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Mart Saarma

  • PL 56 (Viikinkaari 5)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1991 …2040
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Publications 1991 2019

Article

Novel CDNF/MANF Family of Neurotrophic Factors

Lindholm, P. K. & Saarma, M., 2010, In : Developmental Neurobiology. 70, 5, p. 360-371 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel computational models for predicting dopamine interactions

Katritzky, A. R., Dobchev, D. A., Stoyanova-Slavova, I. B., Kuanar, M., Bespalov, M. M., Karelson, M. & Saarma, M., 2008, In : Experimental Neurology. 211, p. 150-171 22 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

Lindholm, P., Voutilainen, M., Lauren, J., Peränen, J., Leppänen, V-M., Andressoo, J-O., Lindahl, M., Janhunen, S., Kalkkinen, N., Timmusk, T., Tuominen, R. K. & Saarma, M., 2007, In : Nature. 448, 7147, p. 73-78 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Ozone-induced programmed cell death in the Arabidopsis radical-induced cell death1 mutant

Overmyer, K., Brosche, M. J., Pellinen, R., Kuittinen, T., Tuominen, H., Ahlfors, R., Keinänen, M., Saarma, M., Scheel, D. & Kangasjärvi, J., 2005, In : Plant Physiology. 137, 3, p. 1092-1104 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Parkinson's disease: towards better preclinical models and personalized treatments

Lindholm, D., Mäkelä, J., Di Liberto, V., Mudo, G., Belluardo, N., Eriksson-Rosenberg, O. & Saarma, M., Apr 2016, In : Cellular and Molecular Life Sciences. 73, 7, p. 1383-1385 3 p.

Research output: Contribution to journalArticleScientific

Open Access
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Persephin signaling through GFR alpha 1: The potential for the treatment of Parkinson's disease

Sidorova, Y., Mätlik, K., Paveliev, M., Lindahl, M., Piranen, E., Milbrandt, J., Arumäe, U., Saarma, M. & Bespalov, M., 2010, In : Molecular and Cellular Neuroscience. 44, 3, p. 223-232 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Phosphorylation down-regulates the RNA binding function of the coat protein of potato virus A

Translated title of the contribution: Phosphorylation down-regulates the RNA binding function of the coat protein of potato virus AIvanov, K. I., Puustinen, P., Merits, A., Saarma, M. & Mäkinen, K., 1 Apr 2001, In : Journal of Biological Chemistry. 276, 17, p. 13530-13540 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Posttraumatic GABA(A)-mediated [Ca2+](i) increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons

Shulga, A., Thomas-Crusells, J., Sigl, T., Blaesse, A., Mestres, P., Meyer, M., Yan, Q., Kaila, K., Saarma, M., Rivera, C. & Giehl, K. M., 2008, In : Journal of Neuroscience. 28, 27, p. 6996-7005 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Posttraumatic GABA[subA]-mediated [Ca²][subi] increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons

Shulga, A., Thomas-Crusells, J., Sigl, T., Blaesse, A., Mestres, P., Meyer, M., Yan, Q., Kaila, K., Saarma, M., Rivera, C. & Giehl, K. M., 2008, In : Journal of Neuroscience. 28, 27, p. 6996-7005 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease

Penttinen, A-M., Parkkinen, I., Voutilainen, M. H., Koskela, M., Bäck, S., Their, A., Richie, C. T., Domanskyi, A., Harvey, B. K., Tuominen, R. K., Nevalaita, L., Saarma, M. & Airavaara, M., 20 Jun 2018, In : Frontiers in neurology. 9, 14 p., 457.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Proteolytic processing of potyviral proteins and polyprotein processing intermediates in insect and plant cells

Merits, A., Rajamaki, M. L., Lindholm, P., Runeberg-Roos, P., Kekarainen, T., Puustinen, P., Makelainen, K., Valkonen, J. P. T. & Saarma, M., 2002, In : Journal of General Virology. 83, p. 1211-1221 11 p.

Research output: Contribution to journalArticleScientificpeer-review

PSPN/GFRalpha4 has a significantly weaker capacity than GDNF/GFRalpha1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth.

