Paula Savola

Publications

Research output per year 2016 2016 2017 2018 2019 2020 2022 2024

• 14 Article
• 6 Meeting Abstract
• 2 Review Article
• 1 Letter
• 1 More
  • 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2024

  Somatic mutations associate with clonal expansion of CD8⁺ T cells

  Lundgren, S., Myllymäki, M., Järvinen, T., Keränen, M. A. I., Theodoropoulos, J., Smolander, J., Kim, D., Salmenniemi, U., Walldin, G., Savola, P., Kelkka, T., Rajala, H., Hellström-Lindberg, E., Itälä-Remes, M., Kankainen, M. & Mustjoki, S., 7 Jun 2024, In: Science Advances. 10, 23, 13 p., eadj0787.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2022

  Anemian laboratoriotutkimusten valinnan ja tulkinnan tueksi interaktiivinen työkalu

  Savola, P., 2022, In: Kliin lab : kliinisen laboratorioalan julkaisu : SKKY:n jäsenlehti.. 39, 4, p. 149-149 1 p.

  Research output: Contribution to journal › Article › Professional

  Open Access

• Novel Ex Vivo DOAC Removal Methods Reduce Interference in Lupus Anticoagulant Testing

  Savola, P., Lemponen, M., Joutsi-Korhonen, L. & Helin, T. A., Oct 2022, In: Diagnostics. 12, 10, 11 p., 2520.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• The spectrum of somatic mutations in large granular lymphocyte leukemia, rheumatoid arthritis, and Felty?s syndrome

  Savola, P., Bhattacharya, D. & Huuhtanen, J., Jul 2022, In: Seminars in Hematology. 59, 3, p. 123-130 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2020

  Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+T Lymphocyte Signature

  Kelkka, T., Savola, P., Bhattacharya, D., Huuhtanen, J., Lönnberg, T., Kankainen, M., Paalanen, K., Tyster, M., Lepistö, M., Ellonen, P., Smolander, J., Eldfors, S., Yadav, B., Khan, S., Koivuniemi, R., Sjöwall, C., Elo, L. L., Lahdesmaki, H., Maeda, Y., Nishikawa, H., & 3 othersLeirisalo-Repo, M., Sokka-Isler, T. & Mustjoki, S., 19 Nov 2020, In: Frontiers in Immunology. 11, 12 p., 578848.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Klonaalinen hematopoieesi : syövän ja terveen solun rajapinnalla

  Savola, P. & Myllymäki, M., 2020, In: Kliin lab : kliinisen laboratorioalan julkaisu : SKKY:n jäsenlehti.. 37, 6, p. 189-193 5 p.

  Research output: Contribution to journal › Article › Professional

  Open Access

• Somatic mutations and T-cell clonality in patients with immunodeficiency

  Savola, P., Martelius, T., Kankainen, M., Huuhtanen, J., Lundgren, S., Koski, Y., Eldfors, S., Kelkka, T., Keränen, M. A. I., Ellonen, P., Kovanen, P. E., Kytölä, S., Saarela, J., Lahdesmaki, H., Seppänen, M. R. J. & Mustjoki, S., Dec 2020, In: Haematologica. 105, 12, p. 2757-2768 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2019

  A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease

  Van Horebeek, L., Hilven, K., Mallants, K., Van Nieuwenhuijze, A., Kelkka, T., Savola, P., Mustjoki, S., Schlenner, S. M., Liston, A., Dubois, B. & Goris, A., 15 Apr 2019, In: Human Molecular Genetics. 28, 8, p. 1369-1380 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Somaattiset mutaatiot terveyden ja sairauden rajapinnalla

  Kelkka, T., Savola, P. & Mustjoki, S., 2019, In: Duodecim. 135, 13-14, p. 1256-1263 8 p.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File

• Somatic mutations in autoimmunity

  Savola, P., 2019, Helsinki : Helsingin yliopisto. 119 p.

  Research output: Thesis › Doctoral Thesis › Collection of Articles

• T Cell Landscape of Immune Aplastic Anemia Reveals a Convergent Antigen-Specific Signature

  Huuhtanen, J., Lundgren, S., Keranen, M. A., Feng, X., Kerr, C. M., Jokinen, E., Heinonen, M., Savola, P., Kelkka, T., Ebeling, F., Ryland, G. L., Fox, L., Blombery, P., Lindberg, E. H., Young, N. S., Maciejewski, J. P., Lahdesmaki, H. & Mustjoki, S., 13 Nov 2019, In: Blood. 134, Suppl. 1, p. 108-108 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review
• 2018

  Clonal hematopoiesis in patients with rheumatoid arthritis

  Savola, P., Lundgren, S., Keränen, M. A. I., Almusa, H., Ellonen, P., Leirisalo-Repo, M., Kelkka, T. & Mustjoki, S., 26 Jul 2018, In: Blood cancer journal. 8, 5 p., 69.

  Research output: Contribution to journal › Letter › Scientific › peer-review

  Open Access

  File

• Next-Generation Sequencing Reveals a T Cell Receptor Signature Characteristic of Patients with Aplastic Anemia

  Lundgren, S., Huuhtanen, J., Keränen, M. A., Hirsch, C. M., Jokinen, E., Heinonen, M., Savola, P., Kelkka, T., Ebeling, F., Maciejewski, J. P., Hellstrom-Lindberg, E., Lähdesmäki, H. & Mustjoki, S., 29 Nov 2018, In: Blood. 132, 3 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Sex bias in MHC I-associated shaping of the adaptive immune system

  Schneider-Hohendorf, T., Goerlich, D., Savola, P., Kelkka, T., Mustjoki, S., Gross, C. C., Owens, G. C., Klotz, L., Dornmair, K., Wiendl, H. & Schwab, N., 27 Feb 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 9, p. 2168-2173 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Somatic Mutations in CD8+T Cells in Patients with Chronic Immune Thrombocytopenia Are Associated with Increased Clonality and Cytotoxic Phenotype of CD8+T Cells

  Rajala, H., Savola, P., Lundgren, S., Eldfors, S., Kelkka, T., Ebeling, F. & Mustjoki, S., 29 Nov 2018, In: Blood. 132, 3 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Somatic Mutations in T Cells As Possible Regulators of Immunodeficiency

  Savola, P., Martelius, T., Kankainen, M., Koski, Y., Eldfors, S., Huuhtanen, J., Kelkka, T., Lundgren, S., Ellonen, P., Kovanen, P., Kytölä, S., Seppanen, M. & Mustjoki, S., 29 Nov 2018, In: Blood. 132, 3 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia

  Savola, P., Brück, O., Olson, T., Kelkka, T., Kauppi, M. J., Kovanen, P. E., Kytölä, S., Sokka-Isler, T., Loughran, T. P., Leirisalo-Repo, M. & Mustjoki, S., Feb 2018, In: Haematologica. 103, 2, p. 304-312 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2017

  Dasatinib Changes Immune Cell Profiles Concomitant with Reduced Tumor Growth in Several Murine Solid Tumor Models

  Hekim, C., Ilander, M., Yan, J., Michaud, E., Smykla, R., Vaha-Koskela, M., Savola, P., Tahtinen, S., Saikko, L., Hemminki, A., Kovanen, P. E., Porkka, K., Lee, F. Y. F. & Mustjoki, S., Feb 2017, In: Cancer immunology research. 5, 2, p. 157-169 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Somaattiset mutaatiot nivelreumassa

  Kelkka, T. & Savola, P., 2017, In: Kliin lab : kliinisen laboratorioalan julkaisu : SKKY:n jäsenlehti.. 34, 5, p. 101-104 4 p.

  Research output: Contribution to journal › Article › Professional

  Open Access

  File

• Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis

  Savola, P., Kelkka, T., Rajala, H. L., Kuuliala, A., Kuuliala, K., Eldfors, S., Ellonen, P., Lagstrom, S., Lepisto, M., Hannunen, T., Andersson, E. I., Khajuria, R. K., Jaatinen, T., Koivuniemi, R., Repo, H., Saarela, J., Porkka, K., Leirisalo-Repo, M. & Mustjoki, S., 21 Jun 2017, In: Nature Communications. 8, 14 p., 15869.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2016

  LGL-leukemia ja autoimmuniteetti : autoimmuunisairauden ja syövän rajapinta hämärtyy

  Savola, P., Rajala, H. & Mustjoki, S., 2016, In: Duodecim. 132, 15, p. 1328-1335 8 p.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File

• Molecular Characterization of Cytotoxic T Cell Repertoire in Aplastic Anemia and Myelodysplastic Syndromes

  Lundgren, S. A., Keränen, M. A., Savola, P., Park, G., Ebeling, F., Walldin, G., Hellstroem-Lindsberg, E. & Mustjoki, S., 2 Dec 2016, In: Blood. 128, 22, 4 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer

  Liikanen, I., Tähtinen, S., Guse, K., Gutmann, T., Savola, P., Oksanen, M., Kanerva, A. & Hemminki, A., 1 Sept 2016, In: Molecular Cancer Therapeutics. 15, 9, p. 2259-2269 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• SOMATIC MUTATIONS IN CLONALLY EXPANDED CD8(+) T CELLS IN PATIENTS WITH NEWLY DIAGNOSED RHEUMATOID ARTHRITIS

  Kelkka, T., Savola, P., Rajala, H., Kuuliala, A., Kuuliala, K., Eldfors, S., Ellonen, P., Lagstrom, S., Khajuria, R. K., Jaatinen, T., Koivuniemi, R., Repo, H., Porkka, K., Leirisalo-Repo, M. & Mustjoki, S., Feb 2016, In: Annals of the Rheumatic Diseases. 75, p. A47-+ 2 p.

  Research output: Contribution to journal › Meeting Abstract