Matti Itkonen - Publications - University of Helsinki

Research activity per year

7 Article
1 Letter
1 Doctoral Thesis

7 results

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2019

Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans
Itkonen, M. K., Tornio, A., Neuvonen, M., Neuvonen, P. J., Niemi, M. & Backman, J. T., 1 Apr 2019, In: Drug Metabolism and Disposition. 47, 4, p. 377-385 9 p.
Research output: Contribution to journal › Article › Scientific › peer-review

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Clopidogrel Increases Dasabuvir Exposure With or Without Ritonavir, and Ritonavir Inhibits the Bioactivation of Clopidogrel
Itkonen, M. K., Tornio, A., Lapatto-Reiniluoto, O., Neuvonen, M., Neuvonen, P. J., Niemi, M. & Backman, J. T., Jan 2019, In: Clinical Pharmacology and Therapeutics. 105, 1, p. 219-228 10 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
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2018

Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans.
Itkonen, M. K., Tornio, A., Filppula, A. M., Neuvonen, M., Neuvonen, P. J., Niemi, M. & Backman, J. T., Sept 2018, In: Clinical Pharmacology and Therapeutics. 104, 3, p. 495-504 10 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
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Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions
Kahma, H., Filppula, A. M., Neuvonen, M., Tarkiainen, E. K., Tornio, A., Holmberg, M. T., Itkonen, M. K., Finel, M., Neuvonen, P. J., Niemi, M. & Backman, J. T., 1 Feb 2018, In: Drug Metabolism and Disposition. 46, 2, p. 141-150 10 p.
Research output: Contribution to journal › Article › Scientific › peer-review
Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects
Neuvonen, M., Tarkiainen, E. K., Tornio, A., Hirvensalo, P., Tapaninen, T., Paile-Hyvärinen, M., Itkonen, M. K., Holmberg, M. T., Karja, V., Männistö, V. T., Neuvonen, P. J., Pihlajamäki, J., Backman, J. T. & Niemi, M., Mar 2018, In: Basic & Clinical Pharmacology & Toxicology. 122, 3, p. 341-345 5 p.
Research output: Contribution to journal › Article › Scientific › peer-review
2016

Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone
Itkonen, M. K., Tornio, A., Neuvonen, M., Neuvonen, P. J., Niemi, M. & Backman, J. T., Aug 2016, In: Drug Metabolism and Disposition. 44, 8, p. 1364-1371 8 p.
Research output: Contribution to journal › Article › Scientific › peer-review
2015

Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin
Itkonen, M. K., Tornio, A., Neuvonen, M., Neuvonen, P. J., Niemi, M. & Backman, J. T., Nov 2015, In: Drug Metabolism and Disposition. 43, 11, p. 1655-1660 6 p.
Research output: Contribution to journal › Article › Scientific › peer-review