Nanna Fyhrquist

2024

Exploratory multi-omics analysis reveals host-microbe interactions associated with disease severity in psoriatic skin

Yang, Y., Olah, P., Radai, Z., Maia, G., Salava, A., Salo, V., Barker, J., Lauerma, A., Andersson, B., Homey, B., Fyhrquist, N. & Alenius, H., Jul 2024, In: EBioMedicine. 105, 16 p., 105222.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

Integrative network analysis suggests prioritised drugs for atopic dermatitis

Federico, A., Mobus, L., Al-Abdulraheem, Z., Pavel, A., Fortino, V., del Giudice, G., Alenius, H., Fyhrquist, N. & Greco, D., 16 Jan 2024, In: Journal of Translational Medicine. 22, 1, 13 p., 64.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Network analysis reveals age- and virus-specific circuits in nasal epithelial cells of extremely premature infants

Wisgrill, L., Martens, A., Kasbauer, R., Eigenschink, M., Pummer, L., Redlberger-Fritz, M., Végvári, Á., Warth, B., Berger, A., Fyhrquist, N. & Alenius, H., 2024, In: Allergy: European Journal of Allergy and Clinical Immunology. 20 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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2023

A short history from Karelia study to biodiversity and public health interventions

Haahtela, T., Alenius, H., Auvinen, P., Fyhrquist, N., von Hertzen, L., Jousilahti, P., Karisola, P., Laatikainen, T., Lehtimäki, J., Paalanen, L., Ruokolainen, L., Saarinen, K., Valovirta, E., Vasankari, T., Vlasoff, T., Erhola, M., Bousquet, J., Vartiainen, E. & Mäkelä, M. J., 14 Mar 2023, In: Frontiers in allergy. 4, 12 p., 1152927.

Research output: Contribution to journal › Review Article › peer-review

Open Access

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Host-microbiome interactions in atopic and allergic diseases

Fyhrquist, N., Werner, P. & Alenius, H., Sept 2023, In: Current opinion in toxicology. 35, 8 p., 100420.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis

Bousquet, J., Melen, E., Haahtela, T., Koppelman, G. H., Togias, A., Valenta, R., Akdis, C. A., Czarlewski, W., Rothenberg, M., Valiulis, A., Wickman, M., Akdis, M., Aguilar, D., Bedbrook, A., Bindslev-Jensen, C., Bosnic-Anticevich, S., Boulet, L. P., Brightling, C. E., Brussino, L., Burte, E., & 230 othersBustamante, M., Canonica, G. W., Cecchi, L., Celedon, J. C., Chaves Loureiro, C., Costa, E., Cruz, A. A., Erhola, M., Gemicioglu, B., Fokkens, W. J., Garcia-Aymerich, J., Guerra, S., Heinrich, J., Ivancevich, J. C., Keil, T., Klimek, L., Kuna, P., Kupczyk, M., Kvedariene, V., Larenas-Linnemann, D. E., Lemonnier, N., Carlsen, K. C. L., Louis, R., Makela, M., Makris, M., Maurer, M., Momas, I., Morais-Almeida, M., Mullol, J., Naclerio, R. N., Nadeau, K., Nadif, R., Niedoszytko, M., Okamoto, Y., Ollert, M., Papadopoulos, N. G., Passalacqua, G., Patella, V., Pawankar, R., Pham-Thi, N., Pfaar, O., Regateiro, F. S., Ring, J., Rouadi, P. W., Samolinski, B., Sastre, J., Savoure, M., Scichilone, N., Shamji, M. H., Sheikh, A., Siroux, V., Sousa-Pinto, B., Standl, M., Sunyer, J., Taborda-Barata, L., Toppila-Salmi, S., Torres, M. J., Tsiligianni, I., Valovirta, E., Vandenplas, O., Ventura, M. T., Weiss, S., Yorgancioglu, A., Zhang, L., Latiff, A. H. A., Aberer, W., Agache, I., Al-Ahmad, M., Alobid, I., Ansotegui, I. J., Arshad, S. H., Asayag, E., Barbara, C., Baharudin, A., Battur, L., Bennoor, K. S., Berghea, E. C., Bergmann, K. C., Bernstein, D., Bewick, M., Blain, H., Bonini, M., Braido, F., Buhl, R., Bumbacea, R. S., Bush, A., Calderon, M., Calvo-Gil, M., Camargos, P., Caraballo, L., Cardona, V., Carr, W., Carreiro-Martins, P., Casale, T., Cepeda Sarabia, A. M., Chandrasekharan, R., Charpin, D., Chen, Y. Z., Cherrez-Ojeda, I., Chivato, T., Chkhartishvili, E., Christoff, G., Chu, D. K., Cingi, C., Correia de Sousa, J., Corrigan, C., Custovic, A., D'Amato, G., Del Giacco, S., De Blay, F., Devillier, P., Didier, A., do Ceu Teixeira, M., Dokic, D., Douagui, H., Doulaptsi, M., Durham, S., Dykewicz, M., Eiwegger, T., El-Sayed, Z. A., Emuzyte, R., Fiocchi, A., Fyhrquist, N., Gomez, R. M., Gotua, M., Guzman, M. A., Hagemann, J., Hamamah, S., Halken, S., Halpin, D. M. G., Hofmann, M., Hossny, E., Hrubisko, M., Irani, C., Ispayeva, Z., Jares, E., Jartti, T., Jassem, E., Julge, K., Just, J., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Kardas, P., Kirenga, B., Kraxner, H., Kull, I., Kulus, M., La Grutta, S., Lau, S., Thi, L. L. T., Levin, M., Lipworth, B., Lourenco, O., Mahboub, B., Martinez-Infante, E., Matricardi, P., Miculinic, N., Migueres, N., Mihaltan, F., Mohammad, Y., Moniuszko, M., Montefort, S., Neffen, H., Nekam, K., Nunes, E., Tshipukane, D. N., O'Hehir, R., Ogulur, I., Ohta, K., Okubo, K., Ouedraogo, S., Olze, H., Pali-Schoell, I., Palomares, O., Palosuo, K., Panaitescu, C., Panzner, P., Park, H. S., Pitsios, C., Plavec, D., Popov, T. A., Puggioni, F., Quirce, S., Recto, M., Repka-Ramirez, M. S., Robalo Cordeiro, C., Roche, N., Rodriguez-Gonzalez, M., Romantowski, J., Rosario Filho, N., Rottem, M., Sagara, H., Serpa, F. S., Sayah, Z., Scheire, S., Schmid-Grendelmeier, P., Sisul, J. C., Sole, D., Soto-Martinez, M., Sova, M., Sperl, A., Spranger, O., Stelmach, R., Ulrik, C. S., Thomas, M., To, T., Todo-Bom, A., Tomazic, P. V., Urrutia-Pereira, M., Valentin-Rostan, M., Van Ganse, E., van Hage, M., Vasankari, T., Vichyanond, P., Viegi, G., Wallace, D., Wang, D. Y., Williams, S., Worm, M., Yiallouros, P., Yusuf, O., Zaitoun, F., Zernotti, M., Zidarn, M., Zuberbier, J., Fonseca, J. A., Zuberbier, T. & Anto, J. M., May 2023, In: Allergy : European journal of allergy and clinical immunology. 78, 5, p. 1169-1203 35 p.

Research output: Contribution to journal › Review Article › peer-review

Open Access

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2022

Bet v 1 triggers antiviral-type immune signalling in birch-pollen-allergic individuals

Wisgrill, L., Fyhrquist, N., Ndika, J., Paalanen, L., Berger, A., Laatikainen, T., Karisola, P., Haahtela, T. & Alenius, H., Aug 2022, In: Clinical and Experimental Allergy. 52, 8, p. 929-941 13 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Ihon normaali mikrobikasvusto ja mikrobiomi

Riskumäki, M. E. A. & Fyhrquist, N., 15 Aug 2022, In: Duodecim Terveyskirjasto.

Research output: Contribution to journal › Article › General public

Influence of FLG loss-of-function mutations in host-microbe interactions during atopic skin inflammation

Olah, P., Szlavicz, E., Kuchner, M., Nemmer, J., Zeeuwen, P., Lefevre-Utile, A., Fyhrquist, N., Prast-Nielsen, S., Skoog, T., Serra, A., Rodriguez, E., Raap, U., Meller, S., Gyulai, R., Hupe, P., Kere, J., Levi-Schaffer, F., Tsoka, S., Alexander, H., Nestle, F. O., & 11 othersSchroeder, J. M., Weidinger, S., van den Bogaard, E., Soumelis, V., Greco, D., Barker, J., Lauerma, A., Ranki, A., Andersson, B., Alenius, H. & Homey, B., Jun 2022, In: Journal of Dermatological Science. 106, 3, p. 132-140 9 p.

