• PL 63 (Haartmaninkatu 8)

    00014

    Finland

19962019
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Publications 1996 2019

1996

VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development

Kukk, E., Lymboussaki, A., Taira, S., Kaipainen, A., Jeltsch, M., Joukov, V. & Alitalo, K., 1996, In : Sustainable Development. 122, p. 3829-3837 9 p.

Research output: Contribution to journalArticleScientificpeer-review

1997

Genomic organization of human and mouse genes for vascular endothelial growth factor C

Chilov, D., Kukk, E., Taira, S., Jeltsch, M., Kaukonen, J., Palotie, A., Joukov, V. & Alitalo, K., 1997, In : Journal of Biological Chemistry. 272, p. 25176-25183 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Hyperplasia of lymphatic vessels in VEGF-C transgenic mice

Jeltsch, M., Kaipainen, A., Joukov, V., Meng, X. J., Lakso, M., Rauvala, H., Swartz, M., Fukumura, D., Jain, R. K. & Alitalo, K., 1997, In : Science. 276, p. 1423-1425 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Proteolytic processing regulates receptor specificity and activity of VEGF-C

Joukov, V., Sorsa, T., Kumar, V., Jeltsch, M., ClaessonWelsh, L., Cao, Y. H., Saksela, O., Kalkkinen, N. & Alitalo, K., 1997, In : EMBO Journal. 16, p. 3898-3911 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Vascular endothelial growth factors VEGF-B and VEGF-C

Joukov, V., Kaipainen, A., Jeltsch, M., Pajusola, K., Olofsson, B., Kumar, V., Eriksson, U. & Alitalo, K., 1997, In : Journal of Cellular Physiology. 1997/173, p. 211-215 5 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

VEGF and VEGF-C: Specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane

Oh, S. J., Jeltsch, M. M., Birkenhager, R., McCarthy, J. E. G., Weich, H. A., Christ, B., Alitalo, K. & Wilting, J., 1997, In : Developmental Biology. 188, p. 96-109 14 p.

Research output: Contribution to journalArticleScientificpeer-review

1998

Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells

Olofsson, B., Korpelainen, E., Pepper, M. S., Mandriota, S. J., Aase, K., Kumar, V., Gunji, Y., Jeltsch, M., Shibuya, M., Alitalo, K. & Eriksson, U., 29 Sep 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 1998/95, 20, p. 11709-11714 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

Achen, M. G., Jeltsch, M., Kukk, E., Makinen, T., Vitali, A., Wilks, A. F., Alitalo, K. & Stacker, S. A., 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, p. 548-553 6 p.

Research output: Contribution to journalArticleScientificpeer-review

1999

Current biology of VEGF-B and VEGF-C

Olofsson, B., Jeltsch, M., Eriksson, U. & Alitalo, K., 1999, In : Current Opinion in Biotechnology. 1999/10, 6, p. 528-535 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2000

Intravascular adenovirus-mediated VEGF-C gene transfer reduces neointima formation in balloon-denuded rabbit aorta

Hiltunen, M. O., Laitinen, M., Turunen, M. P., Jeltsch, M., Hartikainen, J., Rissanen, T. T., Laukkanen, J., Niemi, M., Kossila, M., Hakkinen, T. P., Kivela, A., Enholm, B., Mansukoski, H., Turunen, A. M., Alitalo, K. & Yla-Herttuala, S., 2000, In : Circulation . 102, p. 2262-2268 7 p.

Research output: Contribution to journalArticleScientificpeer-review

VEGF-C adenovirus gene transfer reduces intima formation in rabbits

Jeltsch, M., Hiltunen, M. O., Laitinen, M., Turunen, M. P., Hartikainen, J., Rissanen, T. T., Laukkanen, J., Niemi, M., Kossila, M., Häkkinen, T. P., Kivelä, A., Enholm, B. C., Mansukoski, H., Turunen, A-M., Alitalo, K. & Ylä-Herttala, S., Jul 2000, 1 ed. 1 p. (Atherosclerosis; vol. 151, no. 1)

Research output: Book/ReportAnthology or special issueScientificpeer-review

2001

Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin

Enholm, B., Karpanen, T., Jeltsch, M., Kubo, H., Stenback, F., Prevo, R., Jackson, D. G., Yla-Herttuala, S. & Alitalo, K., 2001, In : Circulation Research. 88, p. 623-629 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice

Veikkola, T. M., Jussila, L., Mäkinen, T. M., Kärpänen, T. H., Jeltsch, M., Petrova, T., Hajime, K., Hajime, K., Gavin, T., McDonald, D. M., Marc G, A., Stacker, S. A. & Alitalo, K., 15 Mar 2001, In : EMBO Journal. 20, 6, p. 1223-1231 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Signalling via VEGFR-3 is sufficient for lymphangiogenesis in transgenic mice.

