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Markus Perola

19992019
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Publications 1999 2019

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2019

A distinctive DNA methylation pattern in insufficient sleep

Lahtinen, A., Puttonen, S., Vanttola, P., Viitasalo, K., Sulkava, S., Pervjakova, N., Joensuu, A., Salo, P., Toivola, A., Härmä, M., Milani, L., Perola, M. & Paunio, T., 4 Feb 2019, In : Scientific Reports. 9, 9 p., 1193.

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A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

Deelen, J., Kettunen, J., Fischer, K., van der Spek, A., Trompet, S., Kastenmueller, G., Boyd, A., Zierer, J., van den Akker, E. B., Ala-Korpela, M., Amin, N., Demirkan, A., Ghanbari, M., van Heemst, D., Ikram, M. A., van Klinken, J. B., Mooijaart, S. P., Peters, A., Salomaa, V., Sattar, N. & 15 othersSpector, T. D., Tiemeier, H., Verhoeven, A., Waldenberger, M., Wuertz, P., Smith, G. D., Metspalu, A., Perola, M., Menni, C., Geleijnse, J. M., Drenos, F., Beekman, M., Jukema, J. W., van Duijn, C. M. & Slagboom, P. E., 20 Aug 2019, In : Nature Communications. 10, 8 p., 3346.

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Associations of increased physical performance and change in body composition with molecular pathways of heart disease and diabetes risk

Kettunen, J., Joensuu, A., Hagnäs, M., Mikkola, I., Wennerström, A., Lee, J. H., Terwilliger, J. D., Borodulin, K., Jousilahti, P., Jauhiainen, M., Jokelainen, J. J., Keinänen-Kiukaanniemi, S. & Perola, M., Feb 2019, In : American Journal of Physiology: Endocrinology and Metabolism. 316, 2, p. E221-E229 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

Ahola-Olli, A. V., Mustelin, L., Kalimeri, M., Kettunen, J., Jokelainen, J., Auvinen, J., Puukka, K., Havulinna, A. S., Lehtimäki, T., Kähönen, M., Juonala, M., Keinänen-Kiukaanniemi, S., Salomaa, V., Perola, M., Järvelin, M-R., Ala-Korpela, M., Raitakari, O. & Würtz, P., 4 Oct 2019, In : Diabetologia.

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Direct Estimation of HDL-Mediated Cholesterol Efflux Capacity from Serum

Kuusisto, S., Holmes, M., Ohukainen, P., Kangas, A. J., Karsikas, M., Tiainen, M., Perola, M., Salomaa, V., Kettunen, J. & Ala-Korpela, M., Aug 2019, In : Clinical Chemistry (Washington, DC). 65, 8, p. 1042-1050 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Disentangling the genetics of lean mass

Karasik, D., Zillikens, M. C., Hsu, Y-H., Aghdassi, A., Akesson, K., Amin, N., Barroso, I., Bennett, D. A., Bertram, L., Bochud, M., Borecki, I. B., Broer, L., Buchman, A. S., Byberg, L., Campbell, H., Campos-Obando, N., Cauley, J. A., Cawthon, P. M., Chambers, J. C., Chen, Z. & 137 othersCho, N. H., Choi, H. J., Chou, W-C., Cummings, S. R., de Groot, L. C. P. G. M., De Jager, P. L., Demuth, I., Diatchenko, L., Econs, M. J., Eiriksdottir, G., Enneman, A. W., Eriksson, J., Eriksson, J. G., Estrada, K., Evans, D. S., Feitosa, M. F., Fu, M., Gieger, C., Grallert, H., Gudnason, V., Lenore, L. J., Hayward, C., Hofman, A., Homuth, G., Huffman, K. M., Husted, L. B., Illig, T., Ingelsson, E., Ittermann, T., Jansson, J-O., Johnson, T., Biffar, R., Jordan, J. M., Jula, A., Karlsson, M., Khaw, K-T., Kilpelainen, T. O., Klopp, N., Kloth, J. S. L., Koller, D. L., Kooner, J. S., Kraus, W. E., Kritchevsky, S., Kutalik, Z., Kuulasmaa, T., Kuusisto, J., Laakso, M., Lahti, J., Lang, T., Langdahl, B. L., Lerch, M. M., Lewis, J. R., Lill, C., Lind, L., Lindgren, C., Liu, Y., Livshits, G., Ljunggren, O., Loos, R. J. F., Lorentzon, M., Luan, J., Luben, R. N., Malkin, I., McGuigan, F. E., Medina-Gomez, C., Meitinger, T., Melhus, H., Mellstrom, D., Michaelsson, K., Mitchell, B. D., Morris, A. P., Mosekilde, L., Nethander, M., Newman, A. B., O'Connell, J. R., Oostra, B. A., Orwoll, E. S., Palotie, A., Peacock, M., Perola, M., Peters, A., Prince, R. L., Psaty, B. M., Räikkönen, K., Ralston, S. H., Ripatti, S., Rivadeneira, F., Robbins, J. A., Rotter, J. I., Rudan, I., Salomaa, V., Satterfield, S., Schipf, S., Shin, C. S., Smith, A. V., Smith, S. B., Soranzo, N., Spector, T. D., Stancakova, A., Stefansson, K., Steinhagen-Thiessen, E., Stolk, L., Streeten, E. A., Styrkarsdottir, U., Swart, K. M. A., Thompson, P., Thomson, C. A., Thorleifsson, G., Thorsteinsdottir, U., Tikkanen, E., Tranah, G. J., Uitterlinden, A. G., van Duijn, C. M., van Schoor, N. M., Vandenput, L., Vollenweider, P., Volzke, H., Wactawski-Wende, J., Walker, M., Wareham, N. J., Waterworth, D., Weedon, M. N., Wichmann, H-E., Widen, E., Williams, F. M. K., Wilson, J. F., Wright, N. C., Yerges-Armstrong, L. M., Yu, L., Zhang, W., Zhao, J. H., Zhou, Y., Nielson, C. M., Harris, T. B., Demissie, S., Kiel, D. P. & Ohlsson, C., Feb 2019, In : American Journal of Clinical Nutrition. 109, 2, p. 276-287 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

