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  • PL 22 (Stenbäckinkatu 11)

    00014

    Finland

19992019
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Publications 1999 2019

2019

A Joint Modeling Approach for Childhood Meat, Fish and Egg Consumption and the Risk of Advanced Islet Autoimmunity

Syrjälä, E., Nevalainen, J., Peltonen, J., Takkinen, H-M., Hakola, L., Åkerlund, M., Veijola, R., Ilonen, J., Toppari, J., Knip, M. & Virtanen, S. M., 23 May 2019, In : Scientific Reports. 9, 10 p., 7760.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Characteristics of familial type 1 diabetes: effects of the relationship to the affected family member on phenotype and genotype at diagnosis

Turtinen, M., Härkönen, T., Parkkola, A., Ilonen, J., Knip, M. & Register, T. F. P. D., 25 Jul 2019, In : Diabetologia.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Circulating CXCR5−PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes

Ekman, I., Ihantola, E-L., Viisanen, T., Rao, D. A., Näntö-Salonen, K., Knip, M., Veijola, R., Toppari, J., Ilonen, J. & Kinnunen, T., 3 Jul 2019, In : Diabetologia. 62, 9, p. 1681-1688 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Coeliac disease and HLA-conferred susceptibility to autoimmunity are associated with IgE sensitization in young children.

Mustonen, N., Siljander, H., Peet, A., Tillmann, V., Härkönen, T., Niemela, O., Uibo, R., Ilonen, J. & Knip, M., 17 Sep 2019, In : Allergy : European journal of allergy and clinical immunology.

Research output: Contribution to journalArticleScientificpeer-review

Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes

Lamichhane, S., Ahonen, L., Dyrlund, T. S., Dickens, A. M., Siljander, H., Hyöty, H., Ilonen, J., Toppari, J., Veijola, R., Hyötyläinen, T., Knip, M. & Oresic, M., Jan 2019, In : Biomolecules. 9, 1, 9 p., 33.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Development of atopic sensitization in Finnish and Estonian children: A latent class analysis in a multicenter cohort

Diabimmune Study Grp, Schmidt, F., Hose, A. J., Siljander, H., Knip, M. & Ege, M. J., May 2019, In : Journal of Allergy and Clinical Immunology. 143, 5, p. 1904-+ 19 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Development of T cell immunity to norovirus and rotavirus in children under five years of age

Malm, M., Hyoty, H., Knip, M., Vesikari, T. & Blazevic, V., 1 Mar 2019, In : Scientific Reports. 9, 9 p., 3199.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes

Ekman, I., Vuorinen, T., Knip, M., Veijola, R., Toppari, J., Hyöty, H., Kinnunen, T., Ilonen, J. & Lempainen, J., Feb 2019, In : Pediatric Diabetes. 20, 1, p. 73-77 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Early childhood infections and the use of antibiotics and antipyretic-analgesics in Finland, Estonia and Russian Karelia.

Mustonen, N., Siljander, H., Peet, A., Tillmann, V., Härkönen, T., Ilonen, J., Hyöty, H. & Knip, M., 27 May 2019, In : Acta Paediatrica.

Research output: Contribution to journalArticleScientificpeer-review

Early-life exposure to common virus infections did not differ between coeliac disease patients and controls

Diabimmune Study Grp, Sep 2019, In : Acta Paediatrica. 108, 9, p. 1709-1716 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children

Viisanen, T., Gazali, A. M., Ihantola, E-L., Ekman, I., Näntö-Salonen, K., Veijola, R., Toppari, J., Knip, M., Ilonen, J. & Kinnunen, T., 22 Jan 2019, In : Frontiers in Immunology. 10, 12 p., 19.

Research output: Contribution to journalArticleScientificpeer-review

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Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life

Vatanen, T., Plichta, D. R., Somani, J., Muench, P. C., Arthur, T. D., Hall, A. B., Rudolf, S., Oakeley, E. J., Ke, X., Young, R. A., Haiser, H. J., Kolde, R., Yassour, M., Luopajärvi, K., Siljander, H., Virtanen, S. M., Ilonen, J., Uibo, R., Tillmann, V., Mokurov, S. & 8 othersDorshakova, N., Porter, J. A., McHardy, A. C., Lahdesmaki, H., Vlamakis, H., Huttenhower, C., Knip, M. & Xavier, R. J., Mar 2019, In : Nature Microbiology. 4, 3, p. 470-479 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Identical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes

Type 1 Diabet TrialNet Study Grp, Triolo, T. M., Romo, M., Knip, M., Siljander, H. & Volin, L., 1 Feb 2019, In : Diabetes Care. 42, 2, p. 192-199 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Introduktion : barnens och pediatrikens framtid i Finland

Knip, M., 2019, In : Finska Läkaresällskapets Handlingar. 179, 1, p. 4-6 3 p.

