Research output per year
Research output per year
Personal profile
Description of research and teaching
Research summary: A key issue in biology is to uncover the mechanisms employed by conserved signaling pathways to generate morphological diversity. The Bone Morphogenetic Proteins (BMPs), members of the TGF-beta superfamily, are a family of highly conserved secreted growth factors involved in metazoan developmental processes as diverse as cell proliferation, apoptosis, differentiation and cell-fate determination. Our studies intend to unveil the mechanisms of how spatial distribution of BMP ligands is regulated for pattern formation and how its modifications contribute to morphological variations in Drosophila and other species.
Teaching: Advanced developmental biology, Stem cells and organogenesis, Developmental biology practical course
Fields of Science
- 1184 Genetics, developmental biology, physiology
- developmental biology
- Drosophila development
- TGF-beta/BMP family signaling
- morphogen diffusion
- 1182 Biochemistry, cell and molecular biology
- epithelial cells
- Signal transduction
- morphogenesis
International and National Collaboration
Publications and projects within past five years.
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Editorial: Cell-to-cell communications in tissue homeostasis and repair
Shimmi, O. & Kankuri, E., 13 Jan 2023, In: Frontiers in Cell and Developmental Biology. 11, 2 p., 1138621.Research output: Contribution to journal › Editorial › Scientific › peer-review
Open AccessFile -
Mechano-chemical feedback mediated competition for BMP signalling leads to pattern formation
Toddie-Moore, D. J., Montanari, M. P., Tran, N. V., Brik, E. M., Antson, H., Salazar-Ciudad, I. & Shimmi, O., Jan 2022, In: Developmental Biology. 481, p. 43-51 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
New resources for the Drosophila 4th chromosome: FRT101F enabled mitotic clones and Bloom syndrome helicase enabled meiotic recombination
Goldsmith, S. L., Shimell, M. J., Tauscher, P., Daly, S. M., Shimmi, O., O'Connor, M. B. & Newfeld, S. J., Apr 2022, In: G3 - Genes genomes genetics. 12, 4, 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Regulation of spatial distribution of BMP ligands for pattern formation
Montanari, M. P., Tran, N. V. & Shimmi, O., Jan 2022, In: Developmental Dynamics. 251, 1, p. 198-212 15 p.Research output: Contribution to journal › Review Article › peer-review
Open AccessFile -
Scribble and alpha-Catenin cooperatively regulate epithelial homeostasis and growth
Huang, Y., Gui, J., Myllymäki, S-M., Roy, K., Tonissoo, T., Mikkola, M. L. & Shimmi, O., 21 Sep 2022, In: Frontiers in Cell and Developmental Biology. 10, 12 p., 912001.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
Projects
- 4 Active
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Interplanar siltojen in vivo -dynamiikka 3D -morfogeneesin aikana
Shimmi, O., Huang, Y., Kracklauer, M. & Shimmi, L.
01/09/2022 → 31/08/2026
Project: Academy of Finland: Academy Project
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Research Program in Developmental Biology
Thesleff, I., Jernvall, J., Di-Poi, N., Shimmi, O. & Saarma, M.
01/01/2014 → 31/12/2040
Project: Research project
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Helsinki EvoDevo (EvoDevo)
Di-Poi, N., Mikkola, M., Fortelius, M., Gilbert, S., Nieminen, P., Salazar Ciudad, I., Shimmi, O., Laakkonen, J., Thesleff, I. & Jernvall, J.
01/09/2013 → …
Project: Research project
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Helsinki EvoDevo (EvoDevo)
Jernvall, J., Fortelius, M., Nieminen, P., Laakkonen, J., Thesleff, I., Salazar Ciudad, I., Gilbert, S., Mikkola, M. & Shimmi, O.
01/08/2013 → …
Project: Research project
Activities
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Developmental Dynamics (Journal)
Osamu Shimmi (Reviewer)
17 Jul 2021Activity: Publication peer-review and editorial work types › Peer review of manuscripts
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Journal of Visualized Experiments (Journal)
Osamu Shimmi (Reviewer)
8 Jul 2019 → 12 Jul 2019Activity: Publication peer-review and editorial work types › Peer review of manuscripts
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Reviewer (Biotechnology and Biological Sciences Research Council)
Osamu Shimmi (Participant)
22 Feb 2019 → 15 Mar 2019Activity: Other activity types › Types for other activities - Other
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Molecular Biology and Evolution (Journal)
Osamu Shimmi (Reviewer)
19 Oct 2019 → 17 Nov 2019Activity: Publication peer-review and editorial work types › Peer review of manuscripts
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PLoS One (Journal)
Osamu Shimmi (Reviewer)
16 Apr 2019 → 29 Apr 2019Activity: Publication peer-review and editorial work types › Peer review of manuscripts