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Publications 2000 2018

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2018

MRI-only based radiation therapy of prostate cancer: workflow and early clinical experience

Tenhunen, M., Korhonen, J., Kapanen, M., Seppälä, T., Koivula, L., Collan, J., Saarilahti, K. & Visapää, H., 2018, In : Acta Oncologica. 57, 7, p. 902-907 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Dosimetric Comparison and Evaluation of 4 Stereotactic Body Radiotherapy Techniques for the Treatment of Prostate Cancer

Seppala, J., Suilamo, S., Tenhunen, M., Sailas, L., Virsunen, H., Kaleva, E. & Keyrilainen, J., Apr 2017, In : Technology in Cancer Research & Treatment. 16, 2, p. 238-245 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Dosimetry software Hermes Internal Radiation Dosimetry: from quantitative image reconstruction to voxel-level absorbed dose distribution

Hippeläinen, E. T., Tenhunen, M. J., Mäenpää, H. O., Heikkonen, J. J. & Sohlberg, A. O., May 2017, In : Nuclear Medicine Communications. 38, 5, p. 357-365 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Ionization chamber radial response deconvolution in megavoltage photon beam

Kulmala, A. & Tenhunen, M., 21 Sep 2017, In : Physics in Medicine and Biology. 62, 18, p. 7505-7519 15 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Quantitative accuracy of Lu-177 SPECT reconstruction using different compensation methods: phantom and patient studies

Hippeläinen, E., Tenhunen, M., Mäenpää, H. & Sohlberg, A., 18 Feb 2016, In : EJNMMI Research. 6, 8 p., 16.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2015

A comparison between two clinically applied plan library strategies in adaptive radiotherapy of bladder cancer

Tuomikoski, L., Valli, A., Tenhunen, M., Muren, L. & Vestergaard, A., Dec 2015, In : Radiotherapy and Oncology. 117, 3, p. 448-452 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Converting from CT- to MRI-only-based target definition in radiotherapy of localized prostate cancer

Seppälä, T., Visapää, H., Collan, J., Kapanen, M., Beule, A., Kouri, M., Tenhunen, M. & Saarilahti, K., Nov 2015, In : Strahlentherapie und Onkologie. 191, 11, p. 862-868 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Fast voxel-level dosimetry for Lu-177 labelled peptide treatments

Hippelainen, E., Tenhunen, M. & Sohlberg, A., 7 Sep 2015, In : Physics in Medicine and Biology. 60, 17, p. 6685-6700 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Feasibility of MRI-based reference images for image-guided radiotherapy of the pelvis with either cone-beam computed tomography or planar localization images

Korhonen, J., Kapanen, M., Sonke, J-J., Wee, L., Salli, E., Keyrilainen, J., Seppälä, T. & Tenhunen, M., Jun 2015, In : Acta Oncologica. 54, 6, p. 889-U190 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Immunological Effects of a Tumor Necrosis Factor Alpha-Armed Oncolytic Adenovirus

Hirvinen, M., Rajecki, M., Kapanen, M., Parviainen, S., Rouvinen-Lagerstrom, N., Diaconu, I., Nokisalmi, P., Tenhunen, M., Hemminki, A. & Cerullo, V., 1 Mar 2015, In : Human Gene Therapy. 26, 3, p. 134-144 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Toward a more patient-specific model of post-radiotherapy saliva secretion for head and neck cancer patients

Tuomikoski, L., Kapanen, M., Collan, J., Keyrilainen, J., Saarilahti, K., Loimu, V., Seppälä, T. & Tenhunen, M., 21 Oct 2015, In : Acta Oncologica. 54, 9, p. 1310-1316 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

A dual model HU conversion from MRI intensity values within and outside of bone segment for MRI-based radiotherapy treatment planning of prostate cancer

Korhonen, J., Kapanen, M., Keyrilainen, J., Seppala, T. & Tenhunen, M., Jan 2014, In : Medical Physics. 41, 1, 12 p., 4842575.

Research output: Contribution to journalArticleScientificpeer-review

Gold seed fiducials in analysis of linear and rotational displacement of the prostate bed

Ålander, E., Visapää, H., Kouri, M. O., Keyriläinen, J., Saarilahti, K. & Tenhunen, M., 2014, In : Radiotherapy and Oncology. 110, 2, p. 256-260 5 p.

Research output: Contribution to journalArticleScientificpeer-review

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Influence of MRI-based bone outline definition errors on external radiotherapy dose calculation accuracy in heterogeneous pseudo-CT images of prostate cancer patients

Korhonen, J., Kapanen, M., Keyrilainen, J., Seppälä, T., Tuomikoski, L. & Tenhunen, M., Aug 2014, In : Acta Oncologica. 53, 8, p. 1100-1106 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Sädehoidon menestystarina jatkuu

Tenhunen, M. & Tarkkanen, M., 2014, In : Duodecim. 130, 4, p. 301-302 2 p.