Yang, J., Lindahl, M. S., Lindholm, P. K., Virtanen, H., Coffey, E., Runeberg-Roos, P. & Saarma, M., 2004, In : FEBS Letters. 2004, 569, p. 267-271

Research output: Contribution to journalArticleScientificpeer-review

Rakumaailma filosoofiline kivi

Saarma, M. & Arumäe, U., 2012, In : Sirp : Eesti kultuurleht.

Research output: Contribution to journalArticleGeneral public

Regulation of cell fate decision of undifferentiated spermatogonia by GDNF

Meng, X. J., Lindahl, M., Hyvönen, M. E., Parvinen, M., de Rooij, D. G., Hess, M. W., Raatikainen-Ahokas, A., Sainio, K., Rauvala, H., Lakso, M., Pichel, J. G., Westphal, H., Saarma, M. & Sariola, H., 2000, In : Science. 287, p. 1489-1493 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Restoring dopaminergic nerve cells in Parkinson’s disease

Ronken, E., Sidorova, Y., Karelson, M. & Saarma, M., 2017, In : Open access government. p. 25-26

Research output: Contribution to journalArticleGeneral public

RET(MEN 2B) is active in the endoplasmic reticulum before reaching the cell surface

Runeberg-Roos, P., Virtanen, H. & Saarma, M., 2007, In : Oncogene. 26, 57, p. 7909-7915 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha 2, a functional neurturin receptor

Rossi, J., Luukko, K., Poteryaev, D., Laurikainen, A., Sun, Y. F., Laakso, T., Eerikainen, S., Tuominen, R., Lakso, M., Rauvala, H., Arumae, U., Pasternack, M., Saarma, M. & Airaksinen, M. S., 1999, In : Neuron. 22, 2, p. 243-252 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Rita levi-Montalcini 1909-2012. Hermostotutkimus toi Nobelin palkinnon

Castrén, E. & Saarma, M., 2013, In : Helsingin Sanomat.

Research output: Contribution to journalArticleGeneral public

RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications

Mutso, M., Nikonov, A., Pihlak, A., Zusinaite, E., Viru, L., Selyutina, A., Reintamm, T., Kelve, M., Saarma, M., Karelson, M. & Merits, A., 3 Jun 2015, In : PLoS One. 10, 6, 25 p., 0128686.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity

Mätlik, K., Yu, L., Eesmaa, A., Hellman, M., Lindholm, P., Peränen, J., Galli, E., Anttila, J., Saarma, M., Permi, P., Airavaara, M. & Arumäe, U., Dec 2015, In : Cell Death and Disease. 6, 8 p., 2032.

Research output: Contribution to journalArticleScientificpeer-review

Sensory neurons from N-syndecan-deficient mice are defective in survival

Paveliev, M., Hienola, A., Jokitalo, E., Planken, A., Bespalov, M. M., Rauvala, H. & Saarma, M., 2008, In : NeuroReport. 19, 14, p. 1397-1400 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Short-term Preoperative Dietary Restriction Is Neuroprotective in a Rat Focal Stroke Model

Varendi, K., Airavaara, M., Anttila, J., Vose, S., Planken, A., Saarma, M., Mitchell, J. R. & Andressoo, J-O., 4 Apr 2014, In : PLoS One. 9, 4, 9 p., 93911.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Small-Molecule Ligands as Potential GDNF Family Receptor Agonists

Ivanova, L., Tammiku-Taul, J., Sidorova, Y., Saarma, M. & Karelson, M., Jan 2018, In : ACS Omega. 3, 1, p. 1022-1030 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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SorLA Controls Neurotrophic Activity by Sorting of GDNF and Its Receptors GFR alpha 1 and RET

Glerup, S., Lume, M., Olsen, D., Nyengaard, J. R., Vaegter, C. B., Gustafsen, C., Christensen, E. I., Kjolby, M., Hay-Schmidt, A., Bender, D., Madsen, P., Saarma, M., Nykjaer, A. & Petersen, C. M., Jan 2013, In : Cell Reports. 3, 1, p. 186-199 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Suppression of RNAi by dsRNA-Degrading RNaseIII Enzymes of Viruses in Animals and Plants

Weinheimer, I., Jiu, Y., Rajamäki, M., Matilainen, O., Kallijärvi, J., Cuellar, W., Lu, R., Saarma, M., Holmberg, C. I., Jäntti, J. & Valkonen, J., 6 Mar 2015, In : PLoS Pathogens. 11, 3, 25 p., e1004711.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Teaduse kvaliteedist ja innovatsioonist

Saarma, M., 2012, In : Riigikogu Toimetised.. 25, p. 9-20 12 p.

