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Mart Saarma

  • PL 56 (Viikinkaari 5)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1991 …2040
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Publications 1991 2019

2008

Posttraumatic GABA[subA]-mediated [Ca²][subi] increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons

Shulga, A., Thomas-Crusells, J., Sigl, T., Blaesse, A., Mestres, P., Meyer, M., Yan, Q., Kaila, K., Saarma, M., Rivera, C. & Giehl, K. M., 2008, In : Journal of Neuroscience. 28, 27, p. 6996-7005 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Sensory neurons from N-syndecan-deficient mice are defective in survival

Paveliev, M., Hienola, A., Jokitalo, E., Planken, A., Bespalov, M. M., Rauvala, H. & Saarma, M., 2008, In : NeuroReport. 19, 14, p. 1397-1400 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Signalling mechanisms underlying development and maintenance of dopamine neurons

Andressoo, J-O. & Saarma, M., 2008, In : Current Opinion in Neurobiology. 18, 3, p. 297-306 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding

Parkash, V., Leppänen, V-M., Virtanen, H., Jurvansuu, J. M., Bespalov, M. M., Sidorova, Y. A., Runeberg-Roos, P., Saarma, M. & Goldman, A., 2008, In : Journal of Biological Chemistry. 283, 12, p. 35164-35172 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Vaurioituneet hermosolut saavat kehityksenaikaisia ominaisuuksia

Shulga, A., Thomas-Crusells, J., Sigl, T., Blaesse, A., Mestres, P., Meyer, M., Yan, Q., Kaila, K., Saarma, M., Rivera Baeza, C. & Giehl, K., 2008, In : Duodecim. 124, p. 1766 1 p.

Research output: Contribution to journalArticleProfessional

Effects of repeated morphine on locomotion, place preference and dopamine in heterozygous glial cell line-derived neurotrophic factor knockout mice

Airavaara, M., Tuomainen, H., Piepponen, P., Saarma, M. & Ahtee, L., 2007, In : Genes, Brain and Behavior. 6, 3, p. 287-298 12 p.

Research output: Contribution to journalArticleScientificpeer-review

GDNF family receptor complexes are emerging drug targets

Bespalov, M. M. & Saarma, M., 2007, In : Trends in Pharmacological Sciences. 28, 2, p. 68-74 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

GDNF receptors as a drug target for neural repair

Bespalov, M. M., Hetenyi, C., Turnova, S., Hienola, A., Sidorova, Y., Rauvala, H., Karelson, M. & Saarma, M., 2007, In : Cell Transplantation. 16, 3, p. 314-314 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

KCC2 interacts with the dendritic cytoskeleton to promote spine development

Li, H., Khirug, S., Cai, C., Ludwig, A., Blaesse, P., Kolikova, J., Afzalov, R., Coleman, S. K., Lauri, S., Airaksinen, M. S., Keinanen, K., Khiroug, L., Saarma, M., Kaila, K. & Rivera, C., 2007, In : Neuron. 56, 6, p. 1019-1033 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Large-scale production of dsRNA and siRNA pools for RNA interference utilizing bacteriophage phi6 RNA-dependent RNA polymerase

Aalto, A., Sarin, L. P., Van Dijk, A. A., Saarma, M., Poranen, M. M., Arumäe, U. & Bamford, D. H., 2007, In : RNA. 13, 3, p. 422-429 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Neurotrophic factor receptor RET: structure, cell biology, and inherited diseases

Runeberg-Roos, P. & Saarma, M., 2007, In : Annals of Medicine. 39, p. 572-580 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Neurotrophic factors switch between two signaling pathways that trigger axonal growth

Paveliev, M., Lume, M., Velthut, A., Phillips, M., Arumäe, U. & Saarma, M., 2007, In : Journal of Cell Science. 120, p. 2507-2516 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

Lindholm, P., Voutilainen, M., Lauren, J., Peränen, J., Leppänen, V-M., Andressoo, J-O., Lindahl, M., Janhunen, S., Kalkkinen, N., Timmusk, T., Tuominen, R. K. & Saarma, M., 2007, In : Nature. 448, 7147, p. 73-78 6 p.

Research output: Contribution to journalArticleScientificpeer-review

RET(MEN 2B) is active in the endoplasmic reticulum before reaching the cell surface

Runeberg-Roos, P., Virtanen, H. & Saarma, M., 2007, In : Oncogene. 26, 57, p. 7909-7915 7 p.

Research output: Contribution to journalArticleScientificpeer-review

The mouse soluble GFR4 receptor activates RET independently of its ligand persephin

Yang, J., Runeberg-Roos, P., Leppänen, V-M. & Saarma, M., 2007, In : Oncogene. 26, p. 3892-3898 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor 4 impairs thyroid calcitonin production in young mice

Lindfors, P. H., Lindahl, M., Rossi, J., Saarma, M., Airaksinen, M. S. & Airaksinen, M. S., 2006, In : Endocrinology. 147, 5, p. 2237-2244 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Drosophila gene encoding a homolog of the novel human neurotrophic factor MANF

Palgi, M., Lindstrom, R., Peranen, J., Piepponen, P., Saarma, M. & Heino, T. I., 2006, In : Journal of Neurogenetics. 20, p. 196-197 2 p.

