Olli Mikael Carpen

Publications

Research output per year 1994 2005 2017 2018 2019 2020 2021 2022 2023 2024 2024

• 138 Article
• 6 Conference article
• 4 Letter
• 3 Meeting Abstract
• 6 More
  • 3 Review Article
  • 2 Comment/debate
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2024

  Endothelial Pim3 kinase protects the vascular barrier during lung metastasis

  Santio, N. M., Ganesh, K., Kaipainen, P. P., Halme, A., Seyednasrollah, F., Arbash, E., Hänninen, S., Kivelä, R., Carpen, O. & Saharinen, P., 3 Dec 2024, In: Nature Communications. 15, 1, 18 p., 10514.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases

  FinnGen, Youssef, O., Loukola, A., Zidi-Mouaffak, Y. H. S., Tamlander, M., Ruotsalainen, S., Kilpeläinen, E., Mars, N., Ripatti, S., Palotie, A., Donner, K., Carpén, O., Hovatta, I. & Mäkitie, A., Apr 2024, In: Laboratory Investigation. 104, 4, 27 p., 100325.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Infective SARS-CoV-2 in Skull Sawdust at Autopsy, Finland

  Kantonen, J. N., Kuivanen, S., Smura, T., Puttonen, H., Kekäläinen, E., Sajantila, A., Myllykangas, L., Kantele, A., Vapalahti, O., Mäyränpää, M. I. & Carpén, O., Aug 2024, In: Emerging Infectious Diseases. 30, 8, p. 1735-1737 3 p.

  Research output: Contribution to journal › Letter › Scientific

• Lifetime Cost-effectiveness of Hereditary Breast and Ovarian Cancer Prevention Based on Finngen and Biobank Data, Data Returning Process, and Prophylaxis

  Soini, E., Asseburg, C., Jalkanen, K., Pehrsson, M., Lundström, T., Meretoja, T., Hautalahti, M., Salminen, E., Auranen, A., Mäkelä, J. & Carpén, O., Jun 2024, In: Value in Health. 27, 6, p. S120-S121 2 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Novel loci and biomedical consequences of iron homoeostasis variation

  DBDS Genomic Consortium, FinnGen Consortium, Allara, E., Bell, S., Wang, F., Palotie, A., Daly, M., Mäkelä, T. P., Kaprio, J., Perola, M., Partanen, J., Raivio, T., Ripatti, S., Carpén, O., Raivio, M., Tienari, P., Partanen, J., Färkkilä, M., Koskela, J. & Pikkarainen, S. & 87 others, Eklund, K., Mars, N., Kauppi, P., Vaura, F., Gordin, D., Sinisalo, J., Taskinen, M.-R., Tuomi, T., Hiltunen, T., Reeve, M. P., Ruotsalainen, S., Meretoja, T., Joensuu, H., Mattson, J., Salminen, E., Karihtala, P., Pitkänen, E., Turunen, J. A., Ollila, T., Karjalainen, J., Hannula-Jouppi, K., Pussinen, P., Salminen, A., Salo, T., Rice, D., Nieminen, P., Palotie, U., Laivuori, H., Kurra, V., Heikinheimo, O., Kalliala, I., Aaltonen, L., Djousse, L., Cho, K., Inouye, M., Burgess, S., Benyamin, B., Oexle, K., Swinkels, D. W., Stefansson, K., Magnusson, M., Ganna, A., Gaziano, M., Ivey, K., Danesh, J., Pereira, A., Wood, A. M., Butterworth, A. S., Di Angelantonio, E., Kivinen, K., Tukiainen, T., Ollila, H., Saarentaus, E., Åberg, F., Kurki, M., Havulinna, A., Mehtonen, J., Palta, P., Hassan, S., Della Briotta Parolo, P., Lemmelä, S., Liu, A., Lehisto, A., Llorens, V., Heyne, H., Rämö, J., Rodosthenous, R., Strausz, S., Lee, J., Kajanne, R., Aavikko, M., Cooper, H., Öller, D., Leinonen, R., Lahtela, L. E., Kaunisto, M., Kilpeläinen, E., Sipilä, T. P., Dada, O. A., Ghazal, A., Kytölä, A., Weldatsadik, R., Donner, K. M., Luo, S., Padmanabhuni, S. S., Hovatta, I. & Mäkitie, A., 2024, In: Communications Biology. 7, 1, 17 p., 1631.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Opening the black box: spatial transcriptomics and the relevance of AI-detected prognostic regions in high grade serous carcinoma

