Päivi Lindholm Pulkkila

Publications

Research output per year 1996 2009 2010 2011 2012 2016 2017 2018 2019 2022 2023

• 39 Article
• 2 Meeting Abstract
• 2 Review Article
• 1 Chapter
• 2 More
  • 1 Conference article
  • 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2023

  MANF regulates neuronal survival and UPR through its ER-located receptor IRE1a

  Kovaleva, V., Yu, L., Ivanova, L., Shpironok, O., Nam, J., Eesmaa, A., Kumpula, E-P. T., Sakson, S., Toots, U., Ustav, M., Huiskonen, J. T., Lindholm Pulkkila, P., Voutilainen, M., Karelson, M. & Saarma, M., 28 Feb 2023, In: Cell Reports. 42, 2, 31 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2022

  CDNF and MANF regulate ER stress in a tissue-specific manner

  Pakarinen, E., Lindholm, P., Saarma, M. & Lindahl, M., Feb 2022, In: Cellular and Molecular Life Sciences. 79, 2, 18 p., 124.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival

  Eesmaa, A., Yu, L-Y., Göös, H., Danilova, T., Nöges, K., Pakarinen, E., Varjosalo, M., Lindahl, M., Lindholm, P. & Saarma, M., Aug 2022, In: International Journal of Molecular Sciences. 23, 16, 27 p., 9489.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism

  Lindholm, P. & Saarma, M., Mar 2022, In: Molecular Psychiatry. 27, 3, p. 1310-1321 12 p.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File
• 2021

  The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor

  Eesmaa, A., Yu, L-Y., Göös, H., Nõges, K., Kovaleva, V., Hellman, M., Zimmermann, R., Jung, M., Permi, P., Varjosalo, M., Lindholm, P. & Saarma, M., 2021, In: Journal of Biological Chemistry. 296, 23 p., 100295.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2020

  Cerebral Dopamine Neurotrophic Factor Is Essential for Enteric Neuronal Development, Maintenance and Regulation of Gastrointestinal Transit

  Chalazonitis, A., Li, Z., Pham, T. D., Chen, J., Rao, M., Lindholm, P., Saarma, M., Lindahl, M. & Gershon, M. D., Oct 2020, In: Journal of Comparative Neurology. 528, 14, p. 2420-2444 25 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2019

  Characterization of CDNF-Secreting ARPE-19 Cell Clones for Encapsulated Cell Therapy

  Galli, E., Lindholm, P., Kontturi, L-S., Saarma, M., Urtti, A. & Yliperttula, M., Apr 2019, In: Cell Transplantation. 28, 4, p. 413-424 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Increased Serum Levels of Mesencephalic Astrocyte-Derived Neurotrophic Factor in Subjects With Parkinson’s Disease

  Galli, E., Planken, A., Kadastik-Eerme, L., Saarma, M., Taba, P. & Lindholm, P., 4 Sep 2019, In: Frontiers in Neuroscience. 13, 8 p., 929.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Levels of glial cell line-derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in parkinson's disease

  Virachit, S., Mathews, K. J., Cottam, V., Werry, E., Galli, E., Rappou, E., Lindholm, P., Saarma, M., Halliday, G. M., Weickert, C. S. & Double, K. L., Nov 2019, In: Brain Pathology. 29, 6, p. 813-825 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function

  Danilova, T., Galli, E., Pakarinen, E., Palm, E., Lindholm, P. K., Saarma, M. & Lindahl, M., Nov 2019, In: Frontiers in Endocrinology. 10, 19 p., 765.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Upregulated with Therapeutic Fasting in Humans and Diet Fat Withdrawal in Obese Mice

  Galli, E., Rossi, J., Neumann, T., Andressoo, J-O., Drinda, S. & Lindholm, P., 4 Oct 2019, In: Scientific Reports. 9, 12 p., 14318.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2018

  Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

  Balboa, D., Saarimäki-Vire, J., Borshagovski, D., Survila, M., Lindholm, P., Galli, E., Eurola, S., Ustinov, J., Grym, H., Huopio, H., Partanen, J., Wartiovaara, K. & Otonkoski, T., 9 Nov 2018, In: eLife. 7, 35 p., 38519.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• MANF protects human pancreatic beta cells against stress-induced cell death

  Hakonen, E., Chandra, V., Fogarty, C. L., Yu, N. Y-L., Ustinov, J., Katayama, S., Galli, E., Danilova, T., Lindholm, P., Vartiainen, A., Einarsdottir, E., Krjutskov, K., Kere, J., Saarma, M., Lindahl, M. & Otonkoski, T., Oct 2018, In: Diabetologia. 61, 10, p. 2202-2214 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Poststroke delivery of MANF promotes functional recovery in rats

  Mätlik, K., Anttila, J. E., Kuan-Yin, T., Smolander, O-P., Pakarinen, E., Lehtonen, L., Abo-Ramadan, U., Lindholm, P., Zheng, C., Harvey, B., Arumäe, U., Lindahl, M. & Airavaara, M., 23 May 2018, In: Science Advances. 4, 5, 8 p., 8957.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2017

  Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action

  Voutilainen, M. H., De Lorenzo, F., Stepanova, P., Bäck, S., Pulkkila, P., Pörsti, E., Saarma, M., Männistö, P. T. & Tuominen, R. K., 2017, In: eNeuro. 4, 1, 14 p., e0117-16.2017.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway

  Lindstrom, R., Lindholm, P., Palgi, M., Saarma, M. & Heino, T. I., 2 Jun 2017, In: BMC Genetics. 18, 19 p., 52.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential

  Lindahl, M., Saarma, M. & Lindholm, P., Jan 2017, In: Neurobiology of Disease. 97, part B, p. 90-102 13 p.

