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Publications 2000 2019

2019

Biopankki muuttaa lääketiedettä - meidän kaikkien eduksi

Niemi, M., 2019, In : Tieteessä tapahtuu. 37, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorialScientific

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Completed suicides of citalopram users-the role of CYP genotypes and adverse drug interactions

Rahikainen, A-L., Vauhkonen, P., Pett, H., Palo, J. U., Haukka, J., Ojanperä, I., Niemi, M. & Sajantila, A., Mar 2019, In : International Journal of Legal Medicine. 133, 2, p. 353-363 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

CYP3A4*22 Impairs the Elimination of Ticagrelor, But Has No Significant Effect on the Bioactivation of Clopidogrel or Prasugrel

Holmberg, M. T., Tornio, A., Paile-Hyvärinen, M., Tarkiainen, E. K., Neuvonen, M., Neuvonen, P. J., Backman, J. T. & Niemi, M., Feb 2019, In : Clinical Pharmacology and Therapeutics. 105, 2, p. 448-457 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Tutkijalääkäriohjelma tarjoaa nopean alun tutkijanuralle

Vihma, K., Uusikangas, S., Bergman, P. H., Renkonen, R., Sariola, H., Lehtisalo, M., Niemi, M., Rice, D. P., Heikinheimo, M., Rahkonen, O. & Mäkitie, A., Feb 2019, In : Duodecim. 135, 3, p. 275-282 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2018

Analgesic Plasma Concentrations of Oxycodone After Surgery for Breast CancerWhich Factors Matter?

Cajanus, K., Neuvonen, M., Koskela, O., Kaunisto, M. A., Neuvonen, P. J., Niemi, M. & Kalso, E., Apr 2018, In : Clinical Pharmacology and Therapeutics. 103, 4, p. 653-662 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans.

Itkonen, M. K., Tornio, A., Filppula, A. M., Neuvonen, M., Neuvonen, P. J., Niemi, M. & Backman, J. T., Sep 2018, In : Clinical Pharmacology and Therapeutics. 104, 3, p. 495-504 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions

Kahma, H., Filppula, A. M., Neuvonen, M., Tarkiainen, E. K., Tornio, A., Holmberg, M. T., Itkonen, M. K., Finel, M., Neuvonen, P. J., Niemi, M. & Backman, J. T., 1 Feb 2018, In : Drug Metabolism and Disposition. 46, 2, p. 141-150 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Comprehensive pharmacogenomic study reveals an important role of UGT1A3 in montelukast pharmacokinetics

Hirvensalo, P., Tornio, A., Neuvonen, M., Tapaninen, T., Paile-Hyvärinen, M., Kärjä, V., Männistö, V. T., Pihlajamäki, J., Backman, J. T. & Niemi, M., Jul 2018, In : Clinical Pharmacology and Therapeutics. 104, 1, p. 158-168 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Effect of Rare Genetic Variants on Organic Anion Transporting Polypeptide 1B1

Kiander, W. H-M., Niemi, M. O. & Kidron, H. T., 20 May 2018.

Research output: Conference materialsAbstractResearchpeer-review

Open Access

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects

Neuvonen, M., Tarkiainen, E. K., Tornio, A., Hirvensalo, P., Tapaninen, T., Paile-Hyvärinen, M., Itkonen, M. K., Holmberg, M. T., Karja, V., Männistö, V. T., Neuvonen, P. J., Pihlajamäki, J., Backman, J. T. & Niemi, M., Mar 2018, In : Basic & Clinical Pharmacology & Toxicology. 122, 3, p. 341-345 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Interactions of (2S,6S;2R,6R)-Hydroxynorketamine, a Secondary Metabolite of (R,S)-Ketamine, with Morphine

Lilius, T. O., Viisanen, H., Jokinen, V., Niemi, M., Kalso, E. A. & Rauhala, P. V., May 2018, In : Basic & Clinical Pharmacology & Toxicology. 122, 5, p. 481-488 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Ketamine and norketamine attenuate oxycodone tolerance markedly less than that of morphine: from behaviour to drug availability

Lilius, T., Kangas, E., Niemi, M., Rauhala, P. & Kalso, E., Apr 2018, In : British Journal of Anaesthesia. 120, 4, p. 818-826 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics

Santos, M., Niemi, M., Hiratsuka, M., Kumondai, M., Ingelman-Sundberg, M., Lauschke, V. M. & Rodriguez-Antona, C., Jun 2018, In : Genetics In Medicine. 20, 6, p. 622-629 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Pharmacokinetic interactions and pharmacogenetics of clopidogrel, prasugrel and ticagrelor

Holmberg, M., 2018, Helsinki: [M. Holmberg]. 103 p.