Research output: Contribution to journal › Article › Scientific › peer-review

2021

A Randomized, Open-Label Trial of Hen's Egg Oral Immunotherapy: Efficacy and Humoral Immune Responses in 50 Children

Palosuo, K., Karisola, P., Savinko, T., Fyhrquist, N., Alenius, H. & Mäkelä, M. J., May 2021, In: Journal of allergy and clinical immunology: In practice. 9, 5, p. 1892-+ 11 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Identification of novel miRNA-mRNA regulatory networks in contact dermatitis by integrated microarray analysis

Werner, P., Wisgrill, L., Riskumäki, M., Jalonen, E., Vendelin, J., Suomela, S., Lauerma, A., Alenius, H. & Fyhrquist, N., Apr 2021, In: Allergy : European journal of allergy and clinical immunology. 76, 4, p. 1257-1261 5 p.

Research output: Contribution to journal › Letter › Scientific

Open Access

Ihon mikrobiomi ja atooppiset taudit

Fyhrquist, N., 2021, In: Duodecim. 137, 23, p. 2553-2559 7 p.

Research output: Contribution to journal › Review Article › peer-review

Open Access

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Immunological resilience and biodiversity for prevention of allergic diseases and asthma

Haahtela, T., Alenius, H., Lehtimäki, J., Sinkkonen, A., Fyhrquist, N., Hyöty, H., Ruokolainen, L. & Mäkelä, M. J., Dec 2021, In: Allergy : European journal of allergy and clinical immunology. 76, 12, p. 3613-3626 14 p.

Research output: Contribution to journal › Review Article › peer-review

Open Access

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Integrative transcriptome analysis deciphers mechanisms of nickel contact dermatitis

Wisgrill, L., Werner, P., Jalonen, E., Berger, A., Lauerma, A., Alenius, H. & Fyhrquist, N., 2021, In: Allergy : European journal of allergy and clinical immunology. 76, 3, p. 804-815 12 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Integrative Transcriptomics Reveals Activation of Innate Immune Responses and Inhibition of Inflammation During Oral Immunotherapy for Egg Allergy in Children

Karisola, P., Palosuo, K., Hinkkanen, V., Wisgrill, L., Savinko, T., Fyhrquist, N., Alenius, H. & Mäkelä, M. J., 15 Dec 2021, In: Frontiers in Immunology. 12, 12 p., 704633.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Interplay between skin microbiota and immunity in atopic individuals

Riskumäki, M., Tessas, I., Ottman, N., Suomalainen, A., Werner, P., Karisola, P., Lauerma, A., Ruokolainen, L., Karkman, A., Wisgrill, L., Sinkko, H., Lehtimäki, J., Alenius, H. & Fyhrquist, N., Apr 2021, In: Allergy: European Journal of Allergy and Clinical Immunology. 76, 4, p. 1280-1284 5 p.

Research output: Contribution to journal › Letter › Scientific

Open Access

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Microbial and transcriptional differences elucidate atopic dermatitis heterogeneity across skin sites

Ottman, N., Barrientos-Somarribas, M., Fyhrquist, N., Alexander, H., Wisgrill, L., Olah, P., Tsoka, S., Greco, D., Levi-Schaffer, F., Soumelis, V., Schroeder, J. M., Kere, J., Nestle, F. O., Barker, J., Ranki, A., Lauerma, A., Homey, B., Andersson, B. & Alenius, H., Apr 2021, In: Allergy : European journal of allergy and clinical immunology. 76, 4, p. 1173-1187 15 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Shared DNA methylation signatures in childhood allergy: The MeDALL study

BIOS Consortium, Xu, C-J., Gruzieva, O., Qi, C., Fyhrquist, N., Haahtela, T. & Koppelman, G. H., Mar 2021, In: Journal of Allergy and Clinical Immunology. 147, 3, p. 1031-1040 10 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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2020

Immune-microbiota interaction in Finnish and Russian Karelia young people with high and low allergy prevalence