  Research output: Contribution to journal › Review Article › peer-review
• 2016

  Comparative Analysis of the Effects of Neurotrophic Factors CDNF and GDNF in a Nonhuman Primate Model of Parkinson's Disease

  Garea-Rodriguez, E., Eesmaa, A., Lindholm, P. K., Schlumbohm, C., König, J., Meller, B., Krieglstein, K., Helms, G., Saarma, M. & Fuchs, E., 22 Feb 2016, In: PLoS One. 11, 2, 21 p., 0149776.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster

  Lindström, R., Lindholm, P., Kallijärvi, J., Palgi, M., Saarma, M. & Heino, T. I., 14 Mar 2016, In: PLoS One. 11, 3, 18 p., 0151550.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes

  Galli, E., Harkonen, T., Sainio, M., Ustav, M., Toots, U., Urtti, A., Yliperttula, M., Lindahl, M., Knip, M., Saarma, M. & Lindholm, P., 30 Jun 2016, In: Scientific Reports. 6, 11 p., 29058.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2015

  Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice

  Kemppainen, S., Pulkkila, P. K., Galli, E. M. C., Lahtinen, H-M., Koivisto, H., Hämäläinen, E., Saarma, M. & Tanila, H., 2015, In: Behavioural Brain Research. 291, p. 1-11 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity

  Mätlik, K., Yu, L., Eesmaa, A., Hellman, M., Lindholm, P., Peränen, J., Galli, E., Anttila, J., Saarma, M., Permi, P., Airavaara, M. & Arumäe, U., Dec 2015, In: Cell Death and Disease. 6, 8 p., 2032.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2014

  MANF is indispensable for the proliferation and survival of pancreatic beta-cells

  Lindahl, M., Danilova, T., Palm, E., Lindholm, P., Voikar, V., Hakonen, E., Ustinov, J., Andressoo, J-O., Harvey, B. K., Otonkoski, T., Rossi, J. & Saarma, M., Apr 2014, In: Cell Reports. 7, 2, p. 366-375 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2013

  Characterization of the Structural and Functional Determinants of MANF/CDNF in Drosophila In Vivo Model

  Lindström, R., Lindholm, P. K., Kallijärvi, J., Yu, L., Piepponen, T. P., Arumäe, U., Saarma, M. & Heino, T., 2013, In: PLoS One. 8, 9, 12 p., e73928.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease

  Bäck, S., Peränen, J., Galli, E., Pulkkila, P., Lonka-Nevalaita, L., Tamminen, T., Voutilainen, M. H., Raasmaja, A., Saarma, M., Männistö, P. T. & Tuominen, R. K., Mar 2013, In: Brain and Behavior. 3, 2, p. 75-88 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2012

  CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery After MPTP Treatment in Mice

  Airavaara, M., Harvey, B. K., Voutilainen, M. H., Shen, H., Chou, J., Lindholm, P., Lindahl, M., Tuominen, R. K., Saarma, M., Hoffer, B. & Wang, Y., 2012, In: Cell Transplantation. 21, 6, p. 1213-1223 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Characterization of the structural and functional determinants of MANF/CDNF proteins using Drosophila model

  Lindstrom, R., Lindholm, P., Yu, L. -Y., Kallijarvi, J., Arumae, U., Saarma, M. & Heino, T., Dec 2012, In: Journal of Neurogenetics. 26, p. 73-74 2 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Neurotrophic Factors

  Saarma, M., Lindholm, P. K. & Arumäe, U., 2012, Movement Disorders. Watts, R. L., Standaert, D. G. & Obeso, J. A. (eds.). 3rd Edition ed. McGraw-Hill Companies, Inc. , p. 129-140 12 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › Scientific › peer-review
• 2011

  CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery After MPTP Treatment n Mice

  Airavaara, M., Harvey, B. K., Voutilainen, M. H., Chou, J., Lindholm, P., Lindahl, M., Tuominen, R. K., Saarma, M., Wang, Y. & Hoffer, B., 2011, In: Cell Transplantation. 20, Supplement 1, p. 544-545 2 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease

  Voutilainen, M. H., Back, S., Peranen, J., Lindholm, P., Raasmaja, A., Mannisto, P. T., Saarma, M. & Tuominen, R. K., 2011, In: Experimental Neurology. 228, 1, p. 99-108 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons

  Hellman, M., Arumäe, U., Yu, L., Lindholm, P. K., Peränen, J., Saarma, M. & Permi, P., 2011, In: Journal of Biological Chemistry. 286, 4, p. 2675-2680 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2010

  Novel CDNF/MANF Family of Neurotrophic Factors

  Lindholm, P. K. & Saarma, M., 2010, In: Developmental Neurobiology. 70, 5, p. 360-371 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Novel Neurotrophic Factor CDNF: Biology and Therapeutic Potential

  Saarma, M., Lindholm, P., Andressoo, J. -O., Perlinen, J. & Lindahl, M., 2010, In: Cell Transplantation. 19, 3, p. 359-360 2 p.

  Research output: Contribution to journal › Meeting Abstract

• Regulation of Brain-Derived Neurotrophic Factor (BDNF) and Cerebral Dopamine Neurotrophic Factor (CDNF) by Anti-Parkinsonian Drug Therapy In Vivo

  Gyarfas, T., Knuuttila, J., Lindholm, P., Rantamäki, T. & Castrén, E., 2010, In: Cellular and Molecular Neurobiology. 30, p. 361-368 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2009

  Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's Disease

  Voutilainen, M., Bäck, S., Pörsti, E., Toppinen, L., Lindgren, L., Lindholm, P., Peränen, J., Saarma, M. & Tuominen, R. K., 2009, In: Journal of Neuroscience. 29, 30, p. 9651-9659 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Novel CDNF/MANF protein family: molecular structure, expression and neurotrophic activity

  Lindholm, P. & Lindholm, P., 2009, Helsinki: University of Helsinki, Institute of Biotechnology & Department of Biological and Environmental Sciences, Division of Genetics. 75 p.

  Research output: Thesis › Doctoral Thesis › Monograph

• The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional

  Parkash, V., Lindholm, P., Peränen, J., Kalkkinen, N., Oksanen, E., Saarma, M., Leppänen, V-M. & Goldman, A., 2009, In: Protein Engineering, Design and Selection. 22, 4, p. 233-241 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2008

  CDNF is a novel neurotrophic factor for doparninergic neurons in vivo

  Voutilainen, M. H., Lindholm, P., Saarma, M. & Tuominen, R. K., 9 Jun 2008, In: European Journal of Pharmaceutical Sciences. 34, 1, p. S9-S9 1 p.

  Research output: Contribution to journal › Conference article › Scientific › peer-review

• MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain

  Lindholm, P., Peränen, J., Andressoo, J-O., Kalkkinen, N., Kokaia, Z., Lindvall, O., Timmusk, T. & Saarma, M., 2008, In: Molecular and Cellular Neuroscience. 39, 3, p. 356-371 16 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2007

  Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

  Lindholm, P., Voutilainen, M., Lauren, J., Peränen, J., Leppänen, V-M., Andressoo, J-O., Lindahl, M., Janhunen, S., Kalkkinen, N., Timmusk, T., Tuominen, R. K. & Saarma, M., 2007, In: Nature. 448, 7147, p. 73-78 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2004

  PSPN/GFRalpha4 has a significantly weaker capacity than GDNF/GFRalpha1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth.

  Yang, J., Lindahl, M. S., Lindholm, P. K., Virtanen, H., Coffey, E., Runeberg-Roos, P. & Saarma, M., 2004, In: FEBS Letters. 2004, 569, p. 267-271

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2002

  Proteolytic processing of potyviral proteins and polyprotein processing intermediates in insect and plant cells

  Merits, A., Rajamaki, M. L., Lindholm, P., Runeberg-Roos, P., Kekarainen, T., Puustinen, P., Makelainen, K., Valkonen, J. P. T. & Saarma, M., 2002, In: Journal of General Virology. 83, p. 1211-1221 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2000

  A novel human processed gene, DAD-R, maps to 12p12 and is expressed in several organs

  Kuittinen, T. P., Eggert, A., Lindholm, P. K., Horelli-Kuitunen, N., Palotie, A., Maris, J. M. & Saarma, M., 2000, In: FEBS Letters. 2000, 473, p. 233-236

  Research output: Contribution to journal › Article › Scientific › peer-review

• Glycosylation of phytepsin and expression of dad1, dad2 and ost1 during onset of cell death in germinating barley scutella

  Lindholm, P. K., Kuittinen, T. P., Sorri, O., Guo, D., Merits, A., Törmäkangas, K. & Runeberg-Roos, P., 2000, In: Mechanisms of Development. 2000, 93, p. 169-173

  Research output: Contribution to journal › Article › Scientific › peer-review
• 1997

  Streptomyces spp. isolated from potato scab lesions under Nordic conditions in Finland

  Lindholm, P., Kortemaa, H., Kokkola, M., Haahtela, K., SalkinojaSalonen, M. & Valkonen, J. P. T., 1997, In: Plant Disease. 81, 11, p. 1317-1322 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 1996

  Suomalaiset perunarupikannat

  Translated title of the contribution: Streptomyces spp. causing common scab in FinlandValkonen, J., Lindholm, P., Kortemaa, H. & Kokkola, M., 1996, In: Tuottava peruna. 23, 4, p. 17-18

  Research output: Contribution to journal › Article › General public