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Niina Sandholm

DSc(tech), Docent

20102019
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Publications 2010 2019

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2019

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

Ahluwalia, T. S., Schulz, C-A., Waage, J., Skaaby, T., Sandholm, N., van Zuydam, N., Charmet, R., Bork-Jensen, J., Almgren, P., Thuesen, B. H., Bedin, M., Brandslund, I., Christensen, C. K., Linneberg, A., Ahlqvist, E., Groop, P-H., Hadjadj, S., Tregouet, D-A., Jorgensen, M. E., Grarup, N. & 9 othersPedersen, O., Simons, M., Groop, L., Orho-Melander, M., McCarthy, M. I., Melander, O., Rossing, P., Kilpeläinen, T. O. & Hansen, T., Feb 2019, In : Diabetologia. 62, 2, p. 292-305 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Biomarker panels associated with progression of renal disease in type 1 diabetes

Finndiane Study Grp, SDRN Type 1 Bioresource Collabora, Colombo, M., Valo, E., Sandholm, N., Groop, P-H., Forsblom, C. & Colhoun, H. M., Sep 2019, In : Diabetologia. 62, 9, p. 1616-1627 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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CACNB2 Is a Novel Susceptibility Gene for Diabetic Retinopathy in Type 1 Diabetes

FinnDiane Study, Vuori, N., Sandholm, N., Kumar, A., Hietala, K., Syreeni, A., Forsblom, C., Juuti-Uusitalo, K., Skottman, H., Imamura, M., Maeda, S., Summanen, P. A., Lehto, M. & Groop, P-H., Nov 2019, In : Diabetes. 68, 11, p. 2165-2174 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Genetic Determinants of Glycated Hemoglobin in Type 1 Diabetes

DCCT EDIC Res Grp, Finndiane Study Grp, Syreeni, A., Sandholm, N., Cao, J., Toppila, I., Maahs, D. M., Rewers, M. J., Snell-Bergeon, J. K., Costacou, T., Orchard, T. J., Caramori, M. L., Mauer, M., Klein, B. E. K., Klein, R., Valo, E., Parkkonen, M., Forsblom, C., Harjutsalo, V., Paterson, A. D. & 1 othersGroop, P-H., 1 Apr 2019, In : Diabetes. 68, 4, p. 858-867 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic risk score predicts risk for overweight and obesity in Finnish preadolescents

Viljakainen, H., Dahlström, E., Figueiredo, R., Sandholm, N., Rounge, T. B. & Weiderpass, E., 9 Oct 2019, In : Clinical Obesity. 0, 0, e12342.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

Family Invest Nephropathy Diabet-E, DCCT EDIC Res Grp, Pollack, S., Groop, L., Toppila, I., Sandholm, N., Groop, P-H. & Sobrin, L., 1 Feb 2019, In : Diabetes. 68, 2, p. 441-456 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Soluble receptor for AGE in diabetic nephropathy and its progression in Finnish individuals with type 1 diabetes

Finndiane Study Grp, Waden, J. M., Dahlström, E. H., Elonen, N., Thorn, L. M., Waden, J., Sandholm, N., Forsblom, C. & Groop, P-H., Jul 2019, In : Diabetologia. 62, 7, p. 1268-1274 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Variations in Risk of End-Stage Renal Disease and Risk of Mortality in an International Study of Patients With Type 1 Diabetes and Advanced Nephropathy

Skupien, J., Smiles, A. M., Valo, E., Ahluwalia, T. S., Gyorgy, B., Sandholm, N., Croall, S., Lajer, M., McDonnell, K., Forsblom, C., Harjutsalo, V., Marre, M., Galecki, A. T., Tregouet, D-A., Wu, C. Y., Mychaleckyj, J. C., Nickerson, H., Pragnell, M., Rich, S. S., Pezzolesi, M. G. & 4 othersHadjadj, S., Rossing, P., Groop, P-H. & Krolewski, A. S., 1 Jan 2019, In : Diabetes Care. 42, 1, p. 93-101 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

