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Mart Saarma

  • PL 56 (Viikinkaari 5)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1991 …2040
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Publications 1991 2019

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2019

CDNF Protein Therapy in Parkinson’s Disease

Huttunen, H. J. & Saarma, M., 4 Apr 2019, In : Cell Transplantation. 28, 4, p. 349-366 18 p.

Research output: Contribution to journalArticleScientificpeer-review

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Characterization of CDNF-Secreting ARPE-19 Cell Clones for Encapsulated Cell Therapy

Galli, E., Lindholm, P., Kontturi, L-S., Saarma, M., Urtti, A. & Yliperttula, M., Apr 2019, In : Cell Transplantation. 28, 4, p. 413-424 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Open Access
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Increased Serum Levels of Mesencephalic Astrocyte-Derived Neurotrophic Factor in Subjects With Parkinson’s Disease

Galli, E., Planken, A., Kadastik-Eerme, L., Saarma, M., Taba, P. & Lindholm, P., 4 Sep 2019, In : Frontiers in Neuroscience. 13, 8 p., 929.

Research output: Contribution to journalArticleScientificpeer-review

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Levels of glial cell line-derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in parkinson's disease

Virachit, S., Mathews, K. J., Cottam, V., Werry, E., Galli, E., Rappou, E., Lindholm, P., Saarma, M., Halliday, G. M., Shannon Weickert, C. & Double, K. L., 29 Apr 2019, In : Brain Pathology.

Research output: Contribution to journalArticleScientificpeer-review

2018

A deep convolutional neural network approach for astrocyte detection

Suleymanova, I., Balassa, T., Tripathi, S., Molnar, C., Saarma, M., Sidorova, Y. & Horvath, P., 27 Aug 2018, In : Scientific Reports. 8, 7 p., 12878.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson's Disease

Huotarinen, A., Penttinen, A-M., Bäck, S., Voutilainen, M. H., Julku, U., Piepponen, T. P., Männistö, P. T., Saarma, M., Tuominen, R., Laakso, A. & Airavaara, M., 15 Mar 2018, In : Neuroscience. 374, p. 250-263 14 p.

Research output: Contribution to journalArticleScientificpeer-review

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Implementation of deep neural networks to count dopamine neurons in substantia nigra

Penttinen, A-M., Parkkinen, I., Blom, S., Kopra, J., Andressoo, J-O., Pitkänen, K., Voutilainen, M. H., Saarma, M. & Airavaara, M., Sep 2018, In : European Journal of Neuroscience. 48, 6, p. 2354-2361 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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MANF protects human pancreatic beta cells against stress-induced cell death

Hakonen, E., Chandra, V., Fogarty, C. L., Yu, N. Y-L., Ustinov, J., Katayama, S., Galli, E., Danilova, T., Lindholm, P., Vartiainen, A., Einarsdottir, E., Krjutskov, K., Kere, J., Saarma, M., Lindahl, M. & Otonkoski, T., Oct 2018, In : Diabetologia. 61, 10, p. 2202-2214 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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Open Access
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Molecular Dynamics Simulations of the Interactions between Glial Cell Line-Derived Neurotrophic Factor Family Receptor GFR alpha 1 and Small-Molecule Ligands

Ivanova, L., Tammiku-Taul, J., Garcia-Sosa, A. T., Sidorova, Y., Saarma, M. & Karelson, M., Sep 2018, In : ACS Omega. 3, 9, p. 11407-11414 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease

Penttinen, A-M., Parkkinen, I., Voutilainen, M. H., Koskela, M., Bäck, S., Their, A., Richie, C. T., Domanskyi, A., Harvey, B. K., Tuominen, R. K., Nevalaita, L., Saarma, M. & Airavaara, M., 20 Jun 2018, In : Frontiers in neurology. 9, 14 p., 457.

Research output: Contribution to journalArticleScientificpeer-review

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Small-Molecule Ligands as Potential GDNF Family Receptor Agonists

Ivanova, L., Tammiku-Taul, J., Sidorova, Y., Saarma, M. & Karelson, M., Jan 2018, In : ACS Omega. 3, 1, p. 1022-1030 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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2017

A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat

Sidorova, Y. A., Bespalov, M. M., Wong, A. W., Kambur, O., Jokinen, V., Lilius, T. O., Suleymanova, I., Karelson, G., Rauhala, P. V., Karelson, M., Osborne, P. B., Keast, J. R., Kalso, E. A. & Saarma, M., 21 Jun 2017, In : Frontiers in Pharmacology. 8, 18 p., 365.

