Olli Juhani Silvennoinen

Publications

Research output per year 2018 2019 2021 2022 2023 2024 2025

• 16 Article
• 4 Review Article
• 1 Chapter
• 1 Comment/debate

Research output per year

Research output per year

Search results

• 2025

  Molecular basis of JAK kinase regulation guiding therapeutic approaches: Evaluating the JAK3 pseudokinase domain as a drug target

  Virtanen, A., Kettunen, V., Musta, K., Räkköläinen, V., Knapp, S., Haikarainen, T. & Silvennoinen, O., Jan 2025, In: Advances in Biological Regulation. 95, 11 p., 101072.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2024

  Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity

  Miao, Y., Virtanen, A., Zmajkovic, J., Hilpert, M., Skoda, R. C., Silvennoinen, O. & Haikarainen, T., 6 Jun 2024, In: Journal of Medicinal Chemistry. 67, 12, p. 10012–10024 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• JAK inhibitor selectivity: new opportunities, better drugs?

  Virtanen, A., Spinelli, F. R., Telliez, J. B., O’Shea, J. J., Silvennoinen, O. & Gadina, M., 2024, In: Nature Reviews Rheumatology. 20, p. 649–665 17 p.

  Research output: Contribution to journal › Review Article › peer-review

• Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling

  Abraham, B. G., Haikarainen, T., Vuorio, J., Girych, M., Virtanen, A. T., Kurttila, A., Karathanasis, C., Heilemann, M., Sharma, V., Vattulainen, I. T. & Silvennoinen, O. J., 8 Mar 2024, In: Science Advances. 10, 10, 15 p., eadl2097.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2023

  Development of an enzyme-coupled activity assay for Janus kinase 2 inhibitor screening

  Pölläniemi, A., Virtanen, A., Silvennoinen, O. & Haikarainen, T., Jun 2023, In: SLAS discovery . 28, 4, p. 180-187 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Differences in JAK Isoform Selectivity Among Different Types of JAK Inhibitors Evaluated for Rheumatic Diseases Through In Vitro Profiling

  Virtanen, A., Palmroth, M., Liukkonen, S., Kurttila, A., Haikarainen, T., Isomäki, P. & Silvennoinen, O., 2023, In: Arthritis & rheumatology. 75, 11, p. 2054-2061 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain

  Virtanen, A. T., Haikarainen, T., Sampathkumar, P., Palmroth, M., Liukkonen, S., Liu, J., Nekhotiaeva, N., Hubbard, S. R. & Silvennoinen, O., Jan 2023, In: Pharmaceuticals. 16, 1, 17 p., 75.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

  Arwood, M. L., Liu, Y., Harkins, S. K., Weinstock, D. M., Yang, L., Stevenson, K. E., Plana, O. D., Dong, J., Cirka, H., Jones, K. L., Virtanen, A. T., Gupta, D. G., Ceas, A., Lawney, B., Yoda, A., Leahy, C., Hao, M., He, Z., Choi, H. G. & Wang, Y. & 5 others, Silvennoinen, O., Hubbard, S. R., Zhang, T., Gray, N. S. & Li, L. S., 15 Jun 2023, In: Cell chemical biology. 30, 6, p. 618-+ 27 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression

  Saarikettu, J., Lehmusvaara, S., Pesu, M., Junttila, I., Partanen, J., Sipilä, P., Poutanen, M., Yang, J., Haikarainen, T. & Silvennoinen, O., May 2023, In: FASEB BioAdvances. 5, 5, p. 183-198 16 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2022

  Aiming for the pocket

  Silvennoinen, O., Haikarainen, T. & Virtanen, A., Dec 2022, In: Nature Chemical Biology. 18, p. 1296–1297 2 p.

  Research output: Contribution to journal › Comment/debate › Scientific

• Inhibition of RNA Binding in SND1 Increases the Levels of miR-1-3p and Sensitizes Cancer Cells to Navitoclax

  Lehmusvaara, S., Haikarainen, T., Saarikettu, J., Nieto, G. M. & Silvennoinen, O., 1 Jul 2022, In: Cancers. 14, 13, 17 p., 3100.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Tofacitinib treatment modulates the levels of several inflammation-related plasma proteins in rheumatoid arthritis and baseline levels of soluble biomarkers associate with the treatment response

  Valli, A., Kuuliala, K., Virtanen, A., Kuuliala, A., Palmroth, M., Peltomaa, R., Vidqvist, K.-L., Leirisalo-Repo, M., Silvennoinen, O. & Isomäki, P., 15 Dec 2022, In: Clinical and Experimental Immunology. 210, 2, p. 141-150 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2021

  IRF2BP2 Mutation Is Associated with Increased STAT1 and STAT5 Activation in Two Family Members with Inflammatory Conditions and Lymphopenia

  Palmroth, M., Viskari, H., Seppänen, M. R. J., Keskitalo, S., Virtanen, A., Varjosalo, M., Silvennoinen, O. & Isomäki, P., Aug 2021, In: Pharmaceuticals. 14, 8, 14 p., 797.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Janus Kinase

  George Abraham, B., Raivola, J., Virtanen, A. & Silvennoinen, O., 2 Apr 2021, (E-pub ahead of print) Encyclopedia of Molecular Pharmacology. Offermanns, S. & Rosenthal, W. (eds.). Cham: Springer International Publishing , p. 1-10 10 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › Scientific › peer-review

• Janus Kinases in Leukemia

  Raivola, J., Haikarainen, T., Abraham, B. G. & Silvennoinen, O., Feb 2021, In: Cancers. 13, 4, 20 p., 800.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File

• Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis In Vivo and Baseline Signaling Profile Associates With Treatment Response

  Palmroth, M., Kuuliala, K., Peltomaa, R., Virtanen, A., Kuuliala, A., Kurttila, A., Kinnunen, A., Leirisalo-Repo, M., Silvennoinen, O. & Isomäki, P., 24 Sept 2021, In: Frontiers in Immunology. 12, 12 p., 738481.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2020

  Characterization of JAK1 Pseudokinase Domain in Cytokine Signaling

  Raivola, J., Haikarainen, T. & Silvennoinen, O., Jan 2020, In: Cancers. 12, 1, 20 p., 78.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• JAK2S523L, a novel gain-of-function mutation in a critical autoregulatory residue in JAK2V617F(-) MPNs

  Pastore, F., Krishnan, A., Hammaren, H. M., Silvennoinen, O., Yan, B. & Levine, R. L., 22 Sept 2020, In: Blood advances. 4, 18, p. 4554-4559 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2019

  Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations

  Hammaren, H. M., Virtanen, A. T., Abraham, B. G., Peussa, H., Hubbard, S. R. & Silvennoinen, O., Apr 2019, In: Journal of Allergy and Clinical Immunology. 143, 4, p. 1549-+ 17 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Janus kinases to jakinibs: from basic insights to clinical practice

  Gadina, M., Le, M. T., Schwartz, D. M., Silvennoinen, O., Nakayamada, S., Yamaoka, K. & O'Shea, J. J., Feb 2019, In: Rheumatology. 58, p. 4-16 13 p.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File

• Selective JAKinibs: Prospects in Inflammatory and Autoimmune Diseases

  T. Virtanen, A., Haikarainen, T., Raivola, J. & Silvennoinen, O., Feb 2019, In: BioDrugs. 33, 1, p. 15-32 18 p.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File
• 2018

  Hyperactivation of Oncogenic JAK3 Mutants Depend on ATP Binding to the Pseudokinase Domain

  Raivola, J., Hammaren, H. M., Virtanen, A. T., Bulleeraz, V., Ward, A. C. & Silvennoinen, O., 3 Dec 2018, In: Frontiers in oncology . 8, 14 p., 560.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File