Jussila, L., Veikkola, T., Jeltsch, M., Thurston, G., McDonald, D., Achen, M., Stacker, S. & Alitalo, K., 2001, In : Clinical Cancer Research. 7, p. 3762S-3762S 1 p.

Research output: Contribution to journalArticleScientificpeer-review

Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis

Mandriota, S. J., Jussila, L., Jeltsch, M., Compagni, A., Baetens, D., Prevo, R., Banerji, S., Huarte, J., Montesano, R., Jackson, D. G., Orci, L., Alitalo, K., Christofori, G. & Pepper, M. S., 2001, In : EMBO Journal. 20, p. 672-682 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2002

Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes

Saaristo, A., Veikkola, T., Enholm, B., Hytonen, M., Arola, J., Pajusola, K., Turunen, P., Jeltsch, M., Karkkainen, M. J., Kerjaschki, D., Bueler, H., Yla-Herttuala, S. & Alitalo, K., 2002, In : FASEB Journal. 16, p. 1041-1049 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Glycosylated VEGF-B and method for increasing the amount of soluble VEGF-B: patent application

Jeltsch, M. M., Alitalo, K. K., Olofsson, B. & Eriksson, U., 6 Jun 2002, US Patent and Trademark Office, Patent No. US 2001/0068694 A1, 6 Jun 2002, Priority date 26 Jun 2000, Priority No. 60/220,824

Research output: PatentScientific

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2003

Genesis and pathogenesis of lymphatic vessels

Jeltsch, M., Tammela, T., Alitalo, K. & Wilting, J., 2003, In : Cell and Tissue Research. 314, p. 69-84 16 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function

Veikkola, T., Lohela, M., Ikenberg, K., Makinen, T., Korff, T., Saaristo, A., Petrova, T., Jeltsch, M., Augustin, H. G. & Alitalo, K., 2003, In : FASEB Journal. 17, p. 2006-2013 8 p.

Research output: Contribution to journalArticleScientificpeer-review

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D. & Betsholtz, C., 2003, In : Journal of Cell Biology. 161, p. 1163-1177 15 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

Kärkkäinen, M. J., Haiko, P., Sainio, K. M. H., Partanen, J. M., Taipale, J., Petrova, T. V., Jeltsch, M., Jackson, D. G., Talikka, M., Rauvala, H., Betsholtz, C. & Alitalo, K., 2004, In : Nature immunology.. 5, 1, p. 74-80 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Dual role of vascular endothelial growth factor in experimental obliterative bronchiolitis

Krebs, R., Tikkanen, J. M., Nykänen, A. I., Wood, J., Jeltsch, M., Ylä-Herttuala, S., Koskinen, P. K. & Lemström, K., 2005, In : American Journal of Respiratory and Critical Care Medicine. 171, 12, p. 1421-1429 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation

Baluk, P., Tammela, T., Ator, E., Lyubynska, N., Achen, M. G., Hicklin, D. J., Jeltsch, M., Petrova, T., Pytowski, B., Stacker, S. A., Ylä-Herttuala, S., Jackson, D. G., Alitalo, K. & McDonald, D. M., 2005, In : Journal of Clinical Investigation. 115, 2, p. 247-257 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Use of VEGF-C to prevent restenosis

Alitalo, K. K., Ylä-Herttuala, S., Hiltunen, M., Jeltsch, M. M. & Achen, M. G., 25 Oct 2005, US Patent and Trademark Office, Patent No. US 6,958,147 B1, 25 Oct 2005, Priority date 26 Oct 1998, Priority No. 60/105,587

Research output: PatentScientific

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Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels

He, Y., Rajantie, I., Pajusola, K., Jeltsch, M., Holopainen, T. T., Ylä-Herttuala, S., Harding, T., Jooss, K., Takahashi, T. & Alitalo, K., 2005, In : Cancer Research. 65, 11, p. 4739-4746 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Functional interaction of VEGF-C and VEGF-D with neuropilin receptors

Kärpänen, T., Heckman, C. A., Keskitalo, S., Jeltsch, M., Ollila, H., Neufeld, G., Tamagnone, L. & Alitalo, K., 2006, In : FASEB Journal. 20, 9, p. 1462.1472 1 p.