van Zuydam, N. R., Ahlqvist, E., Sandholm, N., Deshmukh, H., Rayner, N. W., Abdalla, M., Ladenvall, C., Ziemek, D., Fauman, E., Robertson, N. R., McKeigue, P. M., Valo, E., Forsblom, C., Harjutsalo, V., Perna, A., Rurali, E., Marcovecchio, M. L., Igo, R. P., Salem, R. M., Perico, N. & 30 othersLajer, M., Karajamak, A., Imamura, M., Kubo, M., Takahashi, A., Sim, X., Liu, J., van Dam, R. M., Jiang, G., Tam, C. H. T., Luk, A. O. Y., Lee, H. M., Lim, C. K. P., Szeto, C. C., So, W. Y., Chan, J. C. N., Ang, S. F., Dorajoo, R., Wang, L., Clara, T. S. H., McKnight, A-J., Duffy, S., Pezzolesi, M. G., Marre, M., Gyorgy, B., Hadjadj, S., Hiraki, L. T., Tuomi, T., Groop, P-H. & Groop, L. C., Jul 2018, In : Diabetes. 67, 7, p. 1414-1427 14 p.

Research output: Contribution to journalArticleScientificpeer-review

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A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes

Surrogate Markers Micro-Macro-Vasc, Nov 2018, In : Acta Ophthalmologica. 96, 7, p. E811-E819 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Confirmation of GLRA3 as a susceptibility locus for albuminuria in Finnish patients with type 1 diabetes

Sandholm, N., Haukka, J. K., Toppila, I., Valo, E., Harjutsalo, V., Forsblom, C. & Groop, P-H., 17 Aug 2018, In : Scientific Reports. 8, 8 p., 12408.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Genetic basis of diabetic kidney disease and other diabetic complications

Sandholm, N. & Groop, P-H., 2018, In : Current Opinion in Genetics & Development. 50, p. 17-24 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Metabolomic Profile Predicts Development of Microalbuminuria in Individuals with Type 1 Diabetes

Haukka, J. K., Sandholm, N., Forsblom, C., Cobb, J. E., Groop, P-H. & Ferrannini, E., 14 Sep 2018, In : Scientific Reports. 8, 10 p., 13853.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Association study reveals novel risk loci for sporadic inclusion body myositis

Johari, M., Arumilli, M., Palmio, J., Savarese, M., Tasca, G., Mirabella, M., Sandholm, N., Lohi, H., Hackman, P. & Udd, B., Apr 2017, In : European Journal of Neurology. 24, 4, p. 572-577 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study

Parsa, A., Kanetsky, P. A., Xiao, R., Gupta, J., Mitra, N., Limou, S., Xie, D., Xu, H., Anderson, A. H., Ojo, A., Kusek, J. W., Lora, C. M., Hamm, L. L., He, J., Sandholm, N., Jeff, J., Raj, D. E., Boeger, C. A., Bottinger, E., Salimi, S. & 12 othersParekh, R. S., Adler, S. G., Langefeld, C. D., Bowden, D. W., Forsblom, C., Freedman, B. I., Lipkowitz, M., Fox, C. S., Winkler, C. A., Feldman, H. I., FIND Consortium & Chronic Renal Insufficiency Cohort, Mar 2017, In : Journal of the American Society of Nephrology. 28, 3, p. 923-934 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

The Genetic Landscape of Renal Complications in Type 1 Diabetes

Sandholm, N., Van Zuydam, N., Ahlqvist, E., Juliusdottir, T., Deshmukh, H. A., Rayner, N. W., Di Camillo, B., Forsblom, C., Fadista, J., Ziemek, D., Salem, R. M., Hiraki, L. T., Pezzolesi, M., Tregouet, D., Dahlstrom, E., Valo, E., Oskolkov, N., Ladenvall, C., Marcovecchio, M. L., Cooper, J. & 32 othersSambo, F., Malovini, A., Manfrini, M., McKnight, A. J., Lajer, M., Harjutsalo, V., Gordin, D., Parkkonen, M., Tuomilehto, J., Lyssenko, V., McKeigue, P. M., Rich, S. S., Brosnan, M. J., Fauman, E., Bellazzi, R., Rossing, P., Hadjadj, S., Krolewski, A., Paterson, A. D., Florez, J. C., Hirschhorn, J. N., Maxwell, A. P., Dunger, D., Cobelli, C., Colhoun, H. M., Groop, L., McCarthy, M. I., Groop, P-H., FinnDiane Study Grp, DCCT EDIC Study Grp, GENIE Consortium & SUMMIT Consortium, Feb 2017, In : Journal of the American Society of Nephrology. 28, 2, p. 557-574 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