Chd Exome Consortium, Consortium Genetics Smoking, EPIC-CVD Consortium, Understanding Soc Sci Grp, Brazel, D. M., Jiang, Y., Hughey, J. M., Loukola, A., Qaiser, B., Kaprio, J., Kontto, J., Perola, M. & Dunning, A. M., 1 Jun 2019, In : Biological Psychiatry. 85, 11, p. 946-955 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

FinnGen Project, 24 Sep 2019, In : Nature Communications. 10, 1, 14 p., 4329.

Research output: Contribution to journalArticleScientificpeer-review

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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

23and Me Res Team, eQTLGen Consortium, Int Cannabis Consortium, Soc Sci Genetic Association Con, Linner, R. K., Perola, M., Ripatti, S., Gupta, R., Lahti, J., Eklund, N., Koskinen, S., Latvala, A., Loukola, A., Mäki-Opas, T., Palotie, A., Sarin, A-P., Räikkönen, K., Eriksson, J. G., Kaprio, J., Perola, M. & 3 othersSalomaa, V., Kaasik, K. & Keltikangas-Järvinen, L., Feb 2019, In : Nature Genetics. 51, 2, p. 245-+ 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

eQTLGen Consortium, Timmers, P. R. H. J., Kettunen, J., Perola, M. & Ripatti, S., 15 Jan 2019, In : eLife. 8, 40 p., 39856.

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Geographic Variation and Bias in the Polygenic Scores of Complex Diseases and Traits in Finland

Kerminen, S., Martin, A. R., Koskela, J., Ruotsalainen, S. E., Havulinna, A. S., Surakka, I., Palotie, A., Perola, M., Salomaa, V., Daly, M. J., Ripatti, S. & Pirinen, M., 6 Jun 2019, In : American Journal of Human Genetics. 104, 6, p. 1169-1181 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

eQTLGen Consortium, BIOS Consortium, Porcu, E., Rüeger, S., Lepik, K. & Perola, M., 24 Jul 2019, In : Nature Communications. 10, 12 p., 3300.

Research output: Contribution to journalArticleScientificpeer-review

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Molecular Pathways Mediating Immunosuppression in Response to Prolonged Intensive Physical Training, Low-Energy Availability, and Intensive Weight Loss

Sarin, H. V., Gudelj, I., Honkanen, J., Ihalainen, J. K., Vuorela, A., Lee, J. H., Jin, Z., Terwilliger, J. D., Isola, V., Ahtiainen, J. P., Häkkinen, K., Juric, J., Lauc, G., Kristiansson, K., Hulmi, J. J. & Perola, M., 3 May 2019, In : Frontiers in Immunology. 10, 17 p., 907.

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Noncoding RET variants explain the strong association with Hirschsprung disease in patients without rare coding sequence variant

Virtanen, V. B., Salo, P. P., Gao, J., Löf-Granström, A., Milani, L., Metspalu, A., Rintala, R. J., Saarenpää-Heikkilä, O., Paunio, T., Wester, T., Nordenskjöld, A., Perola, M. & Pakarinen, M. P., Apr 2019, In : European Journal of Medical Genetics. 62, 4, p. 229-234 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

Chd Exome Consortium, Cohorts For Heart Aging Res Genomi, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct, ReproGen Consortium, T2G Genes Consortium & MAGIC Investigators, Mar 2019, In : Nature Genetics. 51, 3, p. 452-+ 21 p.

Research output: Contribution to journalArticleScientificpeer-review

Resistance Training Induces Antiatherogenic Effects on Metabolomic Pathways

Sarin, H. V., Ahtiainen, J. P., Hulmi, J. J., Ihalainen, J. K., Walker, S., Kuusmaa-Schildt, M., Perola, M. & Peltonen, H., Sep 2019, In : Medicine and Science in Sports and Exercise. 51, 9, p. 1866-1875 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Role of Academic Biobanks in Public-Private Partnerships in the European Biobanking and BioMolecular Resources Research Infrastructure Community

Hämäläinen, I., Törnwall, O., Simell, B., Zatloukal, K., Perola, M. & van Ommen, G-J. B., 2019, In : Biopreservation and biobanking. 17, 1, p. 46-51 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Substantial fat mass loss reduces low-grade inflammation and induces positive alteration in cardiometabolic factors in normal-weight individuals

Sarin, H. V., Lee, J. H., Jauhiainen, M., Joensuu, A., Borodulin, K., Männistö, S., Jin, Z., Terwilliger, J. D., Isola, V., Ahtiainen, J. P., Häkkinen, K., Kristiansson, K., Hulmi, J. J. & Perola, M., 5 Mar 2019, In : Scientific Reports. 9, 14 p., 3450.

