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Publications 2006 2019

2019

Bayesian meta-analysis across genome-wide association studies of diverse phenotypes

Trochet, H., Pirinen, M., Band, G., Jostins, L., McVean, G. & Spencer, C. C. A., Jul 2019, In : Genetic Epidemiology. 43, 5, p. 532-547 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Does Evaluation of Tumour Budding in Diagnostic Biopsies have a Clinical Relevance? A Systematic Review

Almangush, A., Youssef, O., Pirinen, M., Sundström, J., Leivo, I. & Mäkitie, A. A., Mar 2019, In : Histopathology. 74, 4, p. 536-544 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access

Geographic Variation and Bias in the Polygenic Scores of Complex Diseases and Traits in Finland

Kerminen, S., Martin, A. R., Koskela, J., Ruotsalainen, S. E., Havulinna, A. S., Surakka, I., Palotie, A., Perola, M., Salomaa, V., Daly, M. J., Ripatti, S. & Pirinen, M., 6 Jun 2019, In : American Journal of Human Genetics. 104, 6, p. 1169-1181 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Healthcare costs and outcomes in adult patients with juvenile idiopathic arthritis: a population-based study

Mars, N. J., Kerola, A. M., Kauppi, M. J., Pirinen, M., Elonheimo, O. & Sokka-Isler, T., 4 Mar 2019, In : Scandinavian Journal of Rheumatology. 48, 2, p. 114-120 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Patients with rheumatic diseases share similar patterns of healthcare resource utilization

Mars, NJ., Kerola, AM., Kauppi, MJ., Pirinen, M., Elonheimo, O. & Sokka-Isler, T., 2019, In : Scandinavian Journal of Rheumatology. 48, 4, p. 300-307 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Variation in neurosurgical management of traumatic brain injury: a survey in 68 centers participating in the CENTER-TBI study

van Essen, T. A., den Boogert, H. F., Cnossen, M. C., CENTER-TBI Investigators Partici, Kaukonen, M., Kivisaari, R., Piippo-Karjalainen, A., Raj, R., Tanskanen, P., Palotie, A., Pirinen, M. & Ripatti, S., Mar 2019, In : Acta Neurochirurgica. 161, 3, p. 435-449 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Differences in the Commonly used Genotype Imputation Algorithms and Their Imputation Accuracy Estimates: 2018 IEEE 14th International Conference on e-Science

Pärn, K., Pirinen, M., Kals, M., Mägi, R., Salomaa, V., Boehnke, M., Hall, I., Stitziel, N., Freimer, N., Daly, M., Palotie, A., Ripatti, S. & Palta, P., 2018, p. 293-294. 2 p.

Research output: Conference materialsPaperResearchpeer-review

Efficient fine-mapping to identify causal genetic variants and quantify their contribution to complex phenotypes

Benner, C., Havulinna, A. S., Salomaa, V., Ripatti, S. & Pirinen, M., Oct 2018, In : Genetic Epidemiology. 42, 7, p. 688-689 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Genetic variation in VAC14 is associated with bacteremia secondary to diverse pathogens in African children

Wellcome Trust Case-Control Conso & Kenyan Bacteraemia Study Grp, 17 Apr 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 16, p. E3601-E3603 3 p.

Research output: Contribution to journalLetterScientificpeer-review

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Psychiat Genomics Consortium, Psychiat Genomics Consortium, Psychosis Endophenotypes Inter, Wellcome Trust Case Control, Ruderfer, D. M., Daly, M. J., Eriksson, J., Karjalainen, J., Lonnqvist, J., Meier, S., Neale, B. M., Palotie, A., Paunio, T., Pietilainen, O., Pirinen, M., Rautanen, A. & Suvisaari, J., 14 Jun 2018, In : Cell. 173, 7, p. 1705–1715.e1–e12 27 p., ARTN 1715.e16.

