Curriculum vitae

 

CURRICULUM VITAE

Pauli Puolakkainen 25.9.2018

 

 

DATE AND PLACE OF BIRTH: 5 April, 1959, Helsinki, Finland

 

CURRENT AND PERMANENT POSITION:

Professor of Surgery, Chairman, Department of Surgery, Helsinki University Hospital and University of Helsinki, Finland, acting since September 1^st, 2010, appointed April 1^st, 2012.

 

PERSONAL DATA

Nationality: Finnish

Address: Home: Pitkänkalliontanhua 4 D 21, FI-02170 Espoo, Finland

Telephone: +358 50 5829785

E-mail. [email protected] or [email protected]

Family: Married (1983), three children (1988, 1989, 1995)

 

EDUCATION AND TRAINING

M.D. (Licentiate of Medicine), University of Helsinki                          1984   

Licence to practise medicine, University of Helsinki                           1985   

Ph.D., Doctor of Medical Sciences, University of Helsinki,                   1989   

Specialist in Surgery, University of Helsinki and Helsinki University

            Central Hospital                                                               1991   

Docent in experimental surgery, University of Helsinki                      1994

Subspecialist in abdominal (GI) surgery, University of Helsinki and

            Helsinki University Central Hospital                                    1997

Docent in abdominal surgery, University of Helsinki                          1999

Specialist in administration, University of Helsinki                            2005   

Professor in Surgery, University of Turku, Finland                             2007   

Specialist in medical education, The Finnish Medical Association        2008

Leadership training                                                                      2008   

 

Official language examinations: Swedish

Language skills: Finnish, Swedish, English, German (basics)

 

PREVIOUS PROFESSIONAL APPOINTMENTS

Resident in anaesthesiology, Maria Hospital, Helsinki,                   1982   

General practitioner, Mänttä Health Care Center, Finland                1982, 1983     

General practitioner, Espoo Health Care Center, Finland                 1983   

General practitioner, Nurmijärvi Health Care Center, Finland            1985   

Resident in surgery, Lahti City Hospital, Finland                            1984-1985      

Resident in radiology, Helsinki University Central Hospital, Finland  1985   

Visiting Scientist, Department of Surgery, University of                                            Cincinnati, OH, USA                                                                   1985   

Senior surgeon, Lahti City Hospital, Finland                                  1985-1986      

Resident in surgery, Department of Surgery, Helsinki University Central                             Hospital                                                                                   1986-1989      

Visiting Scientist, Bristol-Myers Squibb Pharmaceutical Research Institute, and

University of Washington, Seattle, USA                                        1990-1993      

Resident in surgery, Helsinki University Central Hospital                 1993-1994      

Resident in abdominal surgery, Helsinki University Central Hospital 1995-1997      

Senior lecturer/ Assistant Professor / Attending Specialist in Abdominal

            Surgery, Helsinki University Central Hospital                      1997-2000

Visiting Professor, The Hope Heart Institute and University of Washington,

                       Seattle, USA                                                       2000-2002      

Visiting Professor, Dept. of Surgery, University of Sapporo, Japan     2004   

Visiting Professor, Dept. of Surgery, University of Texas Southwestern

                                               Medical Center, Dallas, USA          2005

Senior lecturer/ Assistant Professor / Attending Specialist in Abdominal

            Surgery, Helsinki University Central Hospital                      2002-2007

Professor in Surgery, Chairman, Department of Surgery, Turku University

            Hospital, Turku                                                              2007-2010

Acting Professor in Surgery, Chairman, Department of Surgery, Helsinki

            University Central Hospital and University of Helsinki, Finland,   2010-2012

Professor in Surgery, Chairman, Department of Surgery, Helsinki

            University Hospital and University of Helsinki, Finland   2012-

           

 

RESEARCH AWARDS, HONOURS AND MAJOR GRANTS

Bristol-Myers Squibb Pharmaceutical Research Institute, and

                        University of Washington, Seattle, USA                    1990-1993

The Hope Heart Institute and University of Washington,

                       Seattle, USA                                                          2000-2002      

The Paulo Foundation and Sapporo University, Japan,                       2004

Helsinki University Central Hospital Research Funds (EVO), 88 500 €,  2003-5

Helsinki University Central Hospital Research Funds (EVO), 65 000 €,  2005-7

Helsinki University 3-year research grant, 100 000 E                         2005-7

Sigrid Juselius Foundation, 70 000 €,                                              2005-6

Sigrid Juselius Foundation, 170 000 €,                                            2007-11

Helsinki / Turku University Central Hospital Research Funds (EVO), 400000€  2007-11

Helsinki University Central Hospital Research Funds (EVO), 129 000 €           2013-16

Sigrid Juselius Foundation, 46000 €                                                          2014-16

Sigrid Juselius Foundation, 46000 €                                                          2015-17

Helsinki University Funds, 36000€                                                            2018

 

EDITORIAL BOARD MEMBERSHIPS

Scandinavian Journal of Surgery, Associate Editor                                      2007-

Finnish Textbook of Gastroenterology and Hepatology, Editor                     2011, 2018

Editorial Boards and scientific advisory boards:

                        - Scandinavian Journal of Surgery                                   2005-

                        - The Finnish Medical Journal                                         2010-

                        - World Journal of Gastroenterology                                2009

                        - World Journal of Gastrointestinal Pathophysiology          2010

                        - Journal of Carcinogenesis and Mutagenesis                   2010

                        - JAMA Surgery                                                                               2018

 

MEMBERSHIPS IN SCIENTIFIC SOCIETIES

The Finnish Surgical Society (President 2012-14)

The Finnish Surgical Society (President-Elect 2011)

The Finnish Gastroenterological Association (President 2011-13)

The Finnish Association of Physicians

The Finnish Digestive Surgeons, Board member 2006-2010

The Finnish Medical Society Duodecim, 1985-

Joint CME committee, The Finnish Gastroenterological Association and The

            Finnish Digestive Surgeons

European Surgical Association (ESA) 2015-

International College of Surgeons

Wound Healing Society

American Pancreatic Association

International Society of Surgery

International Gastric Cancer Association (council member) 2013-

 

 

OTHER ACADEMIC AND PROFESSIONAL ACTIVITIES

Visiting Scientist/Professor, Bristol Mayer Squibb, The Hope Heart Institute and

            University of Washington, Seattle, USA                                1990-1993

                                                                                                  2000-2002

Gerson Lehrman Group’s Council of Healthcare advisors, USA              2004

International health professional of the year, International Biographical Centre,

            Cambridge, UK                                                                  2005

Scientific advisory board, European Pancreatic Club Meeting                2006

Scientific board, Nordic Meeting of Gastroenterology                           2007

Abstract committee, International Society of Surgery (ISS),                 2009, 2011

Joint CME committee, The Finnish Gastroenterological Association and

            The Finnish Digestive Surgeons                                            2006-

Permanent expert for National Authority for Medicolegal Affairs in

            Finland (Valvira),                                                                2005-

Expert, Patient Insurance authority (Potilasvahinkolautakunta), Finland  2004-

Program committee (member), The Finnish Medical Convention            2004-

Scientific advisory board, AstraZeneca, Finland                                    2006-8

Scientific advisory board, Leiras, Finland                                            2006-

The Finnish Research Foundation of Digestive Diseases (secretary/member/

            vice chair)                                                                          2004-  

Panelist, Publication Forum, Clinical Medicine, Finland                         2010-

Pro Medico Council, Finland                                                             2010-

Council member, (Issues of heath care professionals, TANK) Ministry of Social

            Affairs and Health, Finland                                                  2010-

Consultant, The Finnish Cultural Foundation, Finland                          2010-

Council of Health Research, Academy of Finland                                 2013-

 

University of Helsinki/ Helsinki University Central Hospital:

- Vice member, Faculty Council, Faculty of Medicine                             2010-

- Vice Chair, Institute of Clinical Medicine, Faculty of Medicine               2010-

- Vice Chair, Department of Surgery, Institute of Clinical Medicine,

            Faculty of Medicine                                                              2010-

- Member, Research Council, Faculty of Medicine                                 2007-

- Member, Council of Basic Medical Education, Faculty of Medicine          2004-

- Coordinator, surgical teaching, Faculty of Medicine                             1997-  

- Ethical committee of Dept. of Surgery, Helsinki University Central Hospital       2003-

- Committee of animal care of Dept. of Surgery, Helsinki University

            Central Hospital                                                                   2002-5

- Committee of teaching, simulator training research and resident training,

            Helsinki University Central Hospital                                        2007-  

- Board of expertees, University of Helsinki                                        2008-

- Meilahti hospital renovation committee, Helsinki University Central Hospital      2010-

- Executive board, Department of Surgery, Helsinki University Central Hospital    2010-

- Head of own research laboratorium, Biomedicum Helsinki, Finland                   2003

- Director, EVO research funds, Operative Unit HUCH                             2011-15

- Member of the Teacher’s Academy of University of Helsinki                 2015-

- Director, Research funds, HUCH Abdominal Centre,                            2016-

University of Turku / Turku University Central Hospital

- Chairman, Department of Surgery                                                   2007-11

- Chair, Executive board of research and education                              2007-11

- Member, SAPA Executive board                                                       2007-11

- Member, PET Executive board                                                         2007-11

- Member, Ethical committee                                                            2007-11

- Member, Institute of Clinical Medicine, Faculty of Medicine                 2007-11

 

Referee for Journals: Journal of Cellular Biochemistry, Histology and Histopathology, Gut, Expert Opinion in Pharmacotherapy, J Histochem Cytochem, Pancreatology, Scandinavian Journal of Gastroenterology, Scandinavian Journal of Surgery, Ann Med, Journal of Pancreas, Duodecim, Leukemia, Molecular Vision, Arch Med Res, Br J Surg, World Journal of Surgery, World Journal of Gastroenterology...

 

Organizing international meetings
- LOC, European Pancreatic Club, Tampere, 2006

- Scientific Committee, The XXXIX Nordic Meeting of Gastroenterology, 2008

- Vice President, Local organizing committee, International Surgical Week, Helsinki, 2013

- Sigrid Juselius Symposium, Helsinki, 2019

 

Organizing national meetings

- President, Finnish Surgical Society, Naantali, 2009

- Chairman of the organizing committee, Meeting of the Finnish Society of Gastroenterology, Tampere 2010.