Research output: Contribution to journalArticleProfessional

Open Access
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Islet Autoantibody Standardization Program 2018 Workshop: Interlaboratory Comparison of Glutamic Acid Decarboxylase Autoantibody Assay Performance

Participating Labs, Sep 2019, In : Clinical Chemistry (Washington, DC). 65, 9, p. 1141-1152 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Microbiome and type 1 diabetes

Siljander, H., Honkanen, J. & Knip, M., 27 Jun 2019, In : EBioMedicine.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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No Association Between Ljungan Virus Seropositivity and the Beta-cell Damaging Process in the Finnish Type 1 Diabetes Prediction and Prevention Study Cohort

Jääskeläinen, A. J., Nurminen, N., Kolehmainen, P., Smura, T., Tauriainen, S., Toppari, J., Ilonen, J., Veijola, R., Knip, M., Hyöty, H., Vapalahti, O. & Kallio-Kokko, H., Mar 2019, In : Pediatric Infectious Disease Journal. 38, 3, p. 314-316 3 p.

Research output: Contribution to journalArticleScientificpeer-review

No evidence of the role of early chemical exposure in the development of β-cell autoimmunity

Diabimmune Study Grp, Salo, H. M., Koponen, J., Kiviranta, H., Rantakokko, P., Honkanen, J., Härkönen, T., Ilonen, J., Virtanen, S. M., Tillmann, V., Knip, M. & Vaarala, O., Jan 2019, In : Environmental Science and Pollution Research. 26, 2, p. 1370-1378 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease

Sen, P., Carlsson, C., Virtanen, S. M., Simell, S., Hyöty, H., Ilonen, J., Toppari, J., Veijola, R., Hyötyläinen, T., Knip, M. & Oresic, M., 10 May 2019, In : Clinical and translational gastroenterology. 10, 10 p., 00044.

Research output: Contribution to journalArticleScientificpeer-review

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Rhinoviruses in infancy and risk of immunoglobulin E sensitization

Diabimmune Study Grp, Korhonen, L., Oikarinen, S., Lehtonen, J., Mustonen, N., Tyni, I., Niemelä, O., Honkanen, H., Huhtala, H., Ilonen, J., Hämäläinen, A-M., Peet, A., Tillmann, V., Siljander, H., Knip, M., Lönnrot, M., Hyöty, H., Härkönen, T., Ryhänen, S., Koski, K. & 13 othersKiviniemi, M., Ahlfors, H., Kallionpää, H., Laajala, E., Lahesmaa, R., Lähdesmäki, H., Moulder, R., Nieminen, J., Ruohtula, T., Vaarala, O., Alahuhta, K., Virtanen, S. M. & Kondrashova, A., Aug 2019, In : Journal of Medical Virology. 91, 8, p. 1470-1478 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes

Mäkinen, M., Löyttyniemi, E., Koskinen, M., Vähä-Mäkilä, M., Siljander, H., Nurmio, M., Mykkänen, J., Virtanen, S. M., Simell, O., Hyöty, H., Ilonen, J., Knip, M., Veijola, R. & Toppari, J., Jun 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 6, p. 2277-2285 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children

TEDDY STUDY GRP, Endesfelder, D., zu Castell, W., Bonifacio, E., Toppari, J. & Knip, M., Jan 2019, In : Diabetes. 68, 1, p. 119-130 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes

Lamichhane, S., Ahonen, L., Dyrlund, T. S., Siljander, H., Hyöty, H., Ilonen, J., Toppari, J., Veijola, R., Hyötyläinen, T., Knip, M. & Oresic, M., 13 Nov 2018, In : Scientific data . 5, 9 p., 180250.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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A novel processing-based classification and conventional food grouping to estimate milk product consumption in Finnish children

Koivusaari, K., Niinistö, S., Takkinen, H-M., Åkerlund, M., Korhonen, T., Ahonen, S., Toppari, J., Ilonen, J., Veijola, R., Knip, M., Alatossava, T. & Virtanen, S., Nov 2018, In : International Dairy Journal. 86, p. 96-102 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk

Type 1 Diabet TrialNet Study Grp, Redondo, M. J., Geyer, S., Steck, A. K. & Knip, M., 1 Sep 2018, In : Diabetes Care. 41, 9, p. 1887-1894 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Carotenoid Intake and Serum Concentration in Young Finnish Children and Their Relation with Fruit and Vegetable Consumption

Prasad, M., Takkinen, H-M., Uusitalo, L., Tapanainen, H., Ovaskainen, M-L., Alfthan, G., Erlund, I., Ahonen, S., Åkerlund, M., Toppari, J., Ilonen, J., Knip, M., Veijola, R. & Virtanen, S. M., Oct 2018, In : Nutrients. 10, 10, 13 p., 1533.

