Photo of Mikko Niemi
  • PL 20 (Tukholmankatu 8 C)

    00014

    Finland

20002019
If you made any changes in Pure these will be visible here soon.

Publications 2000 2019

2015

Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat

Lilius, T., Jokinen, V., Neuvonen, M. S., Niemi, M., Kalso, E. A. & Rauhala, P. V., Jun 2015, In : British Journal of Pharmacology. 172, 11, p. 2799-2813 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid

Tornio, A., Vakkilainen, J., Neuvonen, M., Backman, J. T., Neuvonen, P. J. & Niemi, M., Aug 2015, In : Pharmacogenetics and Genomics. 25, 8, p. 382-387 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Voiko lääkehoitojen hyötyjä lisätä ja haittoja vähentää farmakogeneettisen tiedon avulla?

Paile-Hyvärinen, M. & Niemi, M., 2015, In : Sic! Lääketietoa Fimeasta. 5, 2, p. 34-37 4 p.

Research output: Contribution to journalArticleProfessional

2014

Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug-Drug Interactions

Tornio, A., Filppula, A. M., Kailari, O., Neuvonen, M., Nyrönen, T. H., Tapaninen, T., Neuvonen, P. J., Niemi, M. & Backman, J. T., Oct 2014, In : Clinical Pharmacology and Therapeutics. 96, 4, p. 498-507 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Grapefruit Juice Inhibits the Metabolic Activation of Clopidogrel

Holmberg, M. T., Tornio, A., Neuvonen, M. S., Neuvonen, P. J., Backman, J. T. & Niemi, M., Mar 2014, In : Clinical Pharmacology and Therapeutics. 95, 3, p. 307-313 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Kodeiinin sudenkuopat ja uudet vasta-aiheet

Paile-Hyvärinen, M., Niemi, M., Isohanni, M., Olkkola, K. & Backman, J., 2014, In : Suomen lääkärilehti. 69, 38, p. 2385-2388 4 p.

Research output: Contribution to journalArticleProfessional

Paroxetine Markedly Increases Plasma Concentrations of Ophthalmic Timolol; CYP2D6 Inhibitors May Increase the Risk of Cardiovascular Adverse Effects of 0.5% Timolol Eye Drops

Maenpaa, J., Volotinen-Maja, M., Kautiainen, H., Neuvonen, M., Niemi, M., Neuvonen, P. J. & Backman, J. T., Dec 2014, In : Drug Metabolism and Disposition. 42, 12, p. 2068-2076 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Pharmacogenetically Based Dosing of Thiopurines in Childhood Acute Lymphoblastic Leukemia: Influence on Cure Rates and Risk of Second Cancer

Levinsen, M., Rotevatn, E. O., Rosthoj, S., Nersting, J., Abrahamsson, J., Appell, M. L., Bergan, S., Bechensteen, A-G., Harila-Saari, A., Heyman, M., Jonsson, O. G., Maxild, J. B. C., Niemi, M., Soderhall, S., Schmiegelow, K. & Nordic Soc Paediat Haematology, May 2014, In : Pediatric Blood & Cancer. 61, 5, p. 797-802 6 p.

Research output: Contribution to journalArticleScientificpeer-review

The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1 and Simvastatin-Induced Myopathy: 2014 Update

Ramsey, L. B., Johnson, S. G., Caudle, K. E., Haidar, C. E., Voora, D., Wilke, R. A., Maxwell, W. D., McLeod, L., Krauss, R. M., Roden, D. M., Feng, Q., Cooper-DeHoff, R. M., Gong, L., Klein, T. E., Wadelius, M. & Niemi, M., Oct 2014, In : Clinical Pharmacology and Therapeutics. 96, 4, p. 423-428 6 p.

