Photo of Minna Nyström
  • PL 56 (Viikinkaari 9)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1985 …2020
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Publications 1985 2019

  • 65 Article
  • 2 Chapter
  • 1 Entry for encyclopedia / dictionary
2019

DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression

Mäki-Nevala, S., Valo, S., Ristimaki, A., Sarhadi, V., Knuutila, S., Nyström, M., Renkonen-Sinisalo, L., Lepistö, A., Mecklin, J-P. & Peltomäki, P., Jan 2019, In : EBioMedicine. 39, p. 280-291 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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PMS2 expression decrease causes severe problems in mismatch repair

Kasela, M., Nyström, M. & Kansikas, M., Jul 2019, In : Human Mutation. 40, 7, p. 904-907 4 p.

Research output: Contribution to journalArticleScientific

Open Access
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2018

Mlh1 deficiency in normal mouse colon mucosa associates with chromosomally unstable colon cancer

Pussila, M., Toronen, P., Einarsdottir, E., Katayama, S., Krjutskov, K., Holm, L., Kere, J., Peltomäki, P., Mäkinen, M. J., Linden, J. & Nyström, M., Jun 2018, In : Carcinogenesis. 39, 6, p. 788-797 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Assessment of the InSiGHT Interpretation Criteria for the Clinical Classification of 24 MLH1 and MSH2 Gene Variants

Tricarico, R., Kasela, M., Mareni, C., Thompson, B. A., Drouet, A., Staderini, L., Gorelli, G., Crucianelli, F., Ingrosso, V., Kantelinen, J., Papi, L., De Angioletti, M., Berardi, M., Gaildrat, P., Soukarieh, O., Turchetti, D., Martins, A., Spurdle, A. B., Nyström, M., Genuardi, M. & 1 othersInSiGHT Variant Interpretation, Jan 2017, In : Human Mutation. 38, 1, p. 64-77 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

DNA:n korjausmekanismien häiriöt ja niiden lääketieteellinen merkitys

Kansikas, M., Nyström, M. & Peltomäki, P., 2017, In : Duodecim. 133, 3, p. 259-265 7 p.

Research output: Contribution to journalArticleProfessional

Open Access
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Mismatch Repair Genes

Kansikas, M., Nyström, M. & Peltomäki, P., Sep 2017, eLS: Genetics and Disease. John Wiley & Sons Ltd., p. 1-6 6 p. (eLS).

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia / dictionaryProfessional

Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon

Dermadi, D., Valo, S., Ollila, S., Soliymani, R., Sipari, N., Pussila, M., Sarantaus, L., Linden, J., Baumann, M. & Nystrom, M., 15 Jun 2017, In : Cancer Research. 77, 12, p. 3352-3363 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Human DNA polymerase α interacts with mismatch repair proteins MSH2 and MSH6

Itkonen, H. M., Kantelinen, J., Vaara, M., Parkkinen, S., Schlott, B., Grosse, F., Nystrom, M., Syvaoja, J. E. & Pospiech, H., Dec 2016, In : FEBS Letters. 590, 23, p. 4233-4241 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas

Valo, S., Kaur, S., Ristimaki, A., Renkonen-Sinisalo, L., Järvinen, H., Mecklin, J-P., Nystrom, M. & Peltomäki, P. T., 22 Jul 2015, In : Clinical epigenetics. 7, 13 p., 71.

Research output: Contribution to journalArticleScientificpeer-review

2014

Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

Thompson, B. A., Spurdle, A. B., Plazzer, J-P., Greenblatt, M. S., Akagi, K., Al-Mulla, F., Bapat, B., Bernstein, I., Capella, G., den Dunnen, J. T., du Sart, D., Fabre, A., Farrell, M. P., Farrington, S. M., Frayling, I. M., Frebourg, T., Goldgar, D. E., Heinen, C. D., Holinski-Feder, E., Kohonen-Corish, M. & 22 othersRobinson, K. L., Leung, S. Y., Martins, A., Moller, P., Morak, M., Nystrom, M., Peltomaki, P., Pineda, M., Qi, M., Ramesar, R., Rasmussen, L. J., Royer-Pokora, B., Scott, R. J., Sijmons, R., Tavtigian, S. V., Tops, C. M., Weber, T., Wijnen, J., Woods, M. O., Macrae, F., Genuardi, M. & InSiGHT, Feb 2014, In : Nature Genetics. 46, 2, p. 107-+ 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Assessing How Reduced Expression Levels of the Mismatch Repair Genes MLH1, MSH2, and MSH6 Affect Repair Efficiency

Kansikas, M., Kasela, M., Kantelinen, J. & Nystrom, M., Sep 2014, In : Human Mutation. 35, 9, p. 1123-1127 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Agenesis of the corpus callosum and gray matter heterotopia in three patients with constitutional mismatch repair deficiency syndrome.