The serum uric acid concentration is not causally linked to diabetic nephropathy in type 1 diabetes

Ahola, A. J., Sandholm, N., Forsblom, C., Harjutsalo, V., Dahlstrom, E., Groop, P-H. & FinnDiane Study Grp, May 2017, In : Kidney International. 91, 5, p. 1178-1185 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Association study reveals novel genetic risk factors associated with sporadic inclusion body myositis

Johan, M., Arumilli, M., Sandholm, N., Lohi, H., Hackman, P. & Udd, B., Oct 2016, In : Neuromuscular Disorders. 26, p. S162-S162 1 p.

Research output: Contribution to journalArticleScientificpeer-review

The impact of smoking on the effect of the rs4972593 genetic variant on end-stage renal disease

Feodoroff, M., Harjutsalo, V., Forsblom, C., Sandholm, N., Groop, P. -H. & FinnDiane Study Grp, Sep 2016, In : Diabetic Medicine. 33, 9, p. 1301-1303 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Tiedonlouhinta ja muut uudet tutkimusmenetelmät avaavat diabeettisen munuaistaudin mekanismeja

Sandholm, N., 2016, In : Diabetes ja lääkäri. 45, 5, p. 25-29 5 p.

Research output: Contribution to journalArticleProfessional

Variation in SLC19A3 and Protection From Microvascular Damage in Type 1 Diabetes

Porta, M., Toppila, I., Sandholm, N., Hosseini, S. M., Forsblom, C., Hietala, K., Borio, L., Harjutsalo, V., Klein, B. E., Klein, R., Paterson, A. D., Groop, P-H., DCCT EDIC Res Grp & FinnDiane Study Grp, Apr 2016, In : Diabetes. 65, 4, p. 1022-1030 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Genetic Evidence for a Causal Role of Obesity in Diabetic Kidney Disease

Todd, J. N., Dahlstrom, E. H., Salem, R. M., Sandholm, N., Forsblom, C., McKnight, A. J., Maxwel, A. P., Brennan, E., Sadlier, D., Godson, C., Groop, P-H., Hirschhorn, J. N., Florez, J. C. & FinnDiane Study Group, Dec 2015, In : Diabetes. 64, 12, p. 4238-4246 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic risk factors affecting mitochondrial function are associated with kidney disease in people with Type 1 diabetes

Swan, E. J., Salem, R. M., Sandholm, N., Tarnow, L., Rossing, P., Lajer, M., Groop, P. H., Maxwell, A. P., McKnight, A. J. & GENIE Consortium, Aug 2015, In : Diabetic Medicine. 32, 8, p. 1104-1109 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic studies of body mass index yield new insights for obesity biology

Locke, A. E., Kahali, B., Berndt, S. I., Justice, A. E., Pers, T. H., Day, F. R., Powell, C., Vedantam, S., Buchkovich, M. L., Yang, J., Croteau-Chonka, D. C., Esko, T., Fall, T., Ferreira, T., Gustafsson, S., Kutalik, Z., Luan, J., Maegi, R., Randall, J. C., Winkler, T. W. & 44 othersWood, A. R., Workalemahu, T., Faul, J. D., Smith, J. A., Zhao, J. H., Zhao, W., Chen, J., Fehrmann, R., Hedman, A. K., Karjalainen, J., Schmidt, E. M., Absher, D., Amin, N., Anderson, D., Beekman, M., Bolton, J. L., Bragg-Gresham, L., Eklund, N., Koskenvuo, M., Sandholm, N., Eriksson, J. G., Jousilahti, P., Kaprio, J., Sinisalo, J., Groop, L. C., Kivimaki, M., Perola, M., Tuomilehto, J., LifeLines Cohort Study, ADIPOGen Consortium, AGEN-BMI Working Grp, CARDIOGRAMplusC4D Consortium, CKDGen Consortium, GLGC, ICBP, MAGIC Investigators, MuTHER Consortium, MIGen Consortium, PAGE Consortium, ReproGen Consortium, GENIE Consortium, Int Endogene Consortium, Lokki, M-L. & Ripatti, S. O., 12 Feb 2015, In : Nature. 518, 7538, p. 197-U401 23 p.

