• PL 63 (Haartmaninkatu 8)

    00014

    Finland

19962019
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Publications 1996 2019

2019

KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D

Jha, S. K., Jeltsch, M., Rauniyar, K., Chronowska, E., Maina, E., Koistinen, H., Stenman, U. H., Alitalo, K. & Mattonet, K., 17 May 2019, In : eLife. 8, e44478.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Biology of Vascular Endothelial Growth Factor C in the Morphogenesis of Lymphatic Vessels

Rauniyar, K., Jha, S. K. & Jeltsch, M. M., 12 Feb 2018, In : Frontiers in Bioengineering and Biotechnology. 6, 12 p., 7.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Key molecules in lymphatic development, function, and identification

Jha, S. K., Rauniyar, K. & Jeltsch, M., 2018, In : Annals of Anatomy. 219, p. 25-34 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Was man in der Lymphologie über VEGF-C wissen sollte

Jeltsch, M., 1 Jul 2018, In : Vasomed : die Fachzeitschrift für Gefäßerkrankungen. 30, 4, p. 172-173 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2017

Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1

Jha, S. K., Rauniyar, K., Kärpänen, T., Leppänen, V-M., Brouillard, P., Vikkula, M., Alitalo, K. & Jeltsch, M., 7 Jul 2017, In : Scientific Reports. 7, 13 p., 4916.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Factors regulating the substrate specificity of cytosolic phospholipase A(2)-alpha in vitro

Batchu, K. C., Hänninen, S., Jha, S. K., Jeltsch, M. & Somerharju, P., Nov 2016, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1861, 11, p. 1597-1604 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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From Molecular Genetics and Biology to Effective Treatments of Lymphatic Disorders

Jeltsch, M., 13 May 2016, The European Journal of Lymphology and Related Problems. Vol. 28. p. 11 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientific

Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis

Johns, S. C., Yin, X., Jeltsch, M., Bishop, J. R., Schuksz, M., El Ghazal, R., Wilcox-Adelman, S. A., Alitalo, K. & Fuster, M. M., 8 Jul 2016, In : Circulation Research. 119, 2, p. 210-+ 24 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Ischemia-Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts

Dashkevich, A., Raissadati, A., Syrjala, S. O., Zarkada, G., Keranen, M. A. I., Tuuminen, R., Krebs, R., Anisimov, A., Jeltsch, M., Leppanen, V. -M., Alitalo, K., Nykanen, A. I. & Lemstrom, K. B., Apr 2016, In : American Journal of Transplantation. 16, 4, p. 1160-1172 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Lymphatic Vessels in Regenerative Medicine and Tissue Engineering

Schaupper, M., Jeltsch, M., Rohringer, S., Redl, H. & Holnthoner, W., 2016, In : Tissue Engineering. Part B. Reviews. 22, 5, p. 395-407 13 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2015

Die genetischen Ursachen des primären Lymphödems: Erkrankungen des Lymphgefäßsystems

Wilting, J., Jeltsch, M. & Mattonet, K., 2015, Erkrankungen des Lymphgefäßsystems. Weissleder, H. & Schuchhardt, C. (eds.). 6 ed. Cologne: Viavital Verlag, p. 210-229 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

Functional Dissection of the CCBE1 Protein A Crucial Requirement for the Collagen Repeat Domain

Roukens, M. G., Peterson-Maduro, J., Padberg, Y., Jeltsch, M., Leppanen, V-M., Bos, F. L., Alitalo, K., Schulte-Merker, S. & Schulte, D., 8 May 2015, In : Circulation Research. 116, 10, p. 1660-U153 22 p.

Research output: Contribution to journalArticleScientificpeer-review

Lymphangiogenesis in Health and Disease

Jeltsch, M., 13 May 2015, The European Journal of Lymphology and Related Problems. Vol. 26. p. 8 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientific

Methods and uses related to ADAMTS3

Alitalo, K., Jeltsch, M., Jha, S. K. & Tvorogov, D., 30 Jul 2015, WIPO, Patent No. WO2015/110707, 30 Jul 2015, Priority date 24 Jan 2014, Priority No. 20145073 (FI)

Research output: PatentScientific

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Substrate Efflux Propensity Is the Key Determinant of Ca2+-independent Phospholipase A-beta (iPLA beta)-mediated Glycerophospholipid Hydrolysis