Research output: Contribution to journalArticleScientificpeer-review

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Dampened Amphetamine-Stimulated Behavior and Altered Dopamine Transporter Function in the Absence of Brain GDNF

Kopra, J. J., Panhelainen, A., af Bjerken, S., Porokuokka, L. L., Varendi, K., Olfat, S., Montonen, H., Piepponen, T. P., Saarma, M. & Andressoo, J-O., 8 Feb 2017, In : Journal of Neuroscience. 37, 6, p. 1581-1590 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Development and plasticity of meningeal lymphatic vessels

Antila, S., Karaman, S., Nurmi, H., Airavaara, M., Voutilainen, M. H., Mathivet, T., Chilov, D., Li, Z., Koppinen, T., Park, J-H., Fang, S., Aspelund, A., Saarma, M., Eichmann, A., Thomas, J-L. & Alitalo, K., Dec 2017, In : Journal of Experimental Medicine. 214, 12, p. 3645-3667 23 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra

Mätlik, K., Vihinen, A. H., Bienemann, A., Palgi, J., Voutilainen, M. H., Booms, S., Lindahl, M. S., Jokitalo, E. S., Saarma, M., Huttunen, H. J., Airavaara, M. T. & Arumäe, U., 20 Feb 2017, In : eNeuro. 4, 1, 15 p., e0128-16.2017.

Research output: Contribution to journalArticleScientificpeer-review

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In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway

Lindstrom, R., Lindholm, P., Palgi, M., Saarma, M. & Heino, T. I., 2 Jun 2017, In : BMC Genetics. 18, 19 p., 52.

Research output: Contribution to journalArticleScientificpeer-review

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MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex

Tseng, K-Y., Danilova, T., Domanskyi, A., Saarma, M., Lindahl, M. S. & Airavaara, M. T., 29 Sep 2017, In : eNeuro. 4, 5, 21 p., e0214-17.2017.

Research output: Contribution to journalArticleScientificpeer-review

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Restoring dopaminergic nerve cells in Parkinson’s disease

Ronken, E., Sidorova, Y., Karelson, M. & Saarma, M., 2017, In : Open access government. p. 25-26

Research output: Contribution to journalArticleGeneral public

Zebrafish GDNF and its co-receptor GFR alpha 1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro

Saarenpää, T., Kogan, K., Sidorova, Y., Mahato, A. K., Tascon, I., Kaljunen, H., Yu, L., Kallijärvi, J., Jurvansuu, J., Saarma, M. & Goldman, A., 3 May 2017, In : PLoS One. 12, 5, 18 p., 0176166.

Research output: Contribution to journalArticleScientificpeer-review

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2016

Comparative Analysis of the Effects of Neurotrophic Factors CDNF and GDNF in a Nonhuman Primate Model of Parkinson's Disease

Garea-Rodriguez, E., Eesmaa, A., Lindholm, P. K., Schlumbohm, C., König, J., Meller, B., Krieglstein, K., Helms, G., Saarma, M. & Fuchs, E., 22 Feb 2016, In : PLoS One. 11, 2, 21 p., 0149776.

Research output: Contribution to journalArticleScientificpeer-review

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Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease

Runeberg-Roos, P., Piccinini, E., Penttinen, A-M., Matlik, K., Heikkinen, H., Kuure, S., Bespalov, M. M., Peranen, J., Garea-Rodriguez, E., Fuchs, E., Airavaara, M., Kalkkinen, N., Penn, R. & Saarma, M., Dec 2016, In : Neurobiology of Disease. 96, p. 335-345 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster

Lindström, R., Lindholm, P., Kallijärvi, J., Palgi, M., Saarma, M. & Heino, T. I., 14 Mar 2016, In : PLoS One. 11, 3, 18 p., 0151550.

Research output: Contribution to journalArticleScientificpeer-review

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Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes

Galli, E., Harkonen, T., Sainio, M., Ustav, M., Toots, U., Urtti, A., Yliperttula, M., Lindahl, M., Knip, M., Saarma, M. & Lindholm, P., 30 Jun 2016, In : Scientific Reports. 6, 11 p., 29058.