Research output: Contribution to journalArticleScientificpeer-review

Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland

Martin, A. R., Karczewski, K. J., Kerminen, S., Kurki, M. I., Sarin, A-P., Artomov, M., Eriksson, J. G., Esko, T., Genovese, G., Havulinna, A. S., Kaprio, J., Konradi, A., Korányi, L., Kostareva, A., Männikkö, M., Metspalu, A., Perola, M., Prasad, R. B., Raitakari, O., Rotar, O. & 7 othersSalomaa, V., Groop, L., Palotie, A., Neale, B. M., Ripatti, S., Pirinen, M. & Daly, M. J., 3 May 2018, In : American Journal of Human Genetics. 102, 5, p. 760-775 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

Int IBD Genetics Consortium, NIDDK IBD Genetics Consortium, T2D-Genes Consortium, Rivas, M. A., Koskela, J., Pirinen, M., Kurki, M., Saavalainen, P., Farkkila, M., Kontula, K., Palotie, A. & Daly, M. J., May 2018, In : PLoS Genetics. 14, 5, 25 p., 1007329.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4

Gilchrist, J. J., Rautanen, A., Fairfax, B. P., Mills, T. C., Naranbhai, V., Trochet, H., Pirinen, M., Muthumbi, E., Mwarumba, S., Njuguna, P., Mturi, N., Msefula, C. L., Gondwe, E. N., MacLennan, J. M., Chapman, S. J., Molyneux, M. E., Knight, J. C., Spencer, C. C. A., Williams, T. N., MacLennan, C. A. & 2 othersScott, J. A. G. & Hill, A. V. S., 9 Mar 2018, In : Nature Communications. 9, 11 p., 1014.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Tumour budding in oral squamous cell carcinoma: a meta-analysis

Almangush, A., Pirinen, M., Heikkinen, I., Mäkitie, A. A., Salo, T. & Leivo, I., 20 Feb 2018, In : British Journal of Cancer. 118, 4, p. 577-586 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

biMM: efficient estimation of genetic variances and covariances for cohorts with high-dimensional phenotype measurements

Pirinen, M., Benner, C., Marttinen, P., Jarvelin, M-R., Rivas, M. A. & Ripatti, S., 1 Aug 2017, In : Bioinformatics. 33, 15, p. 2405-2407 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Effect of Reference Panel in ID Score Regression Analysis of Lipid Traits in the Finnish Population

Hautakangas, H., Havulinna, A. S., Salomaa, V., Ripatti, S. & Pirinen, M., 2017, In : Human Heredity. 83, 1, p. 10-10 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Evaluating Robustness and Geographic Differences in Polygenic Risk in Finland

Kerminen, S., Koskela, J., Havulinna, A. S., Surakka, I., Martin, A. R., Palotie, A., Perola, M., Salomaa, V., Daly, M. J., Ripatti, S. & Pirinen, M., 2017, In : Human Heredity. 83, 1, p. 14-14 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Fine-Scale Genetic Structure in Finland

Kerminen, S., Havulinna, A. S., Hellenthal, G., Martin, A. R., Sarin, A-P., Perola, M., Palotie, A., Salomaa, V., Daly, M. J., Ripatti, S. & Pirinen, M., Oct 2017, In : G3 - Genes genomes genetics. 7, 10, p. 3459-3468 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis

Wang, L., Ko, E. R., Gilchrist, J. J., Pittman, K. J., Rautanen, A., Pirinen, M., Thompson, J. W., Dubois, L. G., Langley, R. J., Jaslow, S. L., Salinas, R. E., Rouse, D. C., Moseley, M. A., Mwarumba, S., Njuguna, P., Mturi, N., Williams, T. N., Scott, J. A. G., Hill, A. V. S., Woods, C. W. & 3 othersGinsburg, G. S., Tsalik, E. L. & Ko, D. C., Mar 2017, In : Science Advances. 3, 3, 14 p., 1602096.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Prospects of Fine-Mapping Trait-Associated Genomic Regions by Using Summary Statistics from Genome-wide Association Studies

Benner, C., Havulinna, A. S., Järvelin, M-R., Salomaa, V., Ripatti, S. & Pirinen, M., 5 Oct 2017, In : American Journal of Human Genetics. 101, 4, p. 539-551 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Searching for Genetic Variants Matching a Given Multivariate Target Profile

