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Mart Saarma

  • PL 56 (Viikinkaari 5)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1991 …2040
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Publications 1991 2019

1H, 13C and 15N resonance assignments of the human mesencephalic astrocyte-derived neurotrophic factor.

Hellman, M., Peränen, J., Saarma, M. & Permi, P., 2010, In : Biomolecular NMR assignments. 4, 2, p. 215-217 3 p.

Research output: Contribution to journalArticleScientificpeer-review

3 STRAIN GROUPS OF POTATO-A-POTYVIRUS BASED ON HYPERSENSITIVE RESPONSES IN POTATO, SEROLOGICAL PROPERTIES, AND COAT PROTEIN SEQUENCES

VALKONEN, J. P. T., PUURAND, U., SLACK, S. A., MAKINEN, K. & SAARMA, M., 1995, In : Plant Disease. 79, p. 748-753 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor 4 impairs thyroid calcitonin production in young mice

Lindfors, P. H., Lindahl, M., Rossi, J., Saarma, M., Airaksinen, M. S. & Airaksinen, M. S., 2006, In : Endocrinology. 147, 5, p. 2237-2244 8 p.

Research output: Contribution to journalArticleScientificpeer-review

A deep convolutional neural network approach for astrocyte detection

Suleymanova, I., Balassa, T., Tripathi, S., Molnar, C., Saarma, M., Sidorova, Y. & Horvath, P., 27 Aug 2018, In : Scientific Reports. 8, 7 p., 12878.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Adeno-Associated Viral (AAV) Vector Expressing Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Protects Cortical Neurons Against Ischemia-Induced Toxicity in Rats

Airavaara, M., Harvey, B., Chiocco, M., Howard, D., Peranen, J., Saarma, M., Wang, Y. & Hoffer, B., 2009, In : Cell Transplantation. 18, 2, p. 207-208 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Advanced brain dopamine transporter imaging in mice, using small animal SPECT/CT

Pitkonen, M., Hippeläinen, E. T., Raki, M., Andressoo, J-O., Urtti, A., Männistö, P., Savolainen, S., Saarma, M. & Bergström, K., 2012, In : EJNMMI Research. 2, p. 55

Research output: Contribution to journalArticleScientificpeer-review

A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system

Lauren, J., Airaksinen, M. S., Saarma, M. & Timmusk, T., 2003, In : Genomics. 81, p. 411-421 11 p.

Research output: Contribution to journalArticleScientificpeer-review

A novel human processed gene, DAD-R, maps to 12p12 and is expressed in several organs

Kuittinen, T. P., Eggert, A., Lindholm, P. K., Horelli-Kuitunen, N., Palotie, A., Maris, J. M. & Saarma, M., 2000, In : FEBS Letters. 2000, 473, p. 233-236

Research output: Contribution to journalArticleScientificpeer-review

A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat

Sidorova, Y. A., Bespalov, M. M., Wong, A. W., Kambur, O., Jokinen, V., Lilius, T. O., Suleymanova, I., Karelson, G., Rauhala, P. V., Karelson, M., Osborne, P. B., Keast, J. R., Kalso, E. A. & Saarma, M., 21 Jun 2017, In : Frontiers in Pharmacology. 8, 18 p., 365.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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ANTISENSE INHIBITION OF LOW-AFFINITY NERVE GROWTH-FACTOR RECEPTOR IN KIDNEY CULTURES - POWER AND PITFALLS

SAINIO, K., SAARMA, M., NONCLERCQ, D., PAULIN, L. & SARIOLA, H., 1994, In : Cellular and Molecular Neurobiology. 14, p. 439-457 19 p.

Research output: Contribution to journalArticleScientificpeer-review

A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus

Immonen, T., Alakuijala, A., Hytönen, M., Sainio, K., Poteryaev, D., Saarma, M., Pasternack, M. & Sariola, H., 2008, In : Experimental Neurology. 210, p. 793-796 4 p.