Research output: Contribution to journalArticleScientificpeer-review

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Novel agonist of GDNF family ligand receptor RET for the treatment of experimental neuropathy

Bespalov, M., Sidorova, Y., Suleymanova, I., Thompson, J., Kambur, O., Jokinen, V., Lilius, T. O., Karelson, G., Puusepp, L., Rauhala, P. V., Kalso, E. A., Karelson, M. & Saarma, M., 4 Jul 2016, In : BioRxiv beta : the preprint server for biology.

Research output: Contribution to journalArticleProfessional

Open Access

Parkinson's disease: towards better preclinical models and personalized treatments

Lindholm, D., Mäkelä, J., Di Liberto, V., Mudo, G., Belluardo, N., Eriksson-Rosenberg, O. & Saarma, M., Apr 2016, In : Cellular and Molecular Life Sciences. 73, 7, p. 1383-1385 3 p.

Research output: Contribution to journalArticleScientific

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2015

BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met

Mizui, T., Ishikawa, Y., Kumanogoh, H., Lume, M., Matsumoto, T., Hara, T., Yamawaki, S., Takahashi, M., Shiosaka, S., Itami, C., Uegaki, K., Saarma, M. & Kojima, M., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 23, p. E3067-E3074 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice

Kemppainen, S., Pulkkila, P. K., Galli, E. M. C., Lahtinen, H-M., Koivisto, H., Hämäläinen, E., Saarma, M. & Tanila, H., 2015, In : Behavioural Brain Research. 291, p. 1-11 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

GDNF is not required for catecholaminergic neuron survival in vivo

Kopra, J., Vilenius, C., Grealish, S., Härma, M-A., Varendi, K., Lindholm, J., Castrén, E., Voikar, V., Björklund, A., Piepponen, T. P., Saarma, M. & Andressoo, J-O., Mar 2015, In : Nature Neuroscience. 18, 3, p. 319-322 4 p.

Research output: Contribution to journalArticleScientificpeer-review

GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function

Kumar, A., Kopra, J. J., Varendi, K., Porokuokka, L. L., Panhelainen, A. E., Kuure, S. H., Marshall, P. O. L., Karalija, N., Härma, M-A., Vilenius, C. L., Lilleväli, K., Tekko, T., Mijatovic, J., Pulkkinen, N., Jakobson, M., Jakobson, M., Ola, R., Palm, E., Lindahl, M. S., Strömberg, I. & 4 othersVõikar, V., Piepponen, T. P., Saarma, M. & Andressoo, J-O., 2015, In : PLoS Genetics. 11, 12, 24 p., e1005710.

Research output: Contribution to journalArticleScientificpeer-review

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RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications

Mutso, M., Nikonov, A., Pihlak, A., Zusinaite, E., Viru, L., Selyutina, A., Reintamm, T., Kelve, M., Saarma, M., Karelson, M. & Merits, A., 3 Jun 2015, In : PLoS One. 10, 6, 25 p., 0128686.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity

Mätlik, K., Yu, L., Eesmaa, A., Hellman, M., Lindholm, P., Peränen, J., Galli, E., Anttila, J., Saarma, M., Permi, P., Airavaara, M. & Arumäe, U., Dec 2015, In : Cell Death and Disease. 6, 8 p., 2032.

Research output: Contribution to journalArticleScientificpeer-review

Suppression of RNAi by dsRNA-Degrading RNaseIII Enzymes of Viruses in Animals and Plants

Weinheimer, I., Jiu, Y., Rajamäki, M., Matilainen, O., Kallijärvi, J., Cuellar, W., Lu, R., Saarma, M., Holmberg, C. I., Jäntti, J. & Valkonen, J., 6 Mar 2015, In : PLoS Pathogens. 11, 3, 25 p., e1004711.

Research output: Contribution to journalArticleScientificpeer-review

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2014

MANF is indispensable for the proliferation and survival of pancreatic beta-cells

Lindahl, M., Danilova, T., Palm, E., Lindholm, P., Voikar, V., Hakonen, E., Ustinov, J., Andressoo, J-O., Harvey, B. K., Otonkoski, T., Rossi, J. & Saarma, M., Apr 2014, In : Cell Reports. 7, 2, p. 366-375 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion: MAPK Activity Controls Epithelial Adhesion In Vivo

Iherman-Hella, A., Lume, M., Miinalainen, I., Pirttiniemi, A., Gui, Y., Peränen, J., Charron, J., Saarma, M., Costantini, F. & Kuure, S. H., Mar 2014, In : PLoS Genetics. 10, 3, 15 p., e1004193.