Ruokolainen, L., Fyhrquist, N., Laatikainen, T., Auvinen, P., Fortino, V., Scala, G., Jousilahti, P., Karisola, P., Vendelin, J., Karkman, A., Markelova, O., Mäkelä, M. J., Lehtimäki, S., Ndika, J., Ottman, N., Paalanen, L., Paulin, L., Vartiainen, E., von Hertzen, L., Greco, D., & 2 othersHaahtela, T. & Alenius, H., Oct 2020, In: Clinical and Experimental Allergy. 50, 10, p. 1148-1158 11 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis

Fortino, V., Wisgrill, L., Werner, P., Suomela, S., Linder, N., Jalonen, E., Suomalainen, A., Marwah, V., Kero, M., Pesonen, M., Lundin, J., Lauerma, A., Aalto-Korte, K., Greco, D., Alenius, H. & Fyhrquist, N., 29 Dec 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 52, p. 33474-33485 12 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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2019

An optimized, robust and reproducible protocol to generate well-differentiated primary nasal epithelial models from extremely premature infants

Martens, A., Amann, G., Schmidt, K., Gaupmann, R., Boehm, B., Dehlink, E., Szepfalusi, Z., Foerster-Waldl, E., Berger, A., Fyhrquist, N., Alenius, H. & Wisgrill, L., 27 Dec 2019, In: Scientific Reports. 9, 10 p., 20069.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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CD300a expression is modulated in atopic dermatitis and could influence the inflammatory response

Karra, L., Gangwar, R. S., Puzzovio, P. G., Fyhrquist, N., Minai-Fleminger, Y., Landolina, N., Simon, H-U., Alenius, H., Leibovici, V., Simon, D. & Levi-Schaffer, F., Jul 2019, In: Allergy : European journal of allergy and clinical immunology. 74, 7, p. 1377-1380 4 p.

Research output: Contribution to journal › Letter › Scientific

Cutavirus DNA in Malignant and Nonmalignant Skin of Cutaneous T-Cell Lymphoma and Organ Transplant Patients but Not of Healthy Adults

Väisänen, E., Fu, Y., Koskenmies, S., Fyhrquist, N., Wang, Y., Keinonen, A., Mäkisalo, H., Väkevä, L., Pitkänen, S., Ranki, A., Hedman, K. & Söderlund-Venermo, M., 1 Jun 2019, In: Clinical Infectious Diseases. 68, 11, p. 1904-1910 7 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Microbe-host interplay in atopic dermatitis and psoriasis

Fyhrquist, N., Muirhead, G., Prast-Nielsen, S., Jeanmougin, M., Olah, P., Skoog, T., Jules-Clement, G., Feld, M., Barrientos-Somarribas, M., Sinkko, H., van den Bogaard, E. H., Zeeuwen, P. L. J. M., Rikken, G., Schalkwijk, J., Niehues, H., Däubener, W., Eller, S. K., Alexander, H., Pennino, D., Suomela, S., & 27 othersTessas, I., Lybeck, E., Baran, A. M., Darban, H., Gangwar, R. S., Gerstel, U., Jahn, K., Karisola, P., Yan, L., Hansmann, B., Katayama, S., Meller, S., Bylesjo, M., Hupe, P., Levi-Schaffer, F., Greco, D., Ranki, A., Schröder, J. M., Barker, J., Kere, J., Tsoka, S., Lauerma, A., Soumelis, V., Nestle, F. O., Homey, B., Andersson, B. & Alenius, H., 16 Oct 2019, In: Nature Communications. 10, 15 p., 4703.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Occurrence of newly discovered human polyomaviruses in skin of liver transplant recipients and their relation with squamous cell carcinoma in situ and actinic keratosis - a single-center cohort study

Wang, Y., Keinonen, A., Koskenmies, S., Pitkänen, S., Fyhrquist, N., Sadeghi, M., Mäkisalo, H., Söderlund-Venermo, M. & Hedman, K., May 2019, In: Transplant International. 32, 5, p. 516-522 7 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Soil exposure modifies the gut microbiota and supports immune tolerance in a mouse model

Ottman, N., Ruokolainen, L., Suomalainen, A., Sinkko, H., Karisola, P., Lehtimaki, J., Lehto, M., Hanski, I., Alenius, H. & Fyhrquist, N., Mar 2019, In: Journal of Allergy and Clinical Immunology. 143, 3, p. 1198-1206.e12 21 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Tape-stripping alters the microbe-host correlations in mouse skin

Karisola, P., Suomalainen, A., Fortino, V., Ottman, N., Vendelin, J., Wolff, H. J., Ruokolainen, L., Greco, D., Fyhrquist, N. & Alenius, H., Mar 2019, In: Allergy : European journal of allergy and clinical immunology. 74, 3, p. 617-621 5 p.

Research output: Contribution to journal › Letter › Scientific

The Human Microbiota and Its Relationship with Allergies

Fyhrquist, N., Sept 2019, In: Gastroenterology Clinics of North America. 48, 3, p. 377-+ 13 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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The role of soil exposure in asthma prevention during neonatal period Reply

Ottman, N. & Fyhrquist, N., Oct 2019, In: Journal of Allergy and Clinical Immunology. 144, 4, p. 1139-1140 3 p.

Research output: Contribution to journal › Letter › Scientific

Open Access

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2018

DNA methylation in childhood asthma: an epigenome-wide meta-analysis

Xu, C-J., Soderhall, C., Bustamante, M., Baiz, N., Gruzieva, O., Gehring, U., Mason, D., Chatzi, L., Basterrechea, M., Llop, S., Torrent, M., Forastiere, F., Fantini, M. P., Carlsen, K. C. L., Haahtela, T., Morin, A., Kerkhof, M., Merid, S. K., van Rijkom, B., Jankipersadsing, S. A., & 30 othersBonder, M. J., Ballereau, S., Vermeulen, C. J., Aguirre-Gamboa, R., de Jongste, J. C., Smit, H. A., Kumar, A., Pershagen, G., Guerra, S., Garcia-Aymerich, J., Greco, D., Reinius, L., McEachan, R. R. C., Azad, R., Hovland, V., Mowinckel, P., Alenius, H., Fyhrquist, N., Lemonnier, N., Pellet, J., Auffray, C., van der Vlies, P., van Diemen, C. C., Li, Y., Wijmenga, C., Netea, M. G., Moffatt, M. F., Cookson, W. O. C. M., Anto, J. M. & Kere, J., May 2018, In: The Lancet respiratory medicine. 6, 5, p. 379-388 10 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Isotretinoin and lymecycline treatments modify the skin microbiota in acne

Kelhala, H-L., Aho, V. T. E., Fyhrquist, N., Pereira, P. A. B., Kubin, M. E., Paulin, L., Palatsi, R., Auvinen, P., Tasanen, K. & Lauerma, A., Jan 2018, In: Experimental Dermatology. 27, 1, p. 30-36 7 p.

Research output: Contribution to journal › Article › Scientific › peer-review

2017

Epithelial proteome profiling suggests the essential role of interferon-inducible proteins in patients with allergic rhinitis

Ndika, J., Airaksinen, L., Suojalehto, H., Karisola, P., Fyhrquist, N., Puustinen, A. & Alenius, H., Nov 2017, In: Journal of Allergy and Clinical Immunology. 140, 5, p. 1288-1298 11 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation

Nurmi, K., Kareinen, I., Virkanen, J., Rajamaki, K., Kouri, V-P., Vaali, K., Levonen, A-L., Fyhrquist, N., Matikainen, S., Kovanen, P. T. & Eklund, K. K., 2017, In: Journal of innate immunity. 9, 1, p. 65-82 18 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Holistic view on health: two protective layers of biodiversity

Ruokolainen, L., Lehtimaki, J., Karkman, A., Haahtela, T., von Hertzen, L. & Fyhrquist, N., Apr 2017, In: Annales Zoologici Fennici. 54, 1-4, p. 39-49 11 p.

Research output: Contribution to journal › Review Article › peer-review

Open Access

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Significant disparities in allergy prevalence and microbiota between the young people in Finnish and Russian Karelia

Ruokolainen, L., Paalanen, L., Karkman, A., Laatikainen, T., von Hertzen, L., Vlasoff, T., Markelova, O., Masyuk, V., Auvinen, P., Paulin, L., Alenius, H., Fyhrquist, N., Hanski, I., Mäkelä, M., Zilber, E., Jousilahti, P., Vartiainen, E. & Haahtela, T., May 2017, In: Clinical and Experimental Allergy. 47, 5, p. 665-674 10 p.

Research output: Contribution to journal › Article › Scientific › peer-review