Research output: Contribution to journalArticleScientificpeer-review

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Transnational access to large prospective cohorts in Europe: Current trends and unmet needs

BBMRI-LPC Consortium FP7 GA no, 25 Mar 2019, In : New Biotechnology. 49, p. 98-103 6 p.

Research output: Contribution to journalArticleScientificpeer-review

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2018

Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts

Tynkkynen, J., Chouraki, V., van der Lee, S. J., Hernesniemi, J., Yang, Q., Li, S., Beiser, A., Larson, M. G., Sääksjärvi, K., Shipley, M. J., Singh-Manoux, A., Gerszten, R. E., Wang, T. J., Havulinna, A. S., Würtz, P., Fischer, K., Demirkan, A., Ikram, M. A., Amin, N., Lehtimäki, T. & 11 othersKähönen, M., Perola, M., Metspalu, A., Kangas, A. J., Soininen, P., Ala-Korpela, M., Vasan, R. S., Kivimäki, M., van Duijn, C. M., Seshadri, S. & Salomaa, V., Jun 2018, In : Alzheimer's & Dementia. 14, 6, p. 723-733 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Biomarker Glycoprotein Acetyls Associated With the Risk of a Wide Spectrum of Incident Diseases and Stratifies Mortality Risk in Angiography Patients

Kettunen, J., Ritchie, S. C., Anufrieva, O., Lyytikäinen, L-P., Hernesniemi, J., Karhunen, P. J., Kuukasjärvi, P., Laurikka, J., Kähönen, M., Lehtimaki, T., Havulinna, A. S., Salomaa, V., Männistö, S., Ala-Korpela, M., Perola, M., Inouye, M. & Würtz, P., Nov 2018, In : Circulation-Genomic and precision medicine. 11, 11, 7 p., 002234.

Research output: Contribution to journalArticleScientificpeer-review

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

van der Lee, S. J., Teunissen, C. E., Pool, R., Shipley, M. J., Teumer, A., Chouraki, V., van Lent, D. M., Tynkkynen, J., Fischer, K., Hernesniemi, J., Haller, T., Singh-Manoux, A., Verhoeven, A., Willemsen, G., de Leeuw, F. A., Wagner, H., van Dongen, J., Hertel, J., Budde, K., van Dijk, K. W. & 28 othersWeinhold, L., Ikram, M. A., Pietzner, M., Perola, M., Wagner, M., Friedrich, N., Slagboom, P. E., Scheltens, P., Yang, Q., Gertzen, R. E., Egert, S., Li, S., Hankemeier, T., van Beijsterveldt, C. E. M., Vasan, R. S., Maier, W., Peeters, C. F. W., Grabe, H. J., Ramirez, A., Seshadri, S., Metspalu, A., Kivimäki, M., Salomaa, V., Demirkan, A., Boomsma, D. I., van der Flier, W. M., Amin, N. & van Duijn, C. M., Jun 2018, In : Alzheimer's & Dementia. 14, 6, p. 707-722 16 p.

Research output: Contribution to journalArticleScientificpeer-review

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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Million Vet Program, Oct 2018, In : Nature Genetics. 50, 10, p. 1412-+ 17 p.

Research output: Contribution to journalArticleScientificpeer-review

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Genetic predisposition to obesity, restrained eating and changes in body weight: a population-based prospective study

Konttinen, H., Llewellyn, C., Silventoinen, K., Joensuu, A., Männistö, S., Salomaa, V., Jousilahti, P., Kaprio, J., Perola, M. & Haukkala, A., 2018, In : International Journal of Obesity. 42, 4, p. 858-865 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Genetic Variants in SGLT1, Glucose Tolerance, and Cardiometabolic Risk

Seidelmann, S. B., Feofanova, E., Yu, B., Franceschini, N., Claggett, B., Kuokkanen, M., Puolijoki, H., Ebeling, T., Perola, M., Salomaa, V., Shah, A., Coresh, J., Selvin, E., MacRae, C. A., Cheng, S., Boerwinkle, E. & Solomon, S. D., 9 Oct 2018, In : Journal of the American College of Cardiology. 72, 15, p. 1763-1773 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

LifeLines Cohort Study, CHARGE Inflammation Working Grp & Räikkönen, K., 1 Nov 2018, In : American Journal of Human Genetics. 103, 5, p. 691-706 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-wide analysis of nuclear magnetic resonance metabolites revealed parent-of-origin effect on triglycerides in medium very low-density lipoprotein in PTPRD gene

Pervjakova, N., Kukushkina, V., Haller, T., Kasela, S., Joensuu, A., Kristiansson, K., Annilo, T., Perola, M., Salomaa, V., Jousilahti, P., Metspalu, A. & Magi, R., May 2018, In : Biomarkers in Medicine. 12, 5, p. 439-446 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