Batchu, K. C., Hokynar, K., Jeltsch, M., Somerharju, P. & Mattonet, K., 17 Apr 2015, In : Journal of Biological Chemistry. 290, 16, p. 10093-10103 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Therapeutic use of VEGF-C and CCBE1

Alitalo, K., Jeltsch, M. & Anisimov, A., 19 Feb 2015, WIPO, Patent No. WO2015/022447, 15 Feb 2015, Priority date 14 Aug 2013, Priority No. 20135832 (FI)

Research output: PatentScientific

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The TIE Receptor Family

Saharinen, P. I., Jeltsch, M. M., Santoyo, M. M., Leppänen, V-M. & Alitalo, K. K., 2015, Receptor Tyrosine Kinases: Family and Subfamilies. Wheeler, D. L. & Yarden, Y. (eds.). Springer-Verlag, p. 743-775 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Über die heterogene Herkunft des Lymphgefäßsystems

Jeltsch, M. M. & Mattonet, K., 2015, In : Lymphologie in Forschung und Praxis. 19, 2, p. 84-88 5 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2014

CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3-Mediated Vascular Endothelial Growth Factor-C Activation

Jeltsch, M., Jha, S. K., Tvorogov, D., Anisimov, A., Leppanen, V-M., Holopainen, T., Kivela, R., Ortega, S., Karpanen, T. & Alitalo, K., 13 May 2014, In : Circulation . 129, 19, p. 1962-1971 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Die lymphangiogenen Wachstumsfaktoren VEGF-C und VEGF-D: Teil 2: Die Rolle von VEGF-C und VEGF-D bei Krankheiten des Lymphgefäßsystems

Jeltsch, M., Lackner, M. & Krebs, R., 1 Feb 2014, In : Vasomed : die Fachzeitschrift für Gefäßerkrankungen. 26, 1, p. 48-50 3 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2013

A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development

Villefranc, J. A., Nicoli, S., Bentley, K., Jeltsch, M., Zarkada, G., Moore, J. C., Gerhardt, H., Alitalo, K. & Lawson, N. D., 1 Apr 2013, In : Development. 140, 7, p. 1497-1506 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Die lymphangiogenen Wachstumsfaktoren VEGF-C und VEGF-D: Teil 1: Grundlagen und Embryonalentwicklung

Jeltsch, M. & Krebs, R., 1 Dec 2013, In : Vasomed : die Fachzeitschrift für Gefäßerkrankungen. 25, 6, p. 335-336 2 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Die lymphangiogenen Wachstumsfaktoren VEGF-C und VEGF-D: Teil 1: Grundlagen und Embryonalentwicklung

Krebs, R. & Jeltsch, M., 1 Jun 2013, In : Lymphologie in Forschung und Praxis. 17, 1, p. 30-37 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Die lymphangiogenen Wachstumsfaktoren VEGF-C und VEGF-D. Teil 2. Die Rolle von VEGF-C und VEGF-D bei Krankheiten des Lymphgefäßsystems

Krebs, R. & Jeltsch, M., 1 Dec 2013, In : Lymphologie in Forschung und Praxis. 17, 2, p. 96-104 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Receptor Tyrosine Kinase-Mediated Angiogenesis

Jeltsch, M., Leppänen, V-M., Saharinen, P. & Alitalo, K., Sep 2013, In : Cold Spring Harbor Perspectives in Biology. 5, 9, p. Article Number: a009183 22 p.

Research output: Contribution to journalArticleScientificpeer-review

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation

Leppänen, V-M., Tvorogov, D., Kisko, K., Prota, A. E., Jeltsch, M., Anisimov, A., Markovic-Mueller, S., Stuttfeld, E., Goldie, K. N., Ballmer-Hofer, K. & Alitalo, K., 6 Aug 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 32, p. 12960-12965 6 p.

