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Päivi Saavalainen

20042020
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Publications 2004 2020

2020

Epigenetic and transcriptional analysis supports human regulatory T cell commitment at the CD4+CD8+thymocyte stage

Vanhanen, R., Leskinen, K., Mattila, I. P., Saavalainen, P. & Arstila, T. P., Jan 2020, In : Cellular Immunology. 347, 7 p., 104026.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

Heikkilä, N., Vanhanen, R., Yohannes, D. A., Saavalainen, P., Meri, S., Jokiranta, T. S., Jarva, H., Mattila, I. P., Hamm, D., Sormunen, S., Saramäki, J. & Arstila, T. P., 14 Jan 2020, In : European Journal of Immunology. 4 p.

Research output: Contribution to journalLetterScientific

2019

Deciphering the Antibacterial Mode of Action of Alpha-Mangostin on Staphylococcus epidermidis RP62A Through an Integrated Transcriptomic and Proteomic Approach

Sivaranjani, M., Leskinen, K., Aravindraja, C., Saavalainen, P., Pandian, S. K., Skurnik, M. & Ravi, A. V., 6 Feb 2019, In : Frontiers in Microbiology. 10, 16 p., 150.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy

Göös, H., Fogarty, C. L., Sahu, B., Plagnol, V., Rajamäki, K., Nurmi, K., Liu, X., Einarsdottir, E., Jouppila, A., Pettersson, T., Vihinen, H., Krjutskov, K., Saavalainen, P., Järvinen, A., Muurinen, M., Greco, D., Scala, G., Curtis, J., Nordström, D., Flaumenhaft, R. & 12 others, Vaarala, O., Kovanen, P. E., Keskitalo, S., Ranki, A., Kere, J., Lehto, M., Notarangelo, L. D., Nejentsev, S., Eklund, K. K., Varjosalo, M., Taipale, J. & Seppanen, M. R. J., Nov 2019, In : Journal of Allergy and Clinical Immunology. 144, 5, p. 1364-1376 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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GENETICS OF VACCINATION RELATED NARCOLEPSY

Ollila, H., Wennerstrom, A., Partinen, M., Mignot, E., Saarela, J., Saavalainen, P., Vaarala, O., Tienari, P. & Perola, M., 2019, In : European Neuropsychopharmacology. 29, p. S994-S994 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Gluten Challenge Induces Skin and Small Bowel Relapse in Long-Term Gluten-Free Diet-Treated Dermatitis Herpetiformis

Mansikka, E., Hervonen, K., Kaukinen, K., Ilus, T., Oksanen, P., Lindfors, K., Laurila, K., Hietikko, M., Taavela, J., Jernman, J., Saavalainen, P., Reunala, T. & Salmi, T., Oct 2019, In : Journal of Investigative Dermatology. 139, 10, p. 2108-2114 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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In vitro humanized 3D microfluidic chip for testing personalized immunotherapeutics for head and neck cancer patients

Al-Samadi, A., Poor, B., Tuomainen, K., Liu, V., Hyytiäinen, A., Suleymanova, I., Mesimäki, K., Wilkman, T., Mäkitie, A., Saavalainen, P. & Salo, T., 15 Oct 2019, In : Experimental Cell Research. 383, 2, 7 p., 111508.

Research output: Contribution to journalArticleScientificpeer-review

Serology-based criteria for adult coeliac disease have excellent accuracy across the range of pre-test probabilities

Fuchs, V., Kurppa, K., Huhtala, H., Laurila, K., Maki, M., Collin, P., Salmi, T., Luostarinen, L., Saavalainen, P. & Kaukinen, K., Feb 2019, In : Alimentary Pharmacology & Therapeutics. 49, 3, p. 277-284 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The Phenotype of Celiac Disease Has Low Concordance between Siblings, Despite a Similar Distribution of HLA Haplotypes

Kauma, S., Kaukinen, K., Huhtala, H., Kivelä, L., Pekki, H., Salmi, T., Saavalainen, P., Lindfors, K. & Kurppa, K., Feb 2019, In : Nutrients. 11, 2, 10 p., 479.