Research output: Contribution to journalArticleGeneral public

The first cysteine-rich domain of the receptor GFR alpha 1 stabilizes the binding of GDNF

Virtanen, H., Yang, JM., Bespalov, MM., Hiltunen, JO., Leppanen, VM., Kalkkinen, N., Goldman, A., Saarma, M. & Runeberg-Roos, P., 2005, In : Biochemical Journal. 387, p. 817-824 8 p.

Research output: Contribution to journalArticleScientificpeer-review

The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

Rivera, C., Voipio, J., Payne, J. A., Ruusuvuori, E., Lahtinen, H., Lamsa, K., Pirvola, U., Saarma, M. & Kaila, K., 1999, In : Nature. 397, p. 251-255 5 p.

Research output: Contribution to journalArticleScientificpeer-review

The messenger RNAs for both glial cell line-derived neurotrophic factor receptors, c-ret and GDNFR alpha, are induced in the rat brain in response to kainate-induced excitation

Reeben, M., Laurikainen, A., Hiltunen, J. O., Castren, E. & Saarma, M., 1998, In : Neuroscience. 83, p. 151-159 9 p.

Research output: Contribution to journalArticleScientificpeer-review

The mouse soluble GFR4 receptor activates RET independently of its ligand persephin

Yang, J., Runeberg-Roos, P., Leppänen, V-M. & Saarma, M., 2007, In : Oncogene. 26, p. 3892-3898 7 p.

Research output: Contribution to journalArticleScientificpeer-review

The mouse soluble GFRalpha4 receptor activates RET independently of its ligand persephin.

Yang, J., Runeberg-Roos, P., Leppänen, V-M. & Saarma, M., 2006, In : Oncogene. 26, p. 3892-3898

Research output: Contribution to journalArticleScientificpeer-review

The neuronal ceroid lipofuscinosis Cln8 gene expression is developmentally regulated in mouse brain and up-regulated in the hippocampal kindling model of epilepsy

Lonka, L., Aalto, A. P., Kopra, O., Kuronen, M., Kokaia, Z., Saarma, M. & Lehesjoki, A-E., 2005, In : BMC Neuroscience. 6, 27, p. 1-11 11 p.

Research output: Contribution to journalArticleScientificpeer-review

The rho(1) GABA receptor cloned from rat retina is down-modulated by protons

Wegelius, K., Reeben, M., Rivera, C., Kaila, K., Saarma, M. & Pasternack, M., 1996, In : NeuroReport. 7, p. 2005-2009 5 p.

Research output: Contribution to journalArticleScientificpeer-review

The structure of GFRα1 domain 3 reveals new insights into GDNF binding and RET activation

Leppänen, V-M., Bespalov, M., Runeberg-Roos, P., Puurand, Ü., Merits, A., Saarma, M. & Goldman, A., 2004, In : EMBO Journal. 23, p. 1452-1462

Research output: Contribution to journalArticleScientificpeer-review

The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional

Parkash, V., Lindholm, P., Peränen, J., Kalkkinen, N., Oksanen, E., Saarma, M., Leppänen, V-M. & Goldman, A., 2009, In : Protein Engineering, Design and Selection. 22, 4, p. 233-241 9 p.

Research output: Contribution to journalArticleScientificpeer-review

The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding

Parkash, V., Leppänen, V-M., Virtanen, H., Jurvansuu, J. M., Bespalov, M. M., Sidorova, Y. A., Runeberg-Roos, P., Saarma, M. & Goldman, A., 2008, In : Journal of Biological Chemistry. 283, 12, p. 35164-35172 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Thyroxin regulates BDNF expression to promote survival of injured neurons

Shulga, A., Blaesse, A., Kysenius, K. J., Huttunen, H. J., Tanhuanpää, K., Saarma, M. & Rivera, C., 2009, In : Molecular and Cellular Neuroscience. 42, 4, p. 408-418 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Toward understanding the neuronal pathogenesis of aspartylglucosaminuria: Expression of aspartylglucosaminidase in brain during development

Uusitalo, A., Tenhunen, K., Kopra, O., Hiltunen, J. O., Saarma, M., Haltia, M., Jalanko, A. & Peltonen, L., 1999, In : Molecular Genetics and Metabolism. 67, 4, p. 294-307 14 p.