Topa, H., Havulinna, A. S., Salomaa, V., Kähönen, M., Lehtimaki, T., Raitakari, O. T., Järvelin, M-R., Ala-Korpela, M., Wurtz, P. & Pirinen, M., 2017, In : Human Heredity. 83, 1, p. 25-26 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study

Cnossen, M. C., Huijben, J. A., van der Jagt, M., Volovici, V., van Essen, T., Polinder, S., Nelson, D., Ercole, A., Stocchetti, N., Citerio, G., Peul, W. C., Maas, A. I. R., Menon, D., Steyerberg, E. W., Lingsma, H. F., CENTER-TBI Investigators, Palotie, A., Pirinen, M., Raj, R. & Ripatti, S., 6 Sep 2017, In : Critical Care. 21, 12 p., 233.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Whole-genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom

Chheda, H., Palta, P., Pirinen, M., McCarthy, S., Walter, K., Koskinen, S., Salomaa, V., Daly, M., Durbin, R., Palotie, A., Aittokallio, T., Ripatti, S. & Sequencing Initiative Suomi SISu P, Apr 2017, In : European Journal of Human Genetics. 25, 4, p. 477-484 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2016

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

Sieberts, S. K., Zhu, F., Garcia-Garcia, J., Stahl, E., Pratap, A., Pandey, G., Pappas, D., Aguilar, D., Anton, B., Bonet, J., Eksi, R., Fornes, O., Guney, E., Li, H., Marin, M. A., Panwar, B., Planas-Iglesias, J., Poglayen, D., Cui, J., Falcao, A. O. & 31 othersSuver, C., Hoff, B., Balagurusamy, V. S. K., Dillenberger, D., Neto, E. C., Norman, T., Aittokallio, T., Ammad-ud-din, M., Azencott, C-A., Bellon, V., Boeva, V., Bunte, K., Chheda, H., Cheng, L., Corander, J., Dumontier, M., Goldenberg, A., Gopalacharyulu, P., Hajiloo, M., Hidru, D., Jaiswal, A., Kaski, S., Khalfaoui, B., Khan, S. A., Kramer, E. R., Marttinen, P., Pirinen, M., Saarela, J., Tang, J., Wennerberg, K. & Rheumatoid Arth Challenge, Aug 2016, In : Nature Communications. 7, 9 p., 12460.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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FINEMAP: efficient variable selection using summary data from genome-wide association studies

Benner, C., Spencer, C. C. A., Havulinna, A. S., Salomaa, V., Ripatti, S. & Pirinen, M., 15 May 2016, In : Bioinformatics. 32, 10, p. 1493-1501 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Genetic support for the causal role of insulin in coronary heart disease

Tikkanen, E., Pirinen, M., Sarin, A-P., Havulinna, A. S., Mannisto, S., Saltevo, J., Lokki, M-L., Sinisalo, J., Lundqvist, A., Jula, A., Salomaa, V. & Ripatti, S., 2016, In : Diabetologia. 59, 11, p. 2369-2377 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

Kettunen, J., Demirkan, A., Wurtz, P., Draisma, H. H. M., Haller, T., Rawal, R., Vaarhorst, A., Kangas, A. J., Lyytikäinen, L-P., Pirinen, M., Pool, R., Sarin, A-P., Soininen, P., Tukiainen, T., Wang, Q., Tiainen, M., Tynkkynen, T., Amin, N., Zeller, T., Beekman, M. & 30 othersDeelen, J., van Dijk, K. W., Esko, T., Hottenga, J-J., van Leeuwen, E. M., Lehtimaki, T., Mihailov, E., Rose, R. J., de Craen, A. J. M., Gieger, C., Kahonen, M., Perola, M., Blankenberg, S., Savolainen, M. J., Verhoeven, A., Viikari, J., Willemsen, G., Boomsma, D. I., van Duijn, C. M., Eriksson, J., Jula, A., Jarvelin, M-R., Kaprio, J., Metspalu, A., Raitakari, O., Salomaa, V., Slagboom, P. E., Waldenberger, M., Ripatti, S. & Ala-Korpela, M., Mar 2016, In : Nature Communications. 7, 9 p., 11122.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis

Cichonska, A., Rousu, J., Marttinen, P., Kangas, A. J., Soininen, P., Lehtimaki, T., Raitakari, O. T., Jarvelin, M-R., Salomaa, V., Ala-Korpela, M., Ripatti, S. & Pirinen, M., 1 Jul 2016, In : Bioinformatics. 32, 13, p. 1981-1989 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Multiple Output Regression with Latent Noise

Gillberg, J., Marttinen, P., Pirinen, M., Kangas, A. J., Soininen, P., Ali, M., Havulinna, A. S., Järvelin, M-R., Ala-Korpela, M. & Kaski, S., 1 Jan 2016, In : Journal of Machine Learning Research. 17, 1, p. 4170-4204 35 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The Contribution of GWAS Loci in Familial Dyslipidemias

Ripatti, P., Ramo, J. T., Soderlund, S., Surakka, I., Matikainen, N., Pirinen, M., Pajukanta, P., Sarin, A-P., Service, S. K., Laurila, P-P., Ehnholm, C., Salomaa, V., Wilson, R. K., Palotie, A., Freimer, N. B., Taskinen, M-R. & Ripatti, S., May 2016, In : PLoS Genetics. 12, 5, 14 p., 1006078.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2015

Assessing allele-specific expression across multiple tissues from RNA-seq read data

Pirinen, M., Lappalainen, T., Zaitlen, N. A., Dermitzakis, E. T., Donnelly, P., McCarthy, M. I., Rivas, M. A. & GTEx Consortium, 1 Aug 2015, In : Bioinformatics. 31, 15, p. 2497-2504 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of predicted protein-truncating genetic variants on the human transcriptome

Rivas, M. A., Pirinen, M., Conrad, D. F., Lek, M., Tsang, E. K., Karczewski, K. J., Maller, J. B., Kukurba, K. R., DeLuca, D. S., Fromer, M., Ferreira, P. G., Smith, K. S., Zhang, R., Zhao, F., Banks, E., Poplin, R., Ruderfer, D. M., Purcell, S. M., Tukiainen, T., Minikel, E. V. & 19 othersStenson, P. D., Cooper, D. N., Huang, K. H., Sullivan, T. J., Nedzel, J., Bustamante, C. D., Li, J. B., Daly, M. J., Guigo, R., Donnelly, P., Ardlie, K., Sammeth, M., Dermitzakis, E. T., McCarthy, M. I., Montgomery, S. B., Lappalainen, T., MacArthur, D. G., GTEx Consortium & Geuvadis Consortium, 8 May 2015, In : Science. 348, 6235, p. 666-669 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic Variants on Chromosome 1p13.3 Are Associated with Non-ST Elevation Myocardial Infarction and the Expression of DRAM2 in the Finnish Population

Salo, P. P., Vaara, S., Kettunen, J., Pirinen, M., Sarin, A-P., Huikuri, H., Karhunen, P. J., Eskola, M., Nikus, K., Lokki, M-L., Ripatti, S., Havulinna, A. S., Salomaa, V., Palotie, A., Nieminen, M. S., Sinisalo, J. & Perola, M., 28 Oct 2015, In : PLoS One. 10, 10, 16 p., 0140576.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The fine-scale genetic structure of the British population

Leslie, S., Winney, B., Hellenthal, G., Davison, D., Boumertit, A., Day, T., Hutnik, K., Royrvik, E. C., Cunliffe, B., Lawson, D. J., Falush, D., Freeman, C., Pirinen, M., Myers, S., Robinson, M., Donnelly, P., Bodmer, W., Wellcome Trust Case Control & Int Multiple Sclerosis Genetics, 19 Mar 2015, In : Nature. 519, 7543, p. 309-+ 24 p.

