Research Output per year
International and National Collaboration
Publications and projects within past five years.
Publications
- 5 Article
Lipid mediators in platelet concentrate and extracellular vesicles: Molecular mechanisms from membrane glycerophospholipids to bioactive molecules
Valkonen, S., Holopainen, M., Colas, R. A., Impola, U., Dalli, J., Käkelä, R., Siljander, P. R-M. & Laitinen, S., Aug 2019, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1864, 8, p. 1168-1182 15 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Polyunsaturated fatty acids modify the extracellular vesicle membranes and increase the production of proresolving lipid mediators of human mesenchymal stromal cells
Holopainen, M., Colas, R. A., Valkonen, S., Tigistu-Sahle, F., Hyvärinen, K., Mazzacuva, F., Lehenkari, P., Käkelä, R., Dalli, J., Kerkelä, E. & Laitinen, S., Oct 2019, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1864, 10, p. 1350-1362 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization
Le Joncour, V., Filppu, P., Hyvönen, M., Holopainen, M., Turunen, S. P., Sihto, H., Burghardt, I., Joensuu, H., Tynninen, O., Jääskeläinen, J., Weller, M., Lehti, K., Käkelä, R. & Laakkonen, P., Jun 2019, In : EMBO molecular medicine. 11, 6, 21 p., 9034.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22
Hyvärinen, K., Holopainen, M., Skirdenko, V., Ruhanen, H., Lehenkari, P., Korhonen, M., Käkelä, R., Laitinen, S. & Kerkelä, E., 12 Apr 2018, In : Frontiers in Immunology. 9, 13 p., 771.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Metabolism and phospholipid assembly of polyunsaturated fatty acids in human bone marrow mesenchymal stromal cells
Tigistu-Sahle, F., Lampinen, M., Kilpinen, L., Holopainen, M., Lehenkari, P., Laitinen, S. & Käkelä, R., Jan 2017, In : Journal of Lipid Research. 58, 1, p. 92-110 19 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Equipment
Helsinki University Lipidomics Unit
Reijo Käkelä (Manager), Hanna Elina Ruhanen (Operator), Minna Holopainen (Operator) & Pentti Juhani Somerharju (Manager)
Functional Lipidomics GroupFacility/equipment: Equipment