- President, Finnish Society of Surgery, Lappeenranta 2013

- President, Finnish Society of Surgery, Vaasa 2014

- Chairman of the organizing committee, The Finnish Pancreas club, Helsinki 2017

 

Scientific qualification for professorships

            - Professor May Reed, University of Washington, Seattle, USA, 2008

 

Scientific education

I have received scientific education in the following centres:

Laboratory of Minerva Foundation (Professor J. Schröder) 1983-4, Laboratory of Experimental Surgery, Helsinki University Central Hospital (Dr. T. Schröder, Professor E. Kivilaakso) 1981-, Dept. of Surgery, University of Cincinnati (Professor S. Joffe) 1985, Bristol-Myers Squibb Pharmaceutical  Research  Institute, Seattle, WA, and University of Washington, Seattle, WA, USA (Professors D. Twardzik, J. Olerud, P. Bornstein, H. Sage) (1990-1993), The Hope Heart Institute and University of  Washington, Seattle,WA, USA (Professors E. Sage, J.Olerud, P.Bornstein)(2000-2002). The education includes theoretical and practical basic, experimental and clinical research.

 

Scientific publications

(For complete list of publications, submitted papers and the 20 most representative publications, please, see List of Publications)

- Original publications :                                               PubMed 217

- Submitted/ in preparation original manuscripts:      8

- Reviews, editorials, letters and book chapters:       37

- Abstracts:                                                                  >150

- Others:                                                                      7

- Mean of impact factors of all publications : 4,05

- Number of times cited :                                6576

- h-index:                                             47

- Sum of impact factors of the 20 chosen papers :    269,5

- Mean of impact factors of the 20 chosen papers:    13,5

 

Supervision of doctoral dissertation/ thesis

- Esko Kemppainen: Early phase of acute pancreatitis; screening, diagnosis, and severity grading with   new laboratory markers and imaging techniques, (accepted with special honours, best             surgical dissertation of the year in Finland), 1997                          

- Arto Kokkola: The etiopathogenesis and new diagnostic methods of gastic cancer,1998

- Tuula Ranta-Knuuttila: The protective mechanisms of gastric mucosa, 2000

- Laura Tielinen: The effect of bioabsorbable polylactide pins with polymer paste, containing TGF-            beta1, on the healing of osteotomies and bone defects, 2000

- Leena Kylänpää-Bäck: Acute pancreatitis: diagnosis and assessment of severity with markers of in            flammation,     2001

- Eija Tukiainen: Complex trait of acute pancreatitis: Studies of candidate genes and adipokines, 2008  

- Anna Nieminen: Extracellular matrix proteins and gastric cancer (under supervision) 2012

- Tuuli Kauttu: ADAM’s in esophageal and gastric cancer  2017

- Taru Lehtonen: Severe acute pancreatitis: MODS, infectious complications and operative interventions (under supervision) 2012

- Aino Koski: TAM’s and inflammation in pancreatic cancer 2017

- Johan Back: Complication in gastric cancer surgery (under supervision)

 

Official opponent in adacemic doctoral dissertations

- Markku Haapamäki: Phospholipase A2 in inflammatory bowel disease, Turku 1999

- Hanna Pelli: Recurrence of acute alcoholic pancreatitis, Tampere 2008

- Hai-Tao Jin: Polyamines in experimental taurocholate-induced and clinical acute pancreatitis, Tam-      pere 2009

- Anna Thiel: COX-2 in gastric carcinogenesis, 2012

- Jahangir Khan: Infections and lipids in alcohol induced acute pancreatitis, 2014

- Matias Laaninen: Prediction and management of complications after pancreaticoduodenectomy, 2016

-Jussi Nikkola: Long-term outcome and prevention of recurrences after acute alcoholic pancreatitis, 2017

 

Reviewer of professorships, docentships or doctoral thesis

- Jyri Lepistö: PDGF in Experimental Wound Healing (PhD) 1996

- Juha Ranne: Experimental study of healing and reinnervation of skin flaps and muscle fibers after             nerve transsection (PhD)1999

- Jyrki Kössi: Hexose sugars and sucrose in wound healing (PhD) 2000

- Petri Juvonen: Gastrointestinal perfusion in acute pancreatitis (PhD) 2000

- Sari Räty: The role of gallbladder, cholecystokinin and microbes in gallstone and post-ERCP     pancreatitis (PhD) 2000

- Susanna Sarkio: Gastrointestinal complications after kidney transplantation (PhD) 2005

- Miretta Tommila: Granulation tissue formation. The effect of hydroxyapatite coating of cellulose on                   cellular differentiation, Turku 2010

- Sari Räty: Docentship, Tampere 2007

- Johanna Laukkarinen: Docentship, Tampere 2010

- Runkuan Yang: Docentship, Tampere 2010

- Professorship: May Reed, University of Washington, Seattle, USA, 2004

- Johanna Laukkarinen: Docentship, Tampere 2012

 

Action as a reviewer of international grant applications

- Research into Ageing, UK, 2005

 

Selected invited talks / teaching /scientific activity in scientific congresses, meetings and courses

"Treatment of malignancies with laser surgery, hyperthermia and photodynamic therapy."

            Meeting of the growth regulators study group. Bristol-Myers Squibb Pharmaceutical Re    search Institute, Seattle, WA, 1991

"Growth factors and extracellular matrix proteins in wound healing"

            Senior staff presentation.  Bristol-Myers Squibb Pharmaceutical Research Institute, Seat tle,1992

"Mucosal injury caused by cytotoxic drugs. Experimental models of mucosal damage".

            Cytoprotection meeting, Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle,           1992

“ECM proteins in wound healing”

            Department of Biological Structure Research Seminar, University of Washington, Seattle,            1992

“TGF-beta1 and bone healing”

            Orthopaedic research seminar, School of Medicine, University of  Washington, Seattle,    1993

“Wound healing model: delivery system for growth factors and their effects on extracellular matrix”.             Advanced Tissue Sciences Corp. J. Jolla, CA,  1993

“Models for studying inflammation, regeneration and adaptation in the intestine”

            Immunex Corp. Seattle, WA, 1995

“Current aspects of diagnostics and prognostication of acute pancreatitis,”

            Harvard Medical School, Boston , USA, 1999

“The role of enzymes and their proforms in the the diagnosis and prognostication of acute pancreatitis”             Pancreatic Disease Meeting, Southampton, UK, 2000

“Reduced foreign body reaction in mice lacking matricellular protein SPARC”

            University of Washington, Seattle,  2001

“Reduced  dermal fibrotic response to implanted biomaterials in SPARC-null mice.”

            First Friday Hope Heart Institute Research Seminar  Series, 2001

“Severe  acute  pancreatitis: A continuig clinical challenge”

            UT- Southwestern Medical Center, Dallas, TX, 2002

“Acute Pancreatitis”

            University of Ulm, Germany 2003

“Acute pancreatitis – diagnosis and severity assessment”

            Estonian Surgical Society, Tallinna, Estonia, 2004

“Current concepts of  acute pancreatitis”

            Harvard Medical School, Boston, USA 2000

“SPARC-thrombospondin 2 double–null mice exhibit enhanced epithelial closure and dermal wound             healing”, Annual meeting of the Wound Healing Society, Seattle, USA 2003

“Enhanced growth and decreased levels of apoptosis in pancreatic tumors in SPARC null mice is associated with altered extracellular matrix”

            UEGW, Madrid, 2003.

“Severe acute pancreatitis: A continuing clinical challenge”

            First Dept. of Surgery, Sapporo Medical University , 2004

“Perioperative treatment in abdominal surgery”

            First Dept. of Surgery, Sapporo Medical University , 2004

“Early diagnosis and risk factors of gastric cancer”

            AstraZeneca CME training program, Hanasaari, Espoo, 2004

“The effects of pancreatic elastase are mediated through NFkB and TOLL2”

            American Pancreatic Association, Chicago, USA 2004

“Complications and survival after curative D1 vs. D2-3 resection for gastric cancer”

            International Gastric Cancer Congress, Yokohama, Japan, 2005

“Angiogenesis and wound healing”

            Dept. of Surgery, University of Texas Southwestern Medical Center, Dallas, USA 2005

“Gastric cancer –continuing clinical challenge”

            Dept. of Surgery, University of Texas Southwestern Medical Center, Dallas, USA 2005

“The healing of injury in biliary tract”

            Meeting of the Finnish Gastroenterological Association, Aulanko, Finland, 2005

“Special aspects of biliary acute pancreatitis”

            Pancreas 2000 CME training program, Solvalla, Finland, 2005

“Pathophysiology of chronic pancreatitis”

            The Finnish Pancreatic Club Meeting, Turku, 2005

“Abdominal complaints – how should I treat?”

            CME teaching program in over 20 different health care centres in Finland 2005-6

“How to write a scientific article”

            Meeting of the Finnish Phycicians, Helsinki, 2006

“Acute pancreatitis”, Meeting of The Finnish Gastroenterological Association, Turku, 2006

“Pathophysiology of ulcer disease”

            CME training, Helsinki University Central Hospital, 2006

“Surgical interventions in acute pancreatitis”

            Nordic training for SSAI anesthesiologist, Espoo, 2006

“Immunosupression and MOF in necrotizing pancreatitis”

            The 38^th Meeting of the European Pancreatic Club, Tampere, Finland, 2006

“Exluding oher etiologies than alcohol and biliary disease”

            The 38^th Meeting of the European Pancreatic Club, Tampere, Finland,  2006

“Severity assessment: Biochemical markers and scoring systems”

            The 38^th Meeting of the European Pancreatic Club, Tampere, Finland, 2006

“Acute abdomen”, Herttoniemi Hospital, Helsinki, 2007

“When acute abdomen is not operated in the elderly” , Herttoniemi Hospital, Helsinki, 2007

“Acute abdomen in the elderly”, University of Helsinki /Palmenia, Lahti 2007

“The etiology and clinical examination of acute abdominal pain”, HUCH, 2007

“Acute abdominal pain”; In Emergency medicine lecture course, Meilahti Hospital 2007

“Acute pancreatitis, from basic research to clinics”, University of Turku, 2007

“The role of sentinel node navigation in the treatment of gastric cancer”

            The Annual Meeting of The Finnish Surgical Society, 2007

“Every man’s surgery: Acute Abdomen, clinical examination and treatment” Annual presentation in Fin   nish Medical Convention, 2007, 2008, 2009, 2010, 2011

“When acute abdomen is not operated in the elderly”, Tampere health care center phycicians, 2007

“Old Abdomen”, Finnish Medical Convention, 2006

“Every man’s surgery: Acute Abdomen, clinical examination and treatment” Turku Medical Convention, 2008

“Surgery for pancreatic cancer, up-date”, Satakunta Central Hospital, Pori, 2009.

