No photo of Mart Saarma

Mart Saarma

  • PL 56 (Viikinkaari 5)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1991 …2040
If you made any changes in Pure these will be visible here soon.

Publications 1991 2019

Article

GABA receptor subunit expression in the developing rat brain

Alakuijala, A., Palgi, M., Wegelius, K., Schmidt, M., Enz, R., Paulin, L., Saarma, M. & Pasternack, M., 2005, In : Developmental Brain Research. 154, 1, p. 15-23 9 p.

Research output: Contribution to journalArticleScientificpeer-review

GDNF-deprived sympathetic neurons die via a novel nonmitochondrial pathway

Yu, L. Y., Jokitalo, E., Sun, Y. F., Mehlen, P., Lindholm, D., Saarma, M. & Arumae, U., 2003, In : Journal of Cell Biology. 163, p. 987-997 11 p.

Research output: Contribution to journalArticleScientificpeer-review

GDNF family ligands activate multiple events during axonal growth in mature sensory neurons

Paveliev, M., Airaksinen, M. S. & Saarma, M., 2004, In : Molecular and Cellular Neuroscience. 25, p. 453-459 7 p.

Research output: Contribution to journalArticleScientificpeer-review

GDNF family ligands and receptors are differentially regulated after brain insults in the rat

Kokaia, Z., Airaksinen, M. S., Nanobashvili, A., Larsson, E., Kujamaki, E., Lindvall, O. & Saarma, M., 1999, In : European Journal of Neuroscience. 11, p. 1202-1216 15 p.

Research output: Contribution to journalArticleScientificpeer-review

GDNF family receptors in the embryonic and postnatal rat heart and reduced cholinergic innervation in mice hearts lacking Ret or GFR alpha 2

Hiltunen, J. O., Laurikainen, A., Airaksinen, M. S. & Saarma, M., 2000, In : Developmental Dynamics. 219, p. 28-39 12 p.

Research output: Contribution to journalArticleScientificpeer-review

GDNF is not required for catecholaminergic neuron survival in vivo

Kopra, J., Vilenius, C., Grealish, S., Härma, M-A., Varendi, K., Lindholm, J., Castrén, E., Voikar, V., Björklund, A., Piepponen, T. P., Saarma, M. & Andressoo, J-O., Mar 2015, In : Nature Neuroscience. 18, 3, p. 319-322 4 p.

Research output: Contribution to journalArticleScientificpeer-review

GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function

Kumar, A., Kopra, J. J., Varendi, K., Porokuokka, L. L., Panhelainen, A. E., Kuure, S. H., Marshall, P. O. L., Karalija, N., Härma, M-A., Vilenius, C. L., Lilleväli, K., Tekko, T., Mijatovic, J., Pulkkinen, N., Jakobson, M., Jakobson, M., Ola, R., Palm, E., Lindahl, M. S., Strömberg, I. & 4 others, Võikar, V., Piepponen, T. P., Saarma, M. & Andressoo, J-O., 2015, In : PLoS Genetics. 11, 12, 24 p., e1005710.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease

Bäck, S., Peränen, J., Galli, E., Pulkkila, P., Lonka-Nevalaita, L., Tamminen, T., Voutilainen, M. H., Raasmaja, A., Saarma, M., Männistö, P. T. & Tuominen, R. K., Mar 2013, In : Brain and Behavior. 3, 2, p. 75-88 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
Open Access
File

Glial cell line-derived neurotrophic factor: Characterization of mammalian posttranslational modifications

Piccinini, E., Kalkkinen, N., Saarma, M. & Runeberg-Roos, P., 2013, In : Annals of Medicine. 45, 1, p. 66-73 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium

Sainio, K., Suvanto, P., Davies, J., Wartiovaara, J., Wartiovaara, K., Saarma, M., Arumae, U., Meng, X. J., Lindahl, M., Pachnis, V. & Sariola, H., 1997, In : Development. 124, p. 4077-4087 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin

Bespalov, M. M., Sidorova, Y. A., Tumova, S., Ahonen-Bishopp, A., Magalhaes, A. C., Kulesskiy, E., Paveliev, M., Rivera Baeza, C., Rauvala, H. & Saarma, M., 2011, In : Journal of Cell Biology. 192, 1, p. 153-169 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons

Piltonen, M., Bespalov, M. M., Ervasti, D., Matilainen, T., Sidorova, Y. A., Rauvala, H., Saarma, M. & Männistö, P. T., 2009, In : Experimental Neurology. 219, 2, p. 499-506 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells

Lindahl, M., Poteryaev, D., Yu, L. Y., Arumae, U., Timmusk, T., Bongarzone, I., Aiello, A., Pierotti, M. A., Airaksinen, M. S. & Saarma, M., 2001, In : Journal of Biological Chemistry. 276, p. 9344-9351 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of the genome-linked protein in virions of Potato virus A, with comparison to other members in genus Potyvirus

Oruetxebarria, I., Guo, D. Y., Merits, A., Makinen, K., Saarma, M. & Valkonen, J. P. T., 2001, In : Virus Research. 73, p. 103-112 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Implementation of deep neural networks to count dopamine neurons in substantia nigra

Penttinen, A-M., Parkkinen, I., Blom, S., Kopra, J., Andressoo, J-O., Pitkänen, K., Voutilainen, M. H., Saarma, M. & Airavaara, M., Sep 2018, In : European Journal of Neuroscience. 48, 6, p. 2354-2361 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes

Galli, E., Harkonen, T., Sainio, M., Ustav, M., Toots, U., Urtti, A., Yliperttula, M., Lindahl, M., Knip, M., Saarma, M. & Lindholm, P., 30 Jun 2016, In : Scientific Reports. 6, 11 p., 29058.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Increased extracellular dopamine concentrations and FosB/delta FosB expression in striatal brain areas of heterozygous GDNF knockout mice

Airavaara, M., Planken, A., Gaddnas, H., Piepponen, T. P., Saarma, M. & Ahtee, L., Jul 2004, In : Fundamental & Clinical Pharmacology. 18, p. 55-55 1 p.

Research output: Contribution to journalArticleScientificpeer-review

Increased extracellular dopamine concentrations and FosB/ΔFosB expression in striatal brain areas of heterozygous GDNF knockout mice

Airavaara, M., Planken, A., Gäddnäs, H., Piepponen, T. P., Saarma, M. & Ahtee, L., 2004, In : European Journal of Neuroscience. 20, 9, p. 2336-2344 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Increased Serum Levels of Mesencephalic Astrocyte-Derived Neurotrophic Factor in Subjects With Parkinson’s Disease

Galli, E., Planken, A., Kadastik-Eerme, L., Saarma, M., Taba, P. & Lindholm, P., 4 Sep 2019, In : Frontiers in Neuroscience. 13, 8 p., 929.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Infectious in vitro transcripts from cloned cDNA of the potato A potyvirus

Puurand, U., Valkonen, J. P. T., Makinen, K., Rabenstein, F. & Saarma, M., 1996, In : Virus Research. 40, p. 135-140 6 p.

Research output: Contribution to journalArticleScientificpeer-review

In heterozygous GDNF knockout mice the response of striatal dopaminergic system to acute morphine is altered

Airavaara, M., Mijatovic, J., Vihavainen, T., Piepponen, P., Saarma, M. & Ahtee, L., 2006, In : Synapse (New York). 59, 6, p. 321-329 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra

Mätlik, K., Vihinen, A. H., Bienemann, A., Palgi, J., Voutilainen, M. H., Booms, S., Lindahl, M. S., Jokitalo, E. S., Saarma, M., Huttunen, H. J., Airavaara, M. T. & Arumäe, U., 20 Feb 2017, In : eNeuro. 4, 1, 15 p., e0128-16.2017.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway

Lindstrom, R., Lindholm, P., Palgi, M., Saarma, M. & Heino, T. I., 2 Jun 2017, In : BMC Genetics. 18, 19 p., 52.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

KCC2 interacts with the dendritic cytoskeleton to promote spine development

Li, H., Khirug, S., Cai, C., Ludwig, A., Blaesse, P., Kolikova, J., Afzalov, R., Coleman, S. K., Lauri, S., Airaksinen, M. S., Keinanen, K., Khiroug, L., Saarma, M., Kaila, K. & Rivera, C., 2007, In : Neuron. 56, 6, p. 1019-1033 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Lahkus närvikasvufaktori avastaja Rita Levi-Montalcini

Saarma, M. & Castrén, E., 2013, In : Sirp : Eesti kultuurleht.