Research output: Contribution to journalArticleScientificpeer-review

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Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood

Lietzen, N., Cheng, L., Moulder, R., Siljander, H., Laajala, E., Härkönen, T., Peet, A., Vehtari, A., Tillmann, V., Knip, M., Lahdesmaki, H. & Lahesmaa, R., 12 Apr 2018, In : Scientific Reports. 8, 13 p., 5883.

Research output: Contribution to journalArticleScientificpeer-review

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Class II HLA Genotype Association With First-Phase Insulin Response Is Explained by Islet Autoantibodies

Koskinen, M. K., Lempainen, J., Löyttyniemi, E., Helminen, O., Hekkala, A., Härkönen, T., Kiviniemi, M., Simell, O., Knip, M., Ilonen, J., Toppari, J. & Veijola, R., Aug 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 8, p. 2870-2878 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes

Sioofy-Khojine, A-B., Lehtonen, J., Nurminen, N., Laitinen, O. H., Oikarinen, S., Huhtala, H., Pakkanen, O., Ruokoranta, T., Hankaniemi, M. M., Toppari, J., Vähä-Mäkilä, M., Ilonen, J., Veijola, R., Knip, M. & Hyöty, H., May 2018, In : Diabetologia. 61, 5, p. 1193-1202 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Developing a vaccine for type 1 diabetes by targeting coxsackievirus B

Hyöty, H., Leon, F. & Knip, M., 2 Dec 2018, In : Expert Review of Vaccines. 17, 12, p. 1071-1083 13 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP)

Lamichhane, S., Ahonen, L., Dyrlund, T. S., Kemppainen, E., Siljander, H., Hyoty, H., Ilonen, J., Toppari, J., Veijola, R., Hyotylainen, T., Knip, M. & Oresic, M., 13 Jul 2018, In : Scientific Reports. 8, 12 p., 10635.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk

Diabimmune Study Grp, Mar 2018, In : Pediatric Diabetes. 19, 2, p. 293-299 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Early Infant Diet and Islet Autoimmunity in the TEDDY Study

TEDDY STUDY GRP, Uusitalo, U., Lee, H-S., Aronsson, C. A., Simell, O., Toppari, J., Virtanen, S. M. & Knip, M., Mar 2018, In : Diabetes Care. 41, 3, p. 522-530 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes The TRIGR Randomized Clinical Trial

TRIGR Study Group, Hyytinen, M., Knip, M., Åkerblom, H. K., Al Taji, E., Becker, D., Bruining, J., Castano, L., Danne, T., de Beaufort, C., Dosch, H-M., Dupre, J., Fraser, W. D., Howard, N., Ilonen, J., Konrad, D., Kordonouri, O., Krischer, J. P., Lawson, M. L., Ludvigsson, J. & 27 othersMadacsy, L., Mahon, J. L., Ormisson, A., Palmer, J. P., Pozzilli, P., Savilahti, E., Serrano-Rios, M., Songini, M., Taback, S., Vaarala, O., White, N. H., Virtanen, S. M., Wasikowa, R., Heikkilä, M., Hirvasniemi, M., Luopajärvi, K., Johansson, S. E., Kleemola, P., Parkkola, A., Pigg, H-M., Puttonen, H., Renlund, M., Salonen, K., Suomalainen, H., Teramo, K., Järvenpää, A-L. & Hämäläinen, A-M., 2 Jan 2018, In : JAMA : The Journal of the American Medical Association. 319, 1, p. 38-48 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes

Ihantola, E-L., Viisanen, T., Gazali, A. M., Nanto-Salonen, K., Juutilainen, A., Moilanen, L., Rintamäki, R., Pihlajamäki, J., Veijola, R., Toppari, J., Knip, M., Ilonen, J. & Kinnunen, T., 15 Aug 2018, In : Journal of Immunology. 201, 4, p. 1144-1153 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes

Lietzen, N., An, L. T. T., Jaakkola, M. K., Kallionpää, H., Oikarinen, S., Mykkänen, J., Knip, M., Veijola, R., Ilonen, J., Toppari, J., Hyoty, H., Lahesmaa, R. & Elo, L. L., Feb 2018, In : Diabetologia. 61, 2, p. 381-388 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Enterovirus infection during pregnancy is inversely associated with atopic disease in the offspring

Korhonen, L., Seiskari, T., Lehtonen, J., Puustinen, L., Surcel, H-M., Haapala, A-M., Niemelä, O., Virtanen, S. M., Honkanen, H., Karjalainen, M., Ilonen, J., Veijola, R., Knip, M., Lönnrot, M. & Hyöty, H., Dec 2018, In : Clinical and Experimental Allergy. 48, 12, p. 1698-1704 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Exocrine pancreas function decreases during the progression of the beta-cell damaging process in young prediabetic children