“Acute abdomen in the elderly”, Laakso Hospital, Helsinki, 2009

“Acute abdomen in the elderly”, Haartman hospital, Helsinki, 2010

“Acute pancreatitis as systemic disease” Thursday meeting series, Meilahti hospital, 2010

“Current treatment methods for gastric cancer”, The meeting of the Finnish Society of Gastroenterol       ogy, Tampere, 2009

“Acute pancreatitis as systemic disease”, Tampere University Central Hospital, 2010

“Acute pancreatitis as systemic disease”, University of Turku, 2010

“Acute abdomen”, Haartman Hospital 2010

“Matrix metalloproteinases in GI malignancy - from basic research to clinical applications” The Hungar    ian Society of Gastroenterology, Hungary, 2010

“Acute pancreatitis 2013” International Surgical Week, Helsinki, 2013

“Acute pancreatitis 2014” University of Chicago, USA, 2014

“Acute pancreatitis 2014” Tuft’s institute, Boston, USA, 2014

“Risk group screening in gastric cancer” Meeting of the International Gastric Cancer Association, Sao Paulo 2015

“The role of macrophages in cancer” Meeting of the International Gastric Cancer Association, Beijing 2017

“The treatment of acute pancreatitis” World Congress of Surgery, Basel 2017

“The operative treatment of chronic pancreatitis” World Congress of Surgery, Basel 2017

 

Patents

Method for modulation of inflammatory status and proliferative, invasive and angiogenic properties using micro-organisms by normalizing intestinal epithelial cell function (pending)

Pedagocical training, experience, achievements

For details, please, see Appendix at the end of the CV summarizing all pedagogy and teaching related issues.

Person of the year, Teaching, Medical Faculty, 2012

Member of the Teacher’s Academy (University of Helsinki) 2014-

Clinical portfolio

 

Specialist / clinical positions / Clinical leadership

- Senior lecturer / Professor /  Attending Specialist in surgery and abdominal surgery, 1997-2000, 2002-,

- ongoing surgical activity includes operations, endoscopies, on-call duties

- own clinical interest and expertee mostly in upper-GI (gastro-pancreatico-biliary) surgery

- on call responsibilities cover the fields of abdominal surgery, abdominal emergency/trauma surgery and endocrine surgery

 

Activity as a private practitioner

- Previously: Kannelmäki Medical Center, Hemo Medical Center (Lahti), Diacor Länsi-Pasila, Laseri,       Ars Medicina

- Currently: Pihlajalinna/ Dextra Medical Center, (1997-) Helsinki

 

Own continuing education

Regularly, several times annually, attending numerous international and national courses and workshops. (DDW, UEGW, APA, EPC, Gastric Cancer Congress, Meetings of National societies such as The Finnish Surgical Association, The Finnish Gastroenterological Association, The Finnish Digestive Surgeons etc.)

 

International and national invitations

(For complete list, please, see also the list of invited lectures)

- Harvard Digestive Diseases Center, Boston, USA, 1999

- Pancreatic Disease Meeting, Southampton, UK, 2000

- University of Ulm, Germany, 2003

- Estonian Surgical Society, Tallinna, Estonia, 2004

- Dept. of Surgery, Sapporo University, Japan 2004

- Dept. of Surgery, UT Southerwestern Medical Center, Dallas, USA 2005

- The Hungarian Society of Gastroenterology, Hungary, 2010

- The Chinese College of Surgeons, 2011

- University of Chicago, 2014

- The Tuffts Insitute, Boston, 2014

- Session chair, American Pancreatic Association meeting, San Diego, 2017

 

Contribution in the development of clinical work

- Finding of C-reactive protein being in reliable in assessing severity of acute pancreatitis. It is currently in clinical use all over the world.

- Laboratory diagnostics and treatment of acute pancreatitis

- Prophylactic antibiotics in severe acute pancreatitis

- Surgical treatment of acute pancreatitis

- Development in laser technology (hyperthermia) in medicine.

- Genetic background of gastric cancer

- Gastric cancer surgery

- Use of growth factors in promoting healing of injured tissues

 

LIST OF PUBLICATIONS (Pauli Puolakkainen 2017)

 

 

 

A)        ORIGINAL PUBLICATIONS

 

1984

1. Parkkinen E, Nordling S, Puolakkainen P, Kiviluoto T, Schröder T, Schröder J: Distribution of Ia positive cells in the pig and human pancreas. Eur Surg Res 1984;16:336-9. IF: 1,5  

1985

2. Schröder T, Kivisaari L, Standertskjöld-Nordenstam C-G, Somer K, Lehtola A, Puolakkainen P, Karonen S-L, Kivilaakso E, Lempinen M: Pancreatic blood flow and contrast enhancement in computed tomography during experimental pancreatitis. Eur Surg Res 1985;17:286-91. IF: 1,5

1986

3. Lehtola A, Kivilaakso E, Puolakkainen P, Karonen S-L, Lempinen M, Schröder T: Effects of Dextran-70 versus chrystalloids in the microcirculation of porcine hemorrhagic pancreatitis. Surg Gyn Obstet 1986;162:556-62.

 

4. Puolakkainen P, Lempinen M, Schröder T: Fatal pancreatitis - A study of 64 consecutive cases. Acta Chir Scand 1986;152:379-38.

 

5. Rämö OJ, Schröder T, Kuusi T, Puolakkainen P, Mäkelä A, Jalovaara P: Long-term ethanol ingestion causes an increase of phospholipase A2 activity in acute experimental pancreatitis in rats. J Surg Res 1986;41:362-6. IF: 2,18

 

1987

 

6. Lehtola A, Talja M, Puolakkainen P, Nordling S, Schröder T: Peritoneal lavage combined with volume therapy in porcine hemorrhagic pancreatitis: Effects on hemodynamics, microcirculation  and peritoneal morphology. Scand J Gastroent 1987;22:559-67. IF: 2,08

 

7. Puolakkainen P, Brackett K, Sankar MY, Joffe SN, Schröder T:Effects of electrocautery, CO2-laser and contact Nd:YAG laser scalpel on the healing of intestinal incisions. Lasers Surg Med 1987;7:507-11. IF: 2,60

 

8. Puolakkainen P, Paananen A, Kaarne M, Kuusi T, Lempinen M, Schröder T: Aprotinin and Na2CaEDTA in experimental hemorrhagic pancreatitis in pigs. Scand J Gastroent 1987;22:35-41. IF: 2,08

 

9. Puolakkainen P, Valtonen V, Paananen A, Schröder T: C-reactive protein (CRP) and serum phospholipase A2 in the assessment of the severity of acute pancreatitis. Gut 1987;28:764-71. IF: 9,36

                       

1989

 

10. Hahl J, Ovaska J, Paetau A, Puolakkainen P, Schröder T: Nd:YAG laser in subtotal thyroidectomy: A prospective randomized study. Lasers Med Sci 1989;4:275-8. IF: 2,57

 

11. Hukki J, Lipasti J, Castren M, Puolakkainen P, Schröder T: Lactate dehydrogenase in laser incisions: A comparative analysis of skin wounds made with steel scalpel, electrocautery, superpulse-continuous wave mode carbon-dioxide lasers, and contact Nd:YAG laser. Lasers Surg Med 1989;9:589-94. IF: 2,60

 

12. Puolakkainen P: Early assessment of acute pancreatitis: A comparative study of computed tomography and laboratory tests. Acta Chir Scand 1989;155:25-30.

 

13. Puolakkainen P: Early diagnosis and assessment of the severity of acute pancreatitis: an  experimental and clinical study. A thesis. (Väitöskirja), Helsinki, Finland, 1989.

 

14. Puolakkainen P, Kivisaari L, Sipponen J, Standertskjöld-Nordenstam C-G, Nuutinen P, Schröder T: Magnetic resonance imaging (MRI) in detecting acute oedematous and hemorrhagic pancreatitis: an experimental study in pigs. Eur Surg Res 1989;21:25-33. IF: 1,5

 

15. Rämö OJ, Puolakkainen P, Seppälä K, Schröder T: Self-administration of enzyme substitution in the treatment of exocrine panc-reatic insufficiency. Scand J Gastroenterol 1989;24:688-92. IF: 2,08

 

16. Schröder T, Hukki J, Castren M, Puolakkainen P, Lipasti J: Comparison of surgical lasers and conventional methods in skin incisions. Scand J Plast Reconstr Surg. 1989;23:187-90. IF: 0,55

 

17. Schröder T, Puolakkainen P, Hahl J, Rämö OJ: Fatal air embolism as a complication of laser-induced hyperthermia. Lasers Surg Med 1989;9:183-5. IF: 2,60

 

1990

 

18. Hahl J, Haapiainen R, Puolakkainen P, Schröder T: Laser-induced hyperthermia in the treatment of liver tumors. Lasers Surg Med 1990;10:319-21. IF: 2,60

 

19. Mäkelä A, Sternby B, Kuusi T, Puolakkainen P, Schröder T: Phospholipase A2 activity and concentration in several body fluids in patients with acute pancreatitis. Scand J Gastroent 1990;25:944-50. IF: 2,08

 

20. Schröder T, Puolakkainen P, Rämö J, Nuutinen P, Kivilaakso E, Kiviluoto T, Haapsaari P, Kivisaari L: Long term results after pancreatic resection and peritoneal lavage for acute hemorrhagic pancreatitis. Surg Res Comm 1990;7:145-9.

 

1991

 

21. Castren-Persons M, Schröder T, Rämö OJ, Puolakkainen P, Lehtonen E: The contact Nd:YAG laser potentiates the tumor cell killing effect of hyperthermia. Lasers Surg Med 1991;11:595-600. IF: 2,60

 

22. Puolakkainen P, Haapiainen R, Mecklin J-P, Järvinen H, Schröder T: Ischemic colitis - a clinical study of 7 patients with special emphasis on diagnostic problems. Ann Chir Gyn 1991;80:245-9. IF=Scand J Surg: 0,82

 

23. Schröder T, Sainio V, Kivisaari L, Puolakkainen P, Kivilaakso E, Lempinen M: Pancreatic resection vs. peritoneal lavage in acute necrotizing pancreatitis - A prospective randomized trial. Ann Surg 1991;214: 663-6. IF: 7,9

 

24. Twardzik D, Ranchalis J, Puolakkainen P: Transforming growth factor-ß induces tumor differentiation. In: Waxman S, Rossi GB,  Takaku F (eds.), The status of differentiation therapy of cancer, Vol. II, 133-139, Raven Press, 1991.

 

1992

 

25. Castren-Persons M, Lipasti J, Puolakkainen P, Schröder T: Laser-induced hyperthermia: Comparison of two different methods. Lasers Surg Med 1992;12:665-8. IF: 2,60

 

1993

 

26. Gombotz WR, Pankey SC, Bouchard LS, Ranchalis J, Puolakkainen P: Controlled release of TGF-ß1 from a biodegradable matrix for bone regeneration. J Biomater Sci 1993;5:49-63. IF: 2,51

 

27. Puolakkainen P, Paciucci P, Ranchalis J, Oleksowicz L, Twardzik D: Interleukin-2 (IL-2) augments the expression of transforming growth factor beta in patients with disseminated cancer. In: Growth Factors, Peptides and Receptors. pp. 425-433, Terry W. Moody (ed.) Plenum Press, New York, 1993.