Xue, A., Wu, Y., Zhu, Z., Zhang, F., Kemper, K. E., Zheng, Z., Yengo, L., Lloyd-Jones, L. R., Sidorenko, J., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Awadalla, P., Battle, A., Beutner, F., Bonder, M. J., Boomsma, D., Christiansen, M., Claringbould, A. & 62 othersDeelen, P., Esko, T., Favé, M-J., Franke, L., Frayling, T., Gharib, S., Gibson, G., Hemani, G., Jansen, R., Kähönen, M., Kalnapenkis, A., Kasela, S., Kettunen, J., Kim, Y., Kirsten, H., Kovacs, P., Krohn, K., Kronberg-Guzman, J., Kukushkina, V., Kutalik, Z., Lee, B., Lehtimäki, T., Loeffler, M., Marigorta, U. M., Metspalu, A., Milani, L., Müller-Nurasyid, M., Nauck, M., Nivard, M., Penninx, B., Perola, M., Pervjakova, N., Pierce, B., Powell, J., Prokisch, H., Psaty, B., Raitakari, O., Ring, S., Ripatti, S., Rotzschke, O., Ruëger, S., Saha, A., Scholz, M., Schramm, K., Seppälä, I., Stumvoll, M., Sullivan, P., Teumer, A., Thiery, J., Tong, L., Tönjes, A., van Dongen, J., van Meurs, J., Verlouw, J., Völker, U., Võsa, U., Yaghootkar, H., Zeng, B., McRae, A. F., Visscher, P. M., Zeng, J. & Yang, J., 2018, In : Nature Communications. 9, 1, 14 p., 2941.

Research output: Contribution to journalArticleScientificpeer-review

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Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland

Martin, A. R., Karczewski, K. J., Kerminen, S., Kurki, M. I., Sarin, A-P., Artomov, M., Eriksson, J. G., Esko, T., Genovese, G., Havulinna, A. S., Kaprio, J., Konradi, A., Korányi, L., Kostareva, A., Männikkö, M., Metspalu, A., Perola, M., Prasad, R. B., Raitakari, O., Rotar, O. & 7 othersSalomaa, V., Groop, L., Palotie, A., Neale, B. M., Ripatti, S., Pirinen, M. & Daly, M. J., 3 May 2018, In : American Journal of Human Genetics. 102, 5, p. 760-775 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

eQTLGen Consortium, 2018, In : Nature Communications. 9, 1

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Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up

Gudelj, I., Salo, P. P., Trbojevic-Akmacic, I., Albers, M., Primorac, D., Perola, M. & Lauc, G., Jun 2018, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1864, 6, p. 2034-2039 6 p.

Research output: Contribution to journalArticleScientificpeer-review

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Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment

Sliz, E., Kettunen, J., Holmes, M. V., Williams, C. O., Boachie, C., Wang, Q., Maennikkoe, M., Sebert, S., Walters, R., Lin, K., Millwood, I. Y., Clarke, R., Li, L., Rankin, N., Welsh, P., Delles, C., Jukema, J. W., Trompet, S., Ford, I., Perola, M. & 10 othersSalomaa, V., Jaervelin, M-R., Chen, Z., Lawlor, D. A., Ala-Korpela, M., Danesh, J., Davey Smith, G., Sattar, N., Butterworth, A. & Würtz, P., 27 Nov 2018, In : Circulation . 138, 22, p. 2499-2512 14 p.

Research output: Contribution to journalArticleScientificpeer-review

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Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T. & 41 othersFeitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Kaprio, J., Korhonen, T., Loukola, A., Perola, M., Tuomilehto, J., Chd Exome Consortium, Epic-Cvd Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, Interval Study, ReproGen Consortium, T2D-Genes Consortium, MAGIC Investigators & Understanding Soc Sci Grp, Jan 2018, In : Nature Genetics. 50, 1, p. 26-+ 19 p.

Research output: Contribution to journalArticleScientificpeer-review

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

ExomeBP Consortium, MAGIC Consortium & GIANT Consortium, Apr 2018, In : Nature Genetics. 50, 4, p. 559-+ 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths

Ruuth, M., Nguyen, S. D., Vihervaara, T. M., Hilvo, M., Laajala, T. D., Kondadi, P. K., Gistera, A., Lähteenmäki, H., Kittilä, T., Huusko, J., Uusitupa, M., Schwab, U., Savolainen, M. J., Sinisalo, J., Lokki, M-L., Nieminen, M. S., Jula, A., Perola, M., Ylä-Herttula, S., Rudel, L. & 12 othersÖörni, A., Baumann, M., Baruch, A., Laaksonen, R., Ketelhuth, D. F. J., Aittokallio, T., Jauhiainen, M., Käkelä, R., Boren, J., Williams, K. J., Kovanen, P. T. & Öörni, K., 14 Jul 2018, In : European Heart Journal. 39, 27, p. 2562-2573 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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2017

An interaction map of circulating metabolites, immune gene networks, and their genetic regulation

Nath, A. P., Ritchie, S. C., Byars, S. G., Fearnley, L. G., Havulinna, A. S., Joensuu, A., Kangas, A. J., Soininen, P., Wennerstrom, A., Milani, L., Metspalu, A., Mannisto, S., Wurtz, P., Kettunen, J., Raitoharju, E., Kahonen, M., Juonala, M., Palotie, A., Ala-Korpela, M., Ripatti, S. & 6 othersLehtimaki, T., Abraham, G., Raitakari, O., Salomaa, V., Perola, M. & Inouye, M., 1 Aug 2017, In : Genome Biology. 18, 15 p., 146.

