Panu Luukkonen

Publications

Research output per year 2016 2020 2021 2022 2024 2024

• 35 Article
• 3 Abstract
• 3 Meeting Abstract
• 3 Comment/debate
• 10 More
  • 3 Editorial
  • 3 Letter
  • 2 Review Article
  • 1 Poster
  • 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2024

  Combined use of the CLivD score and FIB-4 for prediction of liver-related outcomes in the population

  Åberg, F., Asteljoki, J., Männistö, V. & Luukkonen, P. K., Jul 2024, In: Hepatology. 80, 1, p. 163-172 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Development and Validation of the Nonalcoholic Fatty Liver Disease Familial Risk Score to Detect Advanced Fibrosis: A Prospective, Multicenter Study

  Huang, D. Q., Ahlholm, N., Luukkonen, P. K., Porthan, K., Amangurbanova, M., Madamba, E., Bettencourt, R., Siddiqi, H., Cervantes, V., Hernandez, C., Lopez, S. J., Richards, L., Nemes, K., Isoniemi, H., Yki-Järvinen, H. & Loomba, R., Jan 2024, In: Clinical Gastroenterology and Hepatology. 22, 1, p. 81-+ 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids

  Sasidharan, K., Caddeo, A., Jamialahmadi, O., Noto, F. R., Tomasi, M., Malvestiti, F., Ciociola, E., Tavaglione, F., Mancina, R. M., Cherubini, A., Bianco, C., Mirarchi, A., Männistö, V., Pihlajamäki, J., Kärjä, V., Grimaudo, S., Luukkonen, P. K., Qadri, S., Yki-Järvinen, H. & Petta, S. & 5 others, Manfrini, S., Vespasiani-Gentilucci, U., Bruni, V., Valenti, L. & Romeo, S., 16 Jan 2024, In: Cell Reports Medicine. 5, 1, 20 p., 101352.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Protein Phosphatase 1 Regulatory Subunit 3 Beta rs4240624 Genotype Is Associated With Gallstones and With Significant Changes in Bile Lipidome

  Männistö, V. T., Kaminska, D., Haal, S., Asteljoki, J., Luukkonen, P. K., Käkelä, P., Tavaglione, F., van Weeghel, M., Neuvonen, M., Niemi, M., Romeo, S., Nieuwdorp, M., Pihlajamäki, J. & Groen, A. K., Jan 2024, In: Gastro Hep Advances. 3, 5, p. 594-601 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access
• 2023

  Abdominal obesity and alcohol use modify the impact of genetic risk for incident advanced liver disease in the general population

  Luukkonen, P. K., Färkkilä, M., Jula, A., Salomaa, V., Männistö, S., Lundqvist, A., Perola, M. & Åberg, F., May 2023, In: Liver International. 43, 5, p. 1035-1045 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Changes over time in the Chronic Liver Disease risk score predict liver-related outcomes: longitudinal analysis of the Whitehall II study

  Åberg, F., Britton, A. & Luukkonen, P. K., 1 Feb 2023, In: Scandinavian Journal of Gastroenterology. 58, 2, p. 170-177 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis

  Luukkonen, P. K., Sakuma, I., Gaspar, R. C., Mooring, M., Nasiri, A., Kahn, M., Zhang, X.-M., Zhang, D., Sammalkorpi, H., Penttilä, A. K., Orho-Melander, M., Arola, J., Juuti, A., Zhang, X., Yimlamai, D., Yki-Järvinen, H., Petersen, K. F. & Shulman, G. I., 24 Jan 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 4, 9 p., e2217543120.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans

  Luukkonen, P. K., Porthan, K., Ahlholm, N., Rosqvist, F., Dufour, S., Zhang, X. M., Lehtimäki, T. E., Seppänen, W., Orho-Melander, M., Hodson, L., Petersen, K. F., Shulman, G. I. & Yki-Järvinen, H., 7 Nov 2023, In: Cell Metabolism. 35, 11, p. 1887-+ 16 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2022

  Association between arterial hypertension and liver outcomes using polygenic risk scores: a population-based study

  Åberg, F., Kantojärvi, K., Männistö, V., But, A., Salomaa, V., Niiranen, T., Färkkilä, M., Luukkonen, P., Männistö, S., Lundqvist, A., Perola, M. & Jula, A., 16 Sept 2022, In: Scientific Reports. 12, 1, 10 p., 15581.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Development and validation of a model to predict incident chronic liver disease in the general population: The CLivD score

  Åberg, F., Luukkonen, P. K., But, A., Salomaa, V., Britton, A., Petersen, K. M., Bojesen, S. E., Balling, M., Nordestgaard, B. G., Puukka, P., Männistö, S., Lundqvist, A., Perola, M., Jula, A. & Färkkilä, M., Aug 2022, In: Journal of Hepatology. 77, 2, p. 302-311 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease

  Luukkonen, P. K., Qadri, S., Ahlholm, N., Porthan, K., Mannisto, V., Sammalkorpi, H., Penttilä, A. K., Hakkarainen, A., Lehtimäki, T. E., Gaggini, M., Gastaldelli, A., Ala-Korpela, M., Orho-Melander, M., Arola, J., Juuti, A., Pihlajamäki, J., Hodson, L. & Yki-Järvinen, H., Mar 2022, In: Journal of Hepatology. 76, 3, p. 526-535 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease

  Sen, P., Qadri, S., Luukkonen, P. K., Ragnarsdottir, O., McGlinchey, A., Jäntti, S., Juuti, A., Arola, J., Schlezinger, J. J., Webster, T. F., Oresic, M., Yki-Järvinen, H. & Hyötyläinen, T., Feb 2022, In: Journal of Hepatology. 76, 2, p. 283-293 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Obesity Modifies the Performance of Fibrosis Biomarkers in Nonalcoholic Fatty Liver Disease

  Qadri, S., Ahlholm, N., Lonsmann, I., Pellegrini, P., Poikola, A., Luukkonen, P. K., Porthan, K., Juuti, A., Sammalkorpi, H., Penttilä, A. K., D'Ambrosio, R., Soardo, G., Leeming, D. J., Karsdal, M., Arola, J., Kechagias, S., Pelusi, S., Ekstedt, M., Valenti, L. & Hagstrom, H. & 1 others, Yki-Järvinen, H., 19 Apr 2022, In: Journal of Clinical Endocrinology and Metabolism. 107, 5, p. e2008-e2020 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• PSD3 downregulation confers protection against fatty liver disease

  Mancina, R. M., Sasidharan, K., Lindblom, A., Wei, Y., Ciociola, E., Jamialahmadi, O., Pingitore, P., Andreasson, A.-C., Pellegrini, G., Baselli, G., Mannisto, V., Pihlajamaki, J., Kärjä, V., Grimaudo, S., Marini, I., Maggioni, M., Becattini, B., Tavaglione, F., Dix, C. & Castaldo, M. & 22 others, Klein, S., Perelis, M., Pattou, F., Thuillier, D., Raverdy, V., Dongiovanni, P., Fracanzani, A. L., Stickel, F., Hampe, J., Buch, S., Luukkonen, P. K., Prati, D., Yki-Järvinen, H., Petta, S., Xing, C., Schafmayer, C., Aigner, E., Datz, C., Lee, R. G., Valenti, L., Linden, D. & Romeo, S., Jan 2022, In: Nature metabolism. 4, 1, p. 60-+ 21 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Risk of advanced fibrosis in first-degree relatives of with nonalcoholic liver disease

  Tamaki, N., Ahlholm, N., Luukkonen, P. K., Porthan, K., Sharpton, S. R., Ajmera, V., Kono, Y., Dave, S., Ahmed, A., Sundaram, V., Wilkinson, M. J., Patton, H., Gupta, H., Cervantes, V., Hernandez, C., Lopez, S. J., Loomba, R., Baumgartner, A., Richards, L. & Arkkila, P. E. T. & 4 others, Nemes, K., Isoniemi, H., Yki-Järvinen, H. & Loomba, R., 1 Nov 2022, In: Journal of Clinical Investigation. 132, 21, 9 p., e162513.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2021

  Assessment of Lifestyle Factors Helps to Identify Liver Fibrosis Due to Non-Alcoholic Fatty Liver Disease in Obesity

  Lahelma, M., Luukkonen, P. K., Qadri, S., Ahlholm, N., Lallukka-Brück, S., Porthan, K., Juuti, A., Sammalkorpi, H., Penttilä, A. K., Arola, J., Orho-Melander, M. & Yki-Järvinen, H., Jan 2021, In: Nutrients. 13, 1, 13 p., 169.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis

  LITMUS Investigators, Selvaraj, E. A., Mózes, F. E., Jayaswal, A. N. A. & Yki-Järvinen, H., 2021, In: Journal of Hepatology. 75, 4, p. 770 – 785 16 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Exome-Wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated With Fatty Liver Disease

  Jamialahmadi, O., Mancina, R. M., Ciociola, E., Tavaglione, F., Luukkonen, P. K., Baselli, G., Malvestiti, F., Thuillier, D., Raverdy, V., Mannisto, V., Pipitone, R. M., Pennisi, G., Prati, D., Spagnuolo, R., Petta, S., Pihlajamaki, J., Pattou, F., Yki-Järvinen, H., Valenti, L. & Romeo, S., Mar 2021, In: Gastroenterology. 160, 5, p. 1634-+ 20 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Impact of short-term overfeeding of saturated or unsaturated fat or sugars on the gut microbiota in relation to liver fat in obese and overweight adults

  Jian, C., Luukkonen, P., Sädevirta, S., Yki-Järvinen, H. & Salonen, A., Jan 2021, In: Clinical Nutrition. 40, 1, p. 207-216 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover

  Tanaka, Y., Shimanaka, Y., Caddeo, A., Kubo, T., Mao, Y., Kubota, T., Kubota, N., Yamauchi, T., Mancina, R. M., Baselli, G., Luukkonen, P., Pihlajamäki, J., Yki-Järvinen, H., Valenti, L., Arai, H., Romeo, S. & Kono, N., Jan 2021, In: Gut. 70, 1, p. 180-193 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Overfeeding saturated fat increases LDL (low-density lipoprotein) aggregation susceptibility while overfeeding unsaturated fat decreases proteoglycan-binding of lipoproteins

  Ruuth, M., Lahelma, M., Luukkonen, P. K., Lorey, M. B., Qadri, S., Sädevirta, S., Hyötyläinen, T., Kovanen, P. T., Hodson, L., Yki-Järvinen, H. & Öörni, K., Nov 2021, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 41, 11, p. 2823-2836 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis

  EU-PNAFLD Investigators, GOLD Consortium, Teo, K., Abeysekera, K. W. M., Luukkonen, P. K. & Yki-Järvinen, H., Jan 2021, In: Journal of Hepatology. 74, 1, p. 20-30 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• The PNPLA3-I148M Variant Confers an Antiatherogenic Lipid Profile in Insulin-resistant Patients

  Luukkonen, P. K., Qadri, S., Lehtimäki, T. E., Juuti, A., Sammalkorpi, H., Penttilä, A. K., Hakkarainen, A., Orho-Melander, M., Arola, J. & Yki-Järvinen, H., Jan 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 1, p. e300-e315 16 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2020

  Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease

  Luukkonen, P. K., Dufour, S., Lyu, K., Zhang, X.-M., Hakkarainen, A., Lehtimäki, T. E., Cline, G. W., Petersen, K. F., Shulman, G. I. & Yki-Järvinen, H., 31 Mar 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 13, p. 7347-7354 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Hydroxysteroid 17-beta dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease

  Luukkonen, P. K., Tukiainen, T., Juuti, A., Sammalkorpi, H., Haridas, P. A. N., Niemelä, O., Arola, J., Orho-Melander, M., Hakkarainen, A., Kovanen, P. T., Dwivedi, O., Groop, L., Hodson, L., Gastaldelli, A., Hyötyläinen, T., Oresic, M. & Yki-Järvinen, H., 12 Mar 2020, In: JCI INSIGHT. 5, 5, 12 p., 132158.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Natural Course of Nonalcoholic Fatty Liver Disease and Type 2 Diabetes in Patients With Human Immunodeficiency Virus With and Without Combination Antiretroviral Therapy-associated Lipodystrophy: A 16-Year Follow-up Study

  Lallukka-Brück, S., Isokuortti, E., Luukkonen, P. K., Hakkarainen, A., Lundbom, N., Sutinen, J. & Yki-Järvinen, H., 15 Apr 2020, In: Clinical Infectious Diseases. 70, 8, p. 1708-1716 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Quantitative PCR provides a simple and accessible method for quantitative microbiota profiling

  Jian, C., Luukkonen, P., Yki-Järvinen, H., Salonen, A. & Korpela, K., 15 Jan 2020, In: PLoS One. 15, 1, 10 p., 0227285.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue

  Qadri, S., Lallukka-Brück, S., Luukkonen, P. K., Zhou, Y., Gastaldelli, A., Orho-Melander, M., Sammalkorpi, H., Juuti, A., Penttilä, A. K., Perttilä, J., Hakkarainen, A., Lehtimäki, T. E., Oresic, M., Hyötyläinen , T., Hodson, L., Olkkonen, V. M. & Yki-Järvinen, H., 12 Aug 2020, In: Liver International. 40, 9, p. 2128-2138 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2019

  Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids

  Luukkonen, P. K., Nick, A., Hölttä-Vuori, M., Thiele, C., Isokuortti, E., Lallukka-Brück, S., Zhou, Y., Hakkarainen, A., Lundbom, N., Peltonen, M., Orho-Melander, M., Oresic, M., Hyötyläinen, T., Hodson, L., Ikonen, E. & Yki-Järvinen, H., 22 Aug 2019, In: JCI INSIGHT. 4, 16, 13 p., 127902.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2018

  Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

  Luukkonen, P. K., Sädevirta, S., Zhou, Y., Kayser, B., Ali, A., Ahonen, L., Lallukka, S., Pelloux, V., Gaggini, M., Jian, C., Hakkarainen, A., Lundbom, N., Gylling, H., Salonen, A., Oresic, M., Hyötyläinen, T., Orho-Melander, M., Rissanen, A., Gastaldelli, A. & Clement, K. & 2 others, Hodson, L. & Yki-Järvinen, H., 1 Aug 2018, In: Diabetes Care. 41, 8, p. 1732-1739 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2017

  Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD

  Luukkonen, P. K., Zhou, Y., Haridas, N. P. A., Dwivedi, O. P., Hyotylainen, T., Ali, A., Juuti, A., Leivonen, M., Tukiainen, T., Ahonen, L., Scott, E., Palmer, J. M., Arola, J., Orho-Melander, M., Vikman, P., Anstee, Q. M., Olkkonen, V. M., Oresic, M., Groop, L. & Yki-Jarvinen, H., Jul 2017, In: Journal of Hepatology. 67, 1, p. 128-136 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans

  Lallukka, S., Luukkonen, P. K., Zhou, Y., Isokuortti, E., Leivonen , M., Juuti, A., Hakkarainen, A., Orho-Melander, M., Lundbom, N., Olkkonen, V. M., Lassila, R. & Yki-Järvinen, H., Feb 2017, In: Thrombosis and Haemostasis. 117, 2, p. 286-294 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) - an 11-Year Prospective Study

  Lallukka, S., Sadevirta, S., Kallio, M. T., Luukkonen, P. K., Zhou, Y., Hakkarainen, A., Lundbom, N., Orho-Melanders, M. & Yki-Jarvinen, H., 6 Nov 2017, In: Scientific Reports. 7, 10 p., 14561.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2016

  Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

  Luukkonen, P. K., Zhou, Y., Sädevirta, S., Leivonen , M., Arola, J., Oresic, M., Hyotylainen, T. & Yki-Jarvinen, H., May 2016, In: Journal of Hepatology. 64, 5, p. 1167-1175 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans

  Luukkonen, P. K., Zhou, Y., Hyotylainen, T., Leivonen , M., Arola, J., Orho-Melander, M., Oresic, M. & Yki-Jarvinen, H., Dec 2016, In: Journal of Hepatology. 65, 6, p. 1263-1265 3 p.

  Research output: Contribution to journal › Article › Scientific

  Open Access

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