 

28. Puolakkainen P, Ranchalis JE, Strong DM, Twardzik DR: The effect of sterilization on transforming growth factor ß isolated from demineralized human bone. Transfusion 1993;33:679-85. IF: 2,98

 

29. Reed M, Puolakkainen P, Lane T, Dickerson D, Bornstein P, Sage H: Differential expression of SPARC and thrombospondin 1 in wound repair: immunolocalization and in situ hybridization. J Histochem Cytochem, 1993;41:1467-77. IF: 2,37

 

1994

 

30. Gombotz WR, Pankey SC, Bouchard LS, Phan DH, Puolakkainen P: Stimulation of bone healing by transforming growth factor beta1 released from polymeric or ceramic implants. J Appl Biomat, 1994;5:141-50. IF: 0,94

 

31. Mumper RJ, Hoffman AS, Bouchard LS, Puolakkainen P, Gombotz WR: Calcium-alginate beads for the oral delivery of TGF-ß1: Stabilization of TGF-ß1 by the addition of polyacrylic acid coupled with acid-hydrolysis of beads. J Contr Rel 1994; 30:241-51. IF: 5,95

 

32. Puolakkainen P, Ranchalis J, Gombotz W, Hofman A, Mumper RJ, Twardzik DR: Novel delivery system for inducing quiescence in intestinal stem cells in rats by TGF-ß1. Gastroenterology, 1994;107:1319-26. IF: 12,90

1995

 

33. Puolakkainen P, Reed M, Gombotz W, Twardzik D, Abrass I, Sage EH. Acceleration of wound healing in aged rats by topical application of transforming growth factor beta1. Wound Rep  Reg 1995;3:330-9. IF: 2,78

 

34. Puolakkainen P, Twardzik D, Ranchalis J, Moroni M, Mandeli J, Paciucci P. Increase of plasma transforming growth factor beta (TGF-beta) during immunotherapy with IL-2. Cancer Invest 1995;13:583-9. IF: 2,11

 

35. Puolakkainen P, Twardzik D, Ranchalis J, Reed M, Pankey S, Gombotz W: The enhancement in wound healing by transforming growth factor beta1 (TGF-ß1)  dependends on the topical delivery system. J Surg Res, 1995;58:321-9. IF: 2,18

 

36. Sainio V, Kemppainen E, Puolakkainen P, Taavitsainen M, Kivisaari L, Valtonen V, Haapiainen R, Schröder T, Kivilaakso E. Early antibiotic treatment in acute necrotising pancreatitis. Lancet 1995;346:663-7. IF: 30,76

 

1996

 

37. Hedström J, Sainio V, Kemppainen E, Puolakkainen P, Haapiainen R, Kivilaakso E, Schauman KO, Stenman UH. Urine trypsinogen-2 as a diagnostic marker for acute pancreatitis. Clin Chem 1996;42:685-90. IF: 6,26

 

38. Kemppainen E, Sainio Vinen R, Kivisaari L, Kivilaakso E, Puolakkainen P. Early localization of necrosis by contrast-enhanced computed tomography can predict outcome in severe acute pancreatitis. Br J Surg 1996;83:924-9.  IF: 4,08

 

39. Kemppainen E, Sand J, Puolakkainen P, Laine S, Hedström J, Sainio V, Haapiainen R, Nordback I. Pancreatitis associated protein as an early marker for acute pancreatitis. Gut 1996;39:675-8. IF: 9,34

 

40. Kokkola A, Haapiainen R, Laxen F, Puolakkainen P, Kivilaakso E, Virtamo J, Sipponen P. Risk of gastric carcinoma in patients with mucosal dysplasia associated with severe atrophic gastritis. A follow-up study. J Clin Pathol 1996; 49:979-84. IF: 2,33

 

41. Kokkola A, Valle J, Haapiainen R, Sipponen P, Kivilaakso E, Puolakkainen P. Helicobacter pylori infection in young patients with gastric carcinoma. Scand J Gastroent 1996;31:643-7. IF: 2,08

 

42. Latvala T, Puolakkainen P, Vesaluoma M, Sage EH, Tervo T. Distribution of SPARC-protein (osteonectin) in normal and wounded feline cornea. Exp Eye Res 1996;63:579-58. IF: 2,54

 

43. Saarialho-Kere U, Vaalamo M, Puolakkainen P, Airola K, Parks W, Karjalainen-Lindsberg ML. Enhanced expression of matrilysin, collagenase and stromelysin-1 in gastrointestinal ulcers. Am J Pathol 1996;148:519-26. IF: 5,67

 

44. Sainio V, Puolakkainen P, Kemppainen E, Hedström J, Haapiainen R, Kivisaari L,  Stenman UH, Schröder T, Kivilaakso E. Serum trypsinogen-2 in the prediction of outcome in acute necrotizing pancreatitis. Scand J Gastroent 1996;31:818-24. IF: 2,08

 

45. Vaalamo M, Weckroth M, Puolakkainen P, Kere J, Saarinen P, Lauharanta J, Saarialho-Kere U. Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds. Br J Derm 1996;135:52-9. IF: 4,26

 

1997

 

46. Kemppainen E, Hedström J, Puolakkainen P, Halttunen J, Sainio V, Haapiainen R, Stenman UH. Urinary trypsinogen-2 test strip in detecting ERCP-induced pancreatitis. Endoscopy, 1997;29:247-51. IF: 4,79

 

47. Kemppainen E, Hedström J, Puolakkainen P, Halttunen J, Sainio V, Haapiainen R, Kivilaakso E, Stenman U-H. Increased serum trypsinogen-2 and trypsin-2-alpha1 antitrypsin complex values identify ERCP-induced pancreatitis with high accuracy. Gut 1997; 41:690-5. IF: 9,36

 

48. Kemppainen E, Hedström J, Puolakkainen P, Sainio V, Haapiainen R, Perhoniemi V, Osman S, Kivilaakso E, Stenman UH. Rapid measurement of urinary trypsinogen-2 as a screening test for acute pancreatitis. N Engl J Med, 1997;336:1788-93. IF: 47,05

 

49. Kokkola A, Monni O, Puolakkainen P, Larramendy ML, Victorzon M, Nordling S, Haapiainen R, Kivilaakso E, Knuutila S. 17q12-21 amplicon, a novel recurrent genetic change in intestinal type of gastric carcinoma: A comparative genomic hybridization study. Genes Chromosomes Cancer 1997; 20:38-43. IF: 3,86

 

50. Kokkola A, Monni O, Puolakkainen P, Larramendy ML, Victorzon M, Nordling S, Haapiainen R, Kivilaakso E, Knuutila S. DNA copy number changes in gastric carcinoma. A comparative genomic hybridization study. In: Progress in Gastric Cancer Research, eds. JR Siewert and JD Roder, 1997, pp. 655-59.

 

51. Sainio V, Puolakkainen P, Kemppainen E, Puolakkainen P, Kivisaari L, Haapiainen R, Schröder T, Lehtonen E, Kivilaakso E. Incorrect estimation of severity of acute pancreatitis by CE-CT. Ann Chir Gyn 1997,86;214-21. IF(=Scand J Surg): 0,82

 

1998

 

52. Hedström J, Svens E, Kenkimäki P, Kemppainen E, Puolakkainen  P, Haapiainen R, Stenman U-H. Evaluation of a new urinary amylase test strip in the diagnosis of acute pancreatitis. Scand J Clin Lab Invest 1998;58:611-6. IF: 1,38

 

53. Kokkola A, Monni O, Puolakkainen P, Nordling S, Haapiainen R, Kivilaakso E, Knuutila S. Presence of high-level DNA copy number gains in gastric carcinoma and severe dysplasia of adenomas but not in moderate dysplasia of adenomas. Cancer Genet Cytogenet 1998;107:32-6. IF: 1, 54

 

54. Kokkola A, Rautelin H, Puolakkainen P, Sipponen P, Färkkilä M, Haapiainen R, Kosunen T. Positive result by serology indicates active H. pylori infection in patients with atrophic gastritis. J Clin Microbiol 1998; 36, 1808-10. IF: 4,16

 

55. Kokkola A, Sjöblom S-M, Haapiainen R, Sipponen P, Puolakkainen P, Järvinen H. The risk of gastric carcinoma and carcinoid tumors in patients with pernicious anemia - A prospective follow-up study. Scand J Gastroent 1998; 33:88-92. IF: 2,08

 

56. Larramendy ML, Wa'el E-R, Kokkola A, Puolakkainen P, Monni O, Salovaara R, Aarnio M, Knuutila S. Comparative genomic hybridization reveals differences in DNA copy number changes between sporadic gastric carcinomas and gastric carcinomas from patients with hereditary nonpolyposis colorectal cancer. Cancer Genet Cytogenet 1998;106:62-5. IF: 1,54

 

57. Tielinen L, Manninen M, Puolakkainen P, Pihlajamäki H, Pohjonen T, Rautavuori J, Törmälä P. Polylactide pin with transforming growth factor b1 in delayed osteotomy fixation. Clin Orthop 1998;355:312-22.

 

58. Vaalamo M, Karjalainen-Lindsberg M-L, Puolakkainen P, Kere J, Saarialho-Kere U. Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12) and tissue inhibitor of metalloproteinase-3 (TIMP-3) in intestinal ulcerations. Am J Pathol 1998;152:1005-14. IF: 5,67

 

1999

 

59. Hietaranta A, Kemppainen E, Puolakkainen P, Sainio V, Haapiainen R, Peuravuori H, Kivilaakso E, Nevalainen T. Extracellular phospholipases A2 in relation to systemic inflammatory response syndrome (SIRS) and systemic complications in severe acute pancreatitis. Pancreas 1999;4:385-91. IF: 2,59

 

60. Kemppainen E, Hietaranta A, Puolakkainen P, Sainio V, Haapiainen R, Kivilaakso E, Nevalainen T. Bactericidal/ permeability-increasing protein, group I and II phospholipase A2 during induction phase of human acute pancreatitis. Pancreas 1999;18:21-7. IF: 2,59

 

61. Puolakkainen P, Reed M, Vento P, Sage EH, Kiviluoto T, Kivilaakso E. Expression of SPARC in the healing intestinal anastomoses and short bowel syndrome in rats. Dig Dis Sci 1999;8:1554-64. IF: 1,84

 

62. Puolakkainen P, Vakkari ML, Kokkola A, Varis A, Haapiainen R, Kivilaakso E, Knuutila S. DNA copy number changes in gastric adenocarcinoma (GC) cell lines as evaluated by comparative genomic hybridization (CGH). In: Kim JP, Min JS, Mok YJ eds. 1999, pp303–306.