Research output: Contribution to journalArticleScientificpeer-review

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CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

Mace, A., Tuke, M. A., Deelen, P., Kristiansson, K., Mattsson, H., Noukas, M., Sapkota, Y., Schick, U., Porcu, E., Rueger, S., McDaid, A. F., Porteous, D., Winkler, T. W., Salvi, E., Shrine, N., Liu, X., Ang, W. Q., Zhang, W., Feitosa, M. F., Venturini, C. & 86 othersvan der Most, P. J., Rosengren, A., Wood, A. R., Beaumont, R. N., Jones, S. E., Ruth, K. S., Yaghootkar, H., Tyrrell, J., Havulinna, A. S., Boers, H., Magi, R., Kriebel, J., Mueller-Nurasyid, M., Perola, M., Nieminen, M., Lokki, M-L., Kahonen, M., Viikari, J. S., Geller, F., Lahti, J., Palotie, A., Koponen, P., Lundqvist, A., Rissanen, H., Bottinger, E. P., Afaq, S., Wojczynski, M. K., Lenzini, P., Nolte, I. M., Sparso, T., Schupf, N., Christensen, K., Perls, T. T., Newman, A. B., Werge, T., Snieder, H., Spector, T. D., Chambers, J. C., Koskinen, S., Melbye, M., Raitakari, O. T., Lehtimaki, T., Tobin, M. D., Wain, L. V., Sinisalo, J., Peters, A., Meitinger, T., Martin, N. G., Wray, N. R., Montgomery, G. W., Medland, S. E., Swertz, M. A., Vartiainen, E., Borodulin, K., Mannisto, S., Murray, A., Bochud, M., Jacquemont, S., Rivadeneira, F., Hansen, T. F., Oldehinkel, A. J., Mangino, M., Province, M. A., Deloukas, P., Kooner, J. S., Freathy, R. M., Pennell, C., Feenstra, B., Strachan, D. P., Lettre, G., Hirschhorn, J., Cusi, D., Heid, I. M., Hayward, C., Mannik, K., Beckmann, J. S., Loos, R. J. F., Nyholt, D. R., Metspalu, A., Eriksson, J. G., Weedon, M. N., Salomaa, V., Franke, L., Reymond, A., Frayling, T. M. & Kutalik, Z., 29 Sep 2017, In : Nature Communications. 8, 11 p., 744.

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Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure

Marques, F. Z., Prestes, P. R., Byars, S. G., Ritchie, S. C., Wurtz, P., Patel, S. K., Booth, S. A., Rana, I., Minoda, Y., Berzins, S. P., Curl, C. L., Bell, J. R., Wai, B., Srivastava, P. M., Kangas, A. J., Soininen, P., Ruohonen, S., Kahonen, M., Lehtimaki, T., Raitoharju, E. & 15 othersHavulinna, A., Perola, M., Raitakari, O., Salomaa, V., Ala-Korpela, M., Kettunen, J., McGlynn, M., Kelly, J., Wlodek, M. E., Lewandowski, P. A., Delbridge, L. M., Burrell, L. M., Inouye, M., Harrap, S. B. & Charchar, F. J., Jun 2017, In : Journal of the American Heart Association. 6, 6, 57 p., 005971.

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Fine-Scale Genetic Structure in Finland

Kerminen, S., Havulinna, A. S., Hellenthal, G., Martin, A. R., Sarin, A-P., Perola, M., Palotie, A., Salomaa, V., Daly, M. J., Ripatti, S. & Pirinen, M., Oct 2017, In : G3 - Genes genomes genetics. 7, 10, p. 3459-3468 10 p.

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Genetic invalidation of Lp-PLA(2) as a therapeutic target: Large-scale study of five functional Lp-PLA(2)-lowering alleles

Gregson, J. M., Freitag, D. F., Surendran, P., Stitziel, N. O., Chowdhury, R., Burgess, S., Kaptoge, S., Gao, P., Staley, J. R., Willeit, P., Nielsen, S. F., Caslake, M., Trompet, S., Polfus, L. M., Kuulasmaa, K., Kontto, J., Perola, M., Blankenberg, S., Veronesi, G., Gianfagna, F. & 36 othersMannisto, S., Kimura, A., Lin, H., Reilly, D. F., Gorski, M., Mijatovic, V., Munroe, P. B., Ehret, G. B., Thompson, A., Uria-Nickelsen, M., Malarstig, A., Dehghan, A., Vogt, T. F., Sasaoka, T., Takeuchi, F., Kato, N., Yamada, Y., Kee, F., Mueller-Nurasyid, M., Ferrieres, J., Arveiler, D., Amouyel, P., Salomaa, V., Boerwinkle, E., Thompson, S. G., Ford, I., Jukema, J. W., Sattar, N., Packard, C. J., Majumder, A. A. S., CKDGen Consortium, Int Consortium Blood Pressure, CHARGE Inflammation Working Grp, MICAD Exome Consortium, EPIC-CVD Consortium & CHD Exome Consortium, Mar 2017, In : European journal of preventive cardiology. 24, 5, p. 492-504 13 p.

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Genetics in an isolated population like Finland: a different basis for genomic medicine?

Kääriäinen, H., Muilu, J., Perola, M. & Kristiansson, K., 2017, In : Journal of Community Genetics. 8, 4, p. 319-326 8 p.