Research output: Contribution to journalConference articleScientific

Effects of repeatedly administered morphine on locomotor activity, conditioned place preference and extracellular dopamine in GDNF +/- knockout mice

Airavaara, M., Tuomainen, H., Piepponen, T. P., Saarma, M. & Ahtee, L., Jul 2006, In : Acta Pharmacologica Sinica. 27, p. 419-419 1 p.

Research output: Contribution to journalConference articleScientific

In heterozygous GDNF knockout mice the response of striatal dopaminergic system to acute morphine is altered

Airavaara, M., Mijatovic, J., Vihavainen, T., Piepponen, P., Saarma, M. & Ahtee, L., 2006, In : Synapse (New York). 59, 6, p. 321-329 9 p.

Research output: Contribution to journalArticleScientificpeer-review

The mouse soluble GFRalpha4 receptor activates RET independently of its ligand persephin.

Yang, J., Runeberg-Roos, P., Leppänen, V-M. & Saarma, M., 2006, In : Oncogene. 26, p. 3892-3898

Research output: Contribution to journalArticleScientificpeer-review

2005

Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75(NTR)

Aurikko, JP., Ruotolo, BT., Grossmann, JG., Moncrieffe, MC., Stephens, E., Leppänen, V-M., Robinson, CV., Saarma, M., Bradshaw, RA. & Blundell, TL., 30 Sep 2005, In : Journal of Biological Chemistry. 280, 39, p. 33453-33460 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75[sup NTR]

Aurikko, J. P., Ruotolo, B. T., Grossmann, J. G., Moncrieffe, M. C., Stephens, E., Leppänen, V-M., Robinson, C. V., Saarma, M., Bradshaw, R. A. & Blundell, T. L., 2005, In : Journal of Biological Chemistry. 280, 39, p. 33453 - 33460 8 p.

Research output: Contribution to journalArticleScientificpeer-review

GABA receptor subunit expression in the developing rat brain

Alakuijala, A., Palgi, M., Wegelius, K., Schmidt, M., Enz, R., Paulin, L., Saarma, M. & Pasternack, M., 2005, In : Developmental Brain Research. 154, 1, p. 15-23 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Morphine-induced conditioned place preference in heterozygous GDNF knockout mice

Airavaara, MA., Piepponen, TP., Saarma, M. & Ahtee, L., Sep 2005, In : Behavioural Pharmacology. 16, p. S75-S75 1 p.

Research output: Contribution to journalConference articleScientific

Neurotrophin-3 is a target-derived neurotrophic factor for penile erection-inducing neurons

Hiltunen, J., Laurikainen, A., Klinge, E. & Saarma, M., 2005, In : Neuroscience. 133, 1, p. 51-58 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Ozone-induced programmed cell death in the Arabidopsis radical-induced cell death1 mutant

Overmyer, K., Brosche, M. J., Pellinen, R., Kuittinen, T., Tuominen, H., Ahlfors, R., Keinänen, M., Saarma, M., Scheel, D. & Kangasjärvi, J., 2005, In : Plant Physiology. 137, 3, p. 1092-1104 13 p.

Research output: Contribution to journalArticleScientificpeer-review

The first cysteine-rich domain of the receptor GFR alpha 1 stabilizes the binding of GDNF

Virtanen, H., Yang, JM., Bespalov, MM., Hiltunen, JO., Leppanen, VM., Kalkkinen, N., Goldman, A., Saarma, M. & Runeberg-Roos, P., 2005, In : Biochemical Journal. 387, p. 817-824 8 p.

Research output: Contribution to journalArticleScientificpeer-review

The neuronal ceroid lipofuscinosis Cln8 gene expression is developmentally regulated in mouse brain and up-regulated in the hippocampal kindling model of epilepsy

Lonka, L., Aalto, A. P., Kopra, O., Kuronen, M., Kokaia, Z., Saarma, M. & Lehesjoki, A-E., 2005, In : BMC Neuroscience. 6, 27, p. 1-11 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

GDNF family ligands activate multiple events during axonal growth in mature sensory neurons

Paveliev, M., Airaksinen, M. S. & Saarma, M., 2004, In : Molecular and Cellular Neuroscience. 25, p. 453-459 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Increased extracellular dopamine concentrations and FosB/delta FosB expression in striatal brain areas of heterozygous GDNF knockout mice

Airavaara, M., Planken, A., Gaddnas, H., Piepponen, T. P., Saarma, M. & Ahtee, L., Jul 2004, In : Fundamental & Clinical Pharmacology. 18, p. 55-55 1 p.

Research output: Contribution to journalArticleScientificpeer-review

Increased extracellular dopamine concentrations and FosB/ΔFosB expression in striatal brain areas of heterozygous GDNF knockout mice

Airavaara, M., Planken, A., Gäddnäs, H., Piepponen, T. P., Saarma, M. & Ahtee, L., 2004, In : European Journal of Neuroscience. 20, 9, p. 2336-2344 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2

Rivera, C., Voipio, J., Thomas-Crusells, J., Li, H., Emri, Z., Sipila, S., Payne, J. A., Minichiello, L., Saarma, M. & Kaila, K., 2004, In : Journal of Neuroscience. 24, p. 4683-4691 9 p.