Research output: Contribution to journalArticleGeneral public

Large-scale production of dsRNA and siRNA pools for RNA interference utilizing bacteriophage phi6 RNA-dependent RNA polymerase

Aalto, A., Sarin, L. P., Van Dijk, A. A., Saarma, M., Poranen, M. M., Arumäe, U. & Bamford, D. H., 2007, In : RNA. 13, 3, p. 422-429 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Levels of glial cell line-derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in parkinson's disease

Virachit, S., Mathews, K. J., Cottam, V., Werry, E., Galli, E., Rappou, E., Lindholm, P., Saarma, M., Halliday, G. M., Shannon Weickert, C. & Double, K. L., 29 Apr 2019, In : Brain Pathology.

Research output: Contribution to journalArticleScientificpeer-review

Localization of glial cell line-derived neurotrophic factor (GDNF) mRNA in embryonic rat by in situ hybridization

Sainio, K., Suvanto, P., Hiltunen, J. O., Arumae, U., Moshnyakov, M., Sariola, H., Sainio, K. & Saarma, M., 1996, In : European Journal of Neuroscience. 8, p. 816-822 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Localization of nerve cells in the developing rat tooth

Luukko, K., Sainio, K., Sariola, H., Saarma, M. & Thesleff, I., 1997, In : Indian Journal of Dental Research. 76, p. 1350-1356 7 p.

Research output: Contribution to journalArticleScientificpeer-review

MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex

Tseng, K-Y., Danilova, T., Domanskyi, A., Saarma, M., Lindahl, M. S. & Airavaara, M. T., 29 Sep 2017, In : eNeuro. 4, 5, 21 p., e0214-17.2017.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

MANF is indispensable for the proliferation and survival of pancreatic beta-cells

Lindahl, M., Danilova, T., Palm, E., Lindholm, P., Voikar, V., Hakonen, E., Ustinov, J., Andressoo, J-O., Harvey, B. K., Otonkoski, T., Rossi, J. & Saarma, M., Apr 2014, In : Cell Reports. 7, 2, p. 366-375 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain

Lindholm, P., Peränen, J., Andressoo, J-O., Kalkkinen, N., Kokaia, Z., Lindvall, O., Timmusk, T. & Saarma, M., 2008, In : Molecular and Cellular Neuroscience. 39, 3, p. 356-371 16 p.

Research output: Contribution to journalArticleScientificpeer-review

MANF protects human pancreatic beta cells against stress-induced cell death

Hakonen, E., Chandra, V., Fogarty, C. L., Yu, N. Y-L., Ustinov, J., Katayama, S., Galli, E., Danilova, T., Lindholm, P., Vartiainen, A., Einarsdottir, E., Krjutskov, K., Kere, J., Saarma, M., Lindahl, M. & Otonkoski, T., Oct 2018, In : Diabetologia. 61, 10, p. 2202-2214 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2

Rivera, C., Voipio, J., Thomas-Crusells, J., Li, H., Emri, Z., Sipila, S., Payne, J. A., Minichiello, L., Saarma, M. & Kaila, K., 2004, In : Journal of Neuroscience. 24, p. 4683-4691 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons

Hellman, M., Arumäe, U., Yu, L., Lindholm, P. K., Peränen, J., Saarma, M. & Permi, P., 2011, In : Journal of Biological Chemistry. 286, 4, p. 2675-2680 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's Disease

Voutilainen, M., Bäck, S., Pörsti, E., Toppinen, L., Lindgren, L., Lindholm, P., Peränen, J., Saarma, M. & Tuominen, R. K., 2009, In : Journal of Neuroscience. 29, 30, p. 9651-9659 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Mesencephalic astrocyte-derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats.