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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Warren, H. R., Evangelou, E., Cabrera, C. P., Gao, H., Ren, M., Mifsud, B., Ntalla, I., Surendran, P., Liu, C., Cook, J. P., Kraja, A. T., Drenos, F., Loh, M., Verweij, N., Marten, J., Karaman, I., Lepe, M. P. S., O'Reilly, P. F., Knight, J., Snieder, H. & 284 othersKato, N., He, J., Tai, E. S., Said, M. A., Porteous, D., Alver, M., Poulter, N., Farrall, M., Gansevoort, R. T., Padmanabhan, S., Magi, R., Stanton, A., Connell, J., Bakker, S. J. L., Metspalu, A., Shields, D. C., Thom, S., Brown, M., Sever, P., Esko, T., Hayward, C., van der Harst, P., Saleheen, D., Chowdhury, R., Chambers, J. C., Chasman, D. I., Chakravarti, A., Newton-Cheh, C., Lindgren, C. M., Levy, D., Kooner, J. S., Keavney, B., Tomaszewski, M., Samani, N. J., Howson, J. M. M., Tobin, M. D., Munroe, P. B., Ehret, G. B., Wain, L. V., Barnes, M. R., Tzoulaki, J., Caulfield, M. J., Elliott, P., Wain, L. V., Vaez, A., Jansen, R., Joehanes, R., van der Most, P. J., Erzurumluoglu, A. M., O'Reilly, P., Cabrera, C. P., Warren, H. R., Rose, L. M., Verwoert, G. C., Hottenga, J-J., Strawbridge, R. J., Esko, T., Arking, D. E., Hwang, S-J., Guo, X., Kutalik, Z., Trompet, S., Shrine, N., Teumer, A., Ried, J. S., Bis, J. C., Smith, A. V., Amin, N., Nolte, I. M., Lyytikainen, L-P., Mahajan, A., Wareham, N. J., Hofer, E., Joshi, P. K., Kristiansson, K., Traglia, M., Havulinna, A. S., Goel, A., Nalls, M. A., Sober, S., Vuckovic, D., Luan, J., Del Greco M, F., Ayers, K. L., Marrugat, J., Ruggiero, D., Lopez, L. M., Niiranen, T., Enroth, S., Jackson, A. U., Nelson, C. P., Huffman, J. E., Zhang, W., Marten, J., Gandin, I., Harris, S. E., Zemonik, T., Lu, Y., Evangelou, E., Shah, N., de Borst, M. H., Mangino, M., Prins, B. P., Campbell, A., Li-Gao, R., Chauhan, G., Oldmeadow, C., Abecasis, G., Abedi, M., Barbieri, C. M., Barnes, M. R., Batini, C., Blake, T., Boehnke, M., Bottinger, E. P., Braund, P. S., Brown, M., Brumat, M., Campbell, H., Chambers, J. C., Cocca, M., Collins, F., Connell, J., Cordell, H. J., Damman, J. J., Davies, G., de Geus, E. J., de Mutsert, R., Deelen, J., Demirkale, Y., Doney, A. S. F., Dorr, M., Farrall, M., Ferreira, T., Franberg, M., Gao, H., Giedraitis, V., Gieger, C., Giulianini, F., Gow, A. J., Hamsten, A., Harris, T. B., Hofman, A., Holliday, E. G., Jarvelin, M-R., Johansson, A., Johnson, A. D., Jousilahti, P., Jula, A., Kahonen, M., Kathiresan, S., Khaw, K-T., Kolcic, I., Koskinen, S., Langenberg, C., Larson, M., Launer, L. J., Lehne, B., Liewald, D. C. M., Lin, L., Lind, L., Mach, F., Mamasoula, C., Menni, C., Mifsud, B., Milaneschi, Y., Morgan, A., Morris, A. D., Morrison, A. C., Munson, P. J., Nandakumar, P., Quang Tri Nguyen, Nutile, T., Oldehinkel, A. J., Oostra, B. A., Org, E., Padmanabhan, S., Palotie, A., Pare, G., Pattie, A., Penninx, B. W. J. H., Poulter, N., Pramstaller, P. P., Raitakari, O. T., Ren, M., Rice, K., Ridker, P. M., Riese, H., Ripatti, S., Robino, A., Rotter, J. I., Rudan, I., Saba, Y., Saint Pierre, A., Sala, C. F., Sarin, A-P., Schmidt, R., Scott, R., Seelen, M. A., Shields, D. C., Siscovick, D., Sorice, R., Stanton, A., Stott, D. J., Sundstrom, J., Swertz, M., Taylor, K. D., Thom, S., Tzoulaki, I., Tzourio, C., Uitterlinden, A. G., Volker, U., Vollenweider, P., Wild, S., Willemsen, G., Wright, A. F., Yao, J., Theriault, S., Conen, D., John, A., Sever, P., Debette, S., Mook-Kanamori, D. O., Zeggini, E., Spector, T. D., van der Harst, P., Palmer, C. N. A., Vergnaud, A-C., Loos, R. J. F., Polasek, O., Starr, J. M., Girotto, G., Hayward, C., Kooner, J. S., Lindgren, C. M., Vitart, V., Samani, N. J., Tuomilehto, J., Gyllensten, U., Knekt, P., Deary, I. J., Ciullo, M., Elosua, R., Keavney, B. D., Hicks, A. A., Scott, R. A., Gasparini, P., Laan, M., Liu, Y., Watkins, H., Hartman, C. A., Salomaa, V., Toniolo, D., Perola, M., Wilson, J. F., Schmidt, H., Zhao, J. H., Lehtimaki, T., van Duijn, C. M., Gudnason, V., Psaty, B. M., Peters, A., Rettig, R., James, A., Jukema, J. W., Strachan, D. P., Palmas, W., Metspalu, A., Ingelsson, E., Boomsma, D. I., Franco, O. H., Bochud, M., Newton-Cheh, C., Munroe, P. B., Elliott, P., Chasman, D. I., Chakravarti, A., Knight, J., Morris, A. P., Levy, D., Tobin, M. D., Snieder, H., Caulfield, M. J. & Ehret, G. B., Mar 2017, In : Nature Genetics. 49, 3, p. 403-415 13 p.

