Photo of Mikko Niemi
  • PL 20 (Tukholmankatu 8 C)

    00014

    Finland

20002019
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Publications 2000 2019

Effects of fluconazole and fluvoxamine on the pharmacokinetics and pharmacodynamics of glimepiride

Niemi, M., Backman, J. T., Neuvonen, M., Laitila, J., Neuvonen, P. J. & Kivisto, K. T., 2001, In : Clinical Pharmacology and Therapeutics. 69, p. 194-200 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of gemfibrozil and atorvastatin on the pharmacokinetics of repaglinide in relation to SLCO1B1 polymorphism

Kalliokoski, A., Backman, J. T., Kurkinen, K., Neuvonen, P. J. & Niemi, M., 2008, In : Clinical Pharmacology and Therapeutics. 84, 4, p. 488-496 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects

Neuvonen, M., Tarkiainen, E. K., Tornio, A., Hirvensalo, P., Tapaninen, T., Paile-Hyvärinen, M., Itkonen, M. K., Holmberg, M. T., Karja, V., Männistö, V. T., Neuvonen, P. J., Pihlajamäki, J., Backman, J. T. & Niemi, M., Mar 2018, In : Basic & Clinical Pharmacology & Toxicology. 122, 3, p. 341-345 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of rifampin on the pharmacokinetics and pharmacodynamics of glyburide and glipizide

Niemi, M., Backman, J. T., Neuvonen, M., Neuvonen, P. J. & Kivisto, K. T., 2001, In : Clinical Pharmacology and Therapeutics. 69, p. 400-406 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of the SLCO1B1*1B haplotype on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide

Kalliokoski, A., Backman, J. T., Neuvonen, P. J. & Niemi, M., 2008, In : Pharmacogenetics and Genomics. 18, 11, p. 937-942 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Enantiospecific pharmacogenomics of fluvastatin

Hirvensalo, P., Tornio, A., Neuvonen, M., Kiander, W., Kidron, H., Paile-Hyvärinen, M., Tapaninen, T., Backman, J. T. & Niemi, M., Sep 2019, In : Clinical Pharmacology and Therapeutics. 106, 3, p. 668-680 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Farmakogeneettinen testaus

Niemi, M. & Backman, J., 2011, Antikoagulaatiohoidon käsikirja. Puhakka, J. (ed.). THL, p. 19-19 1 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Farmakogeneettinen tieto avuksi yksilöllisten lääkeannosten määritykseen

Ranki-Pesonen, M. & Niemi, M., 2008, In : Duodecim. 124, 11, p. 1269-1271 3 p.

Research output: Contribution to journalArticleScientific

Farmakogeneettiset yksilövaihtelut

Niemi, M., 2011, Kliininen farmakologia ja lääkehoito. Neuvonen, P. J., Backman, J. T., Himberg, J-J., Huupponen, R., Keränen, T. & Kivistö, K. T. (eds.). Kandidaattikustannus Oy/ Lääketieteen kandidaattiseura ry, p. 67-74 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Farmakogenetiikka

Niemi, M., 2016, Lääketieteellinen genetiikka. Aittomäki, K., Moilanen, J. & Perola, M. (eds.). 1. p. ed. Helsinki: Duodecim, p. 312-320 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Farmakogenetiikkaa käytännön lääkärille: [lääkeinfo]

Niemi, M. & Kalliokoski, A., 2009, In : Suomen lääkärilehti. 64, 41, p. 3443-3446 4 p.

Research output: Contribution to journalArticleScientific

Farmakogenetiikka ja yksilöllinen lääkehoito [pääkirjoitus]

Translated title of the contribution: Pharmacogenetics and individualized drug therapy [Editorial]Niemi, M., 2006, In : Suomen lääkärilehti. 2006/61, p. 1079

Research output: Contribution to journalArticleScientific

Farmakogenetiikka saapuu klinikkaan

Heliste, J., Elenius, K., Niemi, M. & Elenius, V., 2016, In : Duodecim. 132, 17, p. 1561-1568 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Farmaseuttinen koostumus, joka sisältää gemfibrotsiiliä ja CYP2C8- ja/tai OATP-substraattilääkettä

Translated title of the contribution: Pharmaceutical composition containing gemfibrozil and a CYP2C8- and/or OATP-substrate drugNeuvonen, P., Niemi, M. & Backman, J., 30 Oct 2015, Patentti- ja rekisterihallitus, Patent No. FI 125478 B, 30 Oct 2015

