Photo of Matjaz Barboric
  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

19992019

Research output per year

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Personal profile

Description of research and teaching

Controlling Transcription Elongation by RNA polymerase II: mechanisms, disease and development

We are investigating the fundamental mechanisms of metazoan gene transcription by RNA polymerase II (RNAPII). In particular, we are studying the regulatory factors that modulate RNAPII transcription at the level of elongation, which has been recognized only recently as a major rate-limiting step in gene expression. Our work is focused mainly on the key cyclin-dependent kinases that stimulate RNAPII elongation and phosphorylate the C-terminal domain of the biggest subunit of RNAPII, Rbp1, at serine 2 (Ser2-P CTD). By using biochemistry, genetics and the tools of systems biology, we are aiming to understand mechanisms that enable the function of elongation kinases as well as biological processes that are controlled by them. Because transcription elongation can be intimately connected to pre-mRNA processing in the course of transcription via Ser2-P CTD, we are also studying how elongation kinases affect mRNA maturation events such as alternative splicing. Of note, an important aspect of our work is to uncover how deregulation of RNAPII elongation control contributes to the onset of deadly diseases, including cancer. Finally, revealing the significance of transcription elongation kinases in embryonic development remains a pressing issue in our research group.

Fields of Science

  • 1182 Biochemistry, cell and molecular biology

International and National Collaboration Publications and projects within past five years.

Publications

P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress

Bugai, A., Quaresma, A. J. C., Friedel, C. C., Lenasi, T., Düster, R., Sibley, C. R., Fuginaga, K., Kukanja, P., Hennig, T., Blasius, M., Geyer, M., Ule, J., Dölken, L. & Barboric, M., 18 Apr 2019, In : Molecular Cell. 74, 2, p. 254-+ 24 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb

Christiano Quaresma, A. J., Bugai, A. & Barboric, M., 19 Sep 2016, In : Nucleic Acids Research. 44, 16, p. 7527-7539 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes

Anastasina, M., Le May, N., Bugai, A., Fu, Y., Soderholm, S., Gaelings, L., Ohman, T., Tynell, J., Kyttanen, S., Barboric, M., Nyman, T. A., Matikainen, S., Julkunen, I., Butcher, S. J., Egly, J-M. & Kainov, D. E., Nov 2016, In : Biochimica et Biophysica Acta. Gene Regulatory Mechanisms. 1859, 11, p. 1440-1448 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

The two sides of Tat

Barboric, M. & Fujinaga, K., 19 Jan 2016, In : eLife. 5, 3 p., 12686.

Research output: Contribution to journalArticleScientific

Open Access
File

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

Ekumi, K., Paculova, H., Lenasi, T., Pospichalova, V., Boesken, C. A., Rybarikova, J., Bryja, V., Geyer, M., Blazek, D. & Barboric, M., 11 Mar 2015, In : Nucleic Acids Research. 43, 5, p. 2575-2589 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Projects

Sigrid Juseliuksen Säätiö/Barboric Matjaz 2011

Barboric, M.

Unknown funder

01/06/201130/04/2014

Project: Research project

Activities

  • 1 Pre-examiner of doctoral thesis

Regulation of Pol II polymerase transcriptional reponse to DNA-damage by RBM7 and P-TEFb

Robert Fisher (Opponent), Maciej Lalowski (Other role (describe in more detail in "Relation description, notes" field)), Matjaz Barboric (Supervisor), Dan Bj Lindholm (Supervisor), Lea Sistonen (Pre-examiner), Minna Kaikkonen-Määttä (Pre-examiner)
22 Jan 2020

Activity: Examination typesPre-examiner of doctoral thesis