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Genome-wide association meta-analysis of fish and EPA plus DHA consumption in 17 US and European cohorts

Mozaffarian, D., Dashti, H. S., Wojczynski, M. K., Chu, A. Y., Nettleton, J. A., Mannisto, S., Kristiansson, K., Reedik, M., Lahti, J. M., Houston, D. K., Cornelis, M. C., van Rooij, F. J. A., Dimitriou, M., Kanoni, S., Mikkila, V., Steffen, L. M., Otto, M. C. D. O., Qi, L., Psaty, B., Djousse, L. & 45 othersRotter, J. I., Harald, K., Perola, M., Rissanen, H., Jula, A., Krista, F., Mihailov, E., Feitosa, M. F., Ngwa, J. S., Xue, L., Jacques, P. F., Perälä, M-M., Palotie, A., Liu, Y., Nalls, N. A., Ferrucci, L., Hernandez, D., Manichaikul, A., Tsai, M. Y., Kiefte-de Jong, J. C., Hofman, A., Uitterlinden, A. G., Rallidis, L., Ridker, P. M., Rose, L. M., Buring, J. E., Lehtimäki, T., Kähönen, M., Viikari, J., Lemaitre, R., Salomaa, V., Knekt, P., Metspalu, A., Borecki, I. B., Cupples, L. A., Eriksson, J. G., Kritchevsky, S. B., Bandinelli, S., Siscovick, D., Franco, O. H., Deloukas, P., Dedoussis, G., Chasman, D. I., Raitakari, O. & Tanaka, T., 13 Dec 2017, In : PLoS One. 12, 12, 15 p., 0186456.

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Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors

Ahola-Olli, A. V., Wurtz, P., Havulinna, A. S., Aalto, K., Pitkanen, N., Lehtimaki, T., Kahonen, M., Lyytikainen, L-P., Raitoharju, E., Seppala, I., Sarin, A-P., Ripatti, S., Palotie, A., Perola, M., Viikari, J. S., Jalkanen, S., Maksimow, M., Salomaa, V., Salmi, M., Kettunen, J. & 1 othersRaitakari, O. T., 5 Jan 2017, In : American Journal of Human Genetics. 100, 1, p. 40-50 11 p.

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Genome-Wide Association Study Implicates Atrial Natriuretic Peptide Rather Than B-Type Natriuretic Peptide in the Regulation of Blood Pressure in the General Population

Salo, P. P., Havulinna, A. S., Tukiainen, T., Raitakari, O., Lehtimäki, T., Kähönen, M., Kettunen, J., Männikkö, M., Eriksson, J. G., Jula, A., Blankenberg, S., Zeller, T., Salomaa, V., Kristiansson, K. & Perola, M., Dec 2017, In : Circulation. Cardiovascular genetics. 10, 6, 9 p., 001713.

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Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults

Graff, M., Scott, R. A., Justice, A. E., Young, K. L., Feitosa, M. F., Barata, L., Winkler, T. W., Chu, A. Y., Mahajan, A., Hadley, D., Xue, L., Workalemahu, T., Heard-Costa, N. L., den Hoed, M., Ahluwalia, T. S., Qi, Q., Ngwa, J. S., Renstrom, F., Quaye, L., Eicher, J. D. & 33 othersHayes, J. E., Cornelis, M., Kutalik, Z., Lim, E., Luan, J., Huffman, J. E., Zhang, W., Zhao, W., Griffin, P. J., Haller, T., Ahmad, S., Marques-Vidal, P. M., Bien, S., Yengo, L., Teumer, A., Smith, A. V., Kumari, M., Harder, M. N., Justesen, J. M., Kleber, M. E., Hollensted, M., Lohman, K., Rivera, N. V., Whitfield, J. B., Kristiansson, K., Havulinna, A. S., Koistinen, H. A., Perola, M., Tuomilehto, J., Kivimaki, M., CHARGE Consortium, EPIC-InterAct Consortium & PAGE Consortium, Apr 2017, In : PLoS Genetics. 13, 4, 26 p., 1006528.

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Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis

Schormair, B., Zhao, C., Bell, S., Tilch, E., Salminen, A. V., Puetz, B., Dauvilliers, Y., Stefani, A., Hoegl, B., Poewe, W., Kemlink, D., Sonka, K., Bachmann, C. G., Paulus, W., Trenkwalder, C., Oertel, W. H., Hornyak, M., Teder-Laving, M., Metspalu, A., Hadjigeorgiou, G. M. & 32 othersPolo, O., Fietze, I., Ross, O. A., Wszolek, Z., Butterworth, A. S., Soranzo, N., Ouwehand, W. H., Roberts, D. J., Danesh, J., Allen, R. P., Earley, C. J., Ondo, W. G., Xiong, L., Montplaisir, J., Gan-Or, Z., Perola, M., Vodicka, P., Dina, C., Franke, A., Tittmann, L., Stewart, A. F. R., Shah, S. H., Gieger, C., Peters, A., Rouleau, G. A., Berger, K., Oexle, K., Di Angelantonio, E., Hinds, D. A., Mueller-Myhsok, B., Collaboration 23andMe Res Team & DESIR Study Grp, Nov 2017, In : Lancet Neurology. 16, 11, p. 898-907 10 p.

