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Publications 1991 2019

2019

A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency

Pikkarainen, S., Martelius, T., Ristimäki, A., Siitonen, S., Seppanen, M. R. J. & Färkkilä, M., Apr 2019, In : American Journal of Gastroenterology. 114, 4, p. 648-655 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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C-hepatiitin hoitopolku: Maksasairauden hoidosta infektion eliminaatioon

Brummer-Korvenkontio, H., Färkkilä, M., Lappalainen, M., Nieminen, U., Ristola, M. & Sutinen, J. P., 2019, 22 p. Terveyden ja hyvinvoinnin laitos.

Research output: Other contributionResearch

C-hepatiitin hoitostrategiaa tulee muuttaa

Färkkilä, M. & Rautiainen, H., 2019, In : Suomen lääkärilehti. 74, 34, p. 1783-1783a 2 p.

Research output: Contribution to journalEditorialProfessional

Genetic and lifestyle risk factors for advanced liver disease among men and women

Sahlman, P., Nissinen, M., Puukka, P., Jula, A., Salomaa, V., Männistö, S., Lundqvist, A., Valsta, L., Perola, M., Färkkilä, M. & Åberg, F., 28 Jul 2019, In : Journal of Gastroenterology and Hepatology. 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

FinnGen Project, Tabassum, R., Rämö, J. T., Ripatti, P., Koskela, J. T., Kurki, M., Karjalainen, J., Palta, P., Hassan, S., Nunez-Fontarnau, J., Kiiskinen, T. T. J., Söderlund, S., Matikainen, N., Laivuori, H., Havulinna, A. S., Pirinen, M., Jalanko, A., Kaprio, J., Donner, K., Kaunisto, M. & 70 othersMars, N., Dada, A., Shcherban, A., Ganna, A., Lehisto, A., Kilpeläinen, E., Brein, G., Awaisa, G., Harju, J., Pärn, K., Parolo, P. D. B., Kajanne, R., Lemmelä, S., Sipilä, T. P., Sipilä, T., Lyhs, U., Llorens, V., Niiranen, T., Kristiansson, K., Jiménez, M. G., Perola, M., Hiekkalinna, T., Mattsson, H., Laiho, P., Soini, S., Lehtonen, A., Pulkki, K., Heikkinen, S., Laukkanen, J., Laaksonen, R., Ritari, J., Partanen, J., Hyvärinen, K., Auro, K., Pitkänen, K., Mäkelä, T., Loukola, A., Joensuu, H., Sinisalo, J., Eklund, K., Aaltonen, L., Färkkilä, M., Carpen, O., Kauppi, P., Tienari, P., Ollila, T., Tuomi, T., Meretoja, T., Pitkäranta, A., Turunen, J., Hannula-Jouppi, K., Pikkarainen, S., Seitsonen, S., Koskinen, M., Palomäki, A., Voutilainen, M., Kettunen, J., Pelkonen, M., Julkunen, V., Lehtonen, H., Parkkinen, J., Linden, K., Jussila, A., Laitinen, T., Palin, K., Jauhiainen, M., Daly, M. J., Palotie, A., Taskinen, M-R. & Ripatti, S., 24 Sep 2019, In : Nature Communications. 10, 1, 14 p., 4329.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Incidence, prevalence, and causes of death of patients with autoimmune hepatitis: A nationwide register-based cohort study in Finland

Puustinen, L., Barner-Rasmussen, N., Pukkala, E. & Farkkila, M., Sep 2019, In : Digestive and Liver Disease. 51, 9, p. 1294-1299 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Insulin Resistance and Genetic Risk Predict Liver-Related Outcomes and Death in Nonalcoholic Fatty Liver Disease

Danford, C. J., Jiang, Z. G., Salomaa, V., Färkkilä, M., Jula, A., Männistö, S., Lundqvist, A., Valsta, L., Perola, M. & Åberg, F., 10 Oct 2019, In : Hepatology communications. 0, 0, 2 p.