Baas, A. F., Gabbett, M., Rimac, M., Kansikas, M., Raphael, M., Nievelstein, R. AJ., Nicholls, W., Offerhaus, J., Bodmer, D., Wernstedt, A., Krabichler, B., Strasser, U., Nyström, M., Zschocke, J., Robertson, S. P., van Haelst, M. M. & Wimmer, K., Jan 2013, In : European Journal of Human Genetics. 21, 1, p. 55-61 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Cancer-Predicting Gene Expression Changes in Colonic Mucosa of Western Diet Fed Mlh1(+/-) Mice

Pussila, M., Sarantaus, L., Dermadi Bebek, D., Valo, S., Reyhani, N., Ollila, S., Päivärinta, E. M-A., Peltomäki, P. T., Mutanen, M. & Nyström, M., 8 Oct 2013, In : PLoS One. 8, 10, 12 p., UNSP e76865.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

DNA Alterations in Lynch Syndrome. Functional Analyses Help to Assess the Pathogenicity of MMR Gene Variants of Uncertain Significance

Nyström, M. & Kansikas, M., 2013, DNA Alterations in Lynch Syndrome: Advances in molecular diagnosis and genetic counselling. Vogelsang, M. (ed.). Springer, p. 85-100 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

2012

Functional characterization of MLH1 missense variants identified in Lynch syndrome patients

Andersen, S. D., Liberti, S. E., Lutzen, A., Drost, M., Bernstein, I., Nilbert, M., Dominguez, M., Nyström, M., Hansen, T. V. O., Christoffersen, J. W., Jäger, A. C., de Wind, N., Nielsen, F. C., Torring, P. M. & Rasmussen, L. J., Dec 2012, In : Human Mutation. 33, 12, p. 1647-1655 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Mismatch repair analysis of inherited MSH2 and/or MSH6 variation pairs found in cancer patients.

Kantelinen, J., Kansikas, M., Candelin, S., Hampel, H., Smith, B., Holm, L., Kariola, R. & Nyström, M., 2012, In : Human Mutation. 33, 8, p. 1294-1301 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

A putative Lynch syndrome family carrying MSH2 and MSH6 variants of uncertain significance-functional analysis reveals the pathogenic one

Kantelinen, J., Hansen, T. V. O., Kansikas, M., Krogh, L. N., Korhonen, M. K., Ollila, S., Nystrom, M., Gerdes, A-M. & Kariola, R., 2011, In : Familial Cancer. 2011, 10, p. 515-520 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Verification of the Three-Step Model in Assessing the Pathogenicity of Mismatch Repair Gene Variants

Kansikas, M., Kariola, R. & Nyström, M., 2011, In : Human Mutation. 32, 1, p. 107-115 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

MutSbeta exceeds MutSalpha in dinucleotide loop repair

Kantelinen, J., Kansikas, M., Korhonen, M., Ollila, S., Heinimann, K., Kariola, R. & Nyström, M., 2010, In : British Journal of Cancer. 102, 6, p. 1068–1073 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Diet and epigenetics in colon cancer

Nyström, M. & Mutanen, M., 2009, In : World Journal of Gastroenterology. 15, 3, p. 257-263 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Functional characterization of rare missense mutations in MLH1 and MSH2 identified in Danish colorectal cancer patients

Christensen, L. L., Kariola, R., Korhonen, M. M., Wikman, F. P., Sunde, L., Gerdes, A-M., Okkels, H., Brandt, C. A., Bernstein, I., Hansen, T. V. O., Hagemann-Madsen, R., Andersen, C. L., Nyström, M. & Ørntoft, T. F., 2009, In : Familial Cancer. 8, 4, p. 489-500 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Germline MLH1 and MSH2 mutations in Italian pancreatic cancer patients with suspected Lynch syndrome

Gargiulo, S., Torrini, M., Ollila, S., Nasti, S., Pastorino, L., Cusano, R., Bonelli, L., Battistuzzi, L., Mastracci, L., Bruno, W., Savarino, V., Sciallero, S., Borgonovo, G., Nyström, M., Bianchi-Scarra, G., Mareni, C. & Ghiorzo, P., 2009, In : Familial Cancer. 8, 4, p. 547-553 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Mechanisms of Pathogenicity in Human MSH2 Missense Mutants

Ollila, S., Dermadi Bebek, D., Jiricny, J. & Nyström, M., 2008, In : Human Mutation. 29, 11, p. 1355-1363 9 p.