  Laury, A. R., Zheng, S., Aho, N., Fallegger, R., Hänninen, S., Saez-Rodriguez, J., Tanevski, J., Youssef, O., Tang, J. & Carpén, O. M., 3 May 2024, In: Modern Pathology. 37, 7, 12 p., 100508.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures

  Rausio, H., Cervera, A., Heuser, V. D., West, G., Oikkonen, J., Pianfetti, E., Lovino, M., Ficarra, E., Taimen, P., Hynninen, J., Lehtonen, R., Hautaniemi, S., Carpén, O. & Huhtinen, K., May 2024, In: Neoplasia (United States). 51, 10 p., 100987.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Standardization through education of molecular pathology: a spotlight on the European Masters in Molecular Pathology

  Ilié, M., Lake, V., de Alava, E., Bonin, S., Chlebowski, S., Delort, A., Dequeker, E., Al-Dieri, R., Diepstra, A., Carpén, O., Eloy, C., Fassina, A., Fend, F., Fernandez, P. L., Gorkiewicz, G., Heeke, S., Henrique, R., Hoefler, G., Huertas, P. & Hummel, M. & 9 others, Kashofer, K., van der Laak, J., de Pablos, R. M., Schmitt, F., Schuuring, E., Stanta, G., Timens, W., Westphalen, B. & Hofman, P., Nov 2024, In: Virchows Archiv. 485, 5, p. 761-775 15 p.

  Research output: Contribution to journal › Review Article › peer-review

• Venous thromboembolism incidence and association with overall survival in pancreatic cancer: A Finnish nationwide cohort study

  Aaltonen, P., Mustonen, H., Puolakkainen, P., Haglund, C., Peltola, K., Carpén, O., Lassila, R. & Seppänen, H., Jul 2024, In: Cancer medicine . 13, 14, 12 p., e70014.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2023

  A FinnGen pilot clinical recall study for Alzheimer's disease

  FinnGen, Julkunen, V., Schwarz, C., Kalapudas, J., Hallikainen, M., Piironen, A.-K., Mannermaa, A., Kujala, H., Laitinen, T., Kosma, V.-M., Paajanen, T. I., Kälviäinen, R., Hiltunen, M., Herukka, S.-K., Kärkkäinen, S., Kokkola, T., Urjansson, M., Perola, M., Palotie, A. & Vuoksimaa, E. & 44 others, Runz, H., Mäkitie, A., Pitkäranta, A., Loukola, A., Punkka, E. J. T., Linna, M.-M., Carpen, O., Raivio, T., Aittomäki, K., Salminen, A., Aarnisalo, A., Gordin, D., Rice, D., Isometsä, E., Salminen, E., Joensuu, H., Kalliala, I., Mattson, J., Sinisalo, J., Koskela, J., Eklund, K., Hannula-Jouppi, K. S. E., Aaltonen, L., Taskinen, M.-R., Färkkilä, M., Raivio, M., Heikinheimo, O., Kauppi, P., Nieminen, P., Tienari, P., Pussinen, P., Pikkarainen, S., Ollila, T., Tuomi, T., Meretoja, T., Salo, T., Palotie, U., Åberg, F., Palotie, T., Hovatta, I., Arvas, M., Hyvärinen, K., Ritari, J. & Partanen, J., 3 Aug 2023, In: Scientific Reports. 13, 1, 15 p., 12641.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids

  Senkowski, W., Gall-Mas, L., Falco, M. M., Li, Y., Lavikka, K., Kriegbaum, M. C., Oikkonen, J., Bulanova, D., Pietras, E. J., Vossgrone, K., Chen, Y.-J., Erkan, E. P., Dai, J., Lundgren, A., Hog, M. K. G., Larsen, I. M., Lamminen, T., Kaipio, K., Huvila, J. & Virtanen, A. & 9 others, Engelholm, L., Christiansen, P., Santoni-Rugiu, E., Huhtinen, K., Carpen, O., Hynninen, J., Hautaniemi, S., Vähärautio, A. & Wennerberg, K., 19 Jun 2023, In: Developmental Cell. 58, 12, p. 1106-+ 24 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Characterization of Expression and Function of the Formins FHOD1, INF2, and DAAM1 in HER2-Positive Breast Cancer