Research output: Contribution to journalArticleScientificpeer-review

The mineralocorticoid receptor antagonist spironolactone enhances morphine antinociception

Lilius, T., Jokinen, V., Neuvonen, M. S., Vaananen, A. J., Niemi, M., Rauhala, P. V. & Kalso, E. A., Mar 2014, In : European Journal of Pain. 18, 3, p. 386-395 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1

Nies, A. T., Niemi, M., Burk, O., Winter, S., Zanger, U. M., Stieger, B., Schwab, M. & Schaeffeler, E., 11 Jan 2013, In : Genome medicine. 5, 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects

Holmberg, M. T., Tornio, A., Joutsi-Korhonen, L., Neuvonen, M., Neuvonen, P. J., Lassila, R., Niemi, M. & Backman, J. T., Jun 2013, In : British Journal of Clinical Pharmacology. 75, 6, p. 1488-1496 9 p.

Research output: Contribution to journalArticleScientificpeer-review

International Transporter Consortium Commentary on Clinically Important Transporter Polymorphisms

Giacomini, K. M., Balimane, P. V., Cho, S. K., Eadon, M., Edeki, T., Hillgren, K. M., Huang, S-M., Sugiyama, Y., Weitz, D., Wen, Y., Xia, C. Q., Yee, S. W., Zimdahl, H., Niemi, M. & Int Transporter Consortium, Jul 2013, In : Clinical Pharmacology and Therapeutics. 94, 1, p. 23-26 4 p.

Research output: Contribution to journalArticleScientific

PharmGKB summary: very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 8

Aquilante, C. L., Niemi, M., Gong, L., Altman, R. B. & Klein, T. E., Dec 2013, In : Pharmacogenetics and Genomics. 23, 12, p. 721-728 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

SLCO2B1 c.935G > A single nucleotide polymorphism has no effect on the pharmacokinetics of montelukast and aliskiren

Tapaninen, T., Karonen, T., Backman, J. T., Neuvonen, P. J. & Niemi, M., Jan 2013, In : Pharmacogenetics and Genomics. 23, 1, p. 19-24 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification

Krauss, M., Burghaus, R., Lippert, J., Niemi, M., Neuvonen, P., Schuppert, A., Willmann, S., Kuepfer, L. & Görlitz, L., 16 Apr 2013, In : In Silico Pharmacology. 1, 6, 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

A Mechanistic, Model-Based Approach to Safety Assessment in Clinical Development

Lippert, J., Brosch, M., von Kampen, O., Meyer, M., Siegmund, H. -U., Schafmayer, C., Becker, T., Laffert, B., Görlitz, L., Schreiber, S., Neuvonen, P., Niemi, M., Hampe, J. & Kuepfer, L., 7 Nov 2012, In : CPT : Pharmacometrics & Systems Pharmacology. 1, e13

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Carboxylesterase 1 Polymorphism Impairs Oseltamivir Bioactivation in Humans

Tarkiainen, E. K., Backman, J. T., Neuvonen, M. S., Neuvonen, P. J., Schwab, M. & Niemi, M., 2012, In : Clinical Pharmacology and Therapeutics. 92, 1, p. 68-71 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications

Tornio, A., Niemi, M., Neuvonen, P. J. & Backman, J., 2012, In : Trends in Pharmacological Sciences. 33, 6, p. 312-322 11 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Fluconazole but not the CYP3A4 inhibitor, itraconazole, increases zafirlukast plasma concentrations

Karonen, T., Laitila, J., Niemi, M., Neuvonen, P. J. & Backman, J. T., 2012, In : European Journal of Clinical Pharmacology. 68, 5, p. 681-688 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Gemfibrozil Is a Strong Inactivator of CYP2C8 in Very Small Multiple Doses

Honkalammi, J., Niemi, M., Neuvonen, P. J. & Backman, J. T., 2012, In : Clinical Pharmacology and Therapeutics. 91, 5, p. 846-855 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Gender, but not CYP7A1 or SLCO1B1 polymorphism, affects the fasting plasma concentrations of bile acids in human beings

Xiang, X., Backman, J., Neuvonen, P. J. & Niemi, M., 2012, In : Basic & Clinical Pharmacology & Toxicology. 110, 3, p. 245-252 8 p.

