Photo of Olli Kallioniemi
  • PL 20 (Tukholmankatu 8)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1995 …2022
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Publications 1995 2019

2019

Anagrelide for Gastrointestinal Stromal Tumor

Pulkka, O-P., Gebreyohannes, Y. K., Wozniak, A., Mpindi, J-P., Tynninen, O., Icay, K., Cervera, A., Keskitalo, S., Murumägi, A., Kulesskiy, E., Laaksonen, M., Wennerberg, K., Varjosalo, M., Laakkonen, P., Lehtonen, R., Hautaniemi, S., Kallioniemi, O., Schöffski, P., Sihto, H. & Joensuu, H., 1 Mar 2019, In : Clinical Cancer Research. 25, 5, p. 1676-1687 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Clinical implementation of precision systems oncology in the treatment of ovarian cancer based on ex-vivo drug testing and molecular profiling

Murumagi, A., Ungureanu, D., Khan, S., Hirasawa, A., Arjama, M., Valimaki, K., Mikkonen, P., Niininen, W., Kumar, A., Eldfors, S., Pellinen, T., Pietiainen, V., Magi, A., Koivisto-Korander, R., Tapper, J., Loukovaara, M., Aittokallio, T., Butzow, R. & Kallioniemi, O., Jul 2019, In : Cancer Research. 79, 13, 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Combined epithelial marker analysis of tumour budding in stage II colorectal cancer

Slik, K., Blom, S., Turkki, R., Välimäki, K., Kurki, S., Mustonen, H., Haglund, C., Carpén, O., Kallioniemi, O., Korkeila, E., Sundström, J. & Pellinen, T., Jan 2019, In : The Journal of Pathology: Clinical Research. 5, 1, p. 63-78 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Drug sensitivity testing on patient-derived sarcoma cells predicts patient response to treatment and identifies c-Sarc inhibitors as active drugs for translocation sarcomas

Brodin, B. A., Wennerberg, K., Lidbrink, E., Brosjö, O., Potdar, S., Wilson, J. N., Ma, L., Moens, L. N., Hesla, A., Porovic, E., Bernhardsson, E., Papakonstantinou, A., Bauer, H., Tsagkozis, P., von Sivers, K., Wejde, J., Östling, P., Kallioniemi, O. & Stragliotto, C. L., 19 Feb 2019, In : British Journal of Cancer. 120, 4, p. 435-443 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Elevated expression of S100A8 and S100A9 correlates with resistance to the BCL-2 inhibitor venetoclax in AML

Karjalainen, R., Liu, M., Kumar, A., Malani, D., Parsons, A., Kontro, M., Kallioniemi, O., Porkka, K. & Heckman, C., Oct 2019, In : Leukemia. 33, 10, p. 2548-2553 6 p.

Research output: Contribution to journalLetterScientific

Fibroblast as a critical stromal cell type determining prognosis in prostate cancer

Blom, S., Erickson, A., Östman, A., Rannikko, A., Mirtti, T., Kallioniemi, O. & Pellinen, T., Sep 2019, In : Prostate. 79, 13, p. 1505-1513 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Immune cell constitution in bone marrow microenvironment predicts outcome in adult ALL

Hohtari, H., Bruck, O., Blom, S., Turkki, R., Sinisalo, M., Kovanen, P. E., Kallioniemi, O., Pellinen, T., Porkka, K. & Mustjoki, S., Jul 2019, In : Leukemia. 33, 7, p. 1570-1582 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Individual and stable autoantibody repertoires in healthy individuals

Neiman, M., Hellstrom, C., Just, D., Mattsson, C., Fagerberg, L., Schuppe-Koistinen, I., Gummesson, A., Bergström, G., Kallioniemi, O., Achour, A., Sallinen, R., Uhlen, M. & Nilsson, P., 2 Jan 2019, In : Autoimmunity. 52, 1, p. 1-11 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Multi-parametric single cell evaluation defines distinct drug responses in healthy hematological cells that are retained in corresponding malignant cell types