Research output: Contribution to journalArticleScientificpeer-review

PSPN/GFRalpha4 has a significantly weaker capacity than GDNF/GFRalpha1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth.

Yang, J., Lindahl, M. S., Lindholm, P. K., Virtanen, H., Coffey, E., Runeberg-Roos, P. & Saarma, M., 2004, In : FEBS Letters. 2004, 569, p. 267-271

Research output: Contribution to journalArticleScientificpeer-review

The neuronal ceroid lipofuscinosis Cln8 gene expression in mouse during development and in the hippocampal kindling model of epilepsy

Lonka, L. I., Aalto, A., Kopra, O., Kuronen, M., Ranta, S., Kokaia, Z., Saarma, M. & Lehesjoki, A., 2004, In : Molecular Biology of the Cell. 15, p. 207A-207A 1 p.

Research output: Contribution to journalConference articleScientific

The structure of GFRα1 domain 3 reveals new insights into GDNF binding and RET activation

Leppänen, V-M., Bespalov, M., Runeberg-Roos, P., Puurand, Ü., Merits, A., Saarma, M. & Goldman, A., 2004, In : EMBO Journal. 23, p. 1452-1462

Research output: Contribution to journalArticleScientificpeer-review

2003

A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system

Lauren, J., Airaksinen, M. S., Saarma, M. & Timmusk, T., 2003, In : Genomics. 81, p. 411-421 11 p.

Research output: Contribution to journalArticleScientificpeer-review

DeltaFosB expression is enhanced in heterozygous GDNF knockout mice after repeated morphine treatment

Airavaara, M., Gaddnas, HG., Piepponen, TP., Airaksinen, MS., Saarma, M. & Ahtee, L., Sep 2003, In : Behavioural Pharmacology. 14, p. S50-S50 1 p.

Research output: Contribution to journalConference articleScientific

Developmental up-regulation of KCC2 in the absence of GABAergic and glutamatergic transmission

Ludwig, A., Li, H., Saarma, M., Kaila, K. & Rivera, C., 2003, In : European Journal of Neuroscience. 18, p. 3199-3206 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of acute morphine on metabolism of dopamine in dorsal striatum of heterozygous GDNF knockout mice

Mijatovic, J., Airavaara, M., Piepponen, TP., Saarma, M. & Ahtee, L., Jun 2003, In : European Journal of Pharmaceutical Sciences. 19, p. S26-S26 1 p.

Research output: Contribution to journalConference articleScientific

GDNF-deprived sympathetic neurons die via a novel nonmitochondrial pathway

Yu, L. Y., Jokitalo, E., Sun, Y. F., Mehlen, P., Lindholm, D., Saarma, M. & Arumae, U., 2003, In : Journal of Cell Biology. 163, p. 987-997 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems

Lauren, J., Airaksinen, M. S., Saarma, M. & Timmusk, T., 2003, In : Molecular and Cellular Neuroscience. 24, p. 581-594 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Two potato proteins, including a novel RING finger protein (HIP1), interact with the potyviral multifunctional protein HCpro

Guo, D. Y., Spetz, C., Saarma, M. & Valkonen, J. P. T., 2003, In : Molecular Plant - Microbe Interactions. 16, 5, p. 405-410 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2002

BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion

Rivera, C., Li, H., Thomas-Crusells, J., Lahtinen, H., Viitanen, T., Nanobashvili, A., Kokaia, Z., Airaksinen, M. S., Voipio, J., Kaila, K. & Saarma, M., 2002, In : Journal of Cell Biology. 159, p. 747-752 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Proteolytic processing of potyviral proteins and polyprotein processing intermediates in insect and plant cells

Merits, A., Rajamaki, M. L., Lindholm, P., Runeberg-Roos, P., Kekarainen, T., Puustinen, P., Makelainen, K., Valkonen, J. P. T. & Saarma, M., 2002, In : Journal of General Virology. 83, p. 1211-1221 11 p.

Research output: Contribution to journalArticleScientificpeer-review

The GDNF family: Signalling, biological functions and therapeutic value

Airaksinen, M. S. & Saarma, M., 2002, In : Nature Reviews. Neuroscience. 3, p. 383-394 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2001

Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells

Lindahl, M., Poteryaev, D., Yu, L. Y., Arumae, U., Timmusk, T., Bongarzone, I., Aiello, A., Pierotti, M. A., Airaksinen, M. S. & Saarma, M., 2001, In : Journal of Biological Chemistry. 276, p. 9344-9351 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of the genome-linked protein in virions of Potato virus A, with comparison to other members in genus Potyvirus

Oruetxebarria, I., Guo, D. Y., Merits, A., Makinen, K., Saarma, M. & Valkonen, J. P. T., 2001, In : Virus Research. 73, p. 103-112 10 p.

Research output: Contribution to journalArticleScientificpeer-review