  Peippo, M., Gardberg, M., Kronqvist, P., Carpen, O. & Heuser, V. D., Dec 2023, In: Journal of Breast Cancer. 26, 6, p. 525-543 19 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• DLL4/Notch3/WNT5B axis mediates bidirectional prometastatic crosstalk between melanoma and lymphatic endothelial cells

  Alve, S., Gramolelli, S., Jukonen, J., Juteau, S., Pink, A., Manninen, A. A., Hänninen, S., Monto, E., Lackman, M. H., Carpen, O., Saharinen, P., Karaman, S., Vaahtomeri, K. & Ojala, P. M., 16 Nov 2023, In: JCI INSIGHT. 9, 1, 21 p., e171821.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

  Sliz, E., Tyrmi, J. S., Rahmioglu, N., Zondervan, K. T., Becker, C. M., Uimari, O., Kettunen, J., Palotie, A., Daly, M., Riley-Gills, B., Jacob, H., Paul, D., Matakidou, A., Platt, A., Runz, H., John, S., Okafo, G., Lawless, N., Salminen-Mankonen, H. & Plenge, R. & 306 others, Maranville, J., McCarthy, M., Ehm, M. G., Auro, K., Longerich, S., Fox, C., Malarstig, A., Klinger, K., Chatelain, C., Gossel, M., Estrada, K., Graham, R., Yang, R., O'Donnell, C., Mäkelä, T. P., Kaprio, J., Virolainen, P., Hakanen, A., Kilpi, T., Perola, M., Partanen, J., Pitkäranta, A., Raivio, T., Serpi, R., Laitinen, T., Kosma, V.-M., Laukkanen, J., Hautalahti, M., Tuovila, O., Pakkanen, R., Waring, J., Riley-Gillis, B., Rahimov, F., Tachmazidou, I., Chen, C.-Y., Ding, Z., Jung, M., Biswas, S., Pendergrass, R., Pulford, D., Raghavan, N., Huertas-Vazquez, A., Sul, J.-H., Hu, X., Hedman, A., Rivas, M., Waterworth, D., Renaud, N., Obeidat, M., Ripatti, S., Schleutker, J., Arvas, M., Carpen, O., Hinttala, R., Mannermaa, A., Aalto-Setala, K., Kahonen, M., Mäkelä, J., Kalviainen, R., Julkunen, V., Soininen, H., Remes, A., Hiltunen, M., Peltola, J., Raivio, M., Tienari, P., Rinne, J., Kallionpaa, R., Partanen, J., Abbasi, A., Ziemann, A., Smaoui, N., Lehtonen, A., Eaton, S., Lahdenpera, S., Bowers, N., Teng, E., Xu, F., Addis, L., Eicher, J., Li, Q. S., He, K., Khramtsova, E., Färkkilä, M., Koskela, J., Pikkarainen, S., Jussila, A., Kaukinen, K., Blomster, T., Kiviniemi, M., Voutilainen, M., Lu, T., McCarthy, L., Hart, A., Guan, M., Miller, J., Kalpala, K., Miller, M., Eklund, K., Palomaki, A., Isomaki, P., Pirila, L., Kaipiainen-Seppanen, O., Huhtakangas, J., Mars, N., Lertratanakul, A., Hochfeld, M., Gordillo, J. E., Farias, F., Bing, N., Pelkonen, M., Kauppi, P., Kankaanranta, H., Harju, T., Lahesmaa, R., Lassi, G., Chen, H., Betts, J., Mishra, R., Mouded, M., Ngo, D., Niiranen, T., Vaura, F., Salomaa, V., Metsarinne, K., Aittokallio, J., Hernesniemi, J., Gordin, D., Sinisalo, J., Taskinen, M.