Research output: Contribution to journalArticleScientificpeer-review

TRANSGENIC POTATO PLANTS EXPRESSING MAMMALIAN 2'-5' OLIGOADENYLATE SYNTHETASE ARE PROTECTED FROM POTATO VIRUS-X INFECTION UNDER FIELD CONDITIONS

TRUVE, E., AASPÕLLU, A., HONKANEN, J., PUSKA, R., MEHTO, M., HASSI, A., Teeri, T. H., KELVE, M., SEPPÄNEN, P. & SAARMA, M., 1993, In : Bio/technology. 11, 9, p. 1048-1052 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra

Nadella, R., Voutilainen, M. H., Saarma, M., Gonzalez-Barrios, J. A., Leon-Chavez, B. A., Dueas Jimnez, J. M., Dueas Jimnez, S. H., Escobedo, L. & Martinez-Fong, D., 16 Dec 2014, In : Journal of Neuroinflammation. 11, 18 p., 209.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Tutkija löysi uutta tietoa hermostosta

Saarma, M., Castrén, E. & Lindholm, D. B., 13 Jul 2012, In : Helsingin Sanomat. 1 p.

Research output: Contribution to journalArticleGeneral public

Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems

Lauren, J., Airaksinen, M. S., Saarma, M. & Timmusk, T., 2003, In : Molecular and Cellular Neuroscience. 24, p. 581-594 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Two potato proteins, including a novel RING finger protein (HIP1), interact with the potyviral multifunctional protein HCpro

Guo, D. Y., Spetz, C., Saarma, M. & Valkonen, J. P. T., 2003, In : Molecular Plant - Microbe Interactions. 16, 5, p. 405-410 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Tyroksiini edistää aivoperäisen neurotrofisen tekijän välityksellä vaurioituneiden hermosolujen selviytymistä

Shulga, A., Blaesse, A., Kysenius, K., Huttunen, H. J., Tanhuanpää, K., Saarma, M. & Rivera Baeza, C., 2009, In : Duodecim. 125, 21, p. 2398 1 p.

Research output: Contribution to journalArticleProfessional

Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons in vitro and in vivo

Piltonen, M. H., Planken, A., Leskelä, O., Myöhänen, T. T., Hänninen, A-L., Auvinen, P., Alitalo, K., Anderssoo, J-O., Saarma, M. & Männistö, P., 14 Jul 2011, In : Neuroscience. 192, p. 550-563 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Vaurioituneet hermosolut saavat kehityksenaikaisia ominaisuuksia

Shulga, A., Thomas-Crusells, J., Sigl, T., Blaesse, A., Mestres, P., Meyer, M., Yan, Q., Kaila, K., Saarma, M., Rivera Baeza, C. & Giehl, K., 2008, In : Duodecim. 124, p. 1766 1 p.

Research output: Contribution to journalArticleProfessional

Zebrafish GDNF and its co-receptor GFR alpha 1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro

Saarenpää, T., Kogan, K., Sidorova, Y., Mahato, A. K., Tascon, I., Kaljunen, H., Yu, L., Kallijärvi, J., Jurvansuu, J., Saarma, M. & Goldman, A., 3 May 2017, In : PLoS One. 12, 5, 18 p., 0176166.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
Chapter

Gene expression and cell death in ozone-exposed plants: Is programmed cell death involved in ozone damage in ozone-sensitive Arabidopsis mutants?

Overmyer, K., Kangasjärvi, J., Kuittinen, T. P. & Saarma, M., 1998, Responses of Plant Metabolism to Air Pollution and Global Change. The Hague: SPB Academic Publishing, p. 403-406 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

GFL neurotrophic factors: physiology and pharmacology

Saarma, M., 2009, Encyclopedia of neuroscience. E. L. R. S. (ed.). Amsterdam: Elsevier Academic Press, p. 711-720 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review