Research output per year
Research output per year
Personal profile
Fields of Science
- 1182 Biochemistry, cell and molecular biology
International and National Collaboration
Publications and projects within past five years.
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Molecular basis of JAK kinase regulation guiding therapeutic approaches: Evaluating the JAK3 pseudokinase domain as a drug target
Virtanen, A., Kettunen, V., Musta, K., Räkköläinen, V., Knapp, S., Haikarainen, T. & Silvennoinen, O., Jan 2025, In: Advances in Biological Regulation. 95, 11 p., 101072.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity
Miao, Y., Virtanen, A., Zmajkovic, J., Hilpert, M., Skoda, R. C., Silvennoinen, O. & Haikarainen, T., 6 Jun 2024, In: Journal of Medicinal Chemistry. 67, 12, p. 10012–10024 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
JAK inhibitor selectivity: new opportunities, better drugs?
Virtanen, A., Spinelli, F. R., Telliez, J. B., O’Shea, J. J., Silvennoinen, O. & Gadina, M., 2024, In: Nature Reviews Rheumatology. 20, p. 649–665 17 p.Research output: Contribution to journal › Review Article › peer-review
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Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling
Abraham, B. G., Haikarainen, T., Vuorio, J., Girych, M., Virtanen, A. T., Kurttila, A., Karathanasis, C., Heilemann, M., Sharma, V., Vattulainen, I. T. & Silvennoinen, O. J., 8 Mar 2024, In: Science Advances. 10, 10, 15 p., eadl2097.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Development of an enzyme-coupled activity assay for Janus kinase 2 inhibitor screening
Pölläniemi, A., Virtanen, A., Silvennoinen, O. & Haikarainen, T., Jun 2023, In: SLAS discovery . 28, 4, p. 180-187 8 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
Projects
- 2 Active
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Molecular basis of JAK kinase regulation in cytokine siganaling - Towards selective therapies in hematological and inflammatory diseases
Silvennoinen, O. J. (Project manager), Obaji, E. O. (Participant) & Virtanen, A. T. (Participant)
Suomen Akatemia Projektilaskutus
01/09/2024 → 31/08/2028
Project: Research Council of Finland: Academy Project
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Biocenter: FIRI2023: Biocenter Finland
Donner, K. M. (Project manager), Kuure, S. (Project manager) & Silvennoinen, O. J. (Project manager)
01/01/2024 → 31/12/2025
Project: Research Council of Finland: Research infrastructure