Research output: Contribution to journalLetterScientificpeer-review

Open Access
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Kolorektaalisyövän seulonta uudistuu

Heinävaara, S., Jäntti, M., Färkkilä, M., Hyöty, M., Kairaluoma, M., Rautio, T., Voutilainen, M., Malila, N. & Sarkeala, T., 2019, In : Duodecim. 135, 19, p. 1920-1927 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2018

Akuutti ripuli

Färkkilä, M., 2018, Akuuttihoito-opas . Mäkijärvi, M., Harjola, V-P., Päivä, H., Valli, J. & Vaula, E. (eds.). 20. uud. p. ed. Helsinki: Kustannus Oy Duodecim, p. 212-214 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

C-hepatiitti - maksasairauden hoidosta infektion eliminaatioon: Hoitopolku erikoissairaanhoidosta perusterveydenhuoltoon

Färkkilä, M., 2018, In : Duodecim. 134, 17, p. 1655-1657 3 p.

Research output: Contribution to journalEditorialProfessional

Open Access
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Open Access
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Fecal Calprotectin Test Performed at Home: A Prospective Study of Pediatric Patients with Inflammatory Bowel Disease

Piekkala, M., Alfthan, H., Merras-Salmio, L., Puustinen Wikström, A., Heiskanen, K., Jaakkola, T., Klemetti, P., Färkkilä, M. & Kolho, K-L., Jun 2018, In : Journal of Pediatric Gastroenterology and Nutrition. 66, 6, p. 926-931 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Gastroenterolgia ja Hepatologia

Färkkilä, M. (ed.), Heikkinen, M. (ed.), Isoniemi, H. (ed.) & Puolakkainen, P. (ed.), Jan 2018, 3. uud. p. ed. Helsinki: Kustannus Oy Duodecim. 1039 p.

Research output: Book/ReportBookProfessional

Gastroenterologia ja hepatologia

Färkkilä, M. (ed.), Isoniemi, H. (ed.), Heikkinen, M. & Puolakkainen, P. (ed.), 2018, Helsinki: Kustannus Oy Duodecim.

Research output: Book/ReportBookProfessional

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis

The International PSC Study Group, The UK PSC Consortium, Alberts, R., de Vries, E. M. G., Goode, E. C., Jiang, X., Sampaziotis, F., Rombouts, K., Böttcher, K., Folseraas, T., Weismüller, T. J., Mason, A. L., Wang, W., Alexander, G., Alvaro, D., Bergquist, A., Björkström, N. K., Beuers, U., Björnsson, E., Boberg, K. M. & 56 othersBowlus, C. L., Bragazzi, M. C., Carbone, M., Chazouilleres, O., Cheung, A., Dalekos, G., Eaton, J., Eksteen, B., Ellinghaus, D., Färkkilä, M. A., Festen, E. A. M., Floreani, A., Franceschet, I., Gotthardt, D. N., Hirschfield, G. M., van Hoek, B., Holm, K., Hohenester, S., Hov, J. R., Imhann, F., Invernizzi, P., Juran, B. D., Lenzen, H., Lieb, W., Liu, J. Z., Marschall, H-U., Marzioni, M., Melum, E., Milkiewicz, P., Müller, T., Pares, A., Rupp, C., Rust, C., Sandford, R. N., Schramm, C., Schreiber, S., Schrumpf, E., Silverberg, M. S., Srivastava, B., Sterneck, M., Teufel, A., Vallier, L., Verheij, J., Vila, A. V., de Vries, B., Zachou, K., Chapman, R. W., Manns, M. P., Pinzani, M., Rushbrook, S. M., Lazaridis, K. N., Franke, A., Anderson, C. A., Karlsen, T. H., Ponsioen, C. Y. & Weersma, R. K., 2018, In : Gut. 67, 8, p. 1517-1524 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Inflammatoristen suolistosairauksien akutisoituminen

Färkkilä, M., 2018, Akuuttihoito-opas . Mäkijärvi, M., Harjola, V-P., Päivä, H., Valli, J. & Vaula, E. (eds.). 20. uud. p. ed. Helsinki: Kustannus Oy Duodecim, p. 215-218 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Inflammatory bowel disease and anemia: intravenous iron treatment

Kangaspunta, M., Haapamäki, J., Färkkilä, M. & Arkkila, P., 2018, In : Scandinavian Journal of Gastroenterology. 53, 4, p. 430-434 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

Int IBD Genetics Consortium, NIDDK IBD Genetics Consortium, T2D-Genes Consortium, Rivas, M. A., Koskela, J., Pirinen, M., Kurki, M., Saavalainen, P., Farkkila, M., Kontula, K., Palotie, A. & Daly, M. J., May 2018, In : PLoS Genetics. 14, 5, 25 p., 1007329.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Interaction between alcohol consumption and metabolic syndrome in predicting severe liver disease in the general population

Åberg, F., Helenius-Hietala, J., Puukka, P., Färkkilä, M. & Jula, A., 2018, In : Hepatology. 67, 6, p. 2141-2149 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Kalprotektiinin laajenevat käyttöindikaatiot

Färkkilä, M. & Alfthan, H., 2018, In : Kliin lab : kliinisen laboratorioalan julkaisu : SKKY:n jäsenlehti.. 35, 4, p. 110-114 5 p.