Research output: Contribution to journalArticleScientificpeer-review

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2018

Complement Factor H and Apolipoprotein E Participate in Regulation of Inflammation in THP-1 Macrophages

Nissilä, E., Hakala, P., Leskinen, K., Roig, A., Syed, S., Van Kessel, K. P. M., Metso, J., De Haas, C. J. C., Saavalainen, P., Meri, S., Chroni, A., Van Strijp, J. A. G., Öörni, K., Jauhiainen, M., Jokiranta, T. S. & Haapasalo, K., 21 Nov 2018, In : Frontiers in Immunology. 9, 14 p., 2701.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Development and evaluation of a rapid nucleic acid amplification method to detect influenza A and B viruses in human respiratory specimens

Elf, S., Auvinen, P., Jahn, L., Liikonen, K., Sjöblom, S., Saavalainen, P., Mäki, M. & Eboigbodin, K. E., Sep 2018, In : Diagnostic Microbiology and Infectious Disease. 92, 1, p. 37-42 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

Int IBD Genetics Consortium, NIDDK IBD Genetics Consortium, T2D-Genes Consortium, Rivas, M. A., Koskela, J., Pirinen, M., Kurki, M., Saavalainen, P., Farkkila, M., Kontula, K., Palotie, A. & Daly, M. J., May 2018, In : PLoS Genetics. 14, 5, 25 p., 1007329.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Microbial Biomarkers in Patients with Nonresponsive Celiac Disease

Viitasalo, L., Kurppa, K., Ashorn, M., Saavalainen, P., Huhtala, H., Ashorn, S., Mäki, M., Ilus, T., Kaukinen, K. & Iltanen, S., Dec 2018, In : Digestive Diseases and Sciences. 63, 12, p. 3434-3441 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Small-intestinal TG2-specific plasma cells at different stages of coeliac disease

Hietikko, M., Koskinen, O., Kurppa, K., Laurila, K., Saavalainen, P., Salmi, T., Ilus, T., Huhtala, H., Kaukinen, K. & Lindfors, K., 6 Dec 2018, In : BMC Immunology. 19, 7 p., 36.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The Psoriasis Risk Allele HLA-C*06: 02 Shows Evidence of Association with Chronic or Recurrent Streptococcal Tonsillitis

Haapasalo, K., Koskinen, L. L. E., Suvilehto, J., Jousilahti, P., Wolin, A., Suomela, S., Trembath, R., Barker, J., Vuopio, J., Kere, J., Jokiranta, T. S. & Saavalainen, P., Oct 2018, In : Infection and Immunity. 86, 10, 9 p., ARTN e00304-18.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia

Lokki, A. I., Kaartokallio, T., Holmberg, V., Onkamo, P., Koskinen, L. L. E., Saavalainen, P., Heinonen, S., Kajantie, E., Kere, J., Kivinen, K., Pouta, A., Villa, P. M., Hiltunen, L., Laivuori, H. & Meri, S., 29 May 2017, In : Frontiers in Immunology. 8, 10 p., 589.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Anemia and Iron Deficiency in Children With Potential Celiac Disease

Repo, M., Lindfors, K., Maki, M., Huhtala, H., Laurila, K., Lahdeaho, M-L., Saavalainen, P., Kaukinen, K. & Kurppa, K., Jan 2017, In : Journal of Pediatric Gastroenterology and Nutrition. 64, 1, p. 56-62 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Deep sequencing of blood and gut T-cell receptor beta-chains reveals gluten-induced immune signatures in celiac disease

Yohannes, D. A., Freitag, T. L., de Kauwe, A., Kaukinen, K., Kurppa, K., Wacklin, P., Mäki, M., Arstila, T. P., Anderson, R. P., Greco, D. & Saavalainen, P., 21 Dec 2017, In : Scientific Reports. 7, 12 p., 17977.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

A Prospective Study on the Usefulness of Duodenal Bulb Biopsies in Celiac Disease Diagnosis in Children: Urging Caution

Taavela, J., Popp, A., Korponay-Szabo, I. R., Ene, A., Vornanen, M., Saavalainen, P., Lahdeaho, M-L., Ruuska, T., Laurila, K., Parvan, A., Anca, I., Kurppa, K. & Maki, M., Jan 2016, In : American Journal of Gastroenterology. 111, 1, p. 124-133 10 p.

Research output: Contribution to journalArticleScientificpeer-review

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis

Rivas, M. A., Graham, D., Sulem, P., Stevens, C., Desch, A. N., Goyette, P., Gudbjartsson, D., Jonsdottir, I., Thorsteinsdottir, U., Degenhardt, F., Mucha, S., Kurki, M. I., Li, D., D'Amato, M., Annese, V., Vermeire, S., Weersma, R. K., Halfvarson, J., Paavola-Sakki, A. L. P., Lappalainen, A. M. & 28 others, Lek, M., Cummings, B., Tukiainen, T., Haritunians, T., Halme, L., Koskinen, L. L. E., Ananthakrishnan, A. N., Luo, Y., Heap, G. A., Visschedijk, M. C., MacArthur, D. G., Neale, B. M., Ahmad, T., Anderson, C. A., Brant, S. R., Duerr, R. H., Silverberg, M. S., Cho, J. H., Palotie, A., Saavalainen, P., Kontula, K., Farkkila, M., McGovern, D. P. B., Franke, A., Stefansson, K., Rioux, J. D., Xavier, R. J. & Daly, M. J., Aug 2016, In : Nature Communications. 7, 7 p., 12342.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Dermatitis Herpetiformis Refractory to Gluten-free Dietary Treatment

Hervonen, K., Salmi, T. T., Ilus, T., Paasikivi, K., Vornanen, M., Laurila, K., Lindfors, K., Viiri, K., Saavalainen, P., Collin, P., Kaukinen, K. & Reunala, T., 2016, In : Acta Dermato-Venereologica. 96, 1, p. 82-86 5 p.

Research output: Contribution to journalArticleScientificpeer-review

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Open Access
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Expansion induced microRNA changes in bone marrow mesenchymal stromal cells reveals interplay between immune regulation and cell cycle

Kilpinen, L., Parmar, A., Greco, D., Korhonen, M., Lehenkari, P., Saavalainen, P. & Laitinen, S., Nov 2016, In : Aging Clinical and Experimental Research. 8, 11, p. 2799-2813 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Novel diagnostic techniques for celiac disease

Kurppa, K., Taavela, J., Saavalainen, P., Kaukinen, K. & Lindfors, K., 2016, In : Expert Review of Gastroenterology and Hepatology. 10, 7, p. 795-805 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Serum transglutaminase 3 antibodies correlate with age at celiac disease diagnosis

Salmi, T. T., Kurppa, K., Hervonen, K., Laurila, K., Collin, P., Huhtala, H., Saavalainen, P., Sievanen, H., Reunala, T. & Kaukinen, K., Jun 2016, In : Digestive and Liver Disease. 48, 6, p. 632-637 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2014

Altered Duodenal Microbiota Composition in Celiac Disease Patients Suffering From Persistent Symptoms on a Long-Term Gluten-Free Diet

Wacklin, P., Laurikka, P., Lindfors, K., Collin, P., Salmi, T., Lahdeaho, M-L., Saavalainen, P., Maki, M., Matto, J., Kurppa, K. & Kaukinen, K., Dec 2014, In : American Journal of Gastroenterology. 109, 12, p. 1933-1941 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Antigenic Differences between AS03 Adjuvanted Influenza A (H1N1) Pandemic Vaccines: Implications for Pandemrix-Associated Narcolepsy Risk

Vaarala, O., Vuorela, A., Partinen, M., Baumann, M., Freitag, T. L., Meri, S., Saavalainen, P., Jauhiainen, M., Soliymani, R., Kirjavainen, T., Olsen, P., Saarenpaa-Heikkila, O., Rouvinen, J., Roivainen, M., Nohynek, H., Jokinen, J., Julkunen, I. & Kilpi, T., 15 Dec 2014, In : PLoS One. 9, 12, 23 p., 114361.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Benefits of a Gluten-Free Diet for Asymptomatic Patients With Serologic Markers of Celiac Disease

Kurppa, K., Paavola, A., Collin, P., Sievanen, H., Laurila, K., Huhtala, H., Saavalainen, P., Maki, M. & Kaukinen, K., Sep 2014, In : Gastroenterology. 147, 3, p. 610-+ 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Impaired epithelial integrity in the duodenal mucosa in early stages of celiac disease

Rauhavirta, T., Lindfors, K., Koskinen, O., Laurila, K., Kurppa, K., Saavalainen, P., Maki, M., Collin, P. & Kaukinen, K., Sep 2014, In : Translational Research. 164, 3, p. 223-231 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality

Kilpinen, L., Tigistu-Sahle, F., Oja, S., Greco, D., Parmar, A., Saavalainen, P. M., Nikkilä, J. T., Korhonen, M., Lehenkari, P., Käkelä, R. & Laitinen, S., Mar 2013, In : Journal of Lipid Research. 54, 3, p. 622-635 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Degree of Damage to the Small Bowel and Serum Antibody Titers Correlate With Clinical Presentation of Patients With Celiac Disease

Taavela, J., Kurppa, K., Collin, P., Lahdeaho, M-L., Salmi, T., Saavalainen, P., Haimila, K., Huhtala, H., Laurila, K., Sievanen, H., Maki, M. & Kaukinen, K., Feb 2013, In : Clinical Gastroenterology and Hepatology. 11, 2, p. 166-+ 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Gene Expression Profiling of Gliadin Effects on Intestinal Epithelial Cells Suggests Novel Non-Enzymatic Functions of Pepsin and Trypsin

Parmar, A., Greco, D., Venalainen, J., Gentile, M., Dukes, E. & Saavalainen, P., 18 Jun 2013, In : PLoS One. 8, 6, p. Article Number: UNSP e66307 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2012

Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients

Parmar, A., Lappalainen, A. M., Paavola-Sakki, A. L. P., Halme, L., Färkkilä, M. A., Turunen, U., Kontula, K., Aromaa, A., Salomaa, V., Palotie, L., Halfvarson, J., Törkvist, L., D´Amato, M., Saavalainen, P. M. & Einarsdottir, E., 2012, In : Genes and Immunity. 13, 6, p. 474-480 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Association study of FUT2 (rs601338) with celiac disease and inflammatory bowel disease in the Finnish population

Parmar, A. S., Alakulppi, N., Paavola-Sakki, A. L. P., Kurppa, K., Halme, L., Färkkilä, M. A., Turunen, U., Lappalainen, M., Kontula, K., Kaukinen, K., Maki, M., Lindfors, K., Partanen, J., Sistonen, P., Matto, J., Wacklin, P., Saavalainen, P. & Einarsdottir, E., Dec 2012, In : Tissue Antigens. 80, 6, p. 488-493 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Endomysial antibodies predict celiac disease irrespective of the titers or clinical presentation

Kurppa, K., Rasanen, T., Collin, P., Iltanen, S., Huhtala, H., Ashorn, M., Saavalainen, P., Haimila, K., Partanen, J., Maki, M. & Kaukinen, K., 2012, In : World Journal of Gastroenterology. 18, 20, p. 2511-2516 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Gliadin- or Secalin-Primed CD4+CD62L-CD44high T Cells as Sensors of Dietary Gluten - Practical Application of a Mouse Model of Gluten-Sensitive Enteropathy

Freitag, T. L., Loponen, J., Messing, M., Andersson, L., Sontag-Strohm, T., Saavalainen, P., Schuppan, D., Salovaara, H. & Meri, S., 2012, In : Scandinavian Journal of Immunology. 76, 2, p. 199-199 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

Methods for diagnostic HLA typing in disease association and drug hypersensitivity

Varney, M. D., Castley, A. S. L., Haimila, K. & Saavalainen, P. M., 2012, Immunogenetics: Methods and Applications in Clinical Practice. Christiansen, F. T. & Tait, B. D. (eds.). New York: Springer, Vol. 882. p. 27-46 20 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Persistent Duodenal Intraepithelial Lymphocytosis Despite a Long-Term Strict Gluten-Free Diet in Celiac Disease

Tuire, I., Marja-Leena, L., Teea, S., Katri, H., Jukka, P., Saavalainen, P. M., Heini, H., Markku, M., Pekka, C. & Katri, K., 1 Oct 2012, In : American Journal of Gastroenterology. 107, 10, p. 1563-1569 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Utility of the New ESPGHAN Criteria for the Diagnosis of Celiac Disease in At-risk Groups

Kurppa, K., Salminiemi, J., Ukkola, A., Saavalainen, P. M., Löytynoja, K., Laurila, K., Collin, P., Maki, M. & Kaukinen, K., 2012, In : Journal of Pediatric Gastroenterology and Nutrition. 54, 3, p. 387-391 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Antibodies Against Deamidated Gliadin Peptides in Early-stage Celiac Disease

Kurppa, K., Lindfors, K., Collin, P., Saavalainen, P. M., Partanen, J., Haimila, K., Huhtala, H., Laurila, K., Maki, M. & Kaukinen, K., 2011, In : Journal of Clinical Gastroenterology. 45, 8, p. 673-678 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Functional Polymorphism in IL12B Promoter Site Is Associated with Ulcerative Colitis: [Letters to the editor]

Szperl, A., Saavalainen, P., Weersma, R. K., Lappalainen, A. M., Paavola-Sakki, P., Halme, L., Färkkilä, M. A., Turunen, U., Kontula, K., Ponsioen, C. Y., Wijmenga, C. & van Diemen, C. C., 2011, In : Inflammatory Bowel Diseases. 17, 6, p. E38-E40 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Galactosylation of Serum IgA1 O-Glycans in Celiac Disease

Lindfors, K., Suzuki, H., Novak, J., Collin, P., Saavalainen, P., Koskinen, L. L. E., Maki, M. & Kaukinen, K., 2011, In : Journal of Clinical Immunology. 31, 1, p. 74-79 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-wide analysis of extended pedigrees confirms IL2-IL21 linkage and shows additional regions of interest potentially influencing coeliac disease risk

Einarsdottir, E., Koskinen, L. L. E., de Kauwe, A. L., Dukes, E., Mustalahti, K., Balogh, M., Korponay-Szabo, I. R., Kaukinen, K., Kurppa, K., Adany, R., Pocsai, Z., Szeles, G., Maki, M., Kere, J. & Saavalainen, P., 2011, In : Tissue Antigens. 78, 6, p. 428-437 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Gluten-Sensitive Hypertransaminasemia in Celiac Disease: An Infrequent and Often Subclinical Finding

Korpimaki, S., Kaukinen, K., Collin, P., Haapala, A-M., Holm, P., Laurila, K., Kurppa, K., Saavalainen, P. M., Haimila, K., Partanen, J., Maki, M. & Lahdeaho, M-L., 2011, In : American Journal of Gastroenterology. 106, 9, p. 1689-1696 8 p.

Research output: Contribution to journalArticleScientificpeer-review

IgA-class autoantibodies against neuronal transglutaminase, TG6 in celiac disease: No evidence for gluten dependency

Lindfors, K., Koskinen, O., Laurila, K., Collin, P., Saavalainen, P., Haimila, K., Partanen, J., Maki, M. & Kaukinen, K., 2011, In : Clinica Chimica Acta. 412, 13-14, p. 1187-1190 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Multiple independent variants in 6q21-22 associated with susceptibility to celiac disease in the Dutch, Finnish and Hungarian populations

Einarsdottir, E., Bevova, M., Zhernakova, A., Monsuur, A., Koskinen, L., van't Slot, R., Mulder, C., Mearin, M. L., Korponay-Szabo, I., Kaukinen, K., Kurppa, K., Kere, J., Mäki, M., Wijmenga, C. & Saavalainen, P. M., 2011, In : European Journal of Human Genetics. 19, 6, p. 682-686 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Serodiagnostic Assays for Celiac Disease Based on the Open or Closed Conformation of the Autoantigen, Transglutaminase 2

Lindfors, K., Koskinen, O., Kurppa, K., Laurila, K., Collin, P., Haimila, K., Partanen, J., Saavalainen, P., Maki, M. & Kaukinen, K., 2011, In : Journal of Clinical Immunology. 31, 3, p. 436-442 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Celiac Disease without Villous Atrophy in Children: A Prospective Study

Kurppa, K., Ashorn, M., Iltanen, S., Koskinen, L. L. E., Saavalainen, P., Koskinen, O., Maki, M. & Kaukinen, K., 2010, In : The Journal of Pediatrics. 157, 3, p. 373-80 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Evolutionary and Functional Analysis of Celiac Risk Loci Reveals SH2B3 as a Protective Factor against Bacterial Infection

Zhernakova, A., Elbers, C. C., Ferwerda, B., Romanos, J., Trynka, G., Dubois, P. C., de Kovel, C. G. F., Franke, L., Oosting, M., Barisani, D., Bardella, M. T., Joosten, L. A. B., Saavalainen, P., van Heel, D. A., Catassi, C., Netea, M. G., Wijmenga, C. & Finnish Celiac Dis Study Grp, 2010, In : American Journal of Human Genetics. 86, 6, p. 970-977 8 p.

Research output: Contribution to journalArticleScientificpeer-review