Research output: Contribution to journalArticleScientificpeer-review

PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo

Klein, K., Thomas, M., Winter, S., Nussler, A. K., Niemi, M., Schwab, M. & Zanger, U. M., 2012, In : Clinical Pharmacology and Therapeutics. 91, 6, p. 1044-1052 9 p.

Research output: Contribution to journalArticleScientificpeer-review

The Clinical Pharmacogenomics Implementation Consortium: CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy

Wilke, R. A., Ramsey, L. B., Johnson, S. G., Maxwell, W. D., McLeod, H. L., Voora, D., Krauss, R. M., Roden, D. M., Feng, Q., Cooper-DeHoff, R. M., Gong, L., Klein, T. E., Wadelius, M. & Niemi, M., 2012, In : Clinical Pharmacology and Therapeutics. 92, 1, p. 112-117 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Transporttereiden farmakogenetiikkaa

Niemi, M., 2012, In : Dosis. 28, 1, p. 41-45 5 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2011

Dose-Dependent Interaction between Gemfibrozil and Repaglinide in Humans: Strong Inhibition of CYP2C8 with Subtherapeutic Gemfibrozil Doses

Honkalammi, J., Niemi, M., Neuvonen, P. J. & Backman, J. T., 2011, In : Drug Metabolism and Disposition. 39, 10, p. 1977-86 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Farmakogeneettinen testaus

Niemi, M. & Backman, J., 2011, Antikoagulaatiohoidon käsikirja. Puhakka, J. (ed.). Terveyden ja hyvinvoinnin laitos, p. 19-19 1 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Farmakogeneettiset yksilövaihtelut

Niemi, M., 2011, Kliininen farmakologia ja lääkehoito. Neuvonen, P. J., Backman, J. T., Himberg, J-J., Huupponen, R., Keränen, T. & Kivistö, K. T. (eds.). Kandidaattikustannus Oy/ Lääketieteen kandidaattiseura ry, p. 67-74 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Frequencies of single-nucleotide polymorphisms of SLCO1A2, SLCO1B3 and SLCO2B1 genes in a Finnish population.

Laitinen, A. & Niemi, M., 2011, In : Basic & Clinical Pharmacology & Toxicology. 108, 1, p. 9-13 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren

Tapaninen, T., Backman, J. T., Kurkinen, K. J., Neuvonen, P. J. & Niemi, M., 2011, In : Journal of Clinical Pharmacology. 51, 3, p. 359-367 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Mechanism-Based Inactivation of CYP2C8 by Gemfibrozil Occurs Rapidly in Humans

Honkalammi, J., Niemi, M., Neuvonen, P. J. & Backman, J., 2011, In : Clinical Pharmacology and Therapeutics. 89, 4, p. 579-586

Research output: Contribution to journalArticleScientificpeer-review

No significant effect of the SLCO1B1 polymorphism on the pharmacokinetics of ursodeoxycholic acid

Xiang, X., Vakkilainen, J., Backman, J. T., Neuvonen, P. J. & Niemi, M., 2011, In : European Journal of Clinical Pharmacology. 67, 11, p. 1159-1167 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren

Tapaninen, T., Neuvonen, P. J. & Niemi, M., 2011, In : British Journal of Clinical Pharmacology. 71, 5, p. 718-26 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake

Niemi, M., Pasanen, M. & Neuvonen, P. J., 2011, In : Pharmacological Reviews. 63, 1, p. 157-181 25 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Pharmacokinetics of intravenous paracetamol in elderly patients

Liukas, A., Kuusniemi, K., Aantaa, R., Virolainen, P., Niemi, M., Neuvonen, P. J. & Olkkola, K. T., 2011, In : Clinical Pharmacokinetics. 50, 2, p. 121-129 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Practical recommendations for pharmacogenomics-based prescription: 2010 ESF–UB Conference on Pharmacogenetics and Pharmacogenomics

Becquemont, L., Alfirevic, A., Amstutz​, U., Brauch, H., Jacqz-Aigrain​, E., Laurent-Puig​, P., Molina, M., Niemi, M., Schwab, M., Somogyi, A., Thervet, E., Maitland-van der Zee​, A-H., Kuilenburg, A., van Schaik​, R., Verstuyft, C., Wadelius, M. & Daly, A., 2011, In : Pharmacogenomics. 12, 1, p. 113-124 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Transfer of repaglinide in the dually perfused human placenta and the role of organic anion transporting polypeptides (OATPs)