Majumder, M. M., Leppä, A-M., Hellesøy, M., Dowling, P., Malyutina, A., Kopperud, R., Bazou, D., Andersson, E., Parsons, A., Tang, J., Kallioniemi, O., Mustjoki, S., O'Gorman, P., Wennerberg, K., Porkka, K., Gjertsen, B. T. & Heckman, C. A., 22 Aug 2019, In : Haematologica. p. haematol.2019.217414

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma

Leivonen, S-K., Pollari, M., Brück, O., Pellinen, T., Autio, M., Karjalainen-Lindsberg, M-L., Mannisto, S., Kellokumpu-Lehtinen, P-L., Kallioniemi, O., Mustjoki, S. & Leppä, S., Feb 2019, In : Haematologica. 104, 2, p. 338-346 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Association of tamoxifen resistance and lipid reprogramming in breast cancer

Hultsch, S., Kankainen, M., Paavolainen, L., Kovanen, R-M., Ikonen, E., Kangaspeska, S., Pietiäinen, V. & Kallioniemi, O., 24 Aug 2018, In : BMC Cancer. 18, 14 p., 850.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Case studies investigating genetic heterogeneity between anatomically distinct bone marrow compartments in acute myeloid leukemia

Ojamies, P. N., Kontro, M., Edgren, H., Ellonen, P., Heckman, C., Porkka, K., Wolf, M. & Kallioniemi, O., 2 Dec 2018, In : Leukemia & lymphoma. 59, 12, p. 3002-3005 4 p.

Research output: Contribution to journalLetterScientificpeer-review

Clinical relevance of integrin alpha 4 in gastrointestinal stromal tumours

Pulkka, O-P., Mpindi, J-P., Tynninen, O., Nilsson, B., Kallioniemi, O., Sihto, H. & Joensuu, H., Apr 2018, In : Journal of Cellular and Molecular Medicine. 22, 4, p. 2220-2230 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies

Sveen, A., Bruun, J., Eide, P. W., Eilertsen, I. A., Ramirez, L., Murumägi, A., Arjama, M., Danielsen, S. A., Kryeziu, K., Elez, E., Tabernero, J., Guinney, J., Palmer, H. G., Nesbakken, A., Kallioniemi, O., Dienstmann, R. & Lothe, R. A., 15 Feb 2018, In : Clinical Cancer Research. 24, 4, p. 794-806 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling

Andersson, E. I., Pützer, S., Yadav, B., Dufva, O., Khan, S., He, L., Sellner, L., Schrader, A., Crispatzu, G., Oleś, M., Zhang, H., Adnan-Awad, S., Lagström, S., Bellanger, D., Mpindi, J. P., Eldfors, S., Pemovska, T., Pietarinen, P., Lauhio, A., Tomska, K. & 19 others, Cuesta-Mateos, C., Faber, E., Koschmieder, S., Brümmendorf, T. H., Kytölä, S., Savolainen, E-R., Siitonen, T., Ellonen, P., Kallioniemi, O., Wennerberg, K., Ding, W., Stern, M-H., Huber, W., Anders, S., Tang, J., Aittokallio, T., Zenz, T., Herling, M. & Mustjoki, S., Mar 2018, In : Leukemia. 32, 3, p. 774-787 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug Efficacy

Lepikhova, T., Karhemo, P-R., Louhimo, R., Yadav, B., Murumägi, A., Kulesskiy, E., Kivento, M., Sihto, H., Grenman, R., Syrjänen, S. M., Kallioniemi, O., Aittokallio, T., Wennerberg, K., Joensuu, H. & Monni, O., Sep 2018, In : Molecular Cancer Therapeutics. 17, 9, p. 2060-2071 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML

Bruck, O., Blom, S., Dufva, O., Turkki, R., Chheda, H., Ribeiro, A., Kovanen, P., Aittokallio, T., Koskenvesa, P., Kallioniemi, O., Porkka, K., Pellinen, T. & Mustjoki, S., Jul 2018, In : Leukemia. 32, 7, p. 1643-1656 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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ITGB1-dependent upregulation of Caveolin-1 switches TGF beta signalling from tumour-suppressive to oncogenic in prostate cancer