Research output: Contribution to journalArticleProfessional

Vastine Vainikaiselle ja Nordmanille

Tenhunen, M. & Tarkkanen, M., 2014, In : Duodecim. 130, 9, p. 951 1 p.

Research output: Contribution to journalArticleProfessional

2013

Absorbed doses behind bones with MR image-based dose calculations for radiotherapy treatment planning

Korhonen, J., Kapanen, M., Keyrilainen, J., Seppälä, T., Tuomikoski, L. & Tenhunen, M., Jan 2013, In : Medical Physics. 40, 1, p. Article Number: 011701 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Commissioning of MRI-only based treatment planning procedure for external beam radiotherapy of prostate

Kapanen, M., Collan, J., Anette, B., Seppala, T., Saarilahti, K. & Tenhunen, M., Jul 2013, In : Magnetic Resonance in Medicine. 70, 1, p. 127-135 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Electrocardiography Changes During Adjuvant Breast Cancer Therapy: Incidence and Risk Factors

Elme, A., Saarto, T., Totterman, K. J., Utriainen, M., Kautiainen, H., Jarvenpaa, S., Tenhunen, M. & Blomqvist, C., Nov 2013, In : Anticancer Research. 33, 11, p. 4933-4939 7 p.

Research output: Contribution to journalArticleScientificpeer-review

First-day iodine kinetics is useful for individualizing radiation safety precautions for thyroid carcinoma patients

Tenhunen, M., Lehtonen, S., Heikkonen, J., Halonen, P. & Mäenpää, H., Dec 2013, In : Nuclear Medicine Communications. 34, 12, p. 1208-1215 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Implementation of adaptive radiation therapy for urinary bladder carcinoma: Imaging, planning and image guidance

Tuomikoski, L., Korhonen, J., Collan, J., Keyriläinen, J., Visapää, H., Sairanen, J., Saarilahti, K. & Tenhunen, M., Oct 2013, In : Acta Oncologica. 52, 7, p. 1451-1457 7 p.

Research output: Contribution to journalArticleScientificpeer-review

T1/T2(star)-weighted MRI provides clinically relevant pseudo-CT density data for the pelvic bones in MRI-only based radiotherapy treatment planning

Kapanen, M. & Tenhunen, M., Apr 2013, In : Acta Oncologica. 52, 3, p. 612-618 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Radiation-Induced Upregulation of Gene Expression From Adenoviral Vectors Mediated by DNA Damage Repair and Regulation

Nokisalmi, P., Rajecki, M., Pesonen, S., Escutenaire, S., Soliymani, R., Tenhunen, M., Ahtiainen, L. & Hemminki, A., 2012, In : International Journal of Radiation: Oncology - Biology - Physics. 83, 1, p. 376-384 9 p.

Research output: Contribution to journalArticleScientificpeer-review

SPECT/CT Imaging of hNIS - Expression after Intravenous Delivery of an Oncolytic Adenovirus and I-131

Rajecki, M., Sarparanta, M., Hakkarainen, T., Tenhunen, M., Diaconu, I., Kuhmonen, V., Kairemo, K., Kanerva, A-M., Airaksinen, A. J. & Hemminki, A., 2012, In : PLoS One. 7, 3, p. e32871 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Super-resolution non-parametric deconvolution in modelling the radial response function of a parallel plate ionization chamber

Kulmala, A. & Tenhunen, M., 7 Nov 2012, In : Physics in Medicine and Biology. 57, 21, p. 7075-7088 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Adaptive radiotherapy in muscle invasive urinary bladder cancer - An effective method to reduce the irradiated bowel volume

Tuomikoski, L., Collan, J., Keyriläinen, J., Visapaa, H., Saarilahti, K. & Tenhunen, M., 2011, In : Radiotherapy and Oncology. 99, 1, p. 61-66 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Comparison of in vitro breast cancer visibility in analyser-based computed tomography with histopathology, mammography, computed tomography and magnetic resonance imaging

Keyrilainen, J., Fernandez Martinez, M., Bravin, A., Karjalainen-Lindsberg, M-L., Hannele Leidenius, M., von Smitten, K., Tenhunen, M., Kangasmaki, A., Sipila, P., Nemoz, C., Virkkunen, P. & Suortti, P., 2011, In : Journal of Synchrotron Radiation. 18, 5, p. 689-696 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Epithermal neutron beam interference with cardiac pacemakers

Koivunoro, H., Seren, T., Hyvönen, H., Kotiluoto, P., Iivonen, P., Auterinen, I., Seppälä, T., Kankaanranta, L., Pakarinen, S., Tenhunen, M. & Savolainen, S., 11 Apr 2011, In : Applied Radiation and Isotopes. 69, 12, p. 1904-1906 3 p.