 

63. Tielinen L, Manninen M, Puolakkainen P, Pätiälä H, Pohjonen T, Rautavuori J, Rokkanen P. Combining transforming growth factor b1 to a bioabsorbable self-reinforced polylactide pin for osteotomy healing: an experimental study on rats. J Orthop Sci 1999;4:421-30. IF: 1,03

 

64. Vidgren V, Varis A, Kokkola A, Monni O, Puolakkainen P, Nordling S, Forozan F, Kallioniemi A, Vakkari M-L, Kivilaakso E, Knuutila S. Concomitant gastrin and ERBB2 gene amplifications  at 17q12-21 in the intestinal type of gastric cancer. Genes, Chromosomes and Cancer 1999;24:24-9. IF: 3,86

 

2000

 

65. Halonen K, Leppäniemi A, Puolakkainen P, Lundin J, Kemppainen E, Hietaranta A, Haapiainen R. Severe acute pancreatitis: Prognostic factors in 270 consecutive patients. Pancreas 2000;21:266-71. IF: 2,59

 

66. Kemppainen E, Hietaranta A, Puolakkainen P, Hedström J, Haapiainen R, Stenman UH. Time course profile of serum trypsinogen-2 and trypsin-2-alpha1-antitrypsin in patients with acute pancreatitis. Scand J Gastroenterol 2000;35:1216-20. IF: 2,08

 

67. Kokkola A, Rautelin H, Puolakkainen P, Sipponen P, Färkkilä M, Haapiainen R, Kosunen TU. Diagnosis of Helicobacter pylori infection in patients with atrophic gastritis: comparison of histology, 13C-urea breath test and serology. Scand J Gastroent 2000;35:138-41. IF: 2,08

 

68. Kylänpää-Bäck ML, Kemppainen E, Puolakkainen P, Hedström J, Haapiainen R, Perhoniemi V, Kivilaakso E, Korvuo A, Stenman UH. Reliable screening for acute pancreatitis with rapid urine trypsinogen-2 test strip. Br J Surg 2000;87:49-52. IF: 4,08

 

69. Latvala T, Uusitalo M, Puolakkainen P, Kivelä T, Tervo T. Immunolocalization of transforming growth factor beta1, and tenascin in secondary human cataract. Acta Opthalmol Scand 2000;78:344-7.

 

70. Neoptolemos JP, Kemppainen EA, Mayer JM, Fitzpatrick JM, Raraty MGT, Slavin J, Beger HG, Hietaranta A, Puolakkainen PA. Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: A multicentre study.  Lancet 2000;355:1955-60. IF: 30,76

 

71. Paavonen K, Puolakkainen P, Jussila L, Jahkola T, Alitalo K. Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Am J Pathol 2000;156:1499-504. IF: 5,67

 

2001

 

72. Andersen J, Hedström J, Kemppainen E, Finne P, Puolakkainen P, Stenman UH. The ratio of trypsin-2-AAT to serum trypsinogen-1 discriminates biliary and alcohol-induced acute pancreatitis. Clin Chem 2001;47:231-6. IF: 6,26

 

73. Hedström J, Kemppainen E, Andersen J, Jokela H, Puolakkainen P, Stenman UH. A comparison of trypsinogen-2, trypsin-2-a1-antitrypsin complex with amylase and lipase in the diagnosis and assessment of severity in the early phase of acute pancreatitis. Am J Gastroenterol 2001;96(2):424-30. IF: 6,01

 

74. Kemppainen E, Mayer J, Puolakkainen P, Raraty M, Slavin J, Neoptolemos JP. Plasma trypsinogen activation peptide in patients with acute pancreatitis. Br J  Surg 2001;88:679-80. IF: 4,08

 

75. Kiviluoto T, Watanabe S, Hirose M, Sato N, Mustonen H, Puolakkainen P, Rönty M, Ranta-Knuuttila T, Kivilaakso E. Nitric oxide donors retard wound healing in cultured rabbit gastric epithelial cell monolayers. Am J Physiol Gastrointest Liver Physiol 2001;281:G1151-7. IF: 3,26

 

76. Kylänpää-Bäck M-L, Takala A, Kemppainen E, Puolakkainen P, Kautiainen H, Jansson SE, Haapiainen R, Repo H: Cellular markers of systemic inflammation and immune suppression in patients with organ failure due to severe acute pancreatitis. Scand J Gastroenterol 2001;36:1100-7. IF: 2,08

 

77. Kylänpää-Bäck ML, Takala E, Kemppainen E, Puolakkainen P, Haapiainen R, Repo H. Procalcitonin strip test in early detection of severe acute pancreatitis. Br J Surg 2001;88:222-7. IF: 4,08

 

78. Kylänpää-Bäck ML, Takala A, Kemppainen E, Puolakkainen P, Leppäniemi A, Karonen SL. Orpana R, Haapiainen R, Repo H. Procalcitonin, soluble IL-2r and soluble  E-selectin in predicting the severity of acute pancreatitis. Crit Care Med 2001;29(1):63-9. IF: 6,37

 

79. Lempinen M, Kylänpää-Bäck M-L, Stenman U-H, Puolakkainen P, Haapiainen R, Finne P, Korvuo A, Kemppainen E: Predicting the severity of acute pancreatitis by rapid measurement of trypsinogen-2 in urine. Clin Chemistry 2001;47:2103-7. IF: 6,26

 

80. Rautemaa R, Rautelin H, Puolakkainen P, Kokkola A, Kärkkäinen P, Meri S: Survival of Helicobacter pylori from complement lysis by binding of GP!-anchored protectin (CD59). Gastroenterology 2001;120:470-9. IF: 12,90

 

81. Salmela MT, Karjalainen-Lindsberg ML, Puolakkainen P, Saarialho-Kere U. Upregulation and differential expression of matrilysin (MMP7) and metalloelastase (MMP12) and their inhibitors TIMP-1 and TIMP-3 in Barrett’s oesophageal adenocarcinoma. Br J Cancer 2001;85:383-92. IF: 4,34

 

82. Tielinen L, Manninen M, Puolakkainen P, Kellomäki M, Törmälä P, Rich J, Seppälä J, Rokkanen P. Inability of transforming growth factor beta1, combined with a bioabsorbable polymer paste, to promote healing of bone defects in the rat distal femur. Arch Orthop Trauma Surg 2001;121:191-6. IF: 1,11

 

83. Vanhanen H, Pitkälä K, Puolakkainen P, Strandberg TE, Lonka K. The problem-based learning tutorial laboratory – a method for training medical teachers. Med Teach 2001;23:99-101. IF: 1,33

 

84. Varis A, Puolakkainen P, Savolainen H, Kokkola A, Salo J, Nieminen O, Nordling S, Knuutila S. DNA copy number profiling in Barrett’s adenocarcinoma: comparison with gastric adenocarcinoma and esophageal squamous cell carcinoma. Cancer Genet Cytogenet 2001;127:53-8. IF: 1,54

 

85. Vuola J, Böhling T, Göransson H, Puolakkainen P. Transforming growth factor b released from natural coral implant enhances bone growth at calvarium of mature rat. J Biomed Mater Res 2001;59:152-9.

 

 

2002

 

86. Halonen K, Pettilä V, Lepppäniemi A, Kemppainen E, Puolakkainen P, Haapiainen R. Multiple organ dysfunction associated with severe acute pancreatitis. Crit Care Med 2002;30:1274-9. IF: 6,37

 

87. Kokkola A, Sipponen P, Rautelin H, Härkönen M, Kosunen TU, Haapiainen R, Puolakkainen P.  The effect of Helicobacter pylori eradication on the natural course of atrophic gastritis with dysplasia. Aliment Pharmacol Ther 2002;16:515-20. IF: 4,34

 

88. Kylänpää-Bäck ML, Kemppainen E, Puolakkainen P, Hedström J, Haapiainen R, Korvuo A, Stenman UH. Comparison of urine trypsinogen-2 test strip with serum lipase in the diagnosis of acute pancreatitis. Hepato-Gastroenterology 2002;49:1130-4. IF: 0,67

 

89. Kylänpää-Bäck M-L, Kemppainen E, Puolakkainen P. Trypsin-based laboratory methods and carboxypeptidase activation in acute pancreatitis. J Pancreas 2002;3(2):34-48.

 

90. Lohi H, Mäkelä S, Pulkkinen K, Höglund P, Karjalainen-Lindsberg ML, Puolakkainen P, Kere J. Upregulation of CFTR expression but not SLC26A3 and SLC9A3 in ulcerative colitis. Am J Physiol Gastrointest Liver Physiol 2002;283:G567-75. IF: 3,26

 

91. Mayer JM, Raraty M, Slavin J, Kemppainen E, Fitzpatrick J, Hietaranta A, Puolakkainen P, Beger HG, Neoptolemos JP. Serum amyloid A is a better early predictor of severity than C-reactive protein in acute pancreatitis, Br J Surg 2002;89:163-71. IF: 4,08

 

92. Mayer JM, Raraty M, Slavin J, Kemppainen E, Fitzpatrick J, Hietaranta A, Puolakkainen P, Beger HG, Neoptolemos JP. Severe acute pancreatitis is related to increased early urinary levels of the activation peptide of pancreatic phospholipase A. Pancreatology 2002;2:535-42. IF: 2,20

 

93. Ranta-Knuuttila T, Kiviluoto T, Mustonen H, Puolakkainen P, Watanabe S, Sato N, Kivilaakso E: Migration of primary cultured rabbit gastric epithelial cells cequires intact protein kinase C and Ca²⁺/calmodulin activity. Dig Dis Sci 2002;47(5):1008-14. IF: 1,84

 

94. Tielinen L, Puolakkainen P, Pohjonen T, Rautavuori J, Törmälä P, Rokkanen P: The effect of transforming growth factor-b1, released from a bioabsorbable sef-reinforced polyactide pin, a bone defect. Biomaterials 2002;23:3817-23. IF: 7,37

 

 

2003

95. Bradshaw AD, Puolakkainen P, Dasgupta J, Davidson JM, Wight TN, Sage EH: SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strength. J Invest Dermatol 2003;120:949-55. IF: 5,54

 

96. Brekken RA, Puolakkainen P, Workman G, Graves D, Lubkin SR, Sage EH. Enhanced growth of tumors in SPARC-null mice is associated with changes in the extracellular matrix. J Clin Invest 2003;111:487-95. IF: 15,39

 