Research output: Patent

Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1)

Niemi, M., Kivistö, K. T., Hofmann, U., Schwab, M., Eichelbaum, M. & Fromm, M. F., 2005, In : British Journal of Clinical Pharmacology. 59, 5, p. 602-604 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Fluconazole but not the CYP3A4 inhibitor, itraconazole, increases zafirlukast plasma concentrations

Karonen, T., Laitila, J., Niemi, M., Neuvonen, P. J. & Backman, J. T., 2012, In : European Journal of Clinical Pharmacology. 68, 5, p. 681-688 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Frequencies of single-nucleotide polymorphisms of SLCO1A2, SLCO1B3 and SLCO2B1 genes in a Finnish population.

Laitinen, A. & Niemi, M., 2011, In : Basic & Clinical Pharmacology & Toxicology. 108, 1, p. 9-13 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Functional interaction of intestinal CYP3A4 and P-glycoprotein

Kivisto, K. T., Niemi, M. & Fromm, M. F., 2004, In : Fundamental & Clinical Pharmacology. 18, p. 621-626 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Geenimuunnos statiinien aiheuttaman myopatian taustalla: [pääkirjoitus]

Niemi, M., 2009, In : Duodecim. 125, 3, p. 241-243 3 p.

Research output: Contribution to journalArticleScientific

Gemfibrozil considerably increases the plasma concentrations of rosiglitazone

Niemi, M., Backman, J. T., Schröder, M., Laitila, J., Neuvonen, M. & Neuvonen, P. J., 2003, In : Diabetologia. 46, 10, p. 1319-1323 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Gemfibrozil Is a Strong Inactivator of CYP2C8 in Very Small Multiple Doses

Honkalammi, J., Niemi, M., Neuvonen, P. J. & Backman, J. T., 2012, In : Clinical Pharmacology and Therapeutics. 91, 5, p. 846-855 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Gender, but not CYP7A1 or SLCO1B1 polymorphism, affects the fasting plasma concentrations of bile acids in human beings

Xiang, X., Backman, J., Neuvonen, P. J. & Niemi, M., 2012, In : Basic & Clinical Pharmacology & Toxicology. 110, 3, p. 245-252 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1

Nies, A. T., Niemi, M., Burk, O., Winter, S., Zanger, U. M., Stieger, B., Schwab, M. & Schaeffeler, E., 11 Jan 2013, In : Genome medicine. 5, 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Genomilääketieteen sovelluksia sairauksien hoidossa

Porkka, K., Niemi, M., Leppä, E., Västrik, I., Partanen, J., Ihalainen, J., Jokiranta, S. & Pöllänen, P., 2017, In : Duodecim. 133, 8, p. 782-790 9 p.

Research output: Contribution to journalArticleProfessional

Open Access
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Global analysis of genetic variation in SLCO1B1

Pasanen, M. K., Neuvonen, P. J. & Niemi, M., 2008, In : Pharmacogenomics. 9, 1, p. 19-33 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug-Drug Interactions

Tornio, A., Filppula, A. M., Kailari, O., Neuvonen, M., Nyrönen, T. H., Tapaninen, T., Neuvonen, P. J., Niemi, M. & Backman, J. T., Oct 2014, In : Clinical Pharmacology and Therapeutics. 96, 4, p. 498-507 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Glyburide and glimepiride pharmacokinetics in subjects with different CYP2C9 genotypes

Niemi, M., Cascorbi, I., Timm, R., Kroemer, H. K., Neuvonen, P. J. & Kivisto, K. T., 2002, In : Clinical Pharmacology and Therapeutics. 72, p. 326-332 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Grapefruit Juice Greatly Reduces the Plasma Concentrations of the OATP2B1 and CYP3A4 Substrate Aliskiren

Tapaninen, T., Neuvonen, P. J. & Niemi, M., 2010, In : Clinical Pharmacology and Therapeutics. 88, 3, p. 339-342 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Grapefruit Juice Inhibits the Metabolic Activation of Clopidogrel

Holmberg, M. T., Tornio, A., Neuvonen, M. S., Neuvonen, P. J., Backman, J. T. & Niemi, M., Mar 2014, In : Clinical Pharmacology and Therapeutics. 95, 3, p. 307-313 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects

Holmberg, M. T., Tornio, A., Joutsi-Korhonen, L., Neuvonen, M., Neuvonen, P. J., Lassila, R., Niemi, M. & Backman, J. T., Jun 2013, In : British Journal of Clinical Pharmacology. 75, 6, p. 1488-1496 9 p.