Research output: ThesisDoctoral ThesisCollection of Articles

Reflux aspiration in lungs of dogs with respiratory disease and in healthy West Highland White Terriers

Määttä, O. L. M., Laurila, H. P., Holopainen, S., Lilja-Maula, L., Melamies, M., Viitanen, S. J., Johnson, L. R., Koho, N., Neuvonen, M., Niemi, M. & Rajamäki, M. M., Nov 2018, In : Journal of Veterinary Internal Medicine. 32, 6, p. 2074-2081 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial

Chen, I., Diawara, H., Mahamar, A., Sanogo, K., Keita, S., Kone, D., Diarra, K., Djimde, M., Keita, M., Brown, J., Roh, M. E., Hwang, J., Pett, H., Murphy, M., Niemi, M., Greenhouse, B., Bousema, T., Gosling, R. & Dicko, A., 15 Apr 2018, In : Journal of Infectious Diseases. 217, 8, p. 1298-1308 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Safety of single low-dose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: Two open-label, randomized, safety trials

Bastiaens, G. J. H., Tiono, A. B., Okebe, J., Pett, H. E., Coulibaly, S. A., Goncalves, B. P., Affara, M., Ouedraogo, A., Bougouma, E. C., Sanou, G. S., Nebie, I., Bradley, J., Lanke, K. H. W., Niemi, M., Sirima, S. B., d'Alessandro, U., Bousema, T. & Drakeley, C., 11 Jan 2018, In : PLoS One. 13, 1, 20 p., 0190272.

Research output: Contribution to journalArticleScientificpeer-review

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Transporter-Mediated Alterations in Patients With NASH Increase Systemic and Hepatic Exposure to an OATP and MRP2 Substrate

Ali, I., Slizgi, J. R., Kaullen, J. D., Ivanovic, M., Niemi, M., Stewart, P. W., Barritt, A. S. & Brouwer, K. L. R., Oct 2018, In : Clinical Pharmacology and Therapeutics. 104, 4, p. 749-756 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2017

Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children

Goncalves, B. P., Pett, H., Tiono, A. B., Murry, D., Sirima, S. B., Niemi, M., Bousema, T., Drakeley, C. & ter Heine, R., May 2017, In : Antimicrobial Agents and Chemotherapy. 61, 5, 11 p., 02590.

Research output: Contribution to journalArticleScientificpeer-review

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Do Diuretics have Antinociceptive Actions: Studies of Spironolactone, Eplerenone, Furosemide and Chlorothiazide, Individually and with Oxycodone and Morphine

Jokinen, V., Lilius, T., Laitila, J., Niemi, M., Kambur, O., Kalso, E. & Rauhala, P., Jan 2017, In : Basic & Clinical Pharmacology & Toxicology. 120, 1, p. 38-45 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Genomilääketieteen sovelluksia sairauksien hoidossa

Porkka, K., Niemi, M., Leppä, E., Västrik, I., Partanen, J., Ihalainen, J., Jokiranta, S. & Pöllänen, P., 2017, In : Duodecim. 133, 8, p. 782-790 9 p.

Research output: Contribution to journalArticleProfessional

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Onko farmakogeneettisestä tiedosta apua lasten yksilöllisten lääkeannosten määritykseen kasvun ja kehityksen aikana?

Sistonen, J. & Niemi, M., 2017, In : Duodecim. 133, 19, p. 1835-1842 8 p.

Research output: Contribution to journalArticleProfessional

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Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters

Tornio, A., Neuvonen, P. J., Niemi, M. & Backman, J. T., Jan 2017, In : Expert Opinion on Drug Metabolism & Toxicology. 13, 1, p. 83-95 13 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2016

Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone

Itkonen, M. K., Tornio, A., Neuvonen, M., Neuvonen, P. J., Niemi, M. & Backman, J. T., Aug 2016, In : Drug Metabolism and Disposition. 44, 8, p. 1364-1371 8 p.

Research output: Contribution to journalArticleScientificpeer-review

CML Patients with Primary Resistance or Suboptimal Response to TKI Therapy Have Variants in Genes Affecting Drug Absorption and Metabolism

Pietarinen, P., Koskenvesa, P., Klievink, J., Porkka, K., Niemi, M. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 4 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

CYP2D6-metabolia ja sydänlääkkeet

Backman, J., Niemi, M. & Ruskoaho, H., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., H. H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3. uud. p. ed. Helsinki: Duodecim, p. 87 1 p. kar01736 (006.075)

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Farmakogenetiikka

Niemi, M., 2016, Lääketieteellinen genetiikka. Aittomäki, K., Moilanen, J. & Perola, M. (eds.). 1. p. ed. Helsinki: Duodecim, p. 312-320 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Farmakogenetiikka saapuu klinikkaan

Heliste, J., Elenius, K., Niemi, M. & Elenius, V., 2016, In : Duodecim. 132, 17, p. 1561-1568 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

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High Frequency of CYP2D6 Ultrarapid Metabolizer Genotype in the Finnish Population

Pietarinen, P., Tornio, A. & Niemi, M., Sep 2016, In : Basic & Clinical Pharmacology & Toxicology. 119, 3, p. 291-296 6 p.

