemi, S. & Ojala, P. M., Feb 2016, In : PLoS Pathogens. 12, 2, 26 p., 1005424.

Research output: Contribution to journalArticleScientificpeer-review

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Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells

Santio, N. M., Landor, S. K. -J., Vahtera, L., Ylä-Pelto, J., Paloniemi, E., Imanishi, S. Y., Corthals, G., Varjosalo, M., Manoharan, G. B., Uri, A., Lendahl, U., Sahlgren, C. & Koskinen, P. J., 12 Jul 2016, In : Oncotarget. 7, 28, p. 43220-43238 19 p.

Research output: Contribution to journalArticleScientificpeer-review

Predegenerated Schwann cells-a novel prospect for cell therapy for glaucoma: neuroprotection, neuroregeneration and neuroplasticity

Smedowski, A., Liu, X., Pietrucha-Dutczak, M., Matuszek, I., Varjosalo, M. & Lewin-Kowalik, J., 1 Apr 2016, In : Scientific Reports. 6, 15 p., 23187.

Research output: Contribution to journalArticleScientificpeer-review

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Protein composition of 6K2-induced membrane structures formed during Potato virus A infection

Lohmus, A., Varjosalo, M. & Mäkinen, K., Aug 2016, In : Molecular Plant Pathology. 17, 6, p. 943-958 16 p.

Research output: Contribution to journalArticleScientificpeer-review

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Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms

Kämpjärvi, K., Kim, NH., Keskitalo, S., Clark, AD., von Nandelstadh, P., Turunen, M., Heikkinen, T., Park, M. J., Mäkinen, N., Kivinummi, K., Lintula, S., Hotakainen, K., Nevanlinna, H., Hokland, P., Böhling, T., Butzow, R., Böhm, J., Mecklin, JP., Järvinen, H., Kontro, M. & 5 othersVisakorpi, T., Taipale, J., Varjosalo, M., Boyer, TG. & Vahteristo, P., 2016, In : Prostate. 76, 1, p. 22-31 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Absence of YbeY RNase compromises the growth and enhances the virulence plasmid gene expression of Yersinia enterocolitica O:3

Leskinen, K., Varjosalo, M. & Skurnik, M., Feb 2015, In : Microbiology. 161, Part 2, p. 285-299 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers

Jiu, Y., Lehtimaki, J., Tojkander, S., Cheng, F., Jäälinoja, H., Liu, X., Varjosalo, M., Eriksson, J. E. & Lappalainen, P., 2015, In : Cell Reports. 11, 10, p. 1511-1518 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Colonic metaproteomic signatures of active bacteria and the host in obesity

Kolmeder, C. A., Ritari, J., Verdam, F. J., Muth, T., Keskitalo, S., Varjosalo, M., Fuentes, S., Greve, J. W., Buurman, W. A., Reichl, U., Rapp, E., Martens, L., Palva, A., Salonen, A., Rensen, S. S. & de Vos, W. M., Oct 2015, In : Proteomics (Weinheim). 15, 20, p. 3544-3552 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles

Haapasalo, K., van Kessel, K., Nissilä, E., Metso, J., Johansson, T., Miettinen, S., Varjosalo, M., Kirveskari, J., Kuusela, P., Chroni, A., Jauhiainen, M., van Strijp, J. & Jokiranta, T. S., 27 Nov 2015, In : Journal of Biological Chemistry. 290, 48, p. 28977-28987 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Navigating through metaproteomics data: A logbook of database searching

Muth, T., Kolmeder, C. A., Salojarvi, J., Keskitalo, S., Varjosalo, M., Verdam, F. J., Rensen, S. S., Reichl, U., de Vos, W. M., Rapp, E. & Martens, L., Oct 2015, In : Proteomics (Weinheim). 15, 20, p. 3439-3453 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Quantitative Proteomics Analysis of Vitreous Humor from Diabetic Retinopathy Patients

Loukovaara, S., Nurkkala, H., Tamene, F., Gucciardo, E., Liu, X., Repo, P., Lehti, K. & Varjosalo, M., 2015, In : Journal of Proteome Research. 14, 12, p. 5131-5143 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Rho-kinase inhibitor Y-27632 increases cellular proliferation and migration in human foreskin fibroblast cells

Piltti, J., Varjosalo, M., Qu, C., Häyrinen, J. & Lammi, M. J., Sep 2015, In : Proteomics (Weinheim). 15, 17, p. 2953-2965 13 p.

Research output: Contribution to journalArticleScientificpeer-review

The expression of the Yersinia enterocolitica O:3 lipopolysaccharide O-antigen and outer core gene clusters is RfaH-dependent.

Leskinen, K., Varjosalo, M. T., Li, Z., Li, C. M. & Skurnik, M., 2015, In : Microbiology. 161, p. 1282-1294 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Functional and Structural Properties of a Novel Protein and Virulence Factor (Protein sHIP) in Streptococcus pyogenes

Wisniewska, M., Happonen, L., Kahn, F., Varjosalo, M., Malmstroem, L., Rosenberger, G., Karlsson, C., Cazzamali, G., Pozdnyakova, I., Frick, I-M., Bjorck, L., Streicher, W., Malmstrom, J. & Wikstrom, M., 27 Jun 2014, In : Journal of Biological Chemistry. 289, 26, p. 18175-18188 14 p.

Research output: Contribution to journalArticleScientificpeer-review