Tertti, K., Petsalo, A., Niemi, M., Ekblad, U., Tolonen, A., Ronnemaa, T., Turpeinen, M., Heikkinen, T. & Laine, K., 9 Oct 2011, In : European Journal of Pharmaceutical Sciences. 44, 3, p. 181-186 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Effect of ABCB1 haplotypes on the pharmacokinetics and renin-inhibiting effect of aliskiren

Tapaninen, T., Neuvonen, P. J. & Niemi, M., 2010, In : European Journal of Clinical Pharmacology. 66, 9, p. 865-870 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Grapefruit Juice Greatly Reduces the Plasma Concentrations of the OATP2B1 and CYP3A4 Substrate Aliskiren

Tapaninen, T., Neuvonen, P. J. & Niemi, M., 2010, In : Clinical Pharmacology and Therapeutics. 88, 3, p. 339-342 4 p.

Research output: Contribution to journalArticleScientificpeer-review

High performance liquid chromatography-tandem mass spectrometry for the determination of bile acid concentrations in human plasma

Xiang, X., Han, Y., Neuvonen, M., Laitila, J., Neuvonen, P. J. & Niemi, M. O., 2010, In : Journal of Chromatography. B. 878, 1, p. 51-60 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Membrane transporters in drug development

Giacomini, K. M., Huang, S-M., Tweedie, D. J., Benet, L. Z., Brouwer, K. L. R., Chu, X., Dahlin, A., Evers, R., Fischer, V., Hillgren, K. M., Hoffmaster, K. A., Ishikawa, T., Keppler, D., Kim, R. B., Lee, C. A., Niemi, M., Polli, J. W., Sugiyama, Y., Swaan, P. W., Ware, J. A. & 5 othersWright, S. H., Yee, S. W., Zamek-Gliszczynski, M. J., Zhang, L. & International Transporter, 2010, In : Nature reviews. Drug discovery. 9, p. 215-236 22 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Rifampicin reduces the plasma concentrations and the renin-inhibiting effect of aliskiren

Tapaninen, T., Neuvonen, P. J. & Niemi, M. O., 2010, In : European Journal of Clinical Pharmacology. 66, 5, p. 497-502 6 p.

Research output: Contribution to journalArticleScientificpeer-review

SLCO1B1 Polymorphism and Oral Antidiabetic Drugs

Kalliokoski, A., Neuvonen, P. J. & Niemi, M. O., 2010, In : Basic & Clinical Pharmacology & Toxicology. 107, 4, p. 775-781 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Transporter Pharmacogenetics and Statin Toxicity

Niemi, M. O., 2010, In : Clinical Pharmacology and Therapeutics. 87, 1, p. 130-133 4 p.

Research output: Contribution to journalArticleScientificpeer-review

UDP-Glucuronosyltransferase (UGT) Polymorphisms Affect Atorvastatin Lactonization In Vitro and In Vivo

Riedmaier, S., Klein, K., Hofmann, U., Keskitalo, J. E., Neuvonen, P. J., Schwab, M., Niemi, M. O. & Zanger, U. M., 2010, In : Clinical Pharmacology and Therapeutics. 87, 1, p. 65-73 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin

Keskitalo, J., Zolk, O., Fromm, M. F., Kurkinen, K., Neuvonen, P. J. & Niemi, M., 2009, In : Clinical Pharmacology and Therapeutics. 86, 2, p. 197-203 7 p.

Research output: Contribution to journalArticleScientificpeer-review

CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe

Backman, J. T., Honkalammi, J., Neuvonen, M., Kurkinen, K., Tornio, A., Niemi, M. & Neuvonen, P. J., 2009, In : Drug Metabolism and Disposition. 37, 12, p. 2359-2366 8 p.

Research output: Contribution to journalArticleScientificpeer-review