Research output: Contribution to journalArticleScientificpeer-review

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Klopidogreelin vasteen farmakogeneettinen vaihtelu

Backman, J., Niemi, M. & Ruskoaho, H., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., Huikuri, H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3. uud. p. ed. Helsinki: Duodecim, p. 88-89 2 p. kar01739 (006.090)

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Lääkkeiden aiheuttamat kuolemantapaukset ovat vähentyneet yliopistosairaalassa

Lapatto-Reiniluoto, O., Niemi, M., Backman, J. & Neuvonen, P. J., 2016, In : Suomen lääkärilehti. 71, 5, p. 295-301 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Pregabalin enhances the antinociceptive effect of oxycodone and morphine in thermal models of nociception in the rat without any pharmacokinetic interactions

Jokinen, V., Lilius, T., Laitila, J., Niemi, M., Rauhala, P. V. & Kalso, E. A., Feb 2016, In : European Journal of Pain. 20, 2, p. 297-306 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial

Dicko, A., Brown, J. M., Diawara, H., Baber, I., Mahamar, A., Soumare, H. M., Sanogo, K., Koita, F., Keita, S., Traore, S. F., Chen, I., Poirot, E., Hwang, J., McCulloch, C., Lanke, K., Pett, H., Niemi, M., Nosten, F., Bousema, T. & Gosling, R., Jun 2016, In : Lancet Infectious Diseases. 16, 6, p. 674-684 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions

Backman, J. T., Filppula, A. M., Niemi, M. & Neuvonen, P. J., Jan 2016, In : Pharmacological Reviews. 68, 1, p. 168-241 74 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Statiinien vasteen farmakogeneettinen vaihtelu

Backman, J., Niemi, M. & Ruskoaho, H., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., Huikuri, H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3. uud. p. ed. Helsinki: Duodecim, p. 87 1 p. kar01737 (006.080)

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Sydänlääkkeiden vasteen farmakogeneettinen vaihtelu

Backman, J., Niemi, M. & Ruskoaho, H., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., Huikuri, H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3. uud. p. ed. Helsinki: Duodecim, p. 86-87 2 p. kar01735 (006.070)

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Takrolimuusin vasteen farmakogeneettinen vaihtelu

Backman, J., Niemi, M. & Ruskoaho, H. J., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., Huikuri, H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3. uud. p. ed. Helsinki: Duodecim, p. 89 1 p. kar01740 (006.095)

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Varfariinin ja muiden oraalisten antikoagulanttien vasteen farmakogeneettinen vaihtelu

Backman, J., Niemi, M. & Ruskoaho, H., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., Huikuri, H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3. uud. p. ed. Helsinki: Duodecim, p. 88 1 p. kar01738 (006.085)

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

2015

Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans

Tarkiainen, E. K., Holmberg, M. T., Tornio, A., Neuvonen, M., Neuvonen, P. J., Backman, J. T. & Niemi, M., Jun 2015, In : Clinical Pharmacology and Therapeutics. 97, 6, p. 650-658 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Drug-related inadvertent deaths in a university hospital - a declining trend

Lapatto-Reiniluoto, O., Patinen, L., Niemi, M., Backman, J. T. & Neuvonen, P. J., 2015, In : Basic & Clinical Pharmacology & Toxicology. 117, 6, p. 421-426 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril

Tarkiainen, E. K., Tornio, A., Holmberg, M. T., Launiainen, T., Neuvonen, P. J., Backman, J. T. & Niemi, M., Nov 2015, In : British Journal of Clinical Pharmacology. 80, 5, p. 1131-1138 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of grapefruit juice on the bioactivation of prasugrel

Holmberg, M. T., Tornio, A., Hyvarinen, H., Neuvonen, M., Neuvonen, P. J., Backman, J. T. & Niemi, M., Jul 2015, In : British Journal of Clinical Pharmacology. 80, 1, p. 139-145 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Farmaseuttinen koostumus, joka sisältää gemfibrotsiiliä ja CYP2C8- ja/tai OATP-substraattilääkettä

Neuvonen, P., Niemi, M. & Backman, J., 30 Oct 2015, Patentti- ja rekisterihallitus, Patent No. FI 125478 B, 30 Oct 2015

Research output: PatentScientific

Karboksyyliesteraasin geenimuutos tehostaa klopidogreelin vaikutuksia

Tarkiainen, E. K., Holmberg, M. T., Tornio, A., Neuvonen, M., Neuvonen, P., Backman, J. & Niemi, M., 4 May 2015, In : Duodecim. 131, 9, p. 881 1 p.

Research output: Contribution to journalArticleScientific

Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat

Lilius, T., Jokinen, V., Neuvonen, M. S., Niemi, M., Kalso, E. A. & Rauhala, P. V., Jun 2015, In : British Journal of Pharmacology. 172, 11, p. 2799-2813 15 p.

Research output: Contribution to journalArticleScientificpeer-review

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