Research output: Contribution to journalArticleScientificpeer-review

BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion

Rivera, C., Li, H., Thomas-Crusells, J., Lahtinen, H., Viitanen, T., Nanobashvili, A., Kokaia, Z., Airaksinen, M. S., Voipio, J., Kaila, K. & Saarma, M., 2002, In : Journal of Cell Biology. 159, p. 747-752 6 p.

Research output: Contribution to journalArticleScientificpeer-review

BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met

Mizui, T., Ishikawa, Y., Kumanogoh, H., Lume, M., Matsumoto, T., Hara, T., Yamawaki, S., Takahashi, M., Shiosaka, S., Itami, C., Uegaki, K., Saarma, M. & Kojima, M., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 23, p. E3067-E3074 8 p.

Research output: Contribution to journalArticleScientificpeer-review

c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson's Disease

Lindholm, D., Pham, D. D., Cascone, A., Eriksson, O., Wennerberg, K. & Saarma, M., 26 Oct 2016, In : Frontiers in aging neuroscience. 8, 6 p., 254.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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CDNF is a novel neurotrophic factor for doparninergic neurons in vivo

Voutilainen, M. H., Lindholm, P., Saarma, M. & Tuominen, R. K., 9 Jun 2008, In : European Journal of Pharmaceutical Sciences. 34, 1, p. S9-S9 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery After MPTP Treatment in Mice

Airavaara, M., Harvey, B. K., Voutilainen, M. H., Shen, H., Chou, J., Lindholm, P., Lindahl, M., Tuominen, R. K., Saarma, M., Hoffer, B. & Wang, Y., 2012, In : Cell Transplantation. 21, 6, p. 1213-1223 11 p.

Research output: Contribution to journalArticleScientificpeer-review

CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery After MPTP Treatment n Mice

Airavaara, M., Harvey, B. K., Voutilainen, M. H., Chou, J., Lindholm, P., Lindahl, M., Tuominen, R. K., Saarma, M., Wang, Y. & Hoffer, B., 2011, In : Cell Transplantation. 20, Supplement 1, p. 544-545 2 p.

Research output: Contribution to journalArticleScientificpeer-review

CDNF Protein Therapy in Parkinson’s Disease

Huttunen, H. J. & Saarma, M., 4 Apr 2019, In : Cell Transplantation. 28, 4, p. 349-366 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice

Kemppainen, S., Pulkkila, P. K., Galli, E. M. C., Lahtinen, H-M., Koivisto, H., Hämäläinen, E., Saarma, M. & Tanila, H., 2015, In : Behavioural Brain Research. 291, p. 1-11 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Characterization of CDNF-Secreting ARPE-19 Cell Clones for Encapsulated Cell Therapy

Galli, E., Lindholm, P., Kontturi, L-S., Saarma, M., Urtti, A. & Yliperttula, M., Apr 2019, In : Cell Transplantation. 28, 4, p. 413-424 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75(NTR)

Aurikko, JP., Ruotolo, BT., Grossmann, JG., Moncrieffe, MC., Stephens, E., Leppänen, V-M., Robinson, CV., Saarma, M., Bradshaw, RA. & Blundell, TL., 30 Sep 2005, In : Journal of Biological Chemistry. 280, 39, p. 33453-33460 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75[sup NTR]

Aurikko, J. P., Ruotolo, B. T., Grossmann, J. G., Moncrieffe, M. C., Stephens, E., Leppänen, V-M., Robinson, C. V., Saarma, M., Bradshaw, R. A. & Blundell, T. L., 2005, In : Journal of Biological Chemistry. 280, 39, p. 33453 - 33460 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Characterization of the Intracellular Localization, Processing, and Secretion of Two Glial Cell Line-Derived Neurotrophic Factor Splice Isoforms

Lonka-Nevalaita, L., Lume, M., Leppänen, S. M., Jokitalo, E., Peränen, J. & Saarma, M., 25 Aug 2010, In : Journal of Neuroscience. 30, 34, p. 11403-11413 11 p.