Research output: Contribution to journalArticleScientificpeer-review

The impact of low-frequency and rare variants on lipid levels

Surakka, I., Horikoshi, M., Magi, R., Sarin, A-P., Mahajan, A., Lagou, V., Marullo, L., Ferreira, T., Miraglio, B., Timonen, S., Kettunen, J., Pirinen, M., Karjalainen, J., Thorleifsson, G., Hagg, S., Hottenga, J-J., Isaacs, A., Ladenvall, C., Beekman, M., Esko, T. & 31 othersRied, J. S., Nelson, C. P., Willenborg, C., Gustafsson, S., Westra, H-J., Blades, M., de Craen, A. J. M., de Geus, E. J., Deelen, J., Grallert, H., Hamsten, A., Havulinna, A. S., Hengstenberg, C., Houwing-Duistermaat, J. J., Hypponen, E., Karssen, L. C., Lehtimaki, T., Lyssenko, V., Magnusson, P. K. E., Mihailov, E., Mpindi, J-P., Perola, M., Kaprio, J., Groop, L., Eriksson, J. G., Ikonen, E., Kallioniemi, O., Pietiainen, V., Palotie, A., Ripatti, S. & ENGAGE Consortium, Jun 2015, In : Nature Genetics. 47, 6, p. 589-597 9 p.

Research output: Contribution to journalArticleScientificpeer-review

The landscape of genomic imprinting across diverse adult human tissues

Baran, Y., Subramaniam, M., Biton, A., Tukiainen, T., Tsang, E. K., Rivas, M. A., Pirinen, M., Gutierrez-Arcelus, M., Smith, K. S., Kukurba, K. R., Zhang, R., Eng, C., Torgerson, D. G., Urbanek, C., Li, J. B., Rodriguez-Santana, J. R., Burchard, E. G., Seibold, M. A., MacArthur, D. G., Montgomery, S. B. & 3 othersZaitlen, N. A., Lappalainen, T. & GTEx Consortium, Jul 2015, In : Genome Research. 25, 7, p. 927-936 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis

Morris, D. W., Cormican, P., Kenny, E. M., O'Dushlaine, C. T., Perreault, L-P. L., Giannoulatou, E., Tropea, D., Maher, B. S., Wormley, B., Kelleher, E., Fahey, C., Molinos, I., Bellini, S., Pirinen, M., Strange, A., Freeman, C., Thiselton, D. L., Elves, R. L., Regan, R., Ennis, S. & 38 othersDinan, T. G., McDonald, C., Murphy, K. C., O'Callaghan, E., Waddington, J. L., Walsh, D., O'Donovan, M., Grozeva, D., Craddock, N., Stone, J., Scolnick, E., Purcell, S., Sklar, P., Coe, B., Eichler, E. E., Ophoff, R., Buizer, J., Szatkiewicz, J., Hultman, C., Sullivan, P., Gurling, H., Mcquillin, A., St Clair, D., Rees, E., Kirov, G., Walters, J., Blackwood, D., Johnstone, M., Donohoe, G., O'Neill, F. A., Kendler, K. S., Gill, M., Riley, B. P., Spencer, C. C. A., Corvin, A., Consortium, I. S., Consortium, SGENE. & Consor, W. T. C. C., 15 Jun 2014, In : Human Molecular Genetics. 23, 12, p. 3316-3326 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression

Marttinen, P., Pirinen, M., Sarin, A-P., Gillberg, J., Kettunen, J., Surakka, I., Kangas, A. J., Soininen, P., O'Reilly, P., Kaakinen, M., Kahonen, M., Lehtimaki, T., Ala-Korpela, M., Raitakari, O. T., Salomaa, V., Jarvelin, M-R., Ripatti, S. & Kaski, S., 15 Jul 2014, In : Bioinformatics. 30, 14, p. 2026-2034 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Chromosome X-Wide Association Study Identifies Loci for Fasting Insulin and Height and Evidence for Incomplete Dosage Compensation

Tukiainen, T., Pirinen, M., Sarin, A-P., Ladenvall, C., Kettunen, J., Lehtimaeki, T., Lokki, M-L., Perola, M., Sinisalo, J., Vlachopoulou, E., Eriksson, J. G., Groop, L., Jula, A., Jaervelin, M-R., Raitakari, O. T., Salomaa, V. & Ripatti, S., Feb 2014, In : PLoS Genetics. 10, 2, 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Common variant at 16p11.2 conferring risk of psychosis

