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Mikko Mäyränpää

Lukuvuosikoordinaattori (L2/H2), Lääketieteen tohtori

  • PL 21 (Haartmaninkatu 3)

    00014

    Finland

20032018
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Publications 2003 2018

2018

Human mast cell neutral proteases generate modified LDL particles with increased proteoglycan binding

Maaninka, K., Nguyen, S. D., Mäyränpää, M. I., Plihtari, R., Rajamäki, K., Lindsberg, P. J., Kovanen, P. T. & Öörni, K., Aug 2018, In : Atherosclerosis. 275, p. 390-399 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Morphology and histology of silent and symptom-causing atherosclerotic carotid plaques - Rationale and design of the Helsinki Carotid Endarterectomy Study 2 (the HeCES2)

Nuotio, K., Ijäs, P., Heikkilä, H. M., Koskinen, S. M., Saksi, J., Vikatmaa, P., Sorto, P., Mäkitie, L., Eriksson, H., Kasari, S., Silvennoinen, H., Valanne, L., Mäyränpää, M. I., Kovanen, P. T., Soinne, L. & Lindsberg, P. J., 2018, In : Annals of Medicine. 50, 6, p. 501-510 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Outcome of Cardiac Sarcoidosis Presenting With High-Grade Atrioventricular Block

Nordenswan, H-K., Lehtonen, J., Ekström, K., Kandolin, R., Simonen, P., Mäyränpää, M., Vihinen, T., Miettinen, H., Kaikkonen, K., Haataja, P., Kerola, T., Rissanen, T. T., Kokkonen, J., Alatalo, A., Pietilä-Effati, P., Utriainen, S. & Kupari, M., Aug 2018, In : Circulation. Arrhythmia and electrophysiology. 11, 8, 9 p., 006145.

Research output: Contribution to journalArticleScientificpeer-review

Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours

Närhi, K., Nagaraj, A. S., Parri, E., Turkki, R., van Duijn, P. W., Hemmes, A., Lahtela, J., Uotinen, V., Mäyränpää, M. I., Salmenkivi, K., Räsänen, J., Linder, N., Trapman, J., Rannikko, A., Kallioniemi, O., Af Hällström, T. M., Lundin, J., Sommergruber, W., Anders, S. & Verschuren, E. W., May 2018, In : Journal of Pathology. 245, 1, p. 101-113 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2017

Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1

Nagaraj, A. S., Lahtela, J., Hemmes, A., Pellinen, T., Blom, S., Devlin, J. R., Salmenkivi, K., Kallioniemi, O., Mäyränpää, M., Narhi, K. & Verschuren, E. W., 17 Jan 2017, In : Cell Reports. 18, 3, p. 673-684 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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TET2 mutations in B cells of patients affected by angioimmunoblastic T-cell lymphoma

Schwartz, F. H., Cai, Q., Fellmann, E., Hartmann, S., Mäyränpää, M., Karjalainen-Lindsberg, M-L., Sundstrom, C., Scholtysik, R., Hansmann, M-L. & Kuppers, R., Jun 2017, In : Journal of Pathology. 242, 2, p. 129-133 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Imatinib treatment attenuates growth and inflammation of angiotensin II induced abdominal aortic aneurysm

Vorkapic, E., Dugic, E., Vikingsson, S., Roy, J., Mäyränpää, M., Eriksson, P. & Wagsater, D., Jun 2016, In : Atherosclerosis. 249, p. 101-109 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Novel 6p21.3 Risk Haplotype Predisposes to Acute Coronary Syndrome

Sinisalo, J., Vlachopoulou, E., Marchesani, M., Nokelainen, J., Mayranpaa, M. I., Lappalainen, J., Paakkanen, R., Wennerstrom, A., Salli, K., Niemi, H. J., Mannisto, S., Salo, P., Junttila, J., Eskola, M., Nikus, K., Arstila, T. P., Perola, M., Huikuri, H., Karhunen, P. J., Kovanen, P. T. & 8 othersPalotie, A., Havulinna, A. S., Lluis-Ganella, C., Marrugat, J., Elosua, R., Salomaa, V., Nieminen, M. S. & Lokki, M-L., Feb 2016, In : Circulation. Cardiovascular genetics. 9, 1, p. 55-63 9 p.

Research output: Contribution to journalArticleScientificpeer-review

p38δ MAPK: A Novel Regulator of NLRP3 Inflammasome Activation With Increased Expression in Coronary Atherogenesis

Rajamäki, K., Mäyränpää, M., Risco, A., Tuimala, J., Nurmi, K., Cuenda, A., Eklund, K. K., Öörni, K. & Kovanen, P. T., Sep 2016, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 9, p. 1937-1946 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

TRIF adaptor signaling is important in abdominal aortic aneurysm formation

Vorkapic, E., Lundberg, A. M., Mayranpaa, M. I., Eriksson, P. & Wagsater, D., Aug 2015, In : Atherosclerosis. 241, 2, p. 561-568 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2014

Low-Expression Variant of Fatty Acid-Binding Protein 4 Favors Reduced Manifestations of Atherosclerotic Disease and Increased Plaque Stability

Saksi, J., Ijas, P., Mayranpaa, M. I., Nuotio, K., Isoviita, P. M., Tuimala, J., Lehtonen-Smeds, E., Kaste, M., Jula, A., Nieminen, M. S., Lokki, M-L., Perola, M., Havulinna, A. S., Salomaa, V., Kettunen, J., Jauhiainen, M., Kovanen, P. T. & Lindsberg, P. J., Oct 2014, In : Circulation. Cardiovascular genetics. 7, 5, p. 588-598 11 p.

Research output: Contribution to journalArticleScientificpeer-review

VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

Kivelä, M. R., Bry, M., Robciuc, M. R., Räsänen, M., Taavitsainen, M., Silvola, J. M. U., Saraste, A., Hulmi, J. J., Anisimov, A., Mayranpaa, M. I., Lindeman, J. H., Eklund, L., Hellberg, S., Hlushchuk, R., Zhuang, Z. W., Simons, M., Djonov, V., Knuuti, J., Mervaala, E. & Alitalo, K., Mar 2014, In : EMBO molecular medicine. 6, 3, p. 307-321 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2013

Osbpl8 Deficiency in Mouse Causes an Elevation of High-Density Lipoproteins and Gender-Specific Alterations of Lipid Metabolism

Beaslas, O., Metso, J., Nissila, E., Laurila, P-P., Kaiharju, E., Batchu, K. C., Kaipiainen, L., Mäyränpää, M., Yan, D., Gylling, H., Jauhiainen, M. & Olkkonen, V. M., 15 Mar 2013, In : PLoS One. 8, 3, p. Article Number: e58856 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2012

Imatinib mesylate alleviates diarrhea in a mouse model of intestinal allergy

Vaali, K., Lappalainen, J., Lin, A. H., Mäyränpää, M., Kovanen, P. T., Berstad, A. & Eklund, K. K., 2012, In : Neurogastroenterology and Motility. 24, 7, p. e325-e335 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Serine protease inhibitor A3 in atherosclerosis and aneurysm disease

Wagsater, D., Johansson, D., Fontaine, V., Vorkapic, E., Backlund, A., Razuvaev, A., Mäyränpää, M., Hjerpe, C., Caidahl, K., Hamsten, A., Franco-Cereceda, A., Wilbertz, J., Swedenborg, J., Zhou, X. & Eriksson, P., 2012, In : International Journal of Molecular Medicine. 30, 2, p. 288-294 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Mast Cells Important Players in the Orchestrated Pathogenesis of Abdominal Aortic Aneurysms

Swedenborg, J., Mayranpaa, M. I. & Kovanen, P. T., Apr 2011, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 4, p. 734-740 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2010

Dilated cardiomyopathy alters the expression patterns of CAR and other adenoviral receptors in human heart

Toivonen, R., Mayranpaa, M. I., Kovanen, P. T. & Savontaus, M., Mar 2010, In : Histochemistry and Cell Biology. 133, 3, p. 349-357 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Increased expression of leukotriene C-4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm

Di Gennaro, A., Wagsater, D., Mayranpaa, M. I., Gabrielsen, A., Swedenborg, J., Hamsten, A., Samuelsson, B., Eriksson, P. & Haeggstrom, J. Z., 7 Dec 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 49, p. 21093-21097 5 p.

Research output: Contribution to journalArticleScientific

OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface

Zhou, Y., Li, S., Mäyränpää, M. I., Zhong, W., Bäck, N., Yan, D. & Olkkonen, V. M., 2010, In : Experimental Cell Research. 316, p. 3304-3316 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model

Simolin, M. A., Pedersen, T. X., Bro, S., Mayranpaa, M. I., Helske, S., Nielsen, L. B. & Kovanen, P. T., 3 Mar 2009, In : BMC Cardiovascular Disorders. 9, 10 p., 10.