Research output: Contribution to journalArticleScientificpeer-review

CHARACTERIZATION OF THE RAT LIGHT NEUROFILAMENT (NF-L) GENE PROMOTER AND IDENTIFICATION OF NGF AND CAMP-RESPONSIVE REGIONS

REEBEN, M., NEUMAN, T., PALGI, J., PALM, K., PAALME, V. & SAARMA, M., 1995, In : Journal of Neuroscience Research. 40, 2, p. 177-188 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Characterization of the striatal dopaminergic neurotransmission in MEN2B mice with elevated cerebral tissue dopamine

Mijatovic, J., Patrikainen, O., Yavich, L., Airavaara, M., Ahtee, L., Saarma, M. & Piepponen, P., 2008, In : Journal of Neurochemistry. 105, 5, p. 1716-1725 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Characterization of the Structural and Functional Determinants of MANF/CDNF in Drosophila In Vivo Model

Lindström, R., Lindholm, P. K., Kallijärvi, J., Yu, L., Piepponen, T. P., Arumäe, U., Saarma, M. & Heino, T., 2013, In : PLoS One. 8, 9, 12 p., e73928.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Characterization of the structural and functional determinants of MANF/CDNF proteins using Drosophila model

Lindstrom, R., Lindholm, P., Yu, L. -Y., Kallijarvi, J., Arumae, U., Saarma, M. & Heino, T., Dec 2012, In : Journal of Neurogenetics. 26, p. 73-74 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease

Voutilainen, M. H., Back, S., Peranen, J., Lindholm, P., Raasmaja, A., Mannisto, P. T., Saarma, M. & Tuominen, R. K., 2011, In : Experimental Neurology. 228, 1, p. 99-108 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson's Disease

Huotarinen, A., Penttinen, A-M., Bäck, S., Voutilainen, M. H., Julku, U., Piepponen, T. P., Männistö, P. T., Saarma, M., Tuominen, R., Laakso, A. & Airavaara, M., 15 Mar 2018, In : Neuroscience. 374, p. 250-263 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Comparative Analysis of the Effects of Neurotrophic Factors CDNF and GDNF in a Nonhuman Primate Model of Parkinson's Disease

Garea-Rodriguez, E., Eesmaa, A., Lindholm, P. K., Schlumbohm, C., König, J., Meller, B., Krieglstein, K., Helms, G., Saarma, M. & Fuchs, E., 22 Feb 2016, In : PLoS One. 11, 2, 21 p., 0149776.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Comparison of striatal and nigral administration of CDNF in 6-OHDA rat model of PD

Voutilainen, M. H., Panhelainen, A., Albert, K., Tuominen, R. K., Airavaara, M. & Saarma, M., May 2014, In : Movement Disorders. 29, p. S331-S331 1 p.

Research output: Contribution to journalConference articleScientific

Constitutive Ret signaling is protective for dopaminergic cell bodies but not for axonal terminals

Mijatovic, J., Piltonen, M., Alberton, P., Männistö, P. T., Saarma, M. & Piepponen, T. P., 2011, In : Neurobiology of Aging. 32, 8, p. 1486-1494 9 p.

Research output: Contribution to journalArticleScientificpeer-review

COORDINATED EXPRESSION AND FUNCTION OF NEUROTROPHINS AND THEIR RECEPTORS IN THE RAT INNER-EAR DURING TARGET INNERVATION

PIRVOLA, U., ARUMAE, U., MOSHNYAKOV, M., PALGI, J., SAARMA, M. & YLIKOSKI, J., 1994, In : Hearing Research. 75, p. 131-144 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Current disease modifying approaches to treat Parkinson's disease

Lindholm, D., Mäkelä, J., Di Liberto, V., Mudo, G., Belluardo, N., Eriksson-Rosenberg, O. & Saarma, M., Apr 2016, In : Cellular and Molecular Life Sciences. 73, 7, p. 1365-1379 15 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Dampened Amphetamine-Stimulated Behavior and Altered Dopamine Transporter Function in the Absence of Brain GDNF

Kopra, J. J., Panhelainen, A., af Bjerken, S., Porokuokka, L. L., Varendi, K., Olfat, S., Montonen, H., Piepponen, T. P., Saarma, M. & Andressoo, J-O., 8 Feb 2017, In : Journal of Neuroscience. 37, 6, p. 1581-1590 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Death receptors and caspases but not mitochondria are activated in the GDNF- or BDNF-deprived dopaminergic neurons

Yu, L., Saarma, M. & Arumäe, U., 2008, In : Journal of Neuroscience. 28, 30, p. 7467-7475 9 p.