Research output: Contribution to journalArticleScientificpeer-review

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Short-term Preoperative Dietary Restriction Is Neuroprotective in a Rat Focal Stroke Model

Varendi, K., Airavaara, M., Anttila, J., Vose, S., Planken, A., Saarma, M., Mitchell, J. R. & Andressoo, J-O., 4 Apr 2014, In : PLoS One. 9, 4, 9 p., 93911.

Research output: Contribution to journalArticleScientificpeer-review

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Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra

Nadella, R., Voutilainen, M. H., Saarma, M., Gonzalez-Barrios, J. A., Leon-Chavez, B. A., Dueas Jimnez, J. M., Dueas Jimnez, S. H., Escobedo, L. & Martinez-Fong, D., 16 Dec 2014, In : Journal of Neuroinflammation. 11, 18 p., 209.

Research output: Contribution to journalArticleScientificpeer-review

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2013

Characterization of the Structural and Functional Determinants of MANF/CDNF in Drosophila In Vivo Model

Lindström, R., Lindholm, P. K., Kallijärvi, J., Yu, L., Piepponen, T. P., Arumäe, U., Saarma, M. & Heino, T., 2013, In : PLoS One. 8, 9, 12 p., e73928.

Research output: Contribution to journalArticleScientificpeer-review

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Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease

Bäck, S., Peränen, J., Galli, E., Pulkkila, P., Lonka-Nevalaita, L., Tamminen, T., Voutilainen, M. H., Raasmaja, A., Saarma, M., Männistö, P. T. & Tuominen, R. K., Mar 2013, In : Brain and Behavior. 3, 2, p. 75-88 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Glial cell line-derived neurotrophic factor: Characterization of mammalian posttranslational modifications

Piccinini, E., Kalkkinen, N., Saarma, M. & Runeberg-Roos, P., 2013, In : Annals of Medicine. 45, 1, p. 66-73 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Lahkus närvikasvufaktori avastaja Rita Levi-Montalcini

Saarma, M. & Castrén, E., 2013, In : Sirp : Eesti kultuurleht.

Research output: Contribution to journalArticleGeneral public

Rita levi-Montalcini 1909-2012. Hermostotutkimus toi Nobelin palkinnon

Castrén, E. & Saarma, M., 2013, In : Helsingin Sanomat.

Research output: Contribution to journalArticleGeneral public

SorLA Controls Neurotrophic Activity by Sorting of GDNF and Its Receptors GFR alpha 1 and RET

Glerup, S., Lume, M., Olsen, D., Nyengaard, J. R., Vaegter, C. B., Gustafsen, C., Christensen, E. I., Kjolby, M., Hay-Schmidt, A., Bender, D., Madsen, P., Saarma, M., Nykjaer, A. & Petersen, C. M., Jan 2013, In : Cell Reports. 3, 1, p. 186-199 14 p.

Research output: Contribution to journalArticleScientificpeer-review

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2012

Advanced brain dopamine transporter imaging in mice, using small animal SPECT/CT

Pitkonen, M., Hippeläinen, E. T., Raki, M., Andressoo, J-O., Urtti, A., Männistö, P., Savolainen, S., Saarma, M. & Bergström, K., 2012, In : EJNMMI Research. 2, p. 55

Research output: Contribution to journalArticleScientificpeer-review

CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery After MPTP Treatment in Mice

Airavaara, M., Harvey, B. K., Voutilainen, M. H., Shen, H., Chou, J., Lindholm, P., Lindahl, M., Tuominen, R. K., Saarma, M., Hoffer, B. & Wang, Y., 2012, In : Cell Transplantation. 21, 6, p. 1213-1223 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Characterization of the structural and functional determinants of MANF/CDNF proteins using Drosophila model

Lindstrom, R., Lindholm, P., Yu, L. -Y., Kallijarvi, J., Arumae, U., Saarma, M. & Heino, T., Dec 2012, In : Journal of Neurogenetics. 26, p. 73-74 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Rakumaailma filosoofiline kivi

Saarma, M. & Arumäe, U., 2012, In : Sirp : Eesti kultuurleht.

Research output: Contribution to journalArticleGeneral public