Research output: Contribution to journalArticleProfessional

Open Access
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Kroonisen maksapotilaan akuutit tilanteet

Isoniemi, H. & Färkkilä, M., 2018, Akuuttihoito-opas . Mäkijärvi, M., Harjola, V-P., Päivä, H., Valli, J. & Vaula, E. (eds.). 20. uud. p. ed. Helsinki: Kustannus Oy Duodecim, p. 207-212 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Long-term outcome of patients with steroid-refractory acute severe UC treated with ciclosporin or infliximab

Laharie, D., Bourreille, A., Branche, J., Allez, M., Bouhnik, Y., Filippi, J., Zerbib, F., Savoye, G., Vuitton, L., Moreau, J., Amiot, A., Cosnes, J., Ricart, E., Dewit, O., Lopez-Sanroman, A., Fumery, M., Carbonnel, F., Bommelaer, G., Coffin, B., Roblin, X. & 11 othersvan Assche, G., Esteve, M., Farkkila, M., Gisbert, J. P., Marteau, P., Nahon, S., de Vos, M., Lambert, J., Mary, J. Y., Louis, E. & Grp d'Etudes Therapeutiq, Feb 2018, In : Gut. 67, 2, p. 237-243 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Maksan akuutin vajaatoiminnan diagnostiikka

Isoniemi, H. & Färkkilä, M., 2018, Akuuttihoito-opas . Mäkijärvi, M., Harjola, V-P., Päivä, H., Valli, J. & Vaula, E. (eds.). 20. uud. p. ed. Helsinki: Kustannus Oy Duodecim, p. 202-205 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Maksan akuutin vajaatoiminnan hoito

Isoniemi, H., Koivusalo, A-M. & Färkkilä, M., 2018, Akuuttihoito-opas . Mäkijärvi, M., Harjola, V-P., Päivä, H., Valli, J. & Vaula, E. (eds.). 20. uud. p. ed. Helsinki: Kustannus Oy Duodecim, p. 205-207 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Mikrobilääkehoitoon liittyvä ripuli

Färkkilä, M., 2018, Akuuttihoito-opas . Mäkijärvi, M., Harjola, V-P., Päivä, H., Valli, J. & Vaula, E. (eds.). 20. uud. p. ed. Helsinki: Kustannus Oy Duodecim, p. 214-215 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Noncholesterol Sterols as Surrogate Markers in Patients with Severe Alcoholic Hepatitis

Sahlman, P., Nissinen, M., Simonen, P. & Farkkila, M., Mar 2018, In : Lipids. 53, 3, p. 323-334 12 p.

Research output: Contribution to journalArticleScientificpeer-review

No Superiority of Stents vs Balloon Dilatation for Dominant Strictures in Patients With Primary Sclerosing Cholangitis

Ponsioen, C. Y., Arnelo, U., Bergquist, A., Rauws, E. A., Paulsen, V., Cantu, P., Parzanese, I., De Vries, E. M., van Munster, K. N., Said, K., Chazouilleres, O., Desaint, B., Kemgang, A., Färkkilä, M., Van der Merwe, S., Van Steenbergen, W., Marschall, H-U., Stotzer, P-O., Thorburn, D., Pereira, S. P. & 1 othersAabakken, L., Sep 2018, In : Gastroenterology. 155, 3, p. 752-+ 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Risk of Esophageal Adenocarcinoma After Antireflux Surgery in Patients With Gastroesophageal Reflux Disease in the Nordic Countries

Maret-Ouda, J., Wahlin, K., Artama, M., Brusselaers, N., Färkkilä, M., Lynge, E., Mattsson, F., Pukkala, E., Romundstad, P., Tryggvadottir, L., von Euler-Chelpin, M. & Lagergren, J., Nov 2018, In : JAMA Oncology. 4, 11, p. 1576-1582 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2017