Steinberg, S., de Jong, S., Mattheisen, M., Costas, J., Demontis, D., Jamain, S., Pietiläinen, O. P. H., Lin, K., Papiol, S., Huttenlocher, J., Sigurdsson, E., Vassos, E., Giegling, I., Breuer, R., Fraser, G., Walker, N., Melle, I., Djurovic, S., Agartz, I., Tuulio-Henriksson, A. & 32 othersSuvisaari, J., Lönnqvist, J., Paunio, T., Olsen, L., Hansen, T., Ingason, A., Pirinen, M., Strengman, E., Hougaard, D. M., Orntoft, T., Didriksen, M., Hollegaard, M. V., Nordentoft, M., Abramova, L., Kaleda, V., Arrojo, M., Sanjuan, J., Arango, C., Etain, B., Bellivier, F., Meary, A., Schuerhoff, F., Szoke, A., Ribolsi, M., Magni, V., Siracusano, A., Sperling, S., Rehnstrom, K., Kilpinen, L. H., Palotie, A., GROUP & Wellcome Trust Case Control Consor, Jan 2014, In : Molecular Psychiatry. 19, 1, p. 108-114 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Meta-Analysis of Genome-Wide Association Studies with Multivariate Traits

Cichonska, A., Marttinen, P., Ripatti, S., Rousu, J. & Pirinen, M., 2014, MLSB14: The eighth International Workshop on Machine Learning in Systems Biology 6-7 September 2014 Strasbourg, France. d'Alché-Buc, F. & Geurts, P. (eds.). p. 27-30 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Reappraisal of known malaria resistance loci in a large multicenter study

Rockett, K. A., Clarke, G. M., Fitzpatrick, K., Hubbart, C., Jeffreys, A. E., Rowlands, K., Craik, R., Jallow, M., Conway, D. J., Bojang, K. A., Pinder, M., Usen, S., Sisay-Joof, F., Sirugo, G., Toure, O., Thera, M. A., Konate, S., Sissoko, S., Niangaly, A., Poudiougou, B. & 63 othersMangano, V. D., Bougouma, E. C., Sirima, S. B., Modiano, D., Amenga-Etego, L. N., Ghansah, A., Koram, K. A., Wilson, M. D., Enimil, A., Evans, J., Amodu, O., Olaniyan, S., Apinjoh, T., Mugri, R., Ndi, A., Ndila, C. M., Uyoga, S., Macharia, A., Peshu, N., Williams, T. N., Manjurano, A., Riley, E., Drakeley, C., Reyburn, H., Nyirongo, V., Kachala, D., Molyneux, M., Dunstan, S. J., Phu, N. H., Quyen, N. T. N., Thai, C. Q., Hien, T. T., Manning, L., Laman, M., Siba, P., Karunajeewa, H., Allen, S., Allen, A., Davis, T. M. E., Michon, P., Mueller, I., Green, A., Molloy, S., Johnson, K. J., Kerasidou, A., Cornelius, V., Hart, L., Vanderwal, A., SanJoaquin, M., Band, G., Le, S. Q., Pirinen, M., Sepulveda, N., Spencer, C. C. A., Clark, T. G., Agbenyega, T., Achidi, E., Doumbo, O., Farrar, J., Marsh, K., Taylor, T., Kwiatkowski, D. P. & Netwo, M. G. E., 1 Nov 2014, In : Nature Genetics. 46, 11, p. 1197-1204 8 p.

Research output: Contribution to journalArticleScientificpeer-review

The correlation between reading and mathematics ability at age twelve has a substantial genetic component

Wellcome Trust Case Control , 1 Jul 2014, In : Nature Communications. 5, 6 p., 4204.

Research output: Contribution to journalArticleScientificpeer-review

2013

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Beecham, A. H., Patsopoulos, N. A., Xifara, D. K., Davis, M. F., Kemppinen, A., Cotsapas, C., Shah, T. S., Spencer, C., Booth, D., Goris, A., Oturai, A., Saarela, J., Fontaine, B., Hemmer, B., Martin, C., Zipp, F., D'Alfonso, S., Martinelli-Boneschi, F., Taylor, B., Harbo, H. F. & 32 othersKockum, I., Hillert, J., Olsson, T., Ban, M., Oksenberg, J. R., Hintzen, R., Barcellos, L. F., Agliardi, C., Alfredsson, L., Alizadeh, M., Anderson, C., Andrews, R., Sondergaard, H. B., Baker, A., Band, G., Baranzini, S. E., Barizzone, N., Barrett, J., Bellenguez, C., Bergamaschi, L., Bernardinelli, L., Berthele, A., Biberacher, V., Binder, T. M. C., Blackburn, H., Bomfim, I. L., Brambilla, P., Leppä, V., Pirinen, M., Tienari, P., Wellcome Trust Case Control Consor & Int IBD Genetics Consortium IIBDGC, Nov 2013, In : Nature Genetics. 45, 11, p. 1353-+ 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Assessing association between protein truncating variants and quantitative traits