97. Halonen  KI, Leppäniemi AK, Kemppainen EA, Puolakkainen PA, Haapiainen RK. Long-term health-related quality of life in survivors of severe acute pancreatitis. Intensive Care Med 2003;29:782-6. IF: 5,17

 

98. Halonen KI, Leppäniemi AK, Lundin JE, Puolakkainen PA, Kemppainen EA, Haapiainen RK. Predicting fatal outcome in the early phase of severe acute pancreatitis by using novel prognostic models. Pancreatology 2003;3:309-15. 2,20

 

99. Kokkola A, Kosunen TU, Puolakkainen P, Sipponen P, Härkönen M, Laxen J, Virtamo J, Haapiainen R, Rautelin V. Spontaneous disappearance of Helicobacter pylori antibodies in patients with advanced atrophic corpus gastritis. APMIS 2003;111:619-24. IF: 1,75

 

100. Kokkola A, Sipponen P, Haapiainen R, Rautelin H, Karjalainen-Lindsberg M-L, Puolakkainen P: Developement of Barrett’s esophagus after “spontaneous” healing of atrophic corpus gastritis. Helicobacter 2003;8(4):590-3. IF: 2,85

 

101.Lempinen M, Stenman U-H, Finne P, Puolakkainen P, Haapiainen R, Kemppainen E. Trypsinogen-2 and Trypsinogen activation peptide (TAP) in urine of patients with acute pancreatitis. J Surg Res 2003;111:267-73. IF: 2,18

 

102. Lempinen M, Stenman U-H, Puolakkainen P, Hietaranta A, Haapiainen R, Kemppainen E: Sequential changes in pancreatic markers in acute pancreatitis. Scand J Gastroenterol 2003;38:666-75. IF: 2,08

 

103. Mentula P, Kylänpää-Bäck M-L, Kemppainen E, Eklund K, Orpana A, Puolakkainen P, Haapiainen R, Repo H: Serum levels of mast cell tryptase, vascular endothelial growth factor and basic fibroblast growth factor in patients with acute pancreatitis. Pancreas 2003;27(2):e29-e33. IF: 2,59

 

104. Mentula P, Kylänpää-Bäck ML, Kemppainen E, Takala A, Jansson SE, Kautiainen H, Puolakkainen P, Haapiainen R, Repo H. Decreased HLA-DR expression on peripheral blood monocytes predicts development of organ failure in patients with acute pancreatitis. Clin Sci 2003;105:409-17. IF: 3,98

 

105. Mustonen H, Kiviluoto T, Puolakkainen P, Kivilaakso E.  ETOH increases intracellular Ca2+, closes gap junctions and decreases cell volume in rabbit gastric mucosa. In: Poujeol P and Petersen O (eds), Monduzzi Editore, pages 103-8, 2003

 

106. Puolakkainen P, Bradshaw A, Kyriakides TR,  Reed , Brekken R,  Wight T, Bornstein P, Ratner B, Sage EH. Compromised production of extracellular matrix in mice lacking secreted protein,  acidic and rich  in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials.  Am J Pathol 2003;162(2):627-35. IF: 5,67

 

107. Reed MJ, Koike T, Sadoun E, Sage EH, Puolakkainen P. Inhibition of TIMP-1 enhances angiogenesis in vivo and cell migration in vitro. Microvasc Res 2003;65:9-17. IF: 3,08

 

108. Sage EH, Reed M, Funk SE, Truong T, Steadele M, Puolakkainen P, Maurice DH, Bassuk JA: Cleavage of the matricellular protein SPARC by matrix metalloproteinase 3 produces polypeptides that influence angiogenesis. J Biol Chem 2003;278:37849-57. IF: 5,33

 

2004

109. Bister, V-O, Salmela MT, Karjalainen-Lindsberg M-L, Uria J, Lohi J, Puolakkainen P, Lopez-Otin C, Saarialho-Kere U: Differential expression of three matrix metalloproteinases, MMP-19, MMP-26, and MMP-28, in normal inflamed intestine and colon cancer. Dig Dis Sci 2004;49(4):653-61. IF: 1,84

 

110. Hietaranta A, Mustonen H, Puolakkainen P, Haapiainen R, Kemppainen E: Proinflammatory effects of pancreatic elastase are mediated through TLR4 and NF-kB. Biochem Biophys Res Com 2004;323:192-6. IF: 2,59

 

111. Johnson CD, Lempinen M, Imrie CW, Puolakkainen P, Kemppainen E, Carter R, McKay C: Urinary trypsinogen activation peptide as a marker of severe acute pancreatitis. Br J Surg 2004;91:1027-33. IF: 4,08

 

112. Kakkola L, Kaipio N, Hokynar K, Puolakkainen P, Mattila PS, Kokkola A, Partio EK, Eis-Hübinger A-M, Söderlund-Venermo M, Hedman K. Genoprevalence in human tissues of TT-virus genotype 6. Arch Virol 2004;149:1095-106. IF: 1,91

 

113. Mentula P, Kylänpää-Bäck M-L, Kemppainen E, Jansson S-E, Sarna S, Puolakkainen P, Haapiainen R, Repo H: Plasma anti-inflammatory cytokines and monocyte human leucocyte antigen-DR expression in patients with acute pancreatitis. Scand J Gastroenterol 2004;39:178-87. IF: 2,08

 

114. Mustonen H, Kiviluoto T, Puolakkainen P, Kivilaakso E.  Ethanol induces volume changes and gap-junction closure via intracellular  Ca signalling pathway in cultured rabbit gastric epithelial cells. Scand J Gastroenterol 2004;39:103-10. IF: 2,08

 

115. Puolakkainen PA, Brekken RA, Muneer S, Sage EH: Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis. Molecular Cancer Res 2004;2:215-24. IF: 4,16

 

116. Salmela TM, Pender LF, Karjalainen-Lindsberg M-L, Puolakkainen P, MacDonald TT, Saarialho-Kere U: Collagenase-1 (MMP-1); Matrilysin-1 (MMP-7), and Stromelysin-2 (MMP-10) are expressed by migratin enterocytes during intestinal wound healing. Scand J Gastroenterol 2004;39:1095-104. IF: 2,08

 

117. Varis A, Zaika A, Puolakkainen P, Magy B, Madrigal I, Kokkola A, Väyrynen A, Kärkkäinen P, Moskaluk C, El-Rifai W, Knuutila S:  Coamplified and overexpressed genes at ERBB2 locus in gastric cancer. Int J Cancer 2004;109: 548-53. IF: 4,72

 

2005

118. Barker TH, Framson P, Puolakkainen P, Reed M, Funk SE, Sage EH: Matricelluar homologs in the foreign body response. Hevin suppresses inflammation, but Hevin and SPARC together diminish angiogenesis. Am J Pathol 2005;166(3):923-33. IF: 5,67

 

119. Bidel S, Mustonen H, Khalighi-Sikaroudi G, Lehtonen E, Puolakkainen P, Kiviluoto  T, Kivilaakso E: Effect of the ulcerogenic agents ethanol, acetylsalicylic acid and taurocholate on actin cytoskeleton and cell motility in cultured rat gastric mucosal cells. World J Gastroenterol 2005;11(26):4032-9. IF: 2,09

 

120. Kokkola A, Louhimo J, Puolakkainen P, Alfthan H, Haglund C, Rautelin V: Helicobacter pylori infection and low serum pepsinogen I level as risk factors for gastric carcinoma. World J Gastroenterol 2005;11(7):1032-6. IF: 2,09

 

121. Kylänpää ML, Mentula P, Kemppainen E, Puolakkainen P, Aittomäki S, Silvennoinen O, Haapiainen R, Repo H: Monocyte anergy is present in patients with severe acute pancreatitis and is significantly alleviated by granulocyte-macrophage colony-stimulating factor and interferon-g in vitro. Pancreas 2005;31(1):23-7. IF: 2,58

 

122. Lempinen M, Puolakkainen P, Kemppainen E: Clinical value of severity markers in acute pancreatitis. Scand J Surg 2005;94:118-123. IF: 0,82

 

123. Lempinen M, Stenman U-H, Halttunen J, Puolakkainen P, Haapiainen R, Kemppainen E: Early sequential changes in serum markers of acute pancreatitis induced by endoscopic retrograde cholangiopancreatography. Pancreatology 2005;5:157-64. IF: 2,2

 

124. Mentula P, Kylänpää M-L, Kemppainen E, Jansson S-E, Sarna S, Puolakkainen P, Haapiainen R, Repo H: Early prediction of organ failure by combined markers in patients with acute pancreatitis.  Br J Surg 2005;92:68-67. IF: 4,08

 

125. Mustonen H, Kiviluoto T, Paimela H, Puolakkainen P, Kivilaakso E: Calcium signaling is involved in ethanol-induced volume decrease and gap junction closure in cultured rat gastric mucosal cells. Dig Dis Sci 2005;50 (1):103-10. IF: 1,84

 

126. Mustonen H, Lepistö A, Lehtonen S, Lehtonen E, Puolakkainen P, Kivilaakso E: CD2AP contributes to cell migration and adhesion in cultured gastric epithelium. Biochem Biophys Res Comm 2005;332:426-32. IF: 2,55

 

127. Nurmi JT, Puolakkainen P, Rautonen NE: Bifidobacterium Lactis sp. 420 up-reculates cyclooxynase (Cox)-1 and down-regulates Cox-2 gene expression in a Caco-2 cell culture model. Nutrition and Cancer 2005;51(1):83-92. IF: 1,97

 

128. Nurmi JT, Puolakkainen PA, Rautonen NE: Intron 1 retaining cyclooxygenase 1 splice variant is induced by osmotic stress in human intestinal epithelial cells. Prostaglandins Leukot Essent Fatty Acids 2005;73(5):343-50. IF: 2,53

 

129. Puolakkainen P, Bradshaw AD, Brekken RA, Reed MJ, Kyriakides T, Funk SE, Gooden MD, Vernon RB, Wight TN, Bornstein P, Sage EH: SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alchohol sponges. J Histochem & Cytochem 2005;53:571-81. IF: 2,37

 

130. Reed MJ, Bradshaw AD, Shaw M, Sadoun E, Han N, Ferara N, Funk S, Puolakkainen P, Sage EH: Enhanced angiogenesis characteristic of SPARC-null mice disappears with age. J Cell Physiol 2005;204(3):800-7. IF: 4,59

 

131. Tukiainen E, Kylanpaa ML, Kemppainen E, Nevanlinna H, Paju A, Repo H, Stenman UH, Puolakkainen P: Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis. Pancreas 2005;30(3):239-42. IF: 2,59

 

2006

132. Järveläinen H, Puolakkainen P, Pakkanen S, Brown E, Höök M, Iozzo R, Sage H: A role for decorin in cutaneous wound healing and angiogenesis. Wound Repair Regen 2006;14(4):443-52. IF: 2,78

