20122020

Research output per year

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Publications

2020

Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia

Kuusanmäki, H., Leppä, A-M., Pölönen, P., Kontro, M., Dufva, O., Deb, D., Yadav, B., Bruck, O., Kumar, A., Everaus, H., Gjertsen, B. T., Heinäniemi, M., Porkka, K., Mustjoki, S. & Heckman, C. A., 1 Mar 2020, In : Haematologica. 105, 3, p. 708-720 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2019

8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia

Buettner, R., Le Xuan Truong Nguyen, Kumar, B., Morales, C., Liu, C., Chen, L. S., Pemovska, T., Synold, T. W., Palmer, J., Thompson, R., Li, L., Dinh Hoa Hoang, Zhang, B., Ghoda, L., Kowolik, C., Kontro, M., Leitch, C., Wennerberg, K., Yu, X., Chen, C-C. & 5 others, Horne, D., Gandhi, V., Pullarkat, V., Marcucci, G. & Rosen, S. T., Sep 2019, In : Journal of Cellular Physiology. 234, 9, p. 16295-16303 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Allelic Imbalance of Recurrently Mutated Genes in Acute Myeloid Leukaemia

Batcha, A. M. N., Bamopoulos, S. A., Kerbs, P., Kumar, A., Jurinovic, V., Rothenberg-Thurley, M., Ksienzyk, B., Philippou-Massier, J., Krebs, S., Blum, H., Schneider, S., Konstandin, N., Bohlander, S. K., Heckman, C., Kontro, M., Hiddemann, W., Spiekermann, K., Braess, J., Metzeler, K. H., Greif, P. A. & 2 others, Mansmann, U. & Herold, T., 13 Aug 2019, In : Scientific Reports. 9, 11 p., 11796.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Dasatinib and navitoclax act synergistically to target NUP98-NSD1(+)/FLT3-ITD+ acute myeloid leukemia

Kivioja, J. L., Thanasopoulou, A., Kumar, A., Kontro, M., Yadav, B., Majumder, M. M., Javarappa, K. K., Eldfors, S., Schwaller, J., Porkka, K. & Heckman, C. A., Jun 2019, In : Leukemia. 33, 6, p. 1360-1372 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Elevated expression of S100A8 and S100A9 correlates with resistance to the BCL-2 inhibitor venetoclax in AML

Karjalainen, R., Liu, M., Kumar, A., Malani, D., Parsons, A., Kontro, M., Kallioniemi, O., Porkka, K. & Heckman, C., Oct 2019, In : Leukemia. 33, 10, p. 2548-2553 6 p.

Research output: Contribution to journalLetterScientific

2018

Case studies investigating genetic heterogeneity between anatomically distinct bone marrow compartments in acute myeloid leukemia

Ojamies, P. N., Kontro, M., Edgren, H., Ellonen, P., Heckman, C., Porkka, K., Wolf, M. & Kallioniemi, O., 2 Dec 2018, In : Leukemia & lymphoma. 59, 12, p. 3002-3005 4 p.

Research output: Contribution to journalLetterScientificpeer-review

Chimeric NUP98-NSD1 transcripts from the cryptic t(5;11)(q35.2;p15.4) in adult de novo acute myeloid leukemia

Kivioja, J., Lopez Marti, J. M., Kumar, A., Kontro, M., Edgren, H., Parsons, A., Lundan, T., Wolf, M., Porkka, K. & Heckman, C., 2018, In : Leukemia & lymphoma. 59, 3, p. 725-732 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Combined Targeting of BET Family Proteins and BCL2 Is Synergistic in Acute Myeloid Leukemia Cells Overexpressing S100A8 and S100A9

Karjalainen, R., Liu, M., Kumar, A., Parsons, A., He, L., Malani, D. R., Kontro, M., Porkka, K. & Heckman, C. A., 2018, In : Blood. 132

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access

Neutropenian selvittely

Kontro, M. & Lehto, M., 2018, In : Duodecim. 134, 11, p. 1149-1155 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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2017

Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

Pietarinen, P. O., Eide, C. A., Ayuda-Duran, P., Potdar, S., Kuusanmaki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, K., Hjorth-Hansen, H., Druker, B. J., Enserink, J. M., Tyner, J. W., Mustjoki, S. & Porkka, K., 4 Apr 2017, In : Oncotarget. 8, 14, p. 22606-22615 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML

Malani, D., Murumagi, A., Yadav, B., Kontro, M., Eldfors, S., Kumar, A., Karjalainen, R., Majumder, M. M., Ojamies, P., Pemovska, T., Wennerberg, K., Heckman, C., Porkka, K., Wolf, M., Aittokallio, T. & Kallioniemi, O., May 2017, In : Leukemia. 31, 5, p. 1187-1195 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia

Kontro, M., Kumar, A., Majumder, M. M., Eldfors, S., Parsons, A., Pemovska, T., Saarela, J. S., Yadav, B., Malani, D. R., Fløisand, Y., Höglund, M., Remes, K., Gjertsen, B-T., Kallioniemi, O-P., Wennerberg, J. K., Heckman, C. A. & Porkka, K. V. K., 2017, In : Leukemia. 31, 2, p. 301-309 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia

Eldfors, S., Kuusanmäki, H., Kontro, M., Majumder, M. M., Parsons, A., Edgren, H., Pemovska, T., Kallioniemi, O., Wennerberg, K., Gökbuget, N., Burmeister, T., Porkka, K. & Heckman, C. A., 2017, In : Leukemia. 31, 1, p. 51-57 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Individualizing therapy for acute leukemia

Kontro, M., 2017, Helsinki: [M. Kontro]. 76 p.

Research output: ThesisDoctoral ThesisCollection of Articles

In silico and preclinical drug screening identifies dasatinib as a targeted therapy for T-ALL

Laukkanen, S., Gronroos, T., Polonen, P., Kuusanmaki, H., Mehtonen, J., Cloos, J., Ossenkoppele, G., Gjertsen, B., Oystein, B., Heckman, C., Heinaniemi, M., Kontro, M. & Lohi, O., 8 Sep 2017, In : Blood cancer journal. 7, 4 p., 604.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML

Karjalainen, R., Pemovska, T., Popa, M., Liu, M., Javarappa, K. K., Majumder, M. M., Yadav, B., Tamborero, D., Tang, J., Bychkov, D., Kontro, M., Parsons, A., Suvela, M., Safont, M. M., Porkka, K., Aittokallio, T., Kallioniemi, O., McCormack, E., Gjertsen, B. T., Wennerberg, K. & 2 others, Knowles, J. & Heckman, C. A., 10 Aug 2017, In : Blood. 130, 6, p. 789-802 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Monitoring therapy responses at the leukemic subclone level by ultra-deep amplicon resequencing in acute myeloid leukemia

Ojamies, P., Kontro, M., Edgren, H., Ellonen, P., Lagström, S., Almusa, H., Miettinen, T., Eldfors, S., Tamborero, D., Wennerberg, K., Heckman, C., Porkka, K., Wolf, M. & Kallioniemi, O., 2017, In : Leukemia. 31, 5, p. 1048-1058 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry

Heikkinen, T., Kämpjärvi, K., Keskitalo, S., von Nandelstadh, P., Liu, X., Rantanen, V., Pitkänen, E., Kinnunen, M., Kuusanmäki, H., Kontro, M., Turunen, M., Mäkinen, N., Taipale, J., Heckman, C., Lehti, K., Mustjoki, S., Varjosalo, M. & Vahteristo, P., Mar 2017, In : Human Mutation. 38, 3, p. 269-274 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Somatic MED12 mutations in hematological malignancies

Heikkinen, T., Kampjarvi, K., Leppa, S., Hokland, P., Kuusanmaki, H., Mustjoki, S., Sinisalo, M., Heckman, C., Kontro, M. & Vahteristo, P., Jul 2016, In : Cancer Research. 76, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms

Kämpjärvi, K., Kim, NH., Keskitalo, S., Clark, AD., von Nandelstadh, P., Turunen, M., Heikkinen, T., Park, M. J., Mäkinen, N., Kivinummi, K., Lintula, S., Hotakainen, K., Nevanlinna, H., Hokland, P., Böhling, T., Butzow, R., Böhm, J., Mecklin, JP., Järvinen, H., Kontro, M. & 5 others, Visakorpi, T., Taipale, J., Varjosalo, M., Boyer, TG. & Vahteristo, P., 2016, In : Prostate. 76, 1, p. 22-31 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

Pemovska, T., Johnson, E., Kontro, M., Repasky, G. A., Chen, J., Wells, P., Cronin, C. N., McTigue, M., Kallioniemi, O., Porkka, K., Murray, B. W. & Wennerberg, K., 5 Mar 2015, In : Nature. 519, 7541, p. 102-U225 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing

Pietarinen, P. O., Pemovska, T., Kontro, M., Yadav, B., Mpindi, J. P., Andersson, E. I., Majumder, M. M., Kuusanmaki, H., Koskenvesa, P., Kallioniemi, O., Wennerberg, K., Heckman, C. A., Mustjoki, S. & Porkka, K., May 2015, In : Blood cancer journal. 5, 6 p., 309.