Research output: Contribution to journalArticleScientificpeer-review

Kidney Injury Molecule-1 and the Loss of Kidney Function in Diabetic Nephropathy: A Likely Causal Link in Patients With Type 1 Diabetes

Panduru, N. M., Sandholm, N., Forsblom, C., Saraheimo, M., Dahlstrom, E. H., Thorn, L. M., Gordin, D., Tolonen, N., Waden, J., Harjutsalo, V., Bierhaus, A., Humpert, P. M., Groop, P-H. & FinnDiane Study Grp, Jun 2015, In : Diabetes Care. 38, 6, p. 1130-1137 8 p.

Research output: Contribution to journalArticleScientificpeer-review

New genetic loci link adipose and insulin biology to body fat distribution

Shungin, D., Winkler, T. W., Croteau-Chonka, D. C., Ferreira, T., Lockes, A. E., Maegi, R., Strawbridge, R. J., Pers, T. H., Fischer, K., Justice, A. E., Workalemahu, T., Wu, J. M. W., Buchkovich, M. L., Heard-Costa, N. L., Roman, T. S., Drong, A. W., Song, C., Gustafsson, S., Day, F. R., Esko, T. & 401 othersFall, T., Kutalik, Z., Luan, J., Randall, J. C., Scherag, A., Vedantam, S., Wood, A. R., Chen, J., Fehrmann, R., Karjalainen, J., Kahali, B., Liu, C-T., Schmidt, E. M., Absher, D., Amin, N., Anderson, D., Beekman, M., Bragg-Gresham, J. L., Buyske, S., Demirkan, A., Ehret, G. B., Feitosa, M. F., Goel, A., Jackson, A. U., Johnson, T., Kleber, M. E., Kristiansson, K., Mangino, M., Leach, I. M., Medina-Gomez, C., Palmer, C. D., Pasko, D., Pechlivaniss, S., Peters, M. J., Prokopenko, I., Stancakova, A., Sung, Y. J., Tanakam, T., Teumer, A., Van Vliet-Ostaptchouk, J. V., Yengo, L., Zhang, W., Albrecht, E., Arnlov, J., Arscott, G. M., Bandinelli, S., Barrett, A., Bellis, C., Bennett, A. J., Berne, C., Blueher, M., Buhringer, S., Bonnet, F., Boettcher, Y., Bruinenberg, M., Carba, D. B., Caspersen, I. H., Clarke, R., Daw, E. W., Deelen, J., Deelman, E., Delgado, G., Doney, A. S. F., Eklund, N., Erdos, M. R., Estrada, K., Eury, E., Friedrichs, N., Garcia, M. E., Giedraitis, V., Gigante, B., Go, A. S., Golay, A., Grallert, H., Grammer, T. B., Graessler, J., Grewal, J., Groves, C. J., Haller, T., Hallmans, G., Hartman, C. A., Hassinen, M., Hayward, C., Heikkila, K., Herzig, K-H., Helmer, Q., Hillege, H. L., Holmen, O., Hunt, S. C., Isaacs, A., Ittermann, T., James, A. L., Johansson, I., Juliusdottir, T., Kalafati, I-P., Kinnunen, L., Koenig, W., Kooner, I. K., Kratzer, W., Lamina, C., Leander, K., Lee, N. R., Lichtner, P., Lind, L., Lindstrom, J., Lobbens, S., Lorentzon, M., Mach, F., Magnusson, P. K. E., Mahajan, A., McArdle, W. L., Menni, C., Merger, S., Mihailov, E., Milani, L., Mills, R., Moayyeri, A., Monda, K. L., Mooijaart, S. P., Muehleisen, T. W., Mulas, A., Mueller, G., Mueller-Nurasyid, M., Nagaraja, R., Nalls, M. A., Narisu, N., Glorioso, N., Nolte, I. M., Olden, M., Rayner, N. W., Renstrom, F., Ried, J. S., Robertson, N. R., Rose, L. M., Sanna, S., Scharnagl, H., Scholtens, S., Sennblad, B., Seufferlein, T., Sitlani, C. M., Smith, A. V., Stirrups, K., Stringham, H. M., Sundstrom, J., Swertz, M. A., Swift, A. J., Syvanen, A-C., Tayo, B. O., Thorand, B., Thorleifsson, G., Tomaschitz, A., Troffa, C., van