Airavaara, M., Shen, H., Kuo, C-C., Peränen, J., Saarma, M., Hoffer, B. & Wang, Y., 1 Jul 2009, In : Journal of Comparative Neurology. 515, 1, p. 116-124 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion: MAPK Activity Controls Epithelial Adhesion In Vivo

Iherman-Hella, A., Lume, M., Miinalainen, I., Pirttiniemi, A., Gui, Y., Peränen, J., Charron, J., Saarma, M., Costantini, F. & Kuure, S. H., Mar 2014, In : PLoS Genetics. 10, 3, 15 p., e1004193.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Molecular Dynamics Simulations of the Interactions between Glial Cell Line-Derived Neurotrophic Factor Family Receptor GFR alpha 1 and Small-Molecule Ligands

Ivanova, L., Tammiku-Taul, J., Garcia-Sosa, A. T., Sidorova, Y., Saarma, M. & Karelson, M., Sep 2018, In : ACS Omega. 3, 9, p. 11407-11414 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Monoclonal antibodies specific for Semliki Forest virus replicase protein nsP2

Kujala, P., Rikkonen, M., Ahola, T., Kelve, M., Saarma, M. & Kaariainen, L., Feb 1997, In : Journal of General Virology. 78, p. 343-351 9 p.

Research output: Contribution to journalArticleScientificpeer-review

NEURONAL CHARACTERISTICS IN EMBRYONIC RENAL STROMA

SAINIO, K., NONCLERCQ, D., SAARMA, M., PALGI, J., SAXEN, L. & SARIOLA, H., 1994, In : International journal of plant developmental biology. 38, p. 77-84 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Neurotrophic factors switch between two signaling pathways that trigger axonal growth

Paveliev, M., Lume, M., Velthut, A., Phillips, M., Arumäe, U. & Saarma, M., 2007, In : Journal of Cell Science. 120, p. 2507-2516 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Neurotrophin-3 is a target-derived neurotrophic factor for penile erection-inducing neurons

Hiltunen, J., Laurikainen, A., Klinge, E. & Saarma, M., 2005, In : Neuroscience. 133, 1, p. 51-58 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Neurotrophin mRNA expression in the developing tooth suggests multiple roles in innervation and organogenesis

Luukko, K., Arumae, U., Karavanov, A., Moshnyakov, M., Sainio, K., Sariola, M., Saarma, M. & Thesleff, I., 1997, In : Developmental Dynamics. 210, p. 117-129 13 p.

Research output: Contribution to journalArticleScientificpeer-review

NEUROTROPHINS AND THEIR RECEPTORS IN RAT PERIPHERAL TRIGEMINAL SYSTEM DURING MAXILLARY NERVE GROWTH

ARUMAE, U., PIRVOLA, U., PALGI, J., KIEMA, T. R., PALM, K., MOSHNYAKOV, M., YLIKOSKI, J. & SAARMA, M., 1993, In : European Journal of Cell Biology. 122, p. 1053-1065 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Neurturin evokes MAPK-dependent upregulation of Egr4 and KCC2 in developing neurons

Ludwig, A., Uvarov, P., Pellegrino, C., Thomas-Crusells, J., Schuchmann, S., Saarma, M., Airaksinen, M. & Rivera Baeza, C., 2011, In : Neural Plasticity. 2011, Article ID 641248, p. 1-8 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel agonist of GDNF family ligand receptor RET for the treatment of experimental neuropathy

Bespalov, M., Sidorova, Y., Suleymanova, I., Thompson, J., Kambur, O., Jokinen, V., Lilius, T. O., Karelson, G., Puusepp, L., Rauhala, P. V., Kalso, E. A., Karelson, M. & Saarma, M., 4 Jul 2016, In : BioRxiv beta : the preprint server for biology.

Research output: Contribution to journalArticleProfessional

Open Access