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Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Zillikens, M. C., Demissie, S., Hsu, Y-H., Yerges-Armstrong, L. M., Chou, W-C., Stolk, L., Livshits, G., Broer, L., Johnson, T., Koller, D. L., Kutalik, Z., Luan, J., Malkin, I., Ried, J. S., Smith, A. V., Thorleifsson, G., Vandenput, L., Zhao, J. H., Zhang, W., Aghdassi, A. & 173 othersAkesson, K., Amin, N., Baier, L. J., Barroso, I., Bennett, D. A., Bertram, L., Biffar, R., Bochud, M., Boehnke, M., Borecki, I. B., Buchman, A. S., Byberg, L., Campbell, H., Obanda, N. C., Cauley, J. A., Cawthon, P. M., Cederberg, H., Chen, Z., Cho, N. H., Choi, H. J., Claussnitzer, M., Collins, F., Cummings, S. R., De Jager, P. L., Demuth, I., Dhonukshe-Rutten, R. A. M., Diatchenko, L., Eiriksdottir, G., Enneman, A. W., Erdos, M., Eriksson, J. G., Eriksson, J., Estrada, K., Evans, D. S., Feitosa, M. F., Fu, M., Garcia, M., Gieger, C., Girke, T., Glazer, N. L., Grallert, H., Grewal, J., Han, B-G., Hanson, R. L., Hayward, C., Hofman, A., Hoffman, E. P., Homuth, G., Hsueh, W-C., Hubal, M. J., Hubbard, A., Huffman, K. M., Husted, L. B., Illig, T., Ingelsson, E., Ittermann, T., Jansson, J-O., Jordan, J. M., Jula, A., Karlsson, M., Khaw, K-T., Kilpainen, T. O., Klopp, N., Kloth, J. S. L., Koistinen, H. A., Kraus, W. E., Kritchevsky, S., Kuulasmaa, T., Kuusisto, J., Laakso, M., Lahti, J., Lang, T., Langdahl, B. L., Launer, L. J., Lee, J-Y., Lerch, M. M., Lewis, J. R., Lind, L., Lindgren, C., Liu, Y., Liu, T., Liu, Y., Ljunggren, O., Lorentzon, M., Luben, R. N., Maixner, W., McGuigan, F. E., Medina-Gomez, C., Meitinger, T., Melhus, H., Mellstrom, D., Melov, S., Michaelsson, K., Mitchell, B. D., Morris, A. P., Mosekilde, L., Newman, A., Nielson, C. M., O'Connell, J. R., Oostra, B. A., Orwoll, E. S., Palotie, A., Parker, S. C. J., Peacock, M., Perola, M., Peters, A., Polasek, O., Prince, R. L., Raikkonen, K., Ralston, S. H., Ripatti, S., Robbins, J. A., Rotter, J. I., Rudan, I., Salomaa, V., Satterfield, S., Schadt, E. E., Schipf, S., Scott, L., Sehmi, J., Shen, J., Shin, C. S., Sigurdsson, G., Smith, S., Soranzo, N., Stancakova, A., Steinhagen-Thiessen, E., Streeten, E. A., Styrkarsdottir, U., Swart, K. M. A., Tan, S-T., Tarnopolsky, M. A., Thompson, P., Thomson, C. A., Thorsteinsdottir, U., Tikkanen, E., Tranah, G. J., Tuomilehto, J., van Schoor, N. M., Verma, A., Vollenweider, P., Voelzke, H., Wactawski-Wende, J., Walker, M., Weedon, M. N., Welch, R., Wichmann, H. -E., Widen, E., Williams, F. M. K., Wilson, J. F., Wright, N. C., Xie, W., Yu, L., Zhou, Y., Chambers, J. C., Doring, A., van Duijn, C. M., Econs, M. J., Gudnason, V., Kooner, J. S., Psaty, B. M., Spector, T. D., Stefansson, K., Rivadeneira, F., Uitterlinden, A. G., Wareham, N. J., Ossowski, V., Waterworth, D., Loos, R. J. F., Karasik, D., Harris, T. B., Ohlsson, C. & Kiel, D. P., 19 Jul 2017, In : Nature Communications. 8, 13 p., 80.

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Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions

Saleheen, D., Zhao, W., Young, R., Nelson, C. P., Ho, W., Ferguson, J. F., Rasheed, A., Ou, K., Nurnberg, S. T., Bauer, R. C., Goel, A., Do, R., Stewart, A. F. R., Hartiala, J., Zhang, W., Thorleifsson, G., Strawbridge, R. J., Sinisalo, J., Kanoni, S., Sedaghat, S. & 32 othersMarouli, E., Kristiansson, K., Zhao, J. H., Scott, R., Gauguier, D., Shah, S. H., Smith, A. V., van Zuydam, N., Cox, A. J., Willenborg, C., Kessler, T., Zeng, L., Province, M. A., Ganna, A., Lind, L., Pedersen, N. L., White, C. C., Joensuu, A., Kleber, M. E., Hall, A. S., Maerz, W., Salomaa, V., O'Donnell, C., Ingelsson, E., Feitosa, M. F., Erdmann, J., Bowden, D. W., Palmer, C. N. A., Gudnason, V., Perola, M., PROMIS & Cardiogramplusc4D, 13 Jun 2017, In : Circulation . 135, 24, p. 2336-+ 45 p.

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