Research output: Contribution to journalArticleScientificpeer-review

Sigma-RBI Handbook of Receptor Classification and Signal Transduction: VEGF Receptors

Jeltsch, M. & Alitalo, K., 2006, 5. ed. Natick, MA: Sigma-Aldrich Research Biotechnology, L.P. 3 p.

Research output: Book/ReportAnthology or special issueScientificpeer-review

Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns

Jeltsch, M., Kärpänen, T., Strandin, T., Aho, K., Lankinen, H. & Alitalo, K., 2006, In : Journal of Biological Chemistry. 281, 17, p. 12187-12195 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins

Tammela, T., He, Y., Lyytikkä, J., Jeltsch, M., Markkanen, J., Pajusola, K., Ylä-Herttuala, S. & Alitalo, K., 2007, In : Circulation Research. 100, 10, p. 1468-1475 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Enhanced capillary formation stimulated by a chimeric vascular endothelial growth factor/vascular endothelial growth factor-C silk domain fusion protein

Keskitalo, S., Tammela, T., Lyytikkä, J., Kärpänen, T., Jeltsch, M., Markkanen, J., Ylä-Herttuala, S. & Alitalo, K., 2007, In : Circulation Research. 100, 10, p. 1460-1467 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy

Kärpänen, T., Bry, M., Ollila, H., Seppänen-Laakso, T., Liimatta, E., Leskinen, H., Kivelä, R., Helkamaa, T., Merentie, M., Jeltsch, M., Paavonen, K., Andersson, L. C., Mervaala, E., Hassinen, I., Ylä-Herttuala, S., Oresic, M. & Alitalo, K., 2008, In : Circulation Research. 103, 9, p. 1018-1026 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium

Li, X., Tjwa, M., Van Hove, I., Enholm, B., Neven, E., Paavonen, K., Jeltsch, M., Juan, T. D., Sievers, R. E., Chorianopoulos, E., Wada, H., Vanwildemeersch, M., Noel, A., Foidart, J-M., Springer, M. L., von Degenfeld, G., Dewerchin, M., Blau, H. M., Alitalo, K., Eriksson, U. & 2 othersCarmeliet, P. & Moons, L., 2008, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 9, p. 1614-1620 7 p.

Research output: Contribution to journalArticleScientificpeer-review

The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis

Heckman, C. A., Holopainen, T., Wirzenius, M., Keskitalo, S., Jeltsch, M., Ylä-Herttuala, S., Wedge, S. R., Jurgensmeier, J. M. & Alitalo, K., 2008, In : Cancer Research. 68, 12, p. 4754-4762 9 p.

Research output: Contribution to journalArticleScientificpeer-review

VEGFR-3 fusion proteins

Alitalo, K. K. & Jeltsch, M. M., 9 Sep 2008, US Patent and Trademark Office, Patent No. US 7,422,741 B2, 9 Sep 2008, Priority date 5 Mar 2004, Priority No. 60/550,907

Research output: PatentScientific

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2009

Activated Forms of VEGF-C and VEGF-D Provide Improved Vascular Function in Skeletal Muscle

Anisimov, A., Alitalo, A., Korpisalo, P., Soronen, J., Kaijalainen, S., Leppanen, V-M., Jeltsch, M., Yla-Herttuala, S. & Alitalo, K., 2009, In : Circulation Research. 104, p. 1302-U156 25 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development

Saharinen, P. I., Heloterä, H., Miettinen, J., Norrmen, C., D Amico Lago, G. V., Jeltsch, M., Langenberg, T., Vandevelde, W., Ny, A., Dewerchin, M., Carmeliet, P. & Alitalo, K., 2010, In : Genes & Development. 24, 9, p. 875-880 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization

Tvorogov, D., Anisimov, A., Zheng, W., Leppänen, V-M., Tammela, T., Laurinavicius, S., Holnthoner, W., Heloterä, H., Holopainen, T., Jeltsch, M., Kalkkinen, N., Lankinen, H., Ojala, P. M. & Alitalo, K., 2010, In : Cancer Cell. 18, 6, p. 630-640 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Growth factor binding constructs, materials and methods