Oort, F. V. A., Verweij, N., Vonk, J. M., Waite, L. L., Wennauer, R., Wilsgaard, T., Wojczynski, M. K., Wong, A., Zhang, Q., Zhao, J. H., Brennan, E. P., Choi, M., Eriksson, P., Folkersen, L., Franco-Cereceda, A., Gharavi, A. G., Hedman, A. K., Hivert, M-F., Huang, J., Kanoni, S., Karpe, F., Keildson, S., Kiryluk, K., Liang, L., Lifton, R. P., Ma, B., McKnight, A. J., McPherson, R., Metspalu, A., Min, J. L., Moffatt, M. F., Montgomery, G. W., Murabito, J. M., Nicholson, G., Nyholt, D. R., Olsson, C., Perry, J. R. B., Reinmaa, E., Salem, R. M., Sandholm, N., Schadt, E. E., Scott, R. A., Stolk, L., Vallejo, E. E., Westra, H-J., Zondervan, K. T., Amouyel, P., Arveiler, D., Bakker, S. J. L., Beilby, J., Bergman, R. N., Blangero, J., Brown, M. J., Burnier, M., Campbell, H., Chakravarti, A., Chiness, P. S., Claudi-Boehmi, S., Collins, F. S., Crawford, D. C., Danesh, J., de Faire, U., de Geusl, E. J. C., Doerr, M., Erbel, R., Eriksson, J. G., Farrall, M., Ferrannini, E., Ferrieres, J., Forouhi, N. G., Forrester, T., Franco, O. H., Gansevoort, R. T., Gieger, C., Gudnason, V., Haiman, C. A., Harris, T. B., Hattersley, A. T., Heliovaara, M., Hicks, A. A., Hingorani, A. D., Hoffmann, W., Hofman, A., Homuth, G., Humphries, S. E., Hyppoenen, E., Illig, T., Jarvelin, M-R., Johansen, B., Jousilahti, P., Jula, A. M., Kaprio, J., Kee, F., Keinanen-Kiukaanniemi, S. M., Kooner, J. S., Kooperberg, C., Kovacs, P., Kraja, A. T., Kumari, M., Kuulasmaa, K., Kuusisto, J., Lakka, T. A., Langenberg, C., Le Marchand, L., Lehtimaki, T., Lyssenko, V., Mannisto, S., Marette, A., Matise, T. C., McKenzie, C. A., McKnight, B., Musk, A. W., Mohlenkamp, S., Morris, A. D., Nelis, M., Ohlsson, C., Oldehinkel, A. J., Ong, K. K., Palmer, L. J., Penninx, B. W., Peters, A., Pramstaller, P. P., Raitakari, O. T., Rankinen, T., Rao, D. C., Rice, T. K., Ridker, P. M., Ritchie, M. D., Rudan, I., Salomaa, V., Samani, N. J., Saramies, J., Sarzynski, M. A., Schwarz, P. E. H., Shuldiner, A. R., Staessen, J. A., Steinthorsdottir, V., Stolk, R. P., Strauch, K., Toenjes, A., Tremblay, A., Tremoli, E., Vohl, M-C., Voelker, U., Vollenweider, P., Wilson, J. F., Witteman, J. C., Adair, L. S., Bochud, M., Boehm, B. O., Bornstein, S. R., Bouchard, C., Cauchi, S., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Cooper, R. S., Dedoussis, G., Ferrucci, L., Froguel, P., Grabe, H-J., Hamsten, A., Hui, J., Hveem, K., Joeckel, K-H., Kivimaki, M., Kuh, D., Laakso, M., Liu, Y., Maerz, W., Munroe, P. B., Njolstad, I., Oostra, B. A., Palmer, C. N. A., Pedersen, N. L., Perola, M., Perusse, L., Peters, U., Power, C., Quertermous, T., Rauramaa, R., Rivadeneira, F., Saaristo, T. E., Saleheen, D., Sinisalo, J., Slagboom, P. E., Snieder, H., Spector, T. D., Thorsteinsdottir, U. R., Stumvoll, M., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., van der Harst, P., Veronesi, G., Walker, M., Wareham, N. J., Watkins, H., Wichmann, H-E., Abecasis, G. R., Assimes, T. L., Berndt, S. I., Boehnkes, M., Borecki, I. B., Deloukas, P., Franke, L., Frayling, T. M., Groop, L. C., Hunter, D. J., Kaplan, R. C., O'Connell, J. R., Qi, L., Schlessinger, D., Strachan, D. P., Stefansson, K., van Dujin, C. M., Willer, C. J., Visscher, P. M., Yang, J., Hirschhorn, J. N., Zillikens, M. C., McCarthy, M. I., Speliotes, E. K., North, K. E., Fox, C. S., Barroso, I., Franks, P. W., Ingelsson, E., Heid, I. M., Loos, R. J. F., Cupples, L. A., Morris, A. P., Lindgren, C. M., Mohlke, K. L., ADIPOGEN Consortium, CARDIOGRAMplusC4D Consortium, CKDGen Consortium, GEFOS Consortium, GENIE Consortium, GLGC, ICBP, Int Endogene Consortium, LifeLines Cohort Study, MAGIC Investigators, MuTHER Consortium, PAGE Consortium, ReproGen Consortium, Lokki, M-L. & Ripatti, S. O., 12 Feb 2015, In : Nature. 518, 7538, p. 187-U378 22 p.

