20142020

Research output per year

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2020

Immune profiles in acute myeloid leukemia bone marrow associate with patient age, T-cell receptor clonality, and survival

Brück, O., Dufva, O., Hohtari, H., Blom, S., Turkki, R., Ilander, M., Kovanen, P., Pallaud, C., Ramos, P. M., Lähteenmäki, H., Välimäki, K., El Missiry, M., Ribeiro, A., Kallioniemi, O., Porkka, K., Pellinen, T. & Mustjoki, S., 28 Jan 2020, In : Blood advances. 4, 2, p. 274-286 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity

Dufva, O., Koski, J., Maliniemi, P., Ianevski, A., Klievink, J., Leitner, J., Pölönen, P., Hohtari, H., Saeed, K., Hannunen, T., Ellonen, P., Steinberger, P., Kankainen, M., Aittokallio, T., Keränen, M. A. I., Korhonen, M. & Mustjoki, S., 27 Feb 2020, In : Blood. 135, 9, p. 597-609 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia

Kuusanmäki, H., Leppä, A-M., Pölönen, P., Kontro, M., Dufva, O., Deb, D., Yadav, B., Bruck, O., Kumar, A., Everaus, H., Gjertsen, B. T., Heinäniemi, M., Porkka, K., Mustjoki, S. & Heckman, C. A., 1 Mar 2020, In : Haematologica. 105, 3, p. 708-720 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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RUNX1mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses

Awad, S. A., Dufva, O., Ianevski, A., Ghimire, B., Koski, J., Maliniemi, P., Thomson, D., Schreiber, A., Heckman, C. A., Koskenvesa, P., Korhonen, M., Porkka, K., Branford, S., Aittokallio, T., Kankainen, M. & Mustjoki, S., 11 Aug 2020, In : Leukemia. 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2019

Data-driven characterization of molecular phenotypes across heterogeneous sample collections

Mehtonen, J., Polonen, P., Häyrynen, S., Dufva, O., Lin, J., Liuksiala, T., Granberg, K., Lohi, O., Hautamäki, V., Nykter, M. & Heinäniemi, M., 26 Jul 2019, In : Nucleic Acids Research. 47, 13, 12 p., 76.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target

Dufva, O., Kankainen, M., Kelkka, T., Sekiguchi, N., Awad, S. A., Eldfors, S., Yadav, B., Kuusanmäki, H., Malani, D., Andersson, E. I., Pietarinen, P., Saikko, L., Kovanen, P. E., Ojala, T., Lee, D. A., Loughran, T. P., Nakazawa, H., Suzumiya, J., Suzuki, R., Ko, Y. H. & 7 others, Kim, W. S., Chuang, S-S., Aittokallio, T., Chan, W. C., Ohshima, K., Ishida, F. & Mustjoki, S., 19 Apr 2018, In : Nature Communications. 9, 12 p., 1567.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling

Andersson, E. I., Pützer, S., Yadav, B., Dufva, O., Khan, S., He, L., Sellner, L., Schrader, A., Crispatzu, G., Oleś, M., Zhang, H., Adnan-Awad, S., Lagström, S., Bellanger, D., Mpindi, J. P., Eldfors, S., Pemovska, T., Pietarinen, P., Lauhio, A., Tomska, K. & 19 others, Cuesta-Mateos, C., Faber, E., Koschmieder, S., Brümmendorf, T. H., Kytölä, S., Savolainen, E-R., Siitonen, T., Ellonen, P., Kallioniemi, O., Wennerberg, K., Ding, W., Stern, M-H., Huber, W., Anders, S., Tang, J., Aittokallio, T., Zenz, T., Herling, M. & Mustjoki, S., Mar 2018, In : Leukemia. 32, 3, p. 774-787 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Genomitieto, funktionaalinen lääketestaus ja koneoppiminen yksilöllisen lääkehoidon työkaluna

Keränen, M., Dufva, O. & Kurki, S., 2018, In : Sic! Lääketietoa Fimeasta. 8, 2, p. 29-30 2 p.

Research output: Contribution to journalArticleProfessional

Open Access
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Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML

Bruck, O., Blom, S., Dufva, O., Turkki, R., Chheda, H., Ribeiro, A., Kovanen, P., Aittokallio, T., Koskenvesa, P., Kallioniemi, O., Porkka, K., Pellinen, T. & Mustjoki, S., Jul 2018, In : Leukemia. 32, 7, p. 1643-1656 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling

Kuusanmäki, H., Dufva, O., Parri, E., van Adrichem, A. J., Rajala, H., Majumder, M. M., Yadav, B., Parsons, A., Chan, W. C., Wennerberg, K., Mustjoki, S. & Heckman, C. A., 14 Nov 2017, In : Oncotarget. 8, 57, p. 97516-97527 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The SCLtTAxBCR-ABL transgenic mouse model closely reflects the differential effects of dasatinib on normal and malignant hematopoiesis in chronic phase-CML patients

Schubert, C., Chatain, N., Braunschweig, T., Schemionek, M., Feldberg, K., Hoffmann, M., Dufva, O., Mustjoki, S., Bruemmendorf, T. H. & Koschmieder, S., 23 May 2017, In : Oncotarget. 8, 21, p. 34736-34749 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2015

Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia

Kampjarvi, K., Jaervinen, T. M., Heikkinen, T., Ruppert, A. S., Senter, L., Hoag, K. W., Dufva, O., Kontro, M., Rassenti, L., Hertlein, E., Kipps, T. J., Porkka, K., Byrd, J. C., de la Chapelle, A. & Vahteristo, P., 30 Jan 2015, In : Oncotarget. 6, 3, p. 1884-1888 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2014

Prox1 Promotes Expansion of the Colorectal Cancer Stem Cell Population to Fuel Tumor Growth and Ischemia Resistance

Wiener, Z., Hogstrom, J., Hyvonen, V., Band, A. M., Kallio, P., Holopainen, T., Dufva, O., Haglund, C., Kruuna, O., Oliver, G., Ben-Neriah, Y. & Alitalo, K., 25 Sep 2014, In : Cell Reports. 8, 6, p. 1943-1956 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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