Research output: Contribution to journalArticleScientificpeer-review

Mast cells associate with neovessels in the media and adventitia of abdominal aortic aneurysms

Mäyränpää, M., Trosien, J. A., Fontaine, V., Folkesson, M., Kazi, M., Eriksson, P., Swedenborg, J. & Hedin, U., 2009, In : Journal of Vascular Surgery. 50, 2, p. 388-395 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages

Linder, M., Mäyränpää, M., Peränen, J., Pietilä, T., Pietiäinen, V., Uronen, R-L., Olkkonen, V., Kovanen, P. & Ikonen, E., 2009, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 29, p. 883-888 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Mast cells associate with T cells and neointimal microvessels in giant cell arteritis

Mayranpaa, M. I., Trosien, J. A., Nikkari, S. T. & Kovanen, P. T., 2008, In : Clinical and Experimental Rheumatology. 26, 3, Suppl. 49, p. S63-S66 4 p.

Research output: Contribution to journalArticleScientificpeer-review

OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages

Yan, D., Mäyränpää, M., Wong, J., Perttilä, J., Lehto, M., Jauhiainen, M., Kovanen, P. T., Ehnholm, C., Brown, A. J. & Olkkonen, V. M., 2008, In : Journal of Biological Chemistry. 283, p. 332-340 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Endothelial apoptosis does not determine symptom status in carotid artery disease

Nuotio, K., Mäyränpää, M., Saksi, J., Ijäs, P., Sairanen, T., Carpen, O., Soinne, L., Saimanen, E., Salonen, O., Lepäntalo, M., Kovanen, P. T., Kaste, M. & Lindsberg, P. J., 2007, In : Cerebrovascular Diseases. 23, 1, p. 27-34 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Improved identification of endothelial erosion by simultaneous detection of endothelial cells (CD31/CD34) and platelets (CD42b)

Mayranpaa, M. I., Resendiz, J. C., Heikkila, H. M., Lindstedt, K. A. & Kovanen, P. T., 2007, In : Endothelium. 14, 2, p. 81-87 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Mast cells and endothelial erosion: implications for human atherothrombotic disease

Mäyränpää, M., 2007, Helsinki: M. Mäyränpää. 69 p.

Research output: ThesisDoctoral ThesisCollection of Articles

Mast cells in vulnerable atherosclerotic plaques - a view to a kill

Lindstedt, K. A., Mayranpaa, M. I. & Kovanen, P. T., 2007, In : Journal of Cellular and Molecular Medicine. 11, 4, p. 739-758 20 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Therapia Fennica

Mäyränpää, M. (ed.), Kandidaattikustannus & Lääketieteenkandidaattiseura, 2007, 9. laitos. ed. [Helsinki]: Kandidaattikustannus. 1753 p.

Research output: Book/ReportBookProfessional

2006

Desquamation of human coronary artery endothelium by human mast cell proteases: implications for plaque erosion

Mäyränpää, M. I., Heikkilä, H. A., Lindstedt, K. A., Walls, A. F. & Kovanen, P. T., 2006, In : Coronary Artery Disease. 17, 7, p. 611-621 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Increased expression of elastolytic cathepsins S, K, and V and their inhibitor cystatin C in stenotic aortic valves

Helske, S., Syväranta, S., Lindstedt, K. A., Lappalainen, J., Öörni, K., Mäyränpää, M., Lommi, J., Turto, H., Werkkala, K., Kupari, M. & Kovanen, P. T., 2006, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 26, 8, p. 1791-1798 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Increased expression of bradykinin type-1 receptors in endothelium of intramyocardial coronary vessels in human failing hearts

Liesmaa, I., Kuoppala, A., Shiota, N., Kokkonen, J. O., Kostner, K., Mayranpaa, M., Kovanen, P. T. & Lindstedt, K. A., May 2005, In : American Journal of Physiology: Heart and Circulatory Physiology. 288, 5, p. H2317-H2322 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

Arterial endothelial denudation by intraluminal use of papaverine-NaCl solution in coronary bypass surgery

Mayranpaa, M., Simpanen, J., Hess, MW., Werkkala, K. & Kovanen, P. T., Apr 2004, In : European Journal of Cardio-Thoracic Surgery. 25, 4, p. 560-566 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro

Öörni, K., Sneck, M., Bromme, D., Pentikäinen, M. O., Lindstedt, K. A., Mäyränpää, M., Aitio, H. & Kovanen, P. T., 13 Aug 2004, In : Journal of Biological Chemistry. 279, 33, p. 34776-34784 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2003

Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure

Foldes, G., Horkay, F., Szokodi, T., Vuolteenaho, O., Ilves, M., Lindstedt, A., Mayranpaa, M., Sarman, B., Seres, L., Skoumal, R., Lako-Futo, Z., deChatel, R., Ruskoaho, H. & Toth, M., 29 Aug 2003, In : Biochemical and Biophysical Research Communications. 308, 3, p. 480-485 6 p.

Research output: Contribution to journalArticleScientificpeer-review