Research output: Contribution to journalArticleScientificpeer-review

SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes

Germain, M., Pezzolesi, M. G., Sandholm, N., McKnight, A. J., Susztak, K., Lajer, M., Forsblom, C., Marre, M., Parving, H-H., Rossing, P., Toppila, I., Skupien, J., Roussel, R., Ko, Y-A., Ledo, N., Folkersen, L., Civelek, M., Maxwell, A. P., Tregouet, D-A., Groop, P-H. & 2 othersTarnow, L. & Hadjadj, S., Mar 2015, In : Diabetologia. 58, 3, p. 543-548 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

An Excess of Risk-Increasing Low-Frequency Variants Can Be a Signal of Polygenic Inheritance in Complex Diseases

Chan, Y., Lim, E. T., Sandholm, N., Wang, S. R., McKnight, A. J., Ripke, S., Daly, M. J., Neale, B. M., Salem, R. M., Hirschhorn, J. N., DIAGRAM Consortium, GENIE Consortium, GIANT Consortium, IIBDGC Consortium & PGC Consortium, 6 Mar 2014, In : American Journal of Human Genetics. 94, 3, p. 437-452 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Different Lipid Variables Predict Incident Coronary Artery Disease in Patients With Type 1 Diabetes With or Without Diabetic Nephropathy: The FinnDiane Study

Tolonen, N., Forsblom, C., Mäkinen, V-P., Harjutsalo, V., Gordin, D., Feodoroff, M., Sandholm, N., Thorn, L. M., Waden, J., Taskinen, M-R., Groop, P-H. & FinnDiane Study Grp, Aug 2014, In : Diabetes Care. 37, 8, p. 2374-2382 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes

Sandholm, N., Forsblom, C., Makinen, V-P., McKnight, A. J., Osterholm, A-M., He, B., Harjutsalo, V., Lithovius, R., Gordin, D., Parkkonen, M., Saraheimo, M., Thorn, L. M., Tolonen, N., Waden, J., Tuomilehto, J., Lajer, M., Ahlqvist, E., Mollsten, A., Marcovecchio, M. L., Cooper, J. & 10 othersDunger, D., Paterson, A. D., Zerbini, G., Groop, L., Tarnow, L., Maxwell, A. P., Tryggvason, K., Groop, P-H., SUMMIT Consortium & FinnDiane Study Grp, Jun 2014, In : Diabetologia. 57, 6, p. 1143-1153 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification

Sambo, F., Malovini, A., Sandholm, N., Stavarachi, M., Forsblom, C., Maekinen, V-P., Harjutsalo, V., Lithovius, R., Gordin, D., Parkkonen, M., Saraheimo, M., Thorn, L. M., Tolonen, N., Waden, J., He, B., Osterholm, A-M., Tuomilehto, J., Lajer, M., Salem, R. M., McKnight, A. J. & 11 othersTarnow, L., Panduru, N. M., Barbarini, N., Di Camillo, B., Toffolo, G. M., Tryggvason, K., Bellazzi, R., Cobelli, C., Groop, P-H., GENIE Consortium & FinnDiane Study Grp, Aug 2014, In : Diabetologia. 57, 8, p. 1611-1622 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Osteopontin Is a Strong Predictor of Incipient Diabetic Nephropathy, Cardiovascular Disease, and All-Cause Mortality in Patients With Type 1 Diabetes

Gordin, D., Forsblom, C., Panduru, N. M., Thomas, M. C., Bjerre, M., Soro-Paavonen, A., Tolonen, N., Sandholm, N., Flyvbjerg, A., Harjutsalo, V., Groop, P-H. & FinnDiane Study Grp, Sep 2014, In : Diabetes Care. 37, 9, p. 2593-2600 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

CD2AP is associated with end-stage renal disease in patients with type 1 diabetes

Hyvönen, M. E., Ihalmo, P., Sandholm, N., Stavarachi, M., Forsblom, C., McKnight, A. J., Lajer, M., Maestroni, A., Lewis, G., Tarnow, L., Maestroni, S., Zerbini, G., Parving, H-H., Maxwell, A. P., Groop, P-H. & Lehtonen, S., Dec 2013, In : Acta Diabetologica. 50, 6, p. 887-897 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Chromosome 2q31.1 Associates with ESRD in Women with Type 1 Diabetes

Sandholm, N., McKnight, A. J., Salem, R. M., Brennan, E. P., Forsblom, C., Harjutsalo, V., Makinen, V-P., McKay, G. J., Sadlier, D. M., Williams, W. W., Martin, F., Panduru, N. M., Tarnow, L., Tuomilehto, J., Tryggvason, K., Zerbini, G., Comeau, M. E., Langefeld, C. D., Godson, C., Hirschhorn, J. N. & 6 othersMaxwell, A. P., Florez, J. C., Groop, P. H., FIND Consortium, FinnDiane Study Grp & GENIE Consortium, Oct 2013, In : Journal of the American Society of Nephrology. 24, 10, p. 1537-1543 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy

Williams, W. W., Salem, R. M., McKnight, A. J., Sandholm, N., Forsblom, C., Taylor, A., Guiducci, C., McAteer, J. B., McKay, G. J., Isakova, T., Brennan, E. P., Sadlier, D. M., Palmer, C., Soederlund, J., Fagerholm, E., Harjutsalo, V., Lithovius, R., Gordin, T. D., Hietala, K., Kytö, J. & 21 othersParkkonen, M., Rosengard-Barlund, M., Thorn, L., Syreeni, A., Tolonen, N., Saraheimo, M., Waden, J., Pitkäniemi, J. M., Sarti, C., Tuomilehto, J., Tryggvason, K., Osterholm, A-M., He, B., Bain, S., Martin, F., Godson, C., Hirschhorn, J. N., Maxwel, A. P., Groop, P. H., Florez, J. C. & GENIE Consortium, 2012, In : Diabetes. 61, 8, p. 2187-2194 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications

Soro-Paavonen, A., Gordin, T. D., Forsblom, C., Rosengard-Barlund, M., Waden, J., Thorn, L., Sandholm, N., Thomas, M. C., Groop, P. H. & FinnDiane Study Grp, 2012, In : Journal of Hypertension. 30, p. 375-383 9 p.

Research output: Contribution to journalArticleScientificpeer-review

INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy

Hyvonen, M. E., Ihalmo, P., Forsblom, C., Thorn, L., Sandholm, N., Lehtonen, S. & Groop, P. -H., Dec 2012, In : Diabetic Medicine. 29, 12, p. 1589-1595 7 p.