(31)Phosphorus magnetic resonance spectroscopy of the liver for evaluating inflammation and fibrosis in autoimmune hepatitis

Puustinen, L., Hakkarainen, A., Kivisaari, R., Boyd, S., Nieminen, U., Färkkilä, M., Lundbom, N. & Arkkila, P., 2017, In : Scandinavian Journal of Gastroenterology. 52, 8, p. 886-892 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Bile microbiota in primary sclerosing cholangitis: Impact on disease progression and development of biliary dysplasia

Pereira, P., Aho, V., Arola, J., Boyd, S., Jokelainen, K., Paulin, L., Auvinen, P. & Farkkila, M., 10 Aug 2017, In : PLoS One. 12, 8, 15 p., 0182924.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Biliary Anomalies in Patients With HNF1B Diabetes

Kettunen, J. L. T., Parviainen, H., Miettinen, P. J., Färkkilä, M., Tamminen, M., Salonen, P., Lantto, E. & Tuomi, T., Jun 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 6, p. 2075-2082 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Cohort profile: the Nordic Antireflux Surgery Cohort (NordASCo)

Maret-Ouda, J., Wahlin, K., Artama, M., Brusselaers, N., Farkkila, M., Lynge, E., Mattsson, F., Pukkala, E., Romundstad, P., Tryggvadottir, L., von Euler-Chelpin, M. & Lagergren, J., Jun 2017, In : BMJ Open. 7, 6, 8 p., 016505.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Elinsiirrot - ei pelkkää kirurgiaa

Färkkilä, M., Lommi, J., Halme, M. & Honkanen, E., 2017, In : Duodecim. 133, 24, p. 2399-2401 3 p.

Research output: Contribution to journalEditorialProfessional

Open Access
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Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study

de Vries, E. M. G., Farkkila, M., Milkiewicz, P., Hov, J. R., Eksteen, B., Thorburn, D., Chazouilleres, O., Pares, A., Nygard, S., Gilja, O. H., Wunsch, E., Invernizzi, P., Carbone, M., Bernuzzi, F., Boberg, K. M., Rosjo, H., Rosenberg, W., Beuers, U. H., Ponsioen, C. Y., Karlsen, T. H. & 1 othersVesterhus, M., Oct 2017, In : Liver International. 37, 10, p. 1554-1561 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

Ji, S-G., Juran, B. D., Mucha, S., Folseraas, T., Jostins, L., Melum, E., Kumasaka, N., Atkinson, E. J., Schlicht, E. M., Liu, J. Z., Shah, T., Gutierrez-Achury, J., Boberg, K. M., Bergquist, A., Vermeire, S., Eksteen, B., Durie, P. R., Farkkila, M., Mueller, T., Schramm, C. & 33 othersSterneck, M., Weismueller, T. J., Gotthardt, D. N., Ellinghaus, D., Braun, F., Teufel, A., Laudes, M., Lieb, W., Jacobs, G., Beuers, U., Weersma, R. K., Wijmenga, C., Marschall, H-U., Milkiewicz, P., Pares, A., Kontula, K., Chazouilleres, O., Invernizzi, P., Goode, E., Spiess, K., Moore, C., Sambrook, J., Ouwehand, W. H., Roberts, D. J., Danesh, J., Floreani, A., Gulamhusein, A. F., Eaton, J. E., Schreiber, S., Coltescu, C., UK-PSC Consortium, Int IBD Genetics Consortium & Int PSC Study Grp, Feb 2017, In : Nature Genetics. 49, 2, p. 269-273 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Hepatitis C virus prevalence and level of intervention required to achieve the WHO targets for elimination in the European Union by 2030: a modelling study

The European Union HCV Collaborators, Razavi, H., Robbins, S., Zeuzem, S., Negro, F. & Hatzakis, A., May 2017, In : The Lancet gastroenterology & hepatology. 2, 5, p. 325-336 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Histologic surveillance after liver transplantation due to autoimmune hepatitis

Puustinen, L., Boyd, S., Arkkila, P., Isoniemi, H., Arola, J. & Farkkila, M., May 2017, In : Clinical Transplantation. 31, 5, 7 p., 12936.