-R., Tuomi, T., Elliott, A., Reeve, M. P., Ruotsalainen, S., Challis, B., Chu, A., Reilly, D., Mendelson, M., Parkkinen, J., Meretoja, T., Joensuu, H., Mattson, J., Salminen, E., Auranen, A., Karihtala, P., Auvinen, P., Elenius, K., Pitkänen, E., Popovic, R., Schutzman, J., Kulkarni, D., Porello, A., Loboda, A., Lehtonen, H., McDonough, S., Vuoti, S., Kaarniranta, K., Turunen, J. A., Ollila, T., Uusitalo, H., Karjalainen, J., Liu, M., Loomis, S., Strauss, E., Chen, H., Tasanen, K., Huilaja, L., Hannula-Jouppi, K., Salmi, T., Peltonen, S., Koulu, L., Choy, D., Wu, Y., Pussinen, P., Salminen, A., Salo, T., Rice, D., Nieminen, P., Palotie, U., Siponen, M., Suominen, L., Mäntylä, P., Gursoy, U., Anttonen, V., Sipila, K., Laivuori, H., Kurra, V., Kotaniemi-Talonen, L., Heikinheimo, O., Kalliala, I., Aaltonen, L., Jokimaa, V., Vaarasmaki, M., Morin-Papunen, L., Niinimaki, M., Piltonen, T., Kivinen, K., Widen, E., Tukiainen, T., Välimäki, N., Laakkonen, E., Silven, H., Arffman, R., Savukoski, S., Laisk, T., Pujol, N., Kumar, J., Hovatta, I., Isometsä, E., Ollila, H., Suvisaari, J., Als, T. D., Mäkitie, A., Bizaki-Vallaskangas, A., Toppila-Salmi, S., Willberg, T., Saarentaus, E., Aarnisalo, A., Rahikkala, E., Aittomaki, K., Åberg, F., Kurki, M., Havulinna, A., Mehtonen, J., Palta, P., Hassan, S., Parolo, P. D. B., Zhou, W., Maasha, M., Lemmela, S., Liu, A., Lehisto, A., Ganna, A., Llorens, V., Heyne, H., Rämö, J., Rodosthenous, R., Strausz, S., Palotie, T., Palin, K., Garcia-Tabuenca, J., Siirtola, H., Kiiskinen, T., Lee, J., Tsuo, K., Kristiansson, K., Hyvärinen, K., Ritari, J., Pylkas, K., Karjalainen, M., Mantere, T., Kangasniemi, E., Heikkinen, S., Pitkanen, N., Lessard, S., Chatelain, C., Terho, P., Wahlfors, T., Punkka, E., Siltanen, S., Kuopio, T., Jalanko, A., Shen, H.-Y., Kajanne, R., Aavikko, M., Palin, H., Linna, M.-M., Kanai, M., Zheng, Z., Lahtela, L. E., Kaunisto, M., Kilpeläinen, E., Sipila, T. P., Dada, O. A., Ghazal, A., Kytölä, A., Weldatsadik, R., Donner, K., Loukola, A., Laiho, P., Sistonen, T., Kaiharju, E., Laukkanen, M., Jarvensivu, E., Lahteenmaki, S., Mannikko, L., Wong, R., Toivola, A., Brunfeldt, M., Mattsson, H., Koskelainen, S., Hiekkalinna, T., Paajanen, T., Pärn, K., Kals, M., Luo, S., Padmanabhuni, S. S., Niemi, M., Gracia-Tabuenca, J., Helminen, M., Luukkaala, T., Vahatalo, I., Tammerluoto, J., Smith, S., Southerington, T. & Lehto, P., 1 Feb 2023, In: Nature Communications. 14, 542, 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Evolutionary states and trajectories characterized by distinct pathways stratify patients with ovarian high grade serous carcinoma

  Lahtinen, A., Hautaniemi, S., Lavikka, K. A., Virtanen, A., Li, Y., Jamalzadeh, S., Skorda, A., Rossberg Lauridsen, A., Zhang, K., Marchi, G., Isoviita, V.-M., Ariotta, V., Lehtonen, J. O., Muranen, T. A., Huhtinen, K. L., Carpen, O. M., Hietanen, S., Senkowski, W., Kallunki, T. & Häkkinen, A. & 1 others, Hynninen, J., 12 Jun 2023, In: Cancer Cell. 41, 6, p. 1103-+ 28 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• FinnGen provides genetic insights from a well-phenotyped isolated population

  FinnGen, Kurki, M. I., Karjalainen, J., Palta, P., Sipilä, T. P., Kristiansson, K., Donner, K. M., Reeve, M. P., Laivuori, H., Aavikko, M., Kaunisto, M. A., Loukola, A., Mattsson, H., Laiho, P., Della Briotta Parolo, P., Lehisto, A. A., Mars, N., Rämö, J., Kiiskinen, T. & Heyne, H. O. & 63 others, Rüeger, S., Lemmelä, S., Zhou, W., Ruotsalainen, S., Pärn, K., Hiekkalinna, T., Koskelainen, S., Paajanen, T., Llorens, V., Gracia-Tabuenca, J., Auro, K., Carpen, O., Dada, O. A., Eklund, K., Färkkilä, M., Ganna, A., Ghazal, A., Hovatta, I., Joensuu, H., Julkunen, V., Kajanne, R., Kaprio, J., Kettunen, J., Kilpeläinen, E., Kurra, V., Laukkanen, J., Liu, A., Mäkelä, J., Mäkitie, A., Meretoja, T., Niemi, M. E. K., Niemi, M., Niiranen, T., Ollila, H. M., Palomäki, A., Palotie, T., Partanen, J., Pelkonen, M., Pitkäranta, A., Punkka, E., Pussinen, P., Rodosthenous, R., Saarentaus, E., Salminen, A., Salminen, E., Shen, H.-Y., Silander, K., Soini, S., Tienari, P., Toppila-Salmi, S., Tukiainen, T., Tuomi, T., Turunen, J. A., Vaura, F., Havulinna, A. S., Perola, M., Ripatti, S., Jalanko, A., Laitinen, T., Mäkelä, T. P., Daly, M. J., Palotie, A. & Kanai, M., 19 Jan 2023, In: Nature. 613, 7944, p. 508-+ 20 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• From Biobank Sample to Breast Cancer Prevention-cost-effectiveness Analysis of Returning Genomic Data to Sample Donors

  Soini, E., Asseburg, C., Pehrsson, M., Lundstrom, T., Meretoja, T., Hautalahti, M., Salminen, E., Makela, J. & Carpen, O., Dec 2023, In: Value in Health. 26, 12, p. S120-S120 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes

  Pikkusaari, S., Tumiati, M., Virtanen, A., Oikkonen, J., Li, Y., Perez-Villatoro, F., Muranen, T., Salko, M., Huhtinen, K., Kanerva, A., Koskela, H., Tapper, J., Koivisto-Korander, R., Joutsiniemi, T., Haltia, U.-M., Lassus, H., Hautaniemi, S., Färkkilä, A., Hynninen, J. & Hietanen, S. & 2 others, Carpen, O. & Kauppi, L., 15 Aug 2023, In: Clinical Cancer Research. 29, 16, p. 3110-3123 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Järjestystä munasarjasyövän genomiseen kaaokseen

  Lahtinen, A., Lavikka, K., Virtanen, A., Li, Y., Jamalzadeh, S., Skorda, A., Rossberg Lauridsen, A., Zhang, K., Marchi, G., Isoviita, V.-M., Ariotta, V., Lehtonen, O., Muranen, T. A., Huhtinen, K., Carpen, O., Hietanen, S., Senkowski, W., Kallunki, T., Häkkinen, A. & Hynninen, J. & 2 others, Oikkonen, J. & Hautaniemi, S., 2023, In: Duodecim. 139, 12, p. 1049 1 p.

  Research output: Contribution to journal › Comment/debate › Professional

  Open Access

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• Serum FGF19 predicts outcomes of Kasai portoenterostomy in biliary atresia

  Nyholm, I. A., Hukkinen, M., Pihlajoki, M., Davidson, J. R., Tyraskis, A., Lohi, J., Heikkilä, P., Hänninen, S., Andersson, N., Eloranta, K., Carpen, O., Heikinheimo, M., Davenport, M. & Pakarinen, M. P., Apr 2023, In: Hepatology. 77, 4, p. 1263-1273 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• The impact of implementing current treatment modalities and female sex on gastric cancer outcomes, 2000-2016: a longitudinal nationwide cohort study

  Aaltonen, P., Mustonen, H., Peltola, K., Carpen, O., Puolakkainen, P., Haglund, C., Sund, M. & Seppanen, H., 2023, In: Acta Oncologica. 62, 12, p. 1732-1741 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Uusi työkalu räätälöityyn munasarjasyövän hoitoon

  Translated title of the contribution: Functional homologous recombination assay on FFPE specimens of advanced high-grade serous ovarian cancer predicts clinical outcomesPikkusaari, S., Tumiati, M., Virtanen, A., Oikkonen, J., Li, Y., Perez-Villatoro, F., Muranen, T., Salko, M., Huhtinen, K., Kanerva, A., Koskela, H., Tapper, J., Koivisto-Korander, R., Joutsiniemi, T., Haltia, U.-M., Lassus, H., Hautaniemi, S., Färkkilä, A., Hynninen, J. & Hietanen, S. & 2 others, Carpen, O. & Kauppi, L., 15 Aug 2023, In: Duodecim. 139, 9, p. 760 1 p.

  Research output: Contribution to journal › Article › Professional

  Open Access

  File
• 2022

  Apolipoproteiini E4 (APOE4) voi altistaa vakavalle COVID-19-taudille

  FinnGen, Kurki, S. N., Kantonen, J., Kaivola, K., Hokkanen, L., Mäyranpää, M. I., Puttonen, H., Martola, J., Pöyhönen, M., Kero, M., Tuimala, J., Carpen, O., Kantele, A., Vapalahti, O., Tiainen, M., Tienari, P. J., Kaila, K., Hastbacka, J. & Myllykangas, L., 2022, In: Duodecim. 138, 3, p. 275 1 p.

  Research output: Contribution to journal › Comment/debate › Professional

  Open Access

  File

• A Subset of Secreted Proteins in Ascites Can Predict Platinum-Free Interval in Ovarian Cancer

  Carroll, M. J., Kaipio, K., Hynninen, J., Carpen, O., Hautaniemi, S., Page, D. & Kreeger, P. K., Sept 2022, In: Cancers. 14, 17, 14 p., 4291.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Data-driven comorbidity analysis of 100 common disorders reveals patient subgroups with differing mortality risks and laboratory correlates

  Koskinen, M., Salmi, J. K., Loukola, A., Mäkelä, M. J., Sinisalo, J., Carpen, O. & Renkonen, R., 2 Nov 2022, In: Scientific Reports. 12, 1, 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Dubious effects of methadone as an "anticancer" drug on ovarian cancer cell-lines and patient-derived tumor-spheroids

  Fiegl, H., Hagenbuchner, J., Kyvelidou, C., Seeber, B., Sopper, S., Tsibulak, I., Wieser, V., Reiser, E., Roessler, J., Huhtinen, K., Carpen, O., Parson, W., Sprung, S., Marth, C., Ausserlechner, M. J. & Zeimet, A. G., Apr 2022, In: Gynecologic Oncology. 165, 1, p. 129-136 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Effects of Wee1 inhibitor adavosertib on patient-derived high-grade serous ovarian cancer cells are multiple and independent of homologous recombination status

  Roering, P., Siddiqui, A., Heuser, V. D., Potdar, S., Mikkonen, P., Oikkonen, J., Li, Y., Pikkusaari, S., Wennerberg, K., Hynninen, J., Grenman, S., Huhtinen, K., Auranen, A., Carpen, O. & Kaipio, K., 23 Aug 2022, In: Frontiers in oncology . 12, 14 p., 954430.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer

  Zhang, K., Erkan, E. P., Jamalzadeh, S., Dai, J., Andersson, N., Kaipio, K., Lamminen, T., Mansuri, N., Huhtinen, K., Carpen, O., Hietanen, S., Oikkonen, J., Hynninen, J., Virtanen, A., Häkkinen, A., Hautaniemi, S. & Väharautio, A., Feb 2022, In: Science Advances. 8, 8, 18 p., 1831.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Long-term nationwide trends in the treatment of and outcomes among pancreatic cancer patients

  Aaltonen, P., Carpén, O., Mustonen, H., Puolakkainen, P., Haglund, C., Peltola, K. & Seppänen, H., May 2022, In: European Journal of Surgical Oncology. 48, 5, p. 1087-1092 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Ovarian Cancers with Low CIP2A Tumor Expression Constitute an APR-246-Sensitive Disease Subtype

  Cvrljevic, A. N., Butt, U., Huhtinen, K., Grönroos, T. J., Böckelman, C., Lassus, H., Butzow, R., Haglund, C., Kaipio, K., Arsiola, T., Laajala, T. D., Connolly, D. C., Ristimäki, A., Carpen, O., Pouwels, J. & Westermarck, J., Jul 2022, In: Molecular Cancer Therapeutics. 21, 7, p. 1236-1245 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• QuantISH: RNA in situ hybridization image analysis framework for quantifying cell type-specific target RNA expression and variability

  Jamalzadeh, S., Häkkinen, A., Andersson, N., Huhtinen, K., Laury, A., Hietanen, S., Hynninen, J., Oikkonen, J., Carpen, O., Virtanen, A. & Hautaniemi, S., Jul 2022, In: Laboratory Investigation. 102, 7, p. 753-761 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Screening for potential undiagnosed Gaucher disease patients: Utilisation of the Gaucher earlier diagnosis consensus point-scoring system (GED-C PSS) in conjunction with electronic health record data, tissue specimens, and small nucleotide polymorphism (SNP) genotype data available in Finnish biobanks

  Pehrsson, M., Heikkinen, H., Wartiovaara-Kautto, U., Mäntylahti, S., Bäckström, P., Lassenius, M. I., Uusi-Rauva, K., Carpen, O. & Elomaa, K., Dec 2022, In: Molecular Genetics and Metabolism Reports. 33, 13 p., 100911.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Single-Cell RNA Sequencing-Based Characterization of Resident Lung Mesenchymal Stromal Cells in Bronchopulmonary Dysplasia

  Mizikova, I., Lesage, F., Cyr-Depauw, C., Cook, D. P., Hurskainen, M., Hänninen, S. M., Vadivel, A., Bardin, P., Zhong, S., Carpen, O., Vanderhyden, B. C. & Thebaud, B., 27 May 2022, In: Stem Cells. 40, 5, p. 479-492 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2021

  Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality

  Jukonen, J., Moyano-Galceran, L., Höpfner, K., Pietilä, E. A., Lehtinen, L., Huhtinen, K., Gucciardo, E., Hynninen, J., Hietanen, S., Grenman, S., Ojala, P. M., Carpen, O. & Lehti, K., 23 Apr 2021, In: Scientific Reports. 11, 1, 12 p., 8856.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Agile workflow for interactive analysis of mass cytometry data

  Casado, J., Lehtonen, O., Rantanen, V., Kaipio, K., Pasquini, L., Häkkinen, A., Petrucci, E., Hynninen, J., Hietanen, S., Carpen, O., Biffoni, M., Färkkilä , A. & Hautaniemi, S., 1 May 2021, In: Bioinformatics. 37, 9, p. 1263-1268 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• A Novel Two-Lipid Signature Is a Strong and Independent Prognostic Factor in Ovarian Cancer

  Salminen, L., Braicu, E. I., Laaperi, M., Jylha, A., Oksa, S., Hietanen, S., Sehouli, J., Kulbe, H., du Bois, A., Mahner, S., Harter, P., Carpen, O., Huhtinen, K., Hynninen, J. & Hilvo, M., Apr 2021, In: Cancers. 13, 8, 12 p., 1764.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• APOE epsilon 4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study

  FinnGen, Kurki, S. N., Kantonen, J., Kaivola, K., Hokkanen, L., Mäyranpää, M. I., Puttonen, H., Martola, J., Pöyhönen, M., Kero, M., Tuimala, J., Carpen, O., Kantele, A., Vapalahti, O., Tiainen, M., Tienari, P. J., Kaila, K., Hastbacka, J. & Myllykangas, L., 23 Dec 2021, In: Acta Neuropathologica Communications. 9, 13 p., 199.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Artificial intelligence-based image analysis can predict outcome in high-grade serous carcinoma via histology alone

  Laury, A. R., Blom, S., Ropponen, T., Virtanen, A. & Carpen, O. M., 27 Sept 2021, In: Scientific Reports. 11, 1, 9 p., 19165.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Association of tumor-infiltrating T lymphocytes with intestinal-type gastric cancer molecular subtypes and outcome

  Mansuri, N., Birkman, E.-M., Heuser, V. D., Lintunen, M., Ålgars, A., Sundström, J., Ristamäki, R., Lehtinen, L. & Carpén, O., 2021, In: Virchows Archiv. 478, p. 707–717 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance

  Pietilä, E. A., Gonzalez-Molina, J., Moyano-Galceran, L., Jamalzadeh, S., Zhang, K., Lehtinen, L., Turunen, S. P., Martins, T. A., Gultekin, O., Lamminen, T., Kaipio, K., Joneborg, U., Hynninen, J., Hietanen, S., Grenman, S., Lehtonen, R., Hautaniemi, S., Carpen, O., Carlson, J. W. & Lehti, K., 23 Jun 2021, In: Nature Communications. 12, 1, 19 p., 3904.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• FHOD1 and FMNL1 formin proteins in intestinal gastric cancer: correlation with tumor-infiltrating T lymphocytes and molecular subtypes

  Mansuri, N., Heuser, V. D., Birkman, E., Lintunen, M., Ålgars, A., Sundström, J., Ristamäki, R., Carpen, O. & Lehtinen, L., Nov 2021, In: Gastric Cancer. 24, 6, p. 1254-1263 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• FUNGI: FUsioN Gene Integration toolset

  Cervera, A., Rausio, H., Kähkönen, T., Andersson, N., Partel, G., Rantanen, V., Paciello, G., Ficarra, E., Hynninen, J., Hietanen, S., Carpen, O., Lehtonen, R., Hautaniemi, S. & Huhtinen, K., 15 Sept 2021, In: Bioinformatics. 37, 19, p. 3353-3355 3 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Network-guided identification of cancer-selective combinatorial therapies in ovarian cancer

  He, L., Bulanova, D., Oikkonen, J., Häkkinen, A., Zhang, K., Zheng, S., Wang, W., Erkan, E. P., Carpén, O., Joutsiniemi, T., Hietanen, S., Hynninen, J., Huhtinen, K., Hautaniemi, S., Vähärautio, A., Tang, J., Wennerberg, K. & Aittokallio, T., 3 Nov 2021, In: Briefings in Bioinformatics. 22, 6, 12 p., 272.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• PRISM: recovering cell-type-specific expression profiles from individual composite RNA-seq samples

  Häkkinen, A., Zhang, K., Alkodsi, A., Andersson, N., Erkan, E. P., Dai, J., Kaipio, K., Lamminen, T., Mansuri, N., Huhtinen, K., Vähärautio, A., Carpen, O., Hynninen, J., Hietanen, S., Lehtonen, R. & Hautaniemi, S., 15 Sept 2021, In: Bioinformatics. 37, 18, p. 2882-2888 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• WNT2 activation through proximal germline deletion predisposes to small intestinal neuroendocrine tumors and intestinal adenocarcinomas

  Aavikko, M., Kaasinen, E., Andersson, N., Pentinmikko, N., Sulo, P., Donner, I., Pihlajamaa, P., Kuosmanen, A., Bramante, S., Katainen, R., Sipilä, L. J., Martin, S., Arola, J., Carpén, O., Heiskanen, I., Mecklin, J.-P., Taipale, J., Ristimäki, A., Lehti, K. & Gucciardo, E. & 4 others, Katajisto, P., Schalin-Jäntti, C., Vahteristo, P. & Aaltonen, L. A., 15 Dec 2021, In: Human Molecular Genetics. 30, 24, p. 2429-2440 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• 2020

  ALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors

  Kaipio, K., Chen, P., Roering, P., Huhtinen, K., Mikkonen, P., Östling, P., Lehtinen, L., Mansuri, N., Korpela, T., Potdar, S., Hynninen, J., Auranen, A., Grénman, S., Wennerberg, K., Hautaniemi, S. & Carpén, O., Feb 2020, In: Journal of Pathology. 250, 2, p. 159-169 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• A longitudinal analysis of CA125 glycoforms in the monitoring and follow up of high grade serous ovarian cancer

  Salminen, L., Nadeem, N., Jain, S., Grènman, S., Carpén, O., Hietanen, S., Oksa, S., Lamminmäki, U., Pettersson, K., Gidwani, K., Huhtinen, K. & Hynninen, J., Mar 2020, In: Gynecologic Oncology. 156, 3, p. 689-694 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Androgen deprivation and SARS-CoV-2 in men with prostate cancer

  Koskinen, M., Carpen, O., Honkanen, V., Seppänen, M. R. J., Miettinen, P. J., Tuominen, J. A. & Raivio, T., Oct 2020, In: Annals of Oncology. 31, 10, p. 1417-1418 2 p.

  Research output: Contribution to journal › Letter › Scientific

  Open Access

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• An easily adaptable validated risk score predicts cancer-specific survival in stage II colon cancer

  Heervä, E., Väliaho, V., Salminen, T., Nieminen, L., Carpelan, A., Kurki, S., Sundström, J., Huhtinen, H., Rantala, A., Carpen, O., Minn, H., Österlund, P., Ålgars, A. & Ristamäki, R., 1 Dec 2020, In: Acta Oncologica. 59, 12, p. 1503-1507 5 p.

  Research output: Contribution to journal › Letter › Scientific

  Open Access

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• CA 19-9 doubling time in pancreatic cancer as a predictor of venous thromboembolism: a hospital database study

  Peippo, M. H., Kurki, S., Seppänen, H., Lassila, R. & Carpen, O., 1 Feb 2020, In: Acta Oncologica. 59, 2, p. 237-241 5 p.

  Research output: Contribution to journal › Letter › Scientific