Rivas, M. A., Pirinen, M., Neville, M. J., Gaulton, K. J., Moutsianas, L., Lindgren, C. M., Karpe, F., McCarthy, M. I., Donnelly, P. & GoT2D Consortium, 1 Oct 2013, In : Bioinformatics. 29, 19, p. 2419-2426 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Bayesian Information Sharing Between Noise And Regression Models Improves Prediction of Weak Effects

Gillberg, J., Marttinen, P., Pirinen, M., Kangas, A. J., Soininen, P., Järvelin, M-R., Ala-Korpela, M. & Kaski, S., 16 Oct 2013, In : arXiv.org . 1310.4362v1 , 9 p.

Research output: Contribution to journalArticleScientific

Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis

Fakiola, M., Strange, A., Cordell, H. J., Miller, E. N., Pirinen, M., Su, Z., Mishra, A., Mehrotra, S., Monteiro, G. R., Band, G., Bellenguez, C., Dronov, S., Edkins, S., Freeman, C., Giannoulatou, E., Gray, E., Hunt, S. E., Lacerda, H. G., Langford, C., Pearson, R. & 33 othersPontes, N. N., Rai, M., Singh, S. P., Smith, L., Sousa, O., Vukcevic, D., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C. G., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Wilson, M. E., Deloukas, P., Palotie, L., Christiansen, F., Witt, C., Jeronimo, S. M. B., Sundar, S., Spencer, C. C. A., Blackwell, J. M., Donnelly, P., LeishGEN Consortium & Wellcome Trust Case Control, Feb 2013, In : Nature Genetics. 45, 2, p. 208-213 6 p.

Research output: Contribution to journalArticleScientificpeer-review

EFFICIENT COMPUTATION WITH A LINEAR MIXED MODEL ON LARGE-SCALE DATA SETS WITH APPLICATIONS TO GENETIC STUDIES

Pirinen, M., Donnelly, P. & Spencer, C. C. A., Mar 2013, In : Annals of Applied Statistics. 7, 1, p. 369-390 22 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus

Donnelly, P., WTCCC2, BMES & Pirinen, M. J., 15 Nov 2013, In : Human Molecular Genetics. 22, 22, p. 4653-4660 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Transcriptome and genome sequencing uncovers functional variation in humans

Lappalainen, T., Sammeth, M., Friedlaender, M. R., 't Hoen, P. A. C., Monlong, J., Rivas, M. A., Gonzalez-Porta, M., Kurbatova, N., Griebel, T., Ferreira, P. G., Barann, M., Wieland, T., Greger, L., van Iterson, M., Almloef, J., Ribeca, P., Pulyakhina, I., Esser, D., Giger, T., Tikhonov, A. & 31 othersSultan, M., Bertier, G., MacArthur, D. G., Lek, M., Lizano, E., Buermans, H. P. J., Padioleau, I., Schwarzmayr, T., Karlberg, O., Ongen, H., Kilpinen, H., Beltran, S., Gut, M., Kahlem, K., Amstislavskiy, V., Stegle, O., Pirinen, M., Montgomery, S. B., Donnelly, P., McCarthy, M. I., Flicek, P., Strom, T. M., Lehrach, H., Schreiber, S., Sudbrak, R., Carracedo, A., Antonarakis, S. E., Haesler, R., Syvaenen, A-C., Van Ommen, G-J. & Geuvadis Consortium, 26 Sep 2013, In : Nature. 501, 7468, p. 506-511 6 p.

Research output: Contribution to journalArticleScientificpeer-review