Research output: Contribution to journalArticleScientificpeer-review

HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry

Henriksen, E. K. K., Viken, M. K., Wittig, M., Holm, K., Folseraas, T., Mucha, S., Melum, E., Hov, J. R., Lazaridis, K. N., Juran, B. D., Chazouilleres, O., Farkkila, M., Gotthardt, D. N., Invernizzi, P., Carbone, M., Hirschfield, G. M., Rushbrook, S. M., Goode, E., Ponsioen, C. Y., Weersma, R. K. & 10 othersEksteen, B., Yimam, K. K., Gordon, S. C., Goldberg, D., Yu, L., Bowlus, C. L., Franke, A., Lie, B. A., Karlsen, T. H. & UK-PSC Consortium, Oct 2017, In : HLA. 90, 4, p. 228-233 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Human leucocyte antigens B08, DRB103 and DRB113 are significantly associated with autoimmune liver and biliary diseases in Finnish children

Ylinen, E., Salmela, L., Perasaari, J., Jaatinen, T., Tenca, A., Vapalahti, O., Färkkilä, M., Jalanko, H. & Kolho, K-L., Feb 2017, In : Acta Paediatrica. 106, 2, p. 322-326 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Long-term outcome of inflammatory bowel disease patients with deep remission after discontinuation of TNF-blocking agents

Molander, P., Farkkila, M., Kemppainen, H., Blomster, T., Jussila, A., Mustonen, H. & Sipponen, T., 2017, In : Scandinavian Journal of Gastroenterology. 52, 3, p. 284-290 7 p.

Research output: Contribution to journalArticleScientificpeer-review

norUrsodeoxycholic acid improves cholestasis in primary sclerosing cholangitis

Fickert, P., Hirschfield, G. M., Denk, G., Marschall, H-U., Altorjay, I., Farkkila, M., Schramm, C., Spengler, U., Chapman, R., Bergquist, A., Schrumpf, E., Nevens, F., Trivedi, P., Reiter, F. P., Tornai, I., Halilbasic, E., Greinwald, R., Pröls, M., Manns, M. P., Trauner, M. & 1 othersEuropean PSC norUDCA Study Grp, Sep 2017, In : Journal of Hepatology. 67, 3, p. 549-558 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis

Vesterhus, M., Holm, A., Hov, J. R., Nygard, S., Schrumpf, E., Melum, E., Thorbjornsen, L. W., Paulsen, V., Lundin, K., Dale, I., Gilja, O. H., Zweers, S. J. L. B., Vatn, M., Schaap, F. G., Jansen, P. L. M., Ueland, T., Rosjo, H., Moum, B., Ponsioen, C. Y., Boberg, K. M. & 3 othersFarkkila, M., Karlsen, T. H. & Lund-Johansen, F., Jun 2017, In : Journal of Hepatology. 66, 6, p. 1214-1222 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Outcomes of patients hospitalized with peptic ulcer disease diagnosed in acute upper endoscopy

Malmi, H., Kautiainen, H., Virta, L. J. & Farkkila, M. A., Nov 2017, In : European Journal of Gastroenterology and Hepatology. 29, 11, p. 1251-1257 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis

Weismueller, T. J., Trivedi, P. J., Bergquist, A., Imam, M., Lenzen, H., Ponsioen, C. Y., Holm, K., Gotthardt, D., Färkkilä, M., Marschall, H-U., Thorburn, D., Weersma, R. K., Fevery, J., Mueller, T., Chazouilleres, O., Schulze, K., Lazaridis, K. N., Almer, S., Pereira, S. P., Levy, C. & 31 othersMason, A., Naess, S., Bowlus, C. L., Floreani, A., Halilbasic, E., Yimam, K. K., Milkiewicz, P., Beuers, U., Huynh, D. K., Pares, A., Manser, C. N., Dalekos, G. N., Eksteen, B., Invernizzi, P., Berg, C. P., Kirchner, G. I., Sarrazin, C., Zimmer, V., Fabris, L., Braun, F., Marzioni, M., Juran, B. D., Said, K., Rupp, C., Jokelainen, K., de Valle, M. B., Saffioti, F., Cheung, A., Trauner, M., Schramm, C. & Int PSC Study Grp, Jun 2017, In : Gastroenterology. 152, 8, p. 1975-+ 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Rapid Fecal Calprotectin Test and Symptom Index in Monitoring the Disease Activity in Colonic Inflammatory Bowel Disease

Puolanne, A-M., Kolho, K-L., Alfthan, H., Ristimäki, A., Mustonen, H. & Färkkilä, M., Nov 2017, In : Digestive Diseases and Sciences. 62, 11, p. 3123-3130 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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