Research output: Contribution to journalArticleScientificpeer-review

Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia

Kampjarvi, K., Jaervinen, T. M., Heikkinen, T., Ruppert, A. S., Senter, L., Hoag, K. W., Dufva, O., Kontro, M., Rassenti, L., Hertlein, E., Kipps, T. J., Porkka, K., Byrd, J. C., de la Chapelle, A. & Vahteristo, P., 30 Jan 2015, In : Oncotarget. 6, 3, p. 1884-1888 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2014

Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia

Kontro, M., Kuusanmaki, H., Eldfors, S., Burmeister, T., Andersson, E. I., Bruserud, O., Bruemmendorf, T. H., Edgren, H., Gjertsen, B. T., Itala-Remes, M., Lagström, S., Lohi, O., Lundan, T., Marti, J. M. L., Majumder, M. M., Parsons, A., Pemovska, T., Rajala, H., Vettenranta, K., Kallioniemi, O. & 3 others, Mustjoki, S., Porkka, K. & Heckman, C. A., Aug 2014, In : Leukemia. 28, 8, p. 1738-1742 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies

Yadav, B., Pemovska, T., Szwajda, A., Kulesskiy, E., Kontro, M., Karjalainen, R., Majumder, M. M., Malani, D., Murumagi, A., Knowles, J., Porkka, K., Heckman, C., Kallioniemi, O., Wennerberg, K. & Aittokallio, T., 5 Jun 2014, In : Scientific Reports. 4, 10 p., 5193.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2013

High-throughput drug screening and molecular profiling for therapeutic targeting of NUP98-NSD1-positive AML

Kontro, M. P., Pemovska, T., Heckman, C. A., Kallioniemi, O-P., Wennerberg, J. K. & Porkka, K. V. K., Feb 2013, In : Annals of Hematology. 92, Supplement 1, p. S18

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid Leukemia

Pemovska, T., Kontro, M., Yadav, B., Edgren, H., Eldfors, S., Szwajda, A., Almusa, H., Bespalov, M. M., Ellonen, P., Elonen, E., Gjertsen, B. T., Karjalainen, R., Kulesskiy, E., Lagström, S., Lehto, A., Lepistö, M., Lundan, T., Majumder, M. M., Marti, J. M. L., Mattila, P. & 16 others, Murumagi, A., Mustjoki, S., Palva, A., Parsons, A., Pirttinen, T., Ramet, M. E., Suvela, M., Turunen, L., Vastrik, I., Wolf, M., Knowles, J., Aittokallio, T., Heckman, C. A., Porkka, K., Kallioniemi, O. & Wennerberg, K., Dec 2013, In : Cancer Discovery. 3, 12, p. 1416-1429 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

High-Throughput Ex Vivo Drug Sensitivity and Resistance Testing (DSRT) Integrated with Deep Genomic and Molecular Profiling Reveal New Therapy Options with Targeted Drugs in Subgroups of Relapsed Chemorefractory AML

Heckman, C. A., Kontro, M., Pemovska, T., Eldfors, S., Edgren, H., Kulesskiy, E., Majumder, M. M., Karjalainen, R., Yadav, B., Szwajda, A., Venkata, N. P. K., Murumagi, A., Malani, D., Parsons, A., Hintsanen, P., Almusa, H., Marti, J. M. L., Ellonen, P., Mattila, P., Lepisto, M. & 8 others, Lagstrom, S., Suvela, M., Mustjoki, S., Saarela, J., Aittokallio, T., Kallioniemi, O., Wennerberg, K. & Porkka, K., 16 Nov 2012, In : Blood. 120, 21, 2 p., Meeting Abstract: 288 .

Research output: Contribution to journalMeeting AbstractResearchpeer-review