Kondrashova, A., Nurminen, N., Lehtonen, J., Hyöty, M., Toppari, J., Ilonen, J., Veijola, R., Knip, M. & Hyöty, H., May 2018, In : Pediatric Diabetes. 19, 3, p. 398-402 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Infant Feeding in Relation to the Risk of Advanced Islet Autoimmunity and Type 1 Diabetes in Children With Increased Genetic Susceptibility: A Cohort Study

Hakola, L., Takkinen, H-M., Niinisto, S., Ahonen, S., Nevalainen, J., Veijola, R., Ilonen, J., Toppari, J., Knip, M. & Virtanen, S. M., 1 Jan 2018, In : American Journal of Epidemiology. 187, 1, p. 34-44 11 p.

Research output: Contribution to journalArticleScientificpeer-review

ISPAD Clinical Practice Consensus Guidelines 2018: Other complications and associated conditions in children and adolescents with type 1 diabetes

Mahmud, F. H., Elbarbary, N. S., Fröhlich-Reiterer, E., Holl, R. W., Kordonouri, O., Knip, M., Simmons, K. & Craig, M. E., Oct 2018, In : Pediatric Diabetes. 19, p. 275-286 12 p.

Research output: Contribution to journalArticleScientificpeer-review

ISPAD Clinical Practice Consensus Guidelines 2018: Stages of type 1 diabetes in children and adolescents

Couper, J. J., Haller, M. J., Greenbaum, C. J., Ziegler, A-G., Wherrett, D. K., Knip, M. & Craig, M. E., Oct 2018, In : Pediatric Diabetes. 19, p. 20-27 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Ketoacidosis at diagnosis of type 1 diabetes: Effect of prospective studies with newborn genetic screening and follow up of risk children

Hekkala, A. M., Ilonen, J., Toppari, J., Knip, M. & Veijola, R., Mar 2018, In : Pediatric Diabetes Online. 19, 2, p. 314-319 6 p.

Research output: Contribution to journalArticleScientificpeer-review

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Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes: prospective cohort study

Viskari, H., Oikarinen, S., Hoppu, S., Vuorinen, T., Huhtala, H., Toppari, J., Veijola, R., Ilonen, J., Knip, M. & Hyoty, H., Jan 2018, In : Diabetologia. 61, 1, p. 203-209 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Low-Dose Anti-Thymocyte Globulin (ATG) Preserves -Cell Function and Improves HbA(1c) in New-Onset Type 1 Diabetes

Type 1 Diabet TrialNet ATG-GCSF St, Haller, M. J., Schatz, D. A., Skyler, J. S. & Knip, M., 1 Sep 2018, In : Diabetes Care. 41, 9, p. 1917-1925 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity

TEDDY STUDY GRP, Norris, J. M., Lee, H-S., Frederiksen, B., Erlund, I., Toppari, J., Sundvall, J., Virtanen, S. M. & Knip, M., 1 Jan 2018, In : Diabetes. 67, 1, p. 146-154 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity

Finnish Pediat Diabet Register, Ilonen, J., Lempainen, J., Hammais, A., Laine, A-P., Härkönen, T., Toppari, J., Veijola, R. & Knip, M., Mar 2018, In : Pediatric Diabetes. 19, 2, p. 284-292 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Probiotic intervention in infancy is not associated with development of beta cell autoimmunity and type 1 diabetes

Savilahti, E., Härkönen, T., Savilahti, E. M., Kukkonen, K., Kuitunen, M. & Knip, M., Dec 2018, In : Diabetologia. 61, 12, p. 2668-2670 3 p.

Research output: Contribution to journalLetterScientific

Open Access
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Prospects for primary prevention of type 1 diabetes by restoring a disappearing microbe

Insel, R. & Knip, M., Dec 2018, In : Pediatric Diabetes. 19, 8, p. 1400-1406 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Quality Control Analysis in Real-time (QC-ART): A Tool for Real-time Quality Control Assessment of Mass Spectrometry-based Proteomics Data

TEDDY STUDY GRP, Stanfill, B. A., Nakayasu, E. S., Bramer, L. M. & Knip, M., Sep 2018, In : Molecular & Cellular Proteomics. 17, 9, p. 1824-1836 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes

TEDDY STUDY GRP, Salami, F., Lee, H-S., Freyhult, E., Larsson, H. E., Lernmark, A., Torn, C. & Knip, M., Nov 2018, In : Diabetes. 67, 11, p. 2329-2336 8 p.

Research output: Contribution to journalArticleScientificpeer-review