Pellinen, T., Blom, S., Sanchez, S., Välimäki, K., Mpindi, J-P., Azegrouz, H., Strippoli, R., Nieto, R., Viton, M., Palacios, I., Turkki, R., Wang, Y., Sanchez-Alvarez, M., Nordling, S., Bützow, A., Mirtti, T., Rannikko, A., Montoya, M. C., Kallioniemi, O. & del Pozo, M. A., 5 Feb 2018, In : Scientific Reports. 8, 1, 14 p., 2338.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Longitudinal profiling of autoantibody repertoires in healthy individuals

Neiman, M., Hellström, C., Just, D., Mattsson, C., Fagerberg, L., Schuppe-Koistinen, I., Gummesson, A., Bergström, G., Kallioniemi, O-P., Achour, A., Sallinen, R. J., Uhlén, M. & Nilssom, P., 2018, (Submitted) In : Autoimmunity.

Research output: Contribution to journalArticleScientificpeer-review

Multi-Parametric Single Cell Profiling Defines Distinct Drug Responses in Healthy Hematological Cell Lineages That Are Retained in Corresponding Malignant Cell Types

Majumder, MM., Leppä, A-M., Hellesøy, M., Dowling, P., Malyutina, A., Bazou, D., Andersson, E. I., Parsons, A., Tang, J., Kallioniemi, O-P., Mustjoki, S. M., O'Gorman, P., Wennerberg, J. K., Porkka, K. V. K., Gjertsen, B-T. & Heckman, C. A., 2018, In : Blood. 132

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access

PD-L1(+) tumor-associated macrophages and PD-1(+) tumor-infiltrating lymphocytes predict survival in primary testicular lymphoma

Pollari, M., Brück, O., Pellinen, T., Vähämurto, P., Karjalainen-Lindsberg, M-L., Mannisto, S., Kallioniemi, O., Kellokumpu-Lehtinen, P-L., Mustjoki, S., Leivonen, S-K. & Leppä, S., 31 Oct 2018, In : Haematologica. 103, 11, p. 1908-1914 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer

Bruun, J., Sveen, A., Barros, R., Eide, P. W., Eilertsen, I., Kolberg, M., Pellinen, T., David, L., Svindland, A., Kallioniemi, O., Guren, M. G., Nesbakken, A., Almeida, R. & Lothe, R. A., Sep 2018, In : Molecular oncology. 12, 9, p. 1639-1655 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Quantitative Multiplex Immunohistochemistry Identifies Immunosuppression in the AML Bone Marrow and NK-Cells As Prognostic Biomarker in Intermediate-Risk Patients

Bruck, O., Dufva, O., Blom, S., Turkki, R., Ilander, M., Siitonen, S. M., Kovanen, P., Pallaud, C., Ramos, P. M., Lahteenmaki, H., Valimaki, K., Ribeiro, A., Kallioniemi, O., Porkka, K., Pellinen, T. & Mustjoki, S., 29 Nov 2018, In : Blood. 132, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours

Närhi, K., Nagaraj, A. S., Parri, E., Turkki, R., van Duijn, P. W., Hemmes, A., Lahtela, J., Uotinen, V., Mäyränpää, M. I., Salmenkivi, K., Räsänen, J., Linder, N., Trapman, J., Rannikko, A., Kallioniemi, O., Af Hällström, T. M., Lundin, J., Sommergruber, W., Anders, S. & Verschuren, E. W., May 2018, In : Journal of Pathology. 245, 1, p. 101-113 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2017

Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1

Nagaraj, A. S., Lahtela, J., Hemmes, A., Pellinen, T., Blom, S., Devlin, J. R., Salmenkivi, K., Kallioniemi, O., Mäyränpää, M., Narhi, K. & Verschuren, E. W., 17 Jan 2017, In : Cell Reports. 18, 3, p. 673-684 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Crosstalk between ROR1 and BCR pathways defines novel treatment strategies in mantle cell lymphoma

Karvonen, H., Chiron, D., Niininen, W., Ek, S., Jerkeman, M., Moradi, E., Nykter, M., Heckman, C. A., Kallioniemi, O., Murumägi, A. & Ungureanu, D., 14 Nov 2017, In : Blood advances. 1, 24, p. 2257-2268 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

Pietarinen, P. O., Eide, C. A., Ayuda-Duran, P., Potdar, S., Kuusanmaki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, K., Hjorth-Hansen, H., Druker, B. J., Enserink, J. M., Tyner, J. W., Mustjoki, S. & Porkka, K., 4 Apr 2017, In : Oncotarget. 8, 14, p. 22606-22615 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Drug-screening and genomic analyses of HER2-positive breast cancer cell lines reveal predictors for treatment response

Jernström, S., Hongisto, V., Leivonen, S-K., Due, E. U., Tadele, D. S., Edgren, H., Kallioniemi, O., Perälä, M., Mlandsmo, G. M. & Sahlberg, K. K., 2017, In : Breast Cancer: Targets and Therapy. 9, p. 185-198 14 p.

Research output: Contribution to journalArticleScientificpeer-review

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Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors

Kolberg, M., Bruun, J., Murumagi, A., Mpindi, J. P., Bergsland, C. H., Holand, M., Eilertsen, I. A., Danielsen, S. A., Kallioniemi, O. & Lothe, R. A., Sep 2017, In : Molecular oncology. 11, 9, p. 1156-1171 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML

Malani, D., Murumagi, A., Yadav, B., Kontro, M., Eldfors, S., Kumar, A., Karjalainen, R., Majumder, M. M., Ojamies, P., Pemovska, T., Wennerberg, K., Heckman, C., Porkka, K., Wolf, M., Aittokallio, T. & Kallioniemi, O., May 2017, In : Leukemia. 31, 5, p. 1187-1195 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia

Kontro, M., Kumar, A., Majumder, M. M., Eldfors, S., Parsons, A., Pemovska, T., Saarela, J. S., Yadav, B., Malani, D. R., Fløisand, Y., Höglund, M., Remes, K., Gjertsen, B-T., Kallioniemi, O-P., Wennerberg, J. K., Heckman, C. A. & Porkka, K. V. K., 2017, In : Leukemia. 31, 2, p. 301-309 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia

Eldfors, S., Kuusanmäki, H., Kontro, M., Majumder, M. M., Parsons, A., Edgren, H., Pemovska, T., Kallioniemi, O., Wennerberg, K., Gökbuget, N., Burmeister, T., Porkka, K. & Heckman, C. A., 2017, In : Leukemia. 31, 1, p. 51-57 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Identifying ovarian cancer specific targeted drugs using high-throughput drug sensitivity profiles of primary cancer cells

Murumagi, A., Hirasawa, A., Khan, S., Ungureanu, D., Arjama, M., Pellinen, T., Eldfors, S., Koivisto-Korander, R., Leminen, A., Butzow, R., Aittokallio, T. & Kallioniemi, O., Jul 2017, In : Cancer Research. 77, 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

IMMUNOLOGICAL CHARACTERIZATION OF PH plus ALL BONE MARROW BY MULTIPLEX IMMUNOHISTOCHEMISTRY

Hohtari, H., Bruck, O., Blom, S., Turkki, R., Ribeiro, A., Sinisalo, M., Kovanen, P., Kallioniemi, O., Pellinen, T., Porkka, K. & Mustjoki, S., 26 Jun 2017, In : Haematologica. 102, p. 654-654 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML

Karjalainen, R., Pemovska, T., Popa, M., Liu, M., Javarappa, K. K., Majumder, M. M., Yadav, B., Tamborero, D., Tang, J., Bychkov, D., Kontro, M., Parsons, A., Suvela, M., Safont, M. M., Porkka, K., Aittokallio, T., Kallioniemi, O., McCormack, E., Gjertsen, B. T., Wennerberg, K. & 2 others, Knowles, J. & Heckman, C. A., 10 Aug 2017, In : Blood. 130, 6, p. 789-802 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