Research output: Contribution to journalArticleScientificpeer-review

DeltaFosB expression is enhanced in heterozygous GDNF knockout mice after repeated morphine treatment

Airavaara, M., Gaddnas, HG., Piepponen, TP., Airaksinen, MS., Saarma, M. & Ahtee, L., Sep 2003, In : Behavioural Pharmacology. 14, p. S50-S50 1 p.

Research output: Contribution to journalConference articleScientific

DEPENDENCE OF KIDNEY MORPHOGENESIS ON THE EXPRESSION OF NERVE GROWTH-FACTOR RECEPTOR

SARIOLA, H., SAARMA, M., SAINIO, K., ARUMAE, U., PALGI, J., VAAHTOKARI, A., THESLEFF, I. & KARAVANOV, A., 1991, In : Science Progress. 254, p. 571-573 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease

Runeberg-Roos, P., Piccinini, E., Penttinen, A-M., Matlik, K., Heikkinen, H., Kuure, S., Bespalov, M. M., Peranen, J., Garea-Rodriguez, E., Fuchs, E., Airavaara, M., Kalkkinen, N., Penn, R. & Saarma, M., Dec 2016, In : Neurobiology of Disease. 96, p. 335-345 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Developmental expression of palmitoyl protein thioesterase in normal mice

Isosomppi, J., Heinonen, O., Hiltunen, J. O., Greene, N. D. E., Vesa, J., Uusitalo, A., Mitchison, H. M., Saarma, M., Jalanko, A. & Peltonen, L., 1999, In : Developmental Brain Research. 118, p. 111 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Developmental up-regulation of KCC2 in the absence of GABAergic and glutamatergic transmission

Ludwig, A., Li, H., Saarma, M., Kaila, K. & Rivera, C., 2003, In : European Journal of Neuroscience. 18, p. 3199-3206 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor alpha 2

Nanobashvili, A., Airaksinen, M. S., Kokaia, M., Rossi, J., Asztely, F., Olofsdotter, K., Mohapel, P., Saarma, M., Lindvall, O. & Kokaia, Z., 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, p. 12312-12317 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Development and plasticity of meningeal lymphatic vessels

Antila, S., Karaman, S., Nurmi, H., Airavaara, M., Voutilainen, M. H., Mathivet, T., Chilov, D., Li, Z., Koppinen, T., Park, J-H., Fang, S., Aspelund, A., Saarma, M., Eichmann, A., Thomas, J-L. & Alitalo, K., Dec 2017, In : Journal of Experimental Medicine. 214, 12, p. 3645-3667 23 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Distinct roles for GFR alpha 1 and GFR alpha 2 signalling in different cranial parasympathetic ganglia in vivo

Rossi, J., Tomac, A., Saarma, M. & Airaksinen, M. S., 2000, In : European Journal of Neuroscience. 12, p. 3944-3952 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Distribution of GABA receptor rho subunit transcripts in the rat brain

Wegelius, K., Pasternack, M., Hiltunen, J. O., Rivera, C., Kaila, K., Saarma, M. & Reeben, M., 1998, In : European Journal of Neuroscience. 10, p. 350-357 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Drosophila gene encoding a homolog of the novel human neurotrophic factor MANF

Palgi, M., Lindstrom, R., Peranen, J., Piepponen, P., Saarma, M. & Heino, T. I., 2006, In : Journal of Neurogenetics. 20, p. 196-197 2 p.

Research output: Contribution to journalConference articleScientific