Research output: Contribution to journalArticleScientificpeer-review

High Frequency of CYP2D6 Ultrarapid Metabolizer Genotype in the Finnish Population

Pietarinen, P., Tornio, A. & Niemi, M., Sep 2016, In : Basic & Clinical Pharmacology & Toxicology. 119, 3, p. 291-296 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

High performance liquid chromatography-tandem mass spectrometry for the determination of bile acid concentrations in human plasma

Xiang, X., Han, Y., Neuvonen, M., Laitila, J., Neuvonen, P. J. & Niemi, M. O., 2010, In : Journal of Chromatography. B. 878, 1, p. 51-60 10 p.

Research output: Contribution to journalArticleScientificpeer-review

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

Niemi, M., Schaeffeler, E., Lang, T., Fromm, M. F., Neuvonen, M., Kyrklund, C., Backman, J. T., Kerb, R., Schwab, M., Neuvonen, P. J., Eichelbaum, M. & Kivisto, K. T., 2004, In : Pharmacogenetics and Genomics. 14, p. 429-440 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Impact of OATP transporters on pharmacokinetics: [review]

Kalliokoski, A. & Niemi, M., 2009, In : British Journal of Pharmacology. 158, 3, p. 693-705 13 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin

Igel, M., Arnold, K., Niemi, M., Hofmann, U., Schwab, M., Lutjohann, D., von Bergmann, K., Eichelbaum, M. & Kivistö, K. T., 2006, In : Clinical Pharmacology and Therapeutics. 79, 5, p. 419-426 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans

Kivistö, K. T. & Niemi, M., 2007, In : Pharmaceutical Research. 24, 2, p. 239-247 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Interactions of (2S,6S;2R,6R)-Hydroxynorketamine, a Secondary Metabolite of (R,S)-Ketamine, with Morphine

Lilius, T. O., Viisanen, H., Jokinen, V., Niemi, M., Kalso, E. A. & Rauhala, P. V., May 2018, In : Basic & Clinical Pharmacology & Toxicology. 122, 5, p. 481-488 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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International Transporter Consortium Commentary on Clinically Important Transporter Polymorphisms

Giacomini, K. M., Balimane, P. V., Cho, S. K., Eadon, M., Edeki, T., Hillgren, K. M., Huang, S-M., Sugiyama, Y., Weitz, D., Wen, Y., Xia, C. Q., Yee, S. W., Zimdahl, H., Niemi, M. & Int Transporter Consortium, Jul 2013, In : Clinical Pharmacology and Therapeutics. 94, 1, p. 23-26 4 p.

Research output: Contribution to journalArticleScientific

Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren

Tapaninen, T., Backman, J. T., Kurkinen, K. J., Neuvonen, P. J. & Niemi, M., 2011, In : Journal of Clinical Pharmacology. 51, 3, p. 359-367 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Itraconazole, gemfibrozil and their combination markedly raise the plasma concentrations of loperamide

Niemi, M., Tornio, A., Pasanen, M. K., Fredriksson, H., Neuvonen, P. J. & Backman, J. T., 2006, In : European Journal of Clinical Pharmacology. 62, 6, p. 463-472 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Karboksyyliesteraasin geenimuutos tehostaa klopidogreelin vaikutuksia

Tarkiainen, E. K., Holmberg, M. T., Tornio, A., Neuvonen, M., Neuvonen, P., Backman, J. & Niemi, M., 4 May 2015, In : Duodecim. 131, 9, p. 881 1 p.

Research output: Contribution to journalArticleScientific

Ketamine and norketamine attenuate oxycodone tolerance markedly less than that of morphine: from behaviour to drug availability

Lilius, T., Kangas, E., Niemi, M., Rauhala, P. & Kalso, E., Apr 2018, In : British Journal of Anaesthesia. 120, 4, p. 818-826 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat

Lilius, T., Jokinen, V., Neuvonen, M. S., Niemi, M., Kalso, E. A. & Rauhala, P. V., Jun 2015, In : British Journal of Pharmacology. 172, 11, p. 2799-2813 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Klopidogreelin vasteen farmakogeneettinen vaihtelu

Backman, J., Niemi, M. & Ruskoaho, H., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., Huikuri, H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3. uud. p. ed. Helsinki: Duodecim, p. 88-89 2 p. kar01739 (006.090)

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional