Päivi Lakkisto

Publications

Research output per year 2002 2008 2010 2011 2014 2015 2016 2018 2019 2020 2022 2023

• 48 Article
• 3 Review Article
• 2 Meeting Abstract
• 1 Letter
• 1 More
  • 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2023

  Development of circulating microRNA-based biomarkers for medical decision-making: a friendly reminder of what should NOT be done

  Lakkisto, P., Dalgaard, L. T., Belmonte, T., Pinto-Sietsma, S-J., Devaux, Y. & De Gonzalo-Calvo, D., 17 Feb 2023, In: Critical Reviews in Clinical Laboratory Sciences. 60, 2, p. 141-152 12 p.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File

• Moderate hyperuricaemia ameliorated kidney damage in a low-renin model of experimental renal insufficiency

  Kurra, V., Eräranta, A., Paavonen, T., Honkanen, T., Myllymäki, J., Riutta, A., Tikkanen, I., Lakkisto, P., Mustonen, J. & Pörsti, I., Jan 2023, In: Basic & Clinical Pharmacology & Toxicology. 132, 1, p. 21-32 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2022

  Alterations of Cardiac Protein Kinases in Cyclic Nucleotide-Dependent Signaling Pathways in Human Ischemic Heart Failure

  Wang, C., Taskinen, J. H., Segersvärd, H., Immonen, K., Kosonen, R., Tolva, J. M., Mäyränpää, M. I., Kovanen, P. T., Olkkonen, V. M., Sinisalo, J., Laine, M., Tikkanen, I. & Lakkisto, P., 2022, In: Frontiers in cardiovascular medicine. 9, 18 p., 919355.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Consensus guidelines for the validation of qRT-PCR assays in clinical research by the CardioRNA consortium

  EU-CardioRNA COST Action CA17129, de Gonzalo-Calvo, D., Marchese, M., Hellemans, J., Lakkisto, P. & Devaux, Y., 10 Mar 2022, In: Molecular therapy-Methods & clinical development. 24, p. 171-180 10 p.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File

• MiR-185-5p regulates the development of myocardial fibrosis

  Lin, R., Rahtu-Korpela, L., Szabo, Z., Kemppi, A., Skarp, S., Kiviniemi, A. M., Lepojärvi, E. S., Halmetoja, E., Kilpiö, T., Porvari, K., Pakanen, L., Tolva, J., Paakkanen, R., Segersvärd, H., Tikkanen, I., Laine, M., Sinisalo, J., Lakkisto, P., Huikuri, H., Magga, J., & 2 othersJunttila, J. & Kerkelä, R., Apr 2022, In: Journal of Molecular and Cellular Cardiology. 165, p. 130-140 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Tankyrase Inhibition Attenuates Cardiac Dilatation and Dysfunction in Ischemic Heart Failure

  Wang, H., Segersvärd, H., Siren, J., Perttunen, S., Immonen, K., Kosonen, R., Chen, Y-C., Tolva, J., Laivuori, M., Mäyranpää, M., Kovanen, P. T., Sinisalo, J., Laine, M., Tikkanen, I. & Lakkisto, P., Sep 2022, In: International Journal of Molecular Sciences. 23, 17, 25 p., 10059.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access
• 2021

  GSK3 beta Serine 389 Phosphorylation Modulates Cardiomyocyte Hypertrophy and Ischemic Injury

  Vainio, L., Taponen, S., Kinnunen, S. M., Halmetoja, E., Szabo, Z., Alakoski, T., Ulvila, J., Junttila, J., Lakkisto, P., Magga, J. & Kerkelä, R., Dec 2021, In: International Journal of Molecular Sciences. 22, 24, 17 p., 13586.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Zebrafish Heart Failure Models

  Narumanchi, S., Wang, H., Perttunen, S., Tikkanen, I., Lakkisto, P. & Paavola, J., 20 May 2021, In: Frontiers in Cell and Developmental Biology. 9, 15 p., 662583.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File
• 2020

  Association of miR-21-5p, miR-122-5p, and miR-320a-3p with 90-Day Mortality in Cardiogenic Shock

  Hänninen, M., Jäntti, T., Tolppanen, H., Segersvärd, H., Tarvasmäki, T., Lassus, J., Vausort, M., Devaux, Y., Sionis, A., Tikkanen, I., Harjola, V-P. & Lakkisto, P., Nov 2020, In: International Journal of Molecular Sciences. 21, 21, 12 p., 7925.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Two subphenotypes of septic acute kidney injury are associated with different 90-day mortality and renal recovery

  Wiersema, R., Jukarainen, S., Vaara, S. T., Poukkanen, M., Lakkisto, P., Wong, H., Linder, A., van der Horst, I. C. C. & Pettilä, V., 15 Apr 2020, In: Critical Care. 24, 1, 10 p., 150.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Unfavorable Reduction in the Ratio of Endothelin B to A Receptors in Experimental 5/6 Nephrectomy and Adenine Models of Chronic Renal Insufficiency

  Törmänen, S., Lakkisto, P., Eräranta, A., Kööbi, P., Tikkanen, I., Niemelä, O., Mustonen, J. & Pörsti, I., Feb 2020, In: International Journal of Molecular Sciences. 21, 3, 19 p., 936.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Vezf1 regulates cardiac structure and contractile function

  Paavola, J., Alakoski, T., Ulvila, J., Kilpiö, T., Sirén, J., Perttunen, S., Narumanchi, S., Wang, H., Lin, R., Porvari, K., Junttila, J., Huikuri, H., Immonen, K., Lakkisto, P., Magga, J., Tikkanen, I. & Kerkelä, R., Jan 2020, In: EBioMedicine. 51, 12 p., 102608.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2019

  Association of endothelial and glycocalyx injury biomarkers with fluid administration, development of acute kidney injury, and 90-day mortality: data from the FINNAKI observational study

  FINNAKI Study Grp, 11 Sep 2019, In: Annals of intensive care. 9, 1, 11 p., 103.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Circulating levels of microRNA 423-5p are associated with 90 day mortality in cardiogenic shock

  Jäntti, T., Segersvärd, H., Tolppanen, H., Tarvasmäki, T., Lassus, J., Devaux, Y., Vausort, M., Pulkki, K., Sionis, A., Bayes-Genis, A., Tikkanen, I., Lakkisto, P. & Harjola, V-P., Feb 2019, In: ESC Heart Failure. 6, 1, p. 98-102 5 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Circulating MiRNA Dynamics in ST-Segment Elevation Myocardial Infarction-driven Cardiogenic Shock

  Iborra-Egea, O., Rueda, F., Lakkisto, P., Harjola, V-P., Garcia-Garcia, C. & Bayes-Genis, A., Sep 2019, In: Revista Espanola de Cardiologia (Print). 72, 9, p. 783-786 5 p.

  Research output: Contribution to journal › Letter › Scientific

  Open Access

  File

• Heme oxygenase-1 repeat polymorphism in septic acute kidney injury

  FINNAKI Study Grp, Vilander, L. M., Vaara, S. T., Donner, K. M., Lakkisto, P., Kaunisto, M. A. & Pettilä, V., 23 May 2019, In: PLoS One. 14, 5, 13 p., 0217291.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Inhibition of let-7c Regulates Cardiac Regeneration after Cryoinjury in Adult Zebrafish

  Narumanchi, S., Kalervo, K., Perttunen, S., Wang, H., Immonen, K., Kosonen, R., Laine, M., Ruskoaho, H., Tikkanen, I., Lakkisto, P. & Paavola, J., Jun 2019, In: Journal of Cardiovascular Development and Disease. 6, 2, 12 p., 16.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• The association of endothelial injury and systemic inflammation with perioperative myocardial infarction

  Ollila, A., Vikatmaa, L., Virolainen, J., Nisula, S., Lakkisto, P., Vikatmaa, P., Tikkanen, I., Venermo, M. & Pettila, V., Nov 2019, In: Annals of Clinical Biochemistry. 56, 6, p. 674-683 10 p., 0004563219873357.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2018

  Carbon monoxide releasing molecule improves structural and functional cardiac recovery after myocardial injury

  Segersvärd, H., Lakkisto, P., Hänninen, M., Forsten, H., Siren, J., Immonen, K., Kosonen, R., Sarparanta, M., Laine, M. & Tikkanen, I., 5 Jan 2018, In: European Journal of Pharmacology. 818, p. 57-66 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Characterizing the Key Metabolic Pathways of the Neonatal Mouse Heart Using a Quantitative Combinatorial Omics Approach

  Lalowski, M. M., Björk, S., Finckenberg, P., Soliymani, R., Tarkia, M., Calza, G., Blokhina, D., Tulokas, S., Kankainen, M., Lakkisto, P., Baumann, M., Kankuri, E. & Mervaala, E., 11 Apr 2018, In: Frontiers in Physiology. 9, 20 p., 365.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia

  Kaartokallio, T., Utge, S., Klemetti, M. M., Paananen, J., Pulkki, K., Romppanen, J., Tikkanen, I., Heinonen, S., Kajantie, E., Kere, J., Kivinen, K., Pouta, A., Lakkisto, P. & Laivuori, H., Jan 2018, In: Hypertension. 71, 1, p. 95-102 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Fetal microsatellite in the HMOX-1 promoter is associated with severe and early-onset pre-eclampsia

  Kaartokallio, T., Utge, S., Klemetti, M. M., Paananen, J., Pulkki, K., Romppanen, J., Tikkanen, I., Heinonen, S., Kajantie, E., Kere, J., Kivinen, K., Pouta, A., Lakkisto, P. & Laivuori, H., Oct 2018, In: European Journal of Human Genetics. 26, p. 154-154 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• 2017

  Endothelin A receptor blocker and calcimimetic in the adenine rat model of chronic renal insufficiency

  Törmänen, S., Pörsti, I., Lakkisto, P., Tikkanen, I., Niemelä, O., Paavonen, T., Mustonen, J. & Eräranta, A., 27 Oct 2017, In: BMC Nephrology. 18, 13 p., 323.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Sept7b is required for the subcellular organization of cardiomyocytes and cardiac function in zebrafish

  Dash, S. N., Narumanchi, S., Paavola, J., Perttunen, S., Wang, H., Lakkisto, P. J., Tikkanen, I. T. & Lehtonen, S. H., May 2017, In: American Journal of Physiology: Heart and Circulatory Physiology. 312, 5, p. H1085-H1095 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access
• 2016

  Circulating microRNAs miR-21, miR-122a, miR-320a and miR-423 predict mortality in patients with cardiogenic shock

  Jantti, T. A. J., Segersvard, H., Lassus, J. P., Devaux, Y., Vausort, M., Immonen, K., Pulkki, K., Tikkanen, I., Lakkisto, P. & Harjola, V. -P., 1 Aug 2016, In: European Heart Journal. 37, p. 321-321 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• PLASMA HEME OXYGENASE-1 IN PATIENTS RESUSCITATED FROM OUT-OF-HOSPITAL CARDIAC ARREST

  Siren, J., Vaahersalo, J., Skrifvars, M., Pettilä, V., Tiainen, M., Tikkanen, I., Lakkisto, P. & FINNRESUSCI Study Grp, Mar 2016, In: Shock (Philadelphia). 45, 3, p. 320-325 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Urinary Biomarkers Indicative of Apoptosis and Acute Kidney Injury in the Critically Ill

  Vaara, S. T., Lakkisto, P., Immonen, K., Tikkanen, I., Ala-Kokko, T., Pettila, V. & FINNAKI Study Grp, 26 Feb 2016, In: PLoS One. 11, 2, 13 p., 0149956.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2015

  Effects of angiotensin II blockade on cardiomyocyte regeneration after myocardial infarction in rats

  Segersvard, H., Lakkisto, P., Forsten, H., Immonen, K., Kosonen, R., Palojoki, E., Kankuri, E., Harjula, A., Laine, M. & Tikkanen, I., Mar 2015, In: Journal of the Renin-Angiotensin-Aldosterone System. 16, 1, p. 92-102 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Hemioksygenaasi-1 - mahdollinen uusi merkkiaine?

  Lakkisto, P., 2015, In: Kliin lab : kliinisen laboratorioalan julkaisu : SKKY:n jäsenlehti.. 32, 2, p. 20-23 4 p.

  Research output: Contribution to journal › Article › Professional

• Human plasma cell-free DNA as a predictor of infectious complications of neutropenic fever in hematological patients

  Purhonen, A-K., Juutilainen, A., Vanska, M., Lehtikangas, M., Lakkisto, P., Hamalainen, S., Koivula, I., Jantunen, E. & Pulkki, K., Apr 2015, In: Scandinavian Journal of Infectious Diseases. 47, 4, p. 255-259 5 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2014

  Microsatellite Polymorphism in the Heme Oxygenase-1 Gene Promoter Is Associated with Non-Severe and Late-Onset Pre-Eclampsia

  Klemetti, M. M., Kaartokallio, T., Lakkisto, P. & Laivuori, H., Mar 2014, In: Reproductive Sciences. 21, 3, p. 300A-300A 1 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Microsatellite Polymorphism in the Heme Oxygenase-1 Promoter Is Associated With Nonsevere and Late-Onset Preeclampsia

  Kaartokallio, T., Klemetti, M. M., Timonen, A., Uotila, J., Heinonen, S., Kajantie, E., Kere, J., Kivinen, K., Pouta, A., Lakkisto, P. & Laivuori, H., Jul 2014, In: Hypertension. 64, 1, p. 172-177 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Phosphate Binding Reduces Aortic Angiotensin-Converting Enzyme and Enhances Nitric Oxide Bioactivity in Experimental Renal Insufficiency

  Eraranta, A., Tormanen, S., Koobi, P., Vehmas, T. I., Lakkisto, P., Tikkanen, I., Moilanen, E., Niemela, O., Mustonen, J. & Porsti, I., 2014, In: American journal of nephrology. 39, 5, p. 400-408 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2013

  VEGF overexpression improves mesenchymal stem cell sheet transplantation therapy for acute myocardial infarction

  Augustin, M., Mahar, M. A. A., Lakkisto, P., Tikkanen, I., Vento, A., Pätilä, T. & Harjula, A., Sep 2013, In: Journal of Tissue Engineering and Regenerative Medicine. 7, 9, p. 742-750 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2012

  Dietary Phosphate Binding and Loading Alter Kidney Angiotensin-Converting Enzyme mRNA and Protein Content in 5/6 Nephrectomized Rats

  Eraranta, A., Riutta, A., Fan, M., Koskela, J., Tikkanen, I., Lakkisto, P., Niemela, O., Parkkinen, J., Mustonen, J. & Porsti, I., 2012, In: American journal of nephrology. 35, 5, p. 401-408 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2011

  Effects of Levosimendan on Cardiac Gene Expression Profile and Post-Infarct Cardiac Remodelling in Diabetic Goto-Kakizaki Rats

  Vahtola, E., Storvik, M., Louhelainen, M., Merasto, S., Lakkisto, P., Tikkanen, I., Kaheinen, P., Levijoki, J. & Mervaala, E., 2011, In: Basic & Clinical Pharmacology & Toxicology. 109, 5, p. 387-397 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Heat shock attenuates VEGF expression in three-dimensional myoblast sheets deteriorating therapeutic efficacy in heart failure

  Augustin, M. M., Mahar, M. A. A., Lakkisto, P., Tikkanen, I., Vento, A., Pätilä, T. & Harjula, A., 2011, In: Medical Science Monitor. 17, 12, p. BR345-BR353 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Heme oxygenase-1 induction protects the heart and modulates cellular and extracellular remodelling after myocardial infarction in rats

  Lakkisto, P., Siren, J-M., Kyto, V., Forsten, H., Laine, M., Pulkki, K. & Tikkanen, I., Dec 2011, In: Experimental Biology and Medicine (Maywood). 236, 12, p. 1437-1448 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• hHGF Overexpression in Myoblast Sheets Enhances Their Angiogenic Potential in Rat Chronic Heart Failure

  Siltanen, A., Kitabayashi, K., Lakkisto, P., Mäkelä, J., Pätilä, T., Ono, M., Tikkanen, I., Sawa, Y., Kankuri, E. & Harjula, A., 2011, In: PLoS One. 6, 4, p. art. e19161 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Plasma cell-free DNA in patients needing mechanical ventilation

  Okkonen, M., Lakkisto, P., Korhonen, A-M., Parviai-nen, I., Reinikainen, M., Varpula, T., Pettila, V. & FINNALI Study Grp, 2011, In: Critical Care. 15, 4, p. - 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2010

  Angiotensin receptors in the eyes of arterial hypertensive rats

  Vaajanen, A., Lakkisto, P., Virtanen, I., Kankuri, E., Oksala, O., Vapaatalo, H. & Tikkanen, I., 2010, In: Acta Ophthalmologica. 88, 4, p. 431-438 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Heme oxygenase-1 and carbon monoxide promote neovascularization after myocardial infarction by modulating the expression of HIF-1 alpha, SDF-1 alpha and VEGF-B

  Lakkisto, P., Kyto, V., Forsten, H., Siren, J-M., Segersvard, H., Voipio-Pulkki, L-M., Laine, M., Pulkki, K. & Tikkanen, I., 2010, In: European Journal of Pharmacology. 635, p. 156-164 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Heme oxygenase-1 in cardiovascular diseases

  Lakkisto, P., 2010, Espoo.

  Research output: Thesis › Doctoral Thesis › Collection of Articles

• HEME OXYGENASE 1 POLYMORPHISMS AND PLASMA CONCENTRATIONS IN CRITICALLY ILL PATIENTS

  Saukkonen, K., Lakkisto, P., Kaunisto, M. A., Varpula, M., Voipio-Pulkki, L-M., Varpula, T., Pettila, V. & Pulkki, K., 2010, In: Shock (Philadelphia). 34, 6, p. 558-564 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2009

  Paricalcitol and renin-angiotensin components in remnant kidneys: [letter to the editor]

  Eräranta, A., Lakkisto, P., Tikkanen, I., Mustonen, J. & Pörsti, I., 2009, In: Kidney International. 75, 3, p. 339-340 2 p.

  Research output: Contribution to journal › Article › Scientific

• The heme oxygenase inducer hemin protects against cardiac dysfunction and ventricular fibrillation in ischaemic/reperfused rat hearts: role of connexin 43

  Lakkisto, P., Csonka, C., Fodor, G., Bencsik, P., Voipio-Pulkki, L-M., Ferdinandy, P. & Pulkki, K., 2009, In: Scandinavian Journal of Clinical & Laboratory Investigation. 69, 2, p. 209-218 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2008

  Cell-free plasma DNA as a predictor of outcome in severe sepsis and septic shock

  Saukkonen, K., Lakkisto, P., Pettilä, V., Varpula, M., Karlsson, S., Ruokonen, E., Pulkki, K. & The Finnsepsis study group, 2008, In: Clinical Chemistry (Washington, DC). 54, 6, p. 1000-1007 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Cell-Free Plasma DNA as a Predictor of outcome in Severe Sepsis and Septic Shock

  Marjut Varpula, Sari Karlsson, Esko Ruokonen, Kari Pulkki, 2008, In: Clinical Chemistry (Washington, DC). 2008, p. 1000-1007

  Research output: Contribution to journal › Article › Scientific › peer-review

• Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency

  Eräranta, A., Kurra, V., Tahvanainen, A. M., Vehmas, T., Kööbi, P., Lakkisto, P., Tikkanen, I., Niemelä, O., Mustonen, J. & Pörsti, I., 2008, In: Journal of Hypertension. 26, 8, p. 1661-1668 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• 2007

  Activation of protective and damaging components of the cardiac renin-angiotensin system after myocardial infarction in experimental diabetes

  Bäcklund, T., Lakkisto, P., Palojoki, E., Grönholm, T., Saraste, A., Finckenberg, P., Mervaala, E., Tikkanen, I. & Laine, M., 2007, In: Journal of the Renin-Angiotensin-Aldosterone System. 8, 2, p. 66-73 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review