Alitalo, K. K. & Jeltsch, M. M., 21 Dec 2010, US Patent and Trademark Office, Patent No. US 7,855,178 B2, 21 Dec 2010, Priority date 5 Mar 2004, Priority No. 60/550,907

Research output: PatentScientific

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Structural determinants of growth factor binding and specificity by VEGF receptor 2

Leppänen, V-M., Prota, A. E., Jeltsch, M., Anisimov, A., Kalkkinen, N., Strandin, T., Lankinen, H., Goldman, A., Ballmer-Hofer, K. & Alitalo, K., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 6, p. 2425-2430 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Suppressive Effects of Vascular Endothelial Growth Factor-B on Tumor Growth in a Mouse Model of Pancreatic Neuroendocrine Tumorigenesis

Albrecht, I., Kopfstein, L., Strittmatter, K., Schomber, T., Falkevall, A., Hagberg, C. E., Lorentz, P., Jeltsch, M., Alitalo, K., Eriksson, U., Christofori, G. & Pietras, K., 2010, In : PLoS One. 5, 11, p. Article Number: e14109 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation

Bry, M., Kivelä, R., Holopainen, T., Anisimov, A., Tammela, T., Soronen, J., Silvola, J., Saraste, A., Jeltsch, M., Korpisalo, P., Carmeliet, P., Lemström, K. B., Shibuya, M., Yla-Herttuala, S., Alhonen, L., Mervaala, E., Andersson, L. C., Knuuti, J. & Alitalo, K., 2010, In : Circulation . 122, 17, p. 1725-1733 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Modified VEGF-A with improved angiogenic properties

Alitalo, K. K., Tammela, T. L. H., Keskitalo, S. E., Pajusola, K. M., Jeltsch, M. M., Ylä-Herttuala, S., Kärpänen, T. H., Eriksson, U. & Uutela, M. J. T., 27 Sep 2011, US Patent and Trademark Office, Patent No. US 8,025,886 B2, 27 Sep 2011, Priority date 15 Aug 2005, Priority No. 60/708,226

Research output: PatentScientific

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Structural determinants of vascular endothelial growth factor-D receptor binding and specificity

Leppänen, V-M., Jeltsch, M., Anisimov, A., Tvorogov, D., Aho, K., Kalkkinen, N., Toivanen, P., Ylä-Herttuala, S., Ballmer-Hofer, K. & Alitalo, K., 2011, In : Blood. 117, 5, p. 1507-1515 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Critical Role of VEGF-C/VEGFR-3 Signaling in Innate and Adaptive Immune Responses in Experimental Obliterative Bronchiolitis

Krebs, R., Tikkanen, J. M., Ropponen, J. O., Jeltsch, M., Jokinen, J. J., Yla-Herttuala, S., Nykanen, A. I. & Lemstrom, K. B., Nov 2012, In : The American Journal of Pathology. 181, 5, p. 1607-1620 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins

Alitalo, K. K. & Jeltsch, M., 2 Oct 2012, US Patent and Trademark Office, Patent No. US 8,278,098 B2, 2 Oct 2012, Priority date 25 Feb 2000, Priority No. 60/185,205

Research output: PatentScientific

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VEGFR-2-specific forms of VEGF-D and VEGF-C and uses thereof

Alitalo, K. K., Jeltsch, M. M., Leppänen, V-M., Aho, K. K., Anisimov, A. & Tvorogov, D., 5 Jul 2012, WIPO, Patent No. WO2012/088563, 2 Jul 2012, Priority date 24 Nov 2010, Priority No. 61/458,517 (US)

Research output: PatentScientific

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2013

A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development

Villefranc, J. A., Nicoli, S., Bentley, K., Jeltsch, M., Zarkada, G., Moore, J. C., Gerhardt, H., Alitalo, K. & Lawson, N. D., 1 Apr 2013, In : Development. 140, 7, p. 1497-1506 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Die lymphangiogenen Wachstumsfaktoren VEGF-C und VEGF-D: Teil 1: Grundlagen und Embryonalentwicklung

Jeltsch, M. & Krebs, R., 1 Dec 2013, In : Vasomed : die Fachzeitschrift für Gefäßerkrankungen. 25, 6, p. 335-336 2 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Die lymphangiogenen Wachstumsfaktoren VEGF-C und VEGF-D: Teil 1: Grundlagen und Embryonalentwicklung

Krebs, R. & Jeltsch, M., 1 Jun 2013, In : Lymphologie in Forschung und Praxis. 17, 1, p. 30-37 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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