Research output: Contribution to journalArticleScientificpeer-review

How can a cost/benefit ratio be optimized for an output measurement program of external photon radiotherapy beams?

Kapanen, M., Bly, R., Sipila, P., Jarvinen, H. & Tenhunen, M., 7 Apr 2011, In : Physics in Medicine and Biology. 56, 7, p. 2119-2130 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Patterns of relapse following surgery and postoperative intensity modulated radiotherapy for oral and oropharyngeal cancer

Collan, J., Lundberg, M., Vaalavirta, L., Bäck, L., Kajanti, M., Mäkitie, A. A., Tenhunen, M. & Saarilahti, K., 2011, In : Acta Oncologica. 50, 7, p. 1119-1125 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Surgical management of radiation-associated cutaneous breast angiosarcoma

Lindford, A., Bohling, T., Vaalavirta, L., Tenhunen, M., Jahkola, T. & Tukiainen, E., 2011, In : Journal of Plastic, Reconstructive & Aesthetic Surgery. 64, 8, p. 1036-1042 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Adenoviral E4ORF3 and E4ORF6 proteins, but not E1B55K, increase killing of cancer cells by radiotherapy in vivo

Liikanen, I., Dias, J. D., Nokisalmi, P., Sloniecka, M., Kangasniemi, L., Rajecki, M., Dobner, T., Tenhunen, M., Kanerva, A., Pesonen, S., Ahtiainen, L. & Hemminki, A., 2010, In : International Journal of Radiation: Oncology - Biology - Physics. 78, 4, p. 1201-1209 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Multimodal approach using oncolytic adenovirus, cetuximab, chemotherapy and radiotherapy in HNSCC low passage tumour cell cultures

Dias, J. D., Guse, K., Nokisalmi, P., Eriksson, M., Chen, D-T., Diaconu, I., Tenhunen, M., Liikanen, I., Grenman, R., Savontaus, M., Pesonen, S., Cerullo, V. & Hemminki, A., 2010, In : European Journal of Cancer. 46, 3, p. 625-635 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Linac-based isocentric electron-photon treatment of radically operated breast carcinoma with enhanced dose uniformity in the field gap area

Tenhunen, M., Nyman, H., Strengell, S. & Vaalavirta, L., 2009, In : Radiotherapy and Oncology. 93, 1, p. 80-86 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation

Rajecki, M., af Hällström, T., Hakkarainen, T., Nokisalmi, P., Hautaniemi, S., Nieminen, A. I., Tenhunen, M., Rantanen, V., Desmond, R. A., Chen, D-T., Guse, K., Stenman, U-H., Gargini, R., Kapanen, M., Klefström, J., Kanerva, A., Pesonen, S., Ahtiainen, L. & Hemminki, A., 2009, In : International Journal of Cancer. 125, 10, p. 2441-2449 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

Imaging lobular breast carcinoma: comparison of synchrotron radiation DEI-CT technique with clinical CT, mammography and histology

Fiedler, S., Bravin, A., Keyriläinen, J., Fernandez, M., Suortti, P., Thomlinson, W., Tenhunen, M., Virkkunen, P. & Karjalainen-Lindsberg, M. L., 2004, In : Physics in Medicine and Biology. 49, p. 175-188 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2003

Boron neutron capture therapy of brain tumors: clinical trials at the Finnish facility using boronophenylalanine

Joensuu, H., Kankaanranta, L., Seppälä, T., Auterinen, I., Kallio, M., Kulvik, M., Laakso, J., Vähätalo, J., Kortesniemi, M., Kotiluoto, P., Seren, T., Karila, J., Brander, A., Järviluoma, E., Ryynänen, P., Paetau, A., Ruokonen, I., Minn, H., Tenhunen, M., Jääskeläinen, J. & 2 othersFärkkilä, M. & Savolainen, S., 2003, In : Journal of Neuro-Oncology. 62, 1-2, p. 123-134 12 p.

Research output: Contribution to journalArticleProfessional

2002

Small-angle x-ray scattering studies of human breast tissue samples

Fernandez, M., Keyriläinen, J., Serimaa, R., Torkkeli, M., Karjalainen-Lindsberg, M. L., Tenhunen, M., Thomlinson, W., Urban, V. & Suortti, P., 2002, In : Physics in Medicine and Biology. 47, p. 577-592 16 p.

Research output: Contribution to journalArticleScientificpeer-review

2000

Subclinical cardiotoxicity following adjuvant dose-escalated FEC, high-dose chemotherapy, or CMF in breast cancer

Erselcan, T., Kairemo, KJA., Wiklund, TA., Hernberg, M., Blomqvist, CP., Tenhunen, M., Bergh, J. & Joensuu, H., Feb 2000, In : British Journal of Cancer. 82, 4, p. 777-781 5 p.

Research output: Contribution to journalArticleScientificpeer-review