Research output: Contribution to journalArticleScientificpeer-review

The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor-1 Ligands

Anisimov, A., Leppanen, V-M., Tvorogov, D., Zarkada, G., Jeltsch, M., Holopainen, T., Kaijalainen, S. & Alitalo, K., 2 Jul 2013, In : Science signaling. 6, 282, p. ra52 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Use of VEGF-D gene to prevent restenosis

Alitalo, K. K., Ylä-Hertttuala, S., Hiltunen, M., Jeltsch, M. M. & Achen, M. G., 4 Jun 2013, US Patent and Trademark Office, Patent No. US 8,455,453 B2, 4 Jun 2013, Priority date 26 Oct 1998, Priority No. 60/105,587

Research output: PatentScientific

Open Access
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Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis

Anisimov, A., Tvorogov, D., Alitalo, A., Leppänen, V-M., An, Y., Han, E. C., Orsenigo, F., Gaal, E. I., Holopainen, T., Koh, Y. J., Tammela, T., Korpisalo, P., Keskitalo, S., Jeltsch, M., Yla-Herttuala, S., Dejana, E., Koh, G. Y., Choi, C., Saharinen, P. & Alitalo, K., 2013, In : Circulation . 127, 4, p. 424-434 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Critical Role of VEGF-C/VEGFR-3 Signaling in Innate and Adaptive Immune Responses in Experimental Obliterative Bronchiolitis

Krebs, R., Tikkanen, J. M., Ropponen, J. O., Jeltsch, M., Jokinen, J. J., Yla-Herttuala, S., Nykanen, A. I. & Lemstrom, K. B., Nov 2012, In : The American Journal of Pathology. 181, 5, p. 1607-1620 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins

Alitalo, K. K. & Jeltsch, M., 2 Oct 2012, US Patent and Trademark Office, Patent No. US 8,278,098 B2, 2 Oct 2012, Priority date 25 Feb 2000, Priority No. 60/185,205

Research output: PatentScientific

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VEGFR-2-specific forms of VEGF-D and VEGF-C and uses thereof

Alitalo, K. K., Jeltsch, M. M., Leppänen, V-M., Aho, K. K., Anisimov, A. & Tvorogov, D., 5 Jul 2012, WIPO, Patent No. WO2012/088563, 2 Jul 2012, Priority date 24 Nov 2010, Priority No. 61/458,517 (US)

Research output: PatentScientific

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2011

Modified VEGF-A with improved angiogenic properties

Alitalo, K. K., Tammela, T. L. H., Keskitalo, S. E., Pajusola, K. M., Jeltsch, M. M., Ylä-Herttuala, S., Kärpänen, T. H., Eriksson, U. & Uutela, M. J. T., 27 Sep 2011, US Patent and Trademark Office, Patent No. US 8,025,886 B2, 27 Sep 2011, Priority date 15 Aug 2005, Priority No. 60/708,226

Research output: PatentScientific

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Structural determinants of vascular endothelial growth factor-D receptor binding and specificity

Leppänen, V-M., Jeltsch, M., Anisimov, A., Tvorogov, D., Aho, K., Kalkkinen, N., Toivanen, P., Ylä-Herttuala, S., Ballmer-Hofer, K. & Alitalo, K., 2011, In : Blood. 117, 5, p. 1507-1515 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development

Saharinen, P. I., Heloterä, H., Miettinen, J., Norrmen, C., D Amico Lago, G. V., Jeltsch, M., Langenberg, T., Vandevelde, W., Ny, A., Dewerchin, M., Carmeliet, P. & Alitalo, K., 2010, In : Genes & Development. 24, 9, p. 875-880 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization

Tvorogov, D., Anisimov, A., Zheng, W., Leppänen, V-M., Tammela, T., Laurinavicius, S., Holnthoner, W., Heloterä, H., Holopainen, T., Jeltsch, M., Kalkkinen, N., Lankinen, H., Ojala, P. M. & Alitalo, K., 2010, In : Cancer Cell. 18, 6, p. 630-640 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Growth factor binding constructs, materials and methods

Alitalo, K. K. & Jeltsch, M. M., 21 Dec 2010, US Patent and Trademark Office, Patent No. US 7,855,178 B2, 21 Dec 2010, Priority date 5 Mar 2004, Priority No. 60/550,907

Research output: PatentScientific

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Structural determinants of growth factor binding and specificity by VEGF receptor 2

Leppänen, V-M., Prota, A. E., Jeltsch, M., Anisimov, A., Kalkkinen, N., Strandin, T., Lankinen, H., Goldman, A., Ballmer-Hofer, K. & Alitalo, K., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 6, p. 2425-2430 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Suppressive Effects of Vascular Endothelial Growth Factor-B on Tumor Growth in a Mouse Model of Pancreatic Neuroendocrine Tumorigenesis

Albrecht, I., Kopfstein, L., Strittmatter, K., Schomber, T., Falkevall, A., Hagberg, C. E., Lorentz, P., Jeltsch, M., Alitalo, K., Eriksson, U., Christofori, G. & Pietras, K., 2010, In : PLoS One. 5, 11, p. Article Number: e14109 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation

Bry, M., Kivelä, R., Holopainen, T., Anisimov, A., Tammela, T., Soronen, J., Silvola, J., Saraste, A., Jeltsch, M., Korpisalo, P., Carmeliet, P., Lemström, K. B., Shibuya, M., Yla-Herttuala, S., Alhonen, L., Mervaala, E., Andersson, L. C., Knuuti, J. & Alitalo, K., 2010, In : Circulation . 122, 17, p. 1725-1733 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Activated Forms of VEGF-C and VEGF-D Provide Improved Vascular Function in Skeletal Muscle

Anisimov, A., Alitalo, A., Korpisalo, P., Soronen, J., Kaijalainen, S., Leppanen, V-M., Jeltsch, M., Yla-Herttuala, S. & Alitalo, K., 2009, In : Circulation Research. 104, p. 1302-U156 25 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy

Kärpänen, T., Bry, M., Ollila, H., Seppänen-Laakso, T., Liimatta, E., Leskinen, H., Kivelä, R., Helkamaa, T., Merentie, M., Jeltsch, M., Paavonen, K., Andersson, L. C., Mervaala, E., Hassinen, I., Ylä-Herttuala, S., Oresic, M. & Alitalo, K., 2008, In : Circulation Research. 103, 9, p. 1018-1026 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium

Li, X., Tjwa, M., Van Hove, I., Enholm, B., Neven, E., Paavonen, K., Jeltsch, M., Juan, T. D., Sievers, R. E., Chorianopoulos, E., Wada, H., Vanwildemeersch, M., Noel, A., Foidart, J-M., Springer, M. L., von Degenfeld, G., Dewerchin, M., Blau, H. M., Alitalo, K., Eriksson, U. & 2 othersCarmeliet, P. & Moons, L., 2008, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 9, p. 1614-1620 7 p.

Research output: Contribution to journalArticleScientificpeer-review

The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis

Heckman, C. A., Holopainen, T., Wirzenius, M., Keskitalo, S., Jeltsch, M., Ylä-Herttuala, S., Wedge, S. R., Jurgensmeier, J. M. & Alitalo, K., 2008, In : Cancer Research. 68, 12, p. 4754-4762 9 p.

Research output: Contribution to journalArticleScientificpeer-review

VEGFR-3 fusion proteins

Alitalo, K. K. & Jeltsch, M. M., 9 Sep 2008, US Patent and Trademark Office, Patent No. US 7,422,741 B2, 9 Sep 2008, Priority date 5 Mar 2004, Priority No. 60/550,907

Research output: PatentScientific

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2007

Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins

Tammela, T., He, Y., Lyytikkä, J., Jeltsch, M., Markkanen, J., Pajusola, K., Ylä-Herttuala, S. & Alitalo, K., 2007, In : Circulation Research. 100, 10, p. 1468-1475 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Enhanced capillary formation stimulated by a chimeric vascular endothelial growth factor/vascular endothelial growth factor-C silk domain fusion protein

Keskitalo, S., Tammela, T., Lyytikkä, J., Kärpänen, T., Jeltsch, M., Markkanen, J., Ylä-Herttuala, S. & Alitalo, K., 2007, In : Circulation Research. 100, 10, p. 1460-1467 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Functional interaction of VEGF-C and VEGF-D with neuropilin receptors

Kärpänen, T., Heckman, C. A., Keskitalo, S., Jeltsch, M., Ollila, H., Neufeld, G., Tamagnone, L. & Alitalo, K., 2006, In : FASEB Journal. 20, 9, p. 1462.1472 1 p.

Research output: Contribution to journalArticleScientificpeer-review

Sigma-RBI Handbook of Receptor Classification and Signal Transduction: VEGF Receptors

Jeltsch, M. & Alitalo, K., 2006, 5. ed. Natick, MA: Sigma-Aldrich Research Biotechnology, L.P. 3 p.

Research output: Book/ReportAnthology or special issueScientificpeer-review

Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns

Jeltsch, M., Kärpänen, T., Strandin, T., Aho, K., Lankinen, H. & Alitalo, K., 2006, In : Journal of Biological Chemistry. 281, 17, p. 12187-12195 9 p.

Research output: Contribution to journalArticleScientificpeer-review