KeepEX, a simple dilution protocol for improving extracellular vesicle yields from urine

Puhka, M., Nordberg, M. E., Valkonen, S., Rannikko, A., Kallioniemi, O., Siljander, P. & Hällström, T. M. A., 15 Feb 2017, In : European Journal of Pharmaceutical Sciences. 98, p. 30-39 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Monitoring therapy responses at the leukemic subclone level by ultra-deep amplicon resequencing in acute myeloid leukemia

Ojamies, P., Kontro, M., Edgren, H., Ellonen, P., Lagström, S., Almusa, H., Miettinen, T., Eldfors, S., Tamborero, D., Wennerberg, K., Heckman, C., Porkka, K., Wolf, M. & Kallioniemi, O., 2017, In : Leukemia. 31, 5, p. 1048-1058 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Pharmacogenomic profiling to identify novel therapeutic strategies in colorectal cancer

Bruun, J., Eide, P. W., Kryeziu, K., Sveen, A., Murumagi, A., Kolberg, M., Arjama, M., Kallioniemi, O. & Lothe, R. A., Jul 2017, In : Cancer Research. 77, 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

PLA2G7 associates with hormone receptor negativity in clinical breast cancer samples and regulates epithelial-mesenchymal transition in cultured breast cancer cells

Lehtinen, L., Vainio, P., Wikman, H., Huhtala, H., Mueller, V., Kallioniemi, A., Pantel, K., Kronqvist, P., Kallioniemi, O., Carpèn, O. & Iljin, K., 2017, In : The Journal of Pathology: Clinical Research. 3, 2, p. 123-138 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Precision systems medicine in urological Tumors – Molecular profiling and functional testing

Saeed, K., Ojamies, P., Pellinen, T., Rahkama, V., Eldfors, S., Paavolainen, L., Turkki, R., Horvath, P., Lundin, J., Nisén, H., af Hällström, T. M., Rannikko, A., Mirtti, T., Kallioniemi, O. & Östling, P., 17 Oct 2017, In : Annals of Oncology. 28, Suppl 7, 1 p.

Research output: Contribution to journalConference articleScientific

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Systems pathology by multiplexed immunohistochemistry and whole-slide digital image analysis

Blom, S., Paavolainen, L., Bychkov, D., Turkki, R., Maki-Teeri, P., Hemmes, A., Valimaki, K., Lundin, J., Kallioniemi, O. & Pellinen, T., 14 Nov 2017, In : Scientific Reports. 7, 13 p., 15580.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching

Hildebrand, S., Hultin, S., Subramani, A., Petropoulos, S., Zhang, Y., Cao, X., Mpindi, J., Kallioniemi, O., Johansson, S., Majumdar, A., Lanner, F. & Holmgren, L., 25 Aug 2017, In : Scientific Reports. 7, 17 p., 9540.

Research output: Contribution to journalArticleScientificpeer-review

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The impact of RNA sequence library construction protocols on transcriptomic profiling of leukemia

Kumar, A., Kankainen, M., Parsons, A., Kallioniemi, O., Mattila, P. & Heckman, C. A., 17 Aug 2017, In : BMC Genomics. 18, 13 p., 629.

Research output: Contribution to journalArticleScientificpeer-review

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2016

A loss-of-function genetic screening identifies novel mediators of thyroid cancer cell viability

Cantisani, M. C., Parascandolo, A., Perala, M., Allocca, C., Fey, V., Sahlberg, N., Merolla, F., Basolo, F., Laukkanen, M. O., Kallioniemi, O. P., Santoro, M. & Castellone, M. D., 10 May 2016, In : Oncotarget. 7, 19, p. 28510-28522 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Consistency in drug response profiling

Mpindi, J. P., Yadav, B., Ostling, P., Gautam, P., Malani, D., Murumagi, A., Hirasawa, A., Kangaspeska, S., Wennerberg, K., Kallioniemi, O. & Aittokallio, T., 1 Dec 2016, In : Nature. 540, 7631, p. E5-E6 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access