Research output: Contribution to journalArticleScientificpeer-review

New susceptibility loci associated with kidney disease in type 1 diabetes

Sandholm, N., Salem, R. M., McKnight, A. J., Brennan, E. P., Forsblom, C., Isakova, T., McKay, G. J., Williams, W. W., Sadlier, D. M., Mäkinen, V-P., Swan, E. J., Palmer, C., Boright, A. P., Ahlqvist, E., Deshmukh, H. A., Keller, B. J., Huang, H., Ahola, A., Fagerholm, E., Gordin, T. D. & 72 othersHarjutsalo, V., He, B., Heikkilä, O., Hietala, K., Kytö, J., Lahermo, P., Lehto, M., Lithovius, R., Österholm, A-M., Parkkonen, M., Pitkäniemi, J. M., Rosengård-Bärlund, M., Saraheimo, M., Sarti, C., Söderlun, J., Soro-Paavonen, A., Syreeni, A., Thorn, L., Tikkanen, H. O., Tolonen, N. E., Tryggvason, K., Tuomilehto, J., Waden, J., Gill, G. V., Prior, S., Guiducci, C., Mirel, D. B., Taylor, A., Hosseini, S. M., EDIC Research Group, DCCT., Parving, H-H., Rossing, P., Tarnow, L., Ladenvall, C., Alhenc-Gelas, F., Lefebvre, P., Rigalleau, V., Roussel, R., Tregouet, D-A., Maestroni, A., Falhammar, H., Gu, T., Möllsten, A., Cimponeriu, D., Ioana, M., Mota, M., Mota, E., Serafinceanu, C., Stavarachi, M., Hanson, R. L., Nelson, R. G., Kretzler, M., Colhoun, H. M., Panduru, N. M., Gu, H. F., Brismar, K., Zerbini, G., Hadjadj, S., Marre, M., Groop, L., Lajer, M., Bull, S. B., Waggott, D., Paterson, A. D., Savage, D. A., Bain, S. C., Martin, F., Hirschhorn, J. N., Godson, C., Florez, J. C., Groop, P. H. & Maxwell, A. P., 2012, In : PLoS Genetics. 8, 9, p. e1002921 24 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes

Fagerholm, E., Ahlqvist, E., Forsblom, C., Sandholm, N., Syreeni, A., Parkkonen, M., McKnight, A. J., Tarnov, L., Maxwell, A. P., Parving, H. H., Groop, L., Groop, P. H. & FinnDiane Study Group, 2012, In : Diabetologia. 55, 9, p. 2386-2393 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Candidate Gene Association Study for Diabetic Retinopathy in Persons with Type 2 Diabetes: The Candidate Gene Association Resource (CARe)

Sobrin, L., Green, T., Sim, X., Jensen, R. A., Tai, E. S., Tay, W. T., Wang, J. J., Mitchell, P., Sandholm, N., Liu, Y., Hietala, K., Iyengar, S. K., Brooks, M., Buraczynska, M., Van Zuydam, N., Smith, A. V., Gudnason, V., Doney, A. S. F., Morris, A. D., Leese, G. P. & 17 othersPalmer, C. N. A., Swaroop, A., Taylor, H. A., Wilson, J. G., Penman, A., Chen, C. J., Groop, P. H., Saw, S-M., Aung, T., Klein, B. E., Rotter, J. I., Siscovick, D. S., Cotch, M. F., Klein, R., Daly, M. J., Wong, T. Y. & Wellcome Trust Case Control Consor, Family Invest Nephropathy Diabet-E, 2011, In : Investigative Ophthalmology & Visual Science. 52, p. 7593-7602 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic Examination of SETD7 and SUV39H1/H2 Methyltransferases and the Risk of Diabetes Complications in Patients With Type 1 Diabetes

Syreeni, A., El-Osta, A., Forsblom, C., Sandholm, N., Parkkonen, M., Tarnow, L., Parving, H-H., McKnight, A. J., Maxwell, A. P., Cooper, M. E., Groop, P. H. & FinnDiane Study Grp, 2011, In : Diabetes. 60, p. 3073-3080 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Genetic Polymorphisms in Nitric Oxide Synthase 3 Gene and Implications for Kidney Disease: A Meta-Analysis

McKnight, A. J., Patterson, C. C., Sandholm, N., Kilner, J., Buckham, T. A., Parkkonen, M., Forsblom, C., Sadlier, D. M., Groop, P. H., Maxwell, A. P. & Warren 3 UK Gokind Study Grp, 2010, In : American journal of nephrology. 32, p. 476-481 6 p.

Research output: Contribution to journalArticleScientificpeer-review