Photo of Moshe Finel
  • PL 56 (Viikinkaari 5)

    00014

    Finland

1983 …2020

Research output per year

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Personal profile

Curriculum vitae

Short Curriculum vitae

Name:

Finel, Moshe

Title:

Ph.D., Docent

Occupation:

University Researcher, Group leader, Principal Investigator, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Finland

Date and place of birth:

December 19, 1952, Israel

Citizenship:

Finnish and Israeli

Marital status:        

Divorced, 3 children.

 

 

Education:

 

 

Bachelor of Science, The Hebrew University of Jerusalem, Faculty of Agriculture, Rehovot, Israel. Graduation on 29.6.1982.

 

Master of Science, The Feinberg Graduate School of the Weizmann Institute of Science, Section of Life Sciences, Rehovot, Israel. Graduation on 28.11.1983.

 

Ph.D., University of Helsinki, Natural Sciences Faculty, Department of Biochemistry. Graduation on 22.6.1989

 

Post-doctoral training in the Laboratory of Molecular Biology, Medical Research Council, Cambridge, UK. 10.7.1989 - 9.7.1991

 

Positions held:

 

Research Associate, Department of Medical Chemistry, University of Helsinki, 1984 -1989.

 

Researcher (post doc), Laboratory of Molecular Biology, Medical Research Council (MRC), Cambridge, UK, 1989 – 1991.

 

"Young Researcher", the Academy of Finland, Medical Research Council, 1.8.1991 -31.7.1993.

 

Teaching “assistant” (lecturer), University of Helsinki, Department of Medical Chemistry, 1.1.1993 - 31.12.1997 and 1.1.1998 - 31.12.2002.

 

Chief research scientist, DDTC, Faculty of Pharmacy, University of Helsinki, 1.8.2000-31.9.2007. On January 2008 the name of this position was changed to “University Researcher”.

 

“Academy Researcher” 1.10.2007 - 31.7.2008, Group leader, CDR (Centre for Drug Research, the new name of DDTC), Faculty of Pharmacy, University of Helsinki.

 

“University Researcher” and Group leader, CDR, Faculty of Pharmacy, University of Helsinki. 1.8.2008 –31.7.2012.

“University Researcher” and Principal Investigator, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki. 1.8.2012 –present.

 

 

Docent in medical chemistry, University of Helsinki, 6.6.1994.

Established competencies:

 

Professorship in biochemistry, Faculty of Science, University of Helsinki, 1996.

 

Main research activities:

 

M.Sc. Thesis (1984): Isolation and partial characterization of the ATP synthase, CF0-CF1 complex, of the halotolerant alga Dunaliella bardawil. Department of Biochemistry, Weizmann Institute of Science, Rehovot, Israel.

 

Ph.D. Thesis (1989): Oligomeric structure and subunit requirement of proton-translocating cytochrome oxidase. Department of Medical Chemistry, University of Helsinki, Finland.

 

Bacterial respiratory chain terminal oxidases, 1987 - 1994.

 

Structure and function of mitochondrial NADH:ubiquinone oxidoreductase (Complex I), 1989 - 2006.

 

Mitochondrial diseases, 1992 - 2006.

 

Molecular biology of bacterial NADH:quinone oxidoreductases, Complex I (NDH-1) and NDH-2, 1994 - 2006.

 

The human UDP-glucuronosyltransferase enzymes (UGTs) and glucuronidation of drugs, steroids and other xenobiotics and endogenous molecules, 2001- present.

 

Human drug and drug metabolites efflux ABC-transporters, 2010- present.

 

 

Supervised doctoral dissertations

 

Anna Majander (1996), Department of Medical Chemistry, University of Helsinki.

Marko Kervinen (2006), Department of Medical Biochemistry, University of Oulu.

Ingo Bichlmaier (2008), Faculty of Pharmacy, University of Helsinki.

Anne-Sisko Patana (2009) Institute of Biotechnology, University of Helsinki.

Sanna Siissalo (2009) Faculty of Pharmacy, University of Helsinki.

Anna Alonen (2009) Faculty of Pharmacy, University of Helsinki.

Taina Sten (2010) Faculty of Pharmacy, University of Helsinki.

Sanna Kaivosaari (2010) Faculty of Pharmacy, University of Helsinki.

Katriina Itäaho (2011) Faculty of Pharmacy, University of Helsinki.

Anne Soikkeli (2012) Faculty of Pharmacy, University of Helsinki.

Hongbo Zhang (2012) Faculty of Pharmacy, University of Helsinki.

Nenad Manevski (2013) Faculty of Pharmacy, University of Helsinki.

Nina Sneitz (2013) Faculty of Pharmacy, University of Helsinki.

 

Publications:

 

Currently (December 2015) 125 peer-reviewed articles in scientific journals.

   

 

 

Fields of Science

  • 317 Pharmacy
  • Drug Metabolism
  • 118 Biological sciences
  • Biochemistry

International and National Collaboration Publications and projects within past five years.

Publications

Human Efflux Transport of Testosterone, Epitestosterone and Other Androgen Glucuronides

Järvinen, E., Kidron, H. & Finel, M., Mar 2020, In : Journal of Steroid Biochemistry and Molecular Biology. 197, 9 p., 105518.

Research output: Contribution to journalArticleScientificpeer-review

In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs

Juvonen, R. O., Heikkinen, A. T., Kärkkäinen, O., Jehangir, R., Huuskonen, J., Troberg, J., Raunio, H., Pentikäinen, O. T. & Finel, M., 1 Jan 2020, In : European Journal of Pharmaceutical Sciences. 141, 9 p., 105118.

Research output: Contribution to journalArticleScientificpeer-review

A novel pathogenic UGT1A1 variant in a Sudanese child with type 1 Crigler-Najjar syndrome

Elfar, W., Järvinen, E., Weizhen, J. I., Mosorin, J., Sega, A. G., Iuga, A. C., Lobritto, S. J., Konstantino, M., Chan, A., Finel, M. & Lakhani, S. A., 1 Jan 2019, In : Drug Metabolism and Disposition. 47, 1, p. 45-48 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Case report by Toce and co-authors: Have all the reasons for poor morphine glucuronidation been addressed?

Finel, M. & Järvinen, E., Apr 2019, In : British Journal of Clinical Pharmacology. 85, 4, p. 859-860 2 p.

Research output: Contribution to journalLetterScientific

Characterization of human UGT2A3 expression using a prepared specific antibody against UGT2A3

Gotoh-Saito, S., Abe, T., Furukawa, Y., Oda, S., Yokoi, T., Finel, M., Hatakeyama, M., Fukami, T. & Nakajima, M., Aug 2019, In : Drug Metabolism and Pharmacokinetics. 34, 4, p. 280-286 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Projects

Activities

Conjugation workshop 2016, Scientific advisory committee member

Moshe Finel (Attendee)
Jun 2016

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Tong-Yi Dou

Moshe Finel (Host)
Jan 2015Jun 2015

Activity: Hosting a visitor typesAcademic visit at UH

Darja Gramec Skelander

Moshe Finel (Host)
Jun 2013Dec 2013

Activity: Hosting a visitor typesAcademic visit at UH

Useita julkaisuja (Journal)

Moshe Finel (Member of editorial board)
2013 → …

Activity: Publication peer-review and editorial work typesPeer review of manuscripts

Martin Perreault (Pre-examiner of PhD thesis)

Moshe Finel (Pre-examiner)
2012

Activity: Examination typesPre-examiner of doctoral thesis