 

133. Lindström O, Kylänpää L, Mentula P, Puolakkainen P, Kemppainen E, Haapiainen R, Fernandez JA, Griffin JH, Repo H, Petaja J: Upreculated but insufficient generation of activated protein C is associated with development of multiorgan failure of severe acute pancreatitis. Critical Care 2006;10: R16. IF: 4,93

 

134. Nylander-Koski O, Mustonen H, Puolakkainen P, Kiviluoto T, Kivilaakso E: Epidermal growth factor enhances intracellular pH regulation via calcium signaling in acid exposed primary cultured rabbit gastric epithelial cells. Dig Dis Sci 2006;51(8):1322-30. IF: 1,84

 

135. Stjernberg-Salmela S, Kivisaari A, Puolakkainen P, Farkkila M, Kemppainen E, Ranki A, Pettersson T: Intra-abdominal abscess in a patient with tumour necrosis factor receptor-           associated periodic syndrome. Case report. J Intern Med 2006;259(2): 209-13. IF: 5,94

 

136. Sullivan MM, Barker TH, Funk SE, Karchin A, Sanders J, Starcher B, Wight TN, Puolakkainen P, Sage EH. Matricellular hevin regulates decorin production and collagen assembly. J Biological Chemistry 2006;281(37): 27621-32.  IF: 5,33

 

137. Tukiainen E, Kylänpää M-L, Ebeling P, Kemppainen E, Puolakkainen P, Repo H: Leptin and adiponectin levels in acute pancreatitis. Pancreas 2006;32 (2): 211-4. IF: 2,59

 

138. Weckman L, Kylänpää M-L, Puolakkainen P, Halttunen J. Endoscopic treatment of pancreatic  pseudocysts. Surg Endosc 2006;20:603-7. IF: 3,31

 

 

2007

139. Danielson H, Kokkola A, Kiviluoto T, Sirén J, Louhimo J, Kivilaakso E, Puolakkainen P: Clinical                outcome after D1 vs. D2-3 gastrectomy for treatment of gastric cancer. Scand J Surg 2007;96:35-40. IF: 0,82

 

140. Mentula P, Kylänpää M-L, Kemppainen E, Repo H, Puolakkainen P: Early inflammatory response in acute pancreatitis is little affected by body mass index. Scand J Gastroenterol 2007; 42: 1362-8. IF: 2,08

 

141. Mustonen H, Hietaranta A, Puolakkainen P, Kemppainen E, Paimela H, Kiviluoto T, Kivilaakso E: Ethanol induced KF-kB activation protects against cell injury in cultured rat gastric mucosal epithelium. Am J Physiol Gastrointest Livel Physiol 2007; 292; G1614-G1621. IF: 3,26

 

142. D’Amato M, Bruce S, Bresso F, Zucchelli M, Ezer S, Pulkkinen V, Lindgren C, Astegiano M, Rizzetto M, Gionchetti Riegler G, Sostegni R, Daerno M, D’Alfonso S, Momigliano-Richiardi P, Torkvist L, Puolakkainen P, Lappalainen M, Paavola-Sakki P, Halme L, Färkkilä M, Turunen U, Kontula K, Lofberg R, Pettersson S, Kere J: Neuropeptide S receptor 1 gene polymorphism is associated with susceptibility to inflammatory bowel disease. Gastroenterology 2007; 133: 8088-17. IF: 12,90

 

143. Nylander-Koski O, Kiviluoto T, Puolakkainen P, Kivilaakso E, Mustonen H:The effect of nitric oxide, growth factors, and estrogen on gastric cell migration. J Surg Res 2007; 143: 230-7. IF: 2,18

 

144. Methuen T, Kylänpää M-L, Kekäläinen O, Halonen T, Tukiainen E, Sarna S, Kemppainen E, Haapiainen R, Puolakkainen P, Salaspuro M: Disialotransferrin, determined by capillary electrophoresis, is an accurate biomarker for alcoholic cause of acute pancreatitis. Pancreas 2007;34(4):405-9. IF: 2,59

 

145. Rau BM, Frigerio I, Büchler MW, Wegscheider K, Bassi C, Puolakkainen PA, Beger HG, Schilling MK. Evaluation of procalcitonin for predicting septic multiorgan failure and overall prognosis in secondary peritonitis. A prospective multicenter study. Arch Surg 2007;142:134-42. IF: 4,32

 

146.  Rau BM, Kemppainen EA, Gumbs AA, Uhl W, Büchler MW, Wegscheider K, Bassi C, PA Puolakkainen, Beger HG: Early assessment of pancreatic infections and overall prognosis in severe acute pancreatitis by procalcitonin (PCT). A prospective international multicenter study. Ann Surg  2007;245(5):745-54. IF: 7,90

 

147.Bister V, Skoog T, Virolainen S, Kiviluoto T, Puolakkainen P, Saarialho-Kere U: Increased expession of matrix metalloproteinases-21 -26 and T1MP-4 in pancreatic adenocarcinoma. Mod Pathol 2007; 20(11): 1128-40. IF: 4,41

 

2008

148. Kokkola A, Sipponen P, Arkkila P, Danielson H, Puolakkainen P. Does the eradication of Helicobacter pylori delay the diagnosis of gastric cancer. Scand J Gastroenterol 2008; 43: 1456-60. IF: 2,08

 

149. Mahkonen A, Putaala H, Mustonen H, Rautonen N, Puolakkainen P. Lactobacillus acidophilus 74-2 and butyrate induce cyclooxygenase (COX)-1 expression in gastric cancer cells. Immonopharmacoloy and  Immunotoxicology  2008; 30(3): 503-18.IF: 0,89

 

150. Tukiainen E, Kylänpää ML, Puolakkainen P, Kemppainen E, Halonen K, Orpana A, Methuen T, Salaspuro M, Haapiainen R, Repo H. Polymorphisms of the TNF, CD14, and HSPA1B genes in patients with acute alcohol-induced pancreatitis. Pancreas 2008; 37(1): 56-61. IF: 2,59

 

151. Myllykangas S, Junnila S, Kokkola A, Rautio R, Scheinin T, Kiviluoto T, Karjalainen-Lindsberg ML, Hollmén J, Knuuttila S, Puolakkainen P, Monni A. Integrated gene copy number and expression microarray analysis of gastric cancer highlights potential target genes. Int J Cancer 2008; 123(4): 817-25. IF: 4,72

 

152. Petrova TV, Nykänen A, Norrmen C, Ivanov KI, Andersson LC, Haglund C, Puolakkainen P Wempe F, von Melchner H, Gradwohl G, Vanharanta S, Aaltonen LA, Saharinen J, Gentile M, Clarke A, Taipale J, Oliver G, Alitalo K. Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to hihly dysplastic phenotype. Cancer Cell 2008; 13(5): 407-19. IF: 25,29

 

153. Sullivan MM, Puolakkainen P, Barker TH, Funk SE, Sage EH. Altered tissue repair in hevin-null mice: inhibition of fibroblast migration by a matricellular SPARC homolog.  Wound Repair Regen 2008; 16(2): 310-9. IF: 2,78

 

154. Lindström O, Jarva H, Meri S, Mentula P, Puolakkainen P, Kemppainen E, Haapiainen R, Repo H, Kylänpää L. Elevated levels of the complement regulator protein CD59 in severe acute pancreatitis. Scand J Gastroenterol 2008; 43(3): 350-5. IF: 2,08

 

155. Mentula P, Kylänpää ML, Kemppainen E, Puolakkainen P. Obesity correlates with early hyperglycemia in patients with acute pancreatitis who developed organ failure. Pancreas 2008; 36(1): e21-5. IF: 2,59

 

156. Tiala I, Wakkinen J, Suomela S, Puolakkainen P, Tammi R, Forsberg S, Rollman O, Kainu K, Rozell B, Kere J, Saarialho-Kere U, Elomaa O. The PSORS1 locus gene CCHCR1 affects keratinocyte proliferation in transgenic mice. Hum Mol Genet 2008; (17)7: 1043-51. IF: 7,39

 

157. Vakkila J, Nieminen U, Siitonen S, Turunen U, Halme L, Nuutinen H, Mustonen H, Puolakkainen P, Färkkilä M, Repo H. A novel modification of a flow cytometric assay of phosphorylated STAT1 in whole blood monocytes for immunomonitoring of patients on IFN alpha regimen. Scand J Immunol 2008; 67(1): 95-102. IF: 2,11

 

158. Mustonen H, Kiviluoto T, Puolakkainen P, Paimela H, Mentula P, Kemppainen E, Kivilaakso E. Taurocholate-induced nitric oxide signaling and the ensuing production of reactive oxygen species lead to an increase in epithelial permability in cultivated mouse gastric epithelium. Dig Dis Sci 2008; 53: 3119-27. IF: 1,84

 

2009

159. Nieminen A, Kokkola A, Ylä-Liedenpohja J, Louhimo J, Mustonen H, Puolakkainen P. Early gastric cancer: clinical characteristics and results of surgery. Dig Surg 2009; 26(5): 378-83. IF: 1,37

 

160. Lindström O, Tukiainen E, Kylänpää L, Mentula P, Rouhiainen A, Puolakkainen P, Rauvala H, Repo H: Circulating levels of a soluble form of receptor for advanced glycation end products and high-mobility group box chromosomal protein 1 in patients with acute pancreatitis. Pancreas 2009; 38(2): 215-20 IF: 2,59

 

161. Kauhanen SP, Komar G, Seppänen MP, Dean KI, Minn HR, Kajander SA, Rinta-Kiikka I, Alanen K, Borra RJ, Puolakkainen P, Nuuttila P, Ovaska JT. A prospective diagnostic accuracy study of 18F-fluoreoxyglucose positron emission tomography/computed tomography, multidetector row computed tomography, and magnetic resonance imaging in primary diagnosis and staging of pancreatic cancer.Ann Surg2009; 250: 957-63. IF: 7,9

 

162. Norrmén C, Ivanov KL, Cheng J, Zangger N, Delorenzi M, Jaquwt M, Miura N, Puolakkainen P, Horsley V, Hu J, Augustin HG, Ylä-Herttuala S, Alitalo K, Petrova TV. FOX2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biol 2009; 185(3): 439-57. IF: 9,58

 

163. Tukiainen E, Kylänpää ML, Repo H, Orpana A, Methuen T, Salaspuro M, Kemppainen E, Puolakkainen P. Hemostatic gene polymorphisms in severe acute pancreatitis. Pancreas 2009;38(2): 43-6. IF: 2,59

 

164. Mustonen H, Puolakkainen P, Kemppainen E, Kiviluoto T, Kivilaakso E. Taurocholate potentiates ethanol-induced NF-kappaB activation and inhibits caspase-3 activity in cultured rat gastric mucosal cells. Dig Dis Sci 2009;54(5): 928-36. IF: 1,84