Research output: Contribution to journalArticleScientificpeer-review

The first functional study of MLH3 mutations found in cancer patients

Korhonen, M. K., Vuorenmaa, E. & Nyström, M., 2008, In : Genes, Chromosomes & Cancer. 47, 9, p. 803-809 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Uncertain pathogenicity of MSH2 variants N127S and G322D challenges their classification

Ollila, S., Dermadi Bebek, D., Greenblatt, M. & Nyström, M., 2008, In : International Journal of Cancer. 123, 3, p. 720-724 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Conditional nuclear localization of hMLH3 suggests a minor activity in mismatch repair and supports its role as a low-risk gene in HNPCC

Korhonen, M. K., Raevaara, T. E., Lohi, H. & Nyström, M., 2007, In : Oncology Reports. 17, p. 351-354 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Interpreting missense variants: comparing computational methods in human disease genes CDKN2A, MLH1, MSH2, MECP2, and Tyrosinase (TYR)

Chan, P. A., Duraisamy, S., Miller, P. J., Newell, J. A., McBride, C., Bond, J. P., Raevaara, T. E., Ollila, S., Nyström, M., Grimm, A. J., Christodoulou, J., Oetting, W. S. & Greenblatt, M. S., 2007, In : Human Mutation. 28, 7, p. 683-693 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Pathogenicity of MSH2 missense mutations is typically associated with impaired repair capability of the mutated protein

Ollila, S., Sarantaus, L., Kariola, R., Chan, P., Hampel, H., Holinski-Feder, E., Macrae, F., Kohonen-Corish, M., Gerdes, A-M., Peltomäki, P., Mangold, E., Chapelle, A. D. L., Greenblatt, M. & Nyström, M., 2006, In : Gastroenterology. 131, p. 1408-1417 10 p.

Research output: Contribution to journalArticleScientificpeer-review

The importance of functional testing in the genetic assessment of Muir-Torre syndrome, a clinical subphenotype of HNPCC

Ollila, S., Fitzpatrick, R., Sarantaus, L., Kariola, R., Ambus, I., Velsher, L., Hsieh, E., Klarskov-Andersen, M., Raevaara, T. E., Gerdes, A-M., Mangold, E., Peltomäki, P., Lynch, H. T. & Nyström, M., 2006, In : International Journal of Oncology. 28, p. 149-153 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers

Kariola, R., Abdel-Rahman, W. M., Ollikainen, M., Butzow, R., Peltomäki, P. & Nyström, M., 2005, In : Familial Cancer. 4, 2, p. 187-190 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations

Abdel-Rahman, W. M., Ollikainen, M., Kariola, R., Järvinen, H. J., Mecklin, J-P., Nyström-Lahti, M. K., Knuutila, S. & Peltomäki, P., 2005, In : Oncogene. 24, 9, p. 1542-1551 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Functional significance and clinical phenotype of nontruncating mismatch repair variants of MLH1

Raevaara, T., Korhonen, M. K., Lohi, H., Hampel, H., Lynch, E., Lönnqvist, K. E., Holinski-Feder, E., Sutter, C., McKinnon, W., Duraisamy, S., Gerdes, A-M., Peltomäki, P., Kohonen-Corish, M., Mangold, E., Macrae, F., Greenblatt, M., Chapelle, A. D. L., Nyström, M. & Korhonen, M., 2005, In : Gastroenterology. 129, 2, p. 537-549 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Mismatch repair genes

Peltomäki, P. T. & Nyström, M., 2005, Encyclopedia of Life Sciences.. John Wiley & Sons Ltd. , Vol. 2005.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

2004

HNPCC mutation MLH1 P648S makes the functional protein unstable and homozygosity predisposes to mild neurofibromatosis type 1

Raevaara TE, Gerdes A-M, Lönnqvist KE, Tybjaerg-Hansen A, Abdel-Rahman WM, Kariola R, Peltomäki P, and Nyström-Lahti M. , 2004, In : Genes, Chromosomes & Cancer. 40, p. 261-265

Research output: Contribution to journalArticleScientificpeer-review

MSH6 missense mutations are often associated with no or low cancer susceptibility

Kariola R, Hampel H, Frankel WL, Raevaara TE, de la Chapelle A, and Nyström-Lahti M, 2004, In : British Journal of Cancer. 91, p. 1287-1292

Research output: Contribution to journalArticleScientificpeer-review

2003

Novel MLH1 and MSH2 germline mutations in the first HNPCC families identified in Slovakia

Bartosova Z, Fridrichova I, Bujalkova M, Wolf B, Ilencikova D, Krizan P, Hlavcak P, Palaj J, Lukac L, Lukacova M, Böör A, Haider R, Jiricny J, Nyström-Lahti M, and Marra G, 2003, In : Human Mutation. 21, p. 449

Research output: Contribution to journalArticleScientificpeer-review

Pathogenicity of the hereditary colorectal cancer mutation hMLH1 del616 linked to shortage of the functional protein

Raevaara, T. E., Vaccaro, C., Abdel-Rahman, W. M., Mocetti, E., Bala, S., Lönnqvist, K. E., Kariola, R., Lynch, H. T., Peltomäki, P. & Nyström-Lahti, M., 2003, In : Gastroenterology. 125, p. 501-509 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Two mismatch repair gene mutations found in a colon cancer patient – which one is pathogenic?

Kariola R, Otway R, Lönnqvist KE, Raevaara TE, Macrae F, Vos YJ, Kohonen-Corish M, Hofstra RMW, Nyström-Lahti M, 2003, In : Human Genetics. 112, p. 105-109

Research output: Contribution to journalArticleScientificpeer-review

2002

Description and functional analysis of a novel in frame mutation linked to hereditary nonpolyposis colorectal cancer

Raevaara TE, Timoharju T, Lönnqvist KE, Kariola R, Steinhoff M, Hofstra RMW, Mangold E, Vos YJ, Nyström-Lahti M, 2002, In : Journal of Medical Genetics. 39, p. 747-750

Research output: Contribution to journalArticleScientificpeer-review

Distinct PTEN mutational spectra in hereditary non-polyposis colon cancer syndrome-related endometrial carcinomas compared to sporadic microsatellite unstable tumors

Zhou, X. P., Kuismanen, S., Nyström-Lahti, M., Peltomäki, P. & Eng, C., 2002, In : Human Molecular Genetics. 11, p. 445-450 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability

Kuismanen, S. A., Moisio, A. L., Schweizer, P., Truninger, K., Salovaara, R., Arola, J., Butzow, R., Jiricny, J., Nyström-Lahti, M. & Peltomäki, P., 2002, In : The American Journal of Pathology. 160, p. 1953-1958 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Functional analysis of MLH1 mutations linked to hereditary non-polyposis colon cancer

Nyström-Lahti M, Perrera C, Räschle M, Panyushkina-Seiler E, Marra G, Curci A, Quaresima B, Costanzo F, D’Urso M, Venuta S, Jiricny J, 2002, In : Genes, Chromosomes & Cancer. 33, p. 160-167

Research output: Contribution to journalArticleScientificpeer-review

Functional analysis of MSH6 mutations linked to kindreds with putative hereditary non-polyposis colorectal cancer syndrome

Kariola R, Raevaara TE, Lönnqvist KE, Nyström-Lahti M, 2002, In : Human Molecular Genetics. 11, p. 1303-1310

Research output: Contribution to journalArticleScientificpeer-review

PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers

Zhou, X. P., Loukola, A., Salovaara, R., Nyström-Lahti, M., Peltomäki, P., de la Chapelle, A., Aaltonen, L. A. & Eng, C., 2002, In : The American Journal of Pathology. 161, 2, p. 439-447 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2001

Lack of MSH2 and MSH6 characterizes endometrial but not colon carsinomas in hereditary nonpolyposis colorectal cancer

Schweizer P, Moisio A-L, Kuismanen SA, Truninger K, Vierumäki R, Salovaara R, Arola J, Butzow R, Jiricny J, Peltomäki P, Nyström-Lahti M, 2001, In : Cancer Research. 61, p. 2813-2815

Research output: Contribution to journalArticleScientificpeer-review

Tolerance of human MSH2+/- lymphoblastoid cells to the methylating agent temozolomide

Marra G, D’Atri S, Corti C, Bonmassar L, Cattaruzza MS, Schweizer P, Heinimann K, Bartosova Z, Nyström-Lahti M, Jiricny J, 2001, In : Proceedings of the Academy of Natural Sciences of Philadelphia. 98, p. 7164-7169

Research output: Contribution to journalArticleScientificpeer-review

2000

Predictive genetic testing for hereditary non-polyposis colorectal cancer: uptake and long-term satisfaction

Aktan-Collan, K., Mecklin, J. P., Järvinen, H., Nyström-Lahti, M., Peltomäki, P., Soderling, I., Uutela, A., de la Chapelle, A. & Kääriäinen, H., 2000, In : International Journal of Cancer Research. 89, p. 44-50 7 p.

Research output: Contribution to journalArticleScientificpeer-review

1999

Epigenetic phenotypes distinguish microsatellite-stable and –unstable colorectal cancers

Kuismanen SA, Holmberg MT, Salovaara R, Schweizer P, Aaltonen LA, de la Chapelle A, Nyström-Lahti M, Peltomäki P, 1999, In : Proceedings of the Academy of Natural Sciences of Philadelphia. 96, p. 12661-12666

Research output: Contribution to journalArticleScientificpeer-review