 

2010

165. Junnila S, Kokkola A, Mizuguchi T, Hirata K, Karjalainen-Lindsberg M-L, Puolakkainen P, Monni O. Gene expression analysis identifies over-expression of CXCL1, SPARC, SPPI, and SULF in gastric cancer. Genes, Chromosomes & Cancer  2010: 49 28-39. IF: 3,86

 

166. Norrmén C, Vandevelde W, Ny A, Saharinen P, Gentile M, Haraldsen G, Puolakkainen P, Lukanidin E, Dewerchin M, Alitalo K, Petrova TV. Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity. Blood 2010: 115(4): 906-9. IF: 10,56

 

167. Junnila S, Kokkola A, Karjalainen-Lindsberg M-L, Puolakkainen P, Monni O: Genome-wide copy number and expression analysis of primary gastric tumors and gastric cancer cell lines. BMC Cancer2010: 10:73. IF: 2,74

 

168. Arnold SA, Rivera LB, Miller AF, Carbon JG, Dineen SP, Xie Y, Castrillon DH, Sage EH, Puolakkainen P, Bradshaw A, Brekken RA. Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma. Disease Models & Mechanisms 2010: 3(1-2):57-72. IF: 3,30

 

169. Stjernberg-Salmela S, Ranki A, Karenko L, Siitonen S, Mustonen H, Puolakkainen P, Sarna S, Pettersson T, Repo H. Low TNF-induced NF-kappaB and p38 phosphorylation levels in leucocytes in tumour necrosis factor receptor-associated periodic syndrome. Rheumatology 201049(2): 382-90. IF: 4,24

 

170. Oiva J, Mustonen H, Kylänpää M-L, Kyhälä L, Alanärä T, Aittomäki S, Siitonen S, Kemppainen E, Puolakkainen P, Repo H. Patients with acute pancreatitis complicated by organ failure show highly aberrant monocyte signaling profiles assessed by phospho-specific flow cytometry. Crit Care Med  38(8): 1702-8. IF: 6,37

 

171. Pettilä V, Kyhälä L, Kylänpää M-L, Leppäniemi A, Tallgren M, Markkola A, Puolakkainen P, Repo H, Kemppainen E: APCAP –activated protein C in aucte panceatitis: a double-blind randomized human pilot trial. Crit Care 2010: 14: R139. IF: 4,93

 

172. Mentula P, Hienonen Piia, Kemppainen E, Puolakkainen P, Leppäniemi A. Surgical decompression for abdominal compartment syndrome in severe acute pancreatitis. Arch Surg 2010: 145(8):764-9. IF: 4,32

 

173. Bota PCS, Collie AMB, Puolakkainen P, Vernon RB, Sage EH, Ratner BD, Stayton PS: Biomaterial topography alters healing in vivo and monocyte/macrophage activation in vitro. J Biomed Mat Res  2010: 95(2): 649-57. IF: 2,81

 

174. Oiva J, Mustonen H, Kylänpää ML, Kyhälä L, Kuuliala K, Siitonen S, Kemppainen E, Puolakkainen P, Repo H. Acute pancreatitis with organ dysfunction associates with abnormal blood lymphocyte signaling: controlled laboratory study. Crit Care 2010: 14:(6):R207. IF: 4,91

 

2011

175. Lindström OK, Tukiainen EM, Kylänpää ML, Mentula PJ, Puolakkainen PA, Wartiovaara-Kautto UM, Repo H, Petäjä JM. Thrombin generation in vitro and in vivo and disturbed tissue factor regulation in patients with acute pancreatitis. Pancreatology. 2011;11(6):557-66. Epub 2011 Dec 29.

176. Oiva J, Itkonen O, Koistinen R, Hotakainen K, Zhang WM, Kemppainen E, Puolakkainen P, Kylänpää L, Stenman UH, KKoistinen H. Specific immunoassay reveals increased serum trypsinogen 3 in acute pancreatitis. Clin Chem 2011; 57:1506-13

177. Kauttu T, Rantanen T, Sihvo E, Räsänen J, Puolakkainen P, Salo J. Esophageal adenocarcinoma arising after antireflux surgery: a population based analysis. Eur J Cardiothorac Surg 2011: 40:1450-4.

 

 

2012

178. Shen Z, Kauttu T, Seppänen H, Vainionpää S, Ye Y, Wang S, Mustonen H,Puolakkainen P. Vasohibin-1 and vasohibin-2 expression in gastric cancer cells and TAMs. Med Oncol. 29:2718-26, 2012 

 

179. Kokkola A, Louhimo J, Puolakkainen P.Does non-curative gastrectomy improve survival in patients with metastatic gastric cancer? J Surg Oncol. 2012 Feb 21. doi: 10.1002/jso.23066.

 

180. Kauttu T, Räsänen J, Krogerus L, Sihvo E, Puolakkainen P, Salo JA.Long-term results of ablation with antireflux surgery for Barrett's esophagus: a clinical and molecular biologic study. Surg Endosc. 2012 Jan 5.

181. Shen Z, Ye Y, Dong L, Vainionpää S, Mustonen H, Puolakkainen P, Wang S. Kindlin-2: a novel adhesion protein related to tumor invasion, lymph node metastasis, and patient outcome in gastric cancer. Am J Surg. 2012 Feb;203(2):222-9. Epub 2011 Nov 5.

182. Kyhälä L, Mentula P, Kylänpää L, Moilanen E, Puolakkainen P, Pettilä V, Repo H. Activated protein C does not alleviate the course of systemic inflammation in the APCAP trial. Int J Inflamm 2012: 712739, 2012

 

183. Shen Z, Seppänen H, Vainionpää S, Ye Y, Wang S, Mustonen H, Puolakkainen P. IL10, IL11, IL18 are differently expressed in CD14+ TAMs and play different role in regulating the invasion of gastric cancer cells under hypoxia. Cytokine. 59:352-7, 2012

 

184. Dellinger EP, Forsmark CE, Layer P, Puolakkainen P, et al. determinant-based classification of acute pancreatitis severity: an international multidisciplinary consultation. Ann Surg 256(6):875-80, 2012

 

2013

 

185. Shen Z, Ye Y, Kauttu T, Seppänen H, Vainionpää S, Wang S, Mustonen H, Puolakkainen P. The novel focal adhesion gene kindlin-2 promotes the invasion of gastric cancer cells mediated by tumor-associated macrophages. Oncol Rep.29:791-7, 2013

              

186. Shen Z, Ye Y, Kauttu T, Seppänen H, Vainionpää S, Wang S, Mustonen H, Puolakkainen P. Novel focal adhesion protein kindlin-2 promotes the invasion of gastric cancer cells through phosphorylation of integrin β1 and β3. J Surg Oncol. 2013;108:106-12, 201

 

187. Kuuliala K, Lappalainen M. Turunen U, Puolakkainen P, Kemppainen E, Siitonen S, Repo H, Mustonen H. Detection of muramyl dipeptide-sensing pathway defects in monocytes of patients with Crohn’s disease using phospho-specific whole blood flow cytometry. Scand J Clin Lab Invest 73(6):494-502,2013

 

188. Layer P, Dellinger EP, Forsmark CE, Puolakkainen P, Pancreatitis Across Nations Clinical Research and Education Alliance (PANCREA). Determinant-based classification of acute pancreatitis severity. International multidisciplinary classification of acute pancreatitis severity: the 2013 German edition. Z Gastroentrol 51 (6)544-50, 2013

 

189. Shen Z, Seppänen H, Kauttu T, Vainionpää S, Ye Y, Wang S, Mustonen H, Puolakkainen P. Vasohibin-1 Expression Is Regulated by Transforming Growth Factor-β/Bone Morphogenic Protein Signaling Pathway Between Tumor-Associated Macrophages and Pancreatic Cancer Cells. J Interferon Cytokine Res 33(8) 428-33, 2013

 

190. Oiva J, Mustonen H, Kylänpää ML, Kuuliala K, Siitonen S, Kemppainen E, Puolakkainen P, Repo H. Patients with acute pancreatitis complicated by organ dysfunction show abnormal peripeheral blood polymorphonuclear leukocyte signaling. Pancreatology 13(2)118-24, 2013

 

191. Shen Z, Kauttu T, Cao J, Seppänen H, Vainionpää S, Ye Y, Wang S, Mustonen H, Puolakkainen P. Macrophage coculture enhanced invasion of gastric cancer cells via TGF-β and BMP pathways. Scand J Gastroenterol. 48:466-72, 2013

 

192. Shen Z, Kauttu T, Seppänen H, Vainionpää S, Ye Y, Wang S, Mustonen H, Puolakkainen P. Both macrophages and hypoxia play critical role in regulating invasion of gastric cancer in vitro. Acta Oncol. 52:852-60, 2013

 

193. Maravi-Poma E, Dellinger EP, Puolakkainen P et Pancareatitis Across Nations Clinical Research and Education Alliance (PANCREA). International multidisciplinary classification of acute pancreatitis severity. Med Intensiva 2014 38(4)211-7

 

2014

194. Nieminen A, Maksimow M, Mentula P, Kyhälä L, Kylänpää L, Puolakkainen P, Kemppainen E, Repo H, Salmi M. Circulating cytokines in predicting development of severe acute pancreatitis. Crit Care. 2014 May 21;18(3):R104. [Epub ahead of print]

195. Puolakkainen P, Koski A, Vainionpää S, Shen Z, Repo H, Kemppainen E, Mustonen H, Seppänen H. Anti-inflammatory macrophages activate invasion in pancreatic adenocarcinoma by increasing the MMP9 and ADAM8 expression. Med Oncol. 2014 Mar;31(3):884. doi: 10.1007/s12032-014-0884-9. Epub 2014 Feb 14.

196. Maraví-Poma E, Patchen Dellinger E, Forsmark CE, Layer P, Lévy P, Shimosegawa T, Siriwardena AK, Uomo G, Whitcomb DC, Windsor JA, Petrov MS; Pancreatitis Across Nations Clinical Research and Education Alliance (PANCREA). [International multidisciplinary classification of acute pancreatitis severity: the 2013 Spanish edition]. Med Intensiva. 2014 May;38(4):211-7. doi: 10.1016/j.medin.2013.03.013. Epub 2013 Jun 7. Spanish.

197. Yan Y, Shen Z, Ye Y, Jiang K, Zhang H, Shen C, Mustonen H, Puolakkainen P, Wang S. A novel molecular marker of prognosis in colorectal cancer: Vasohibin-1.Med Oncol. 2014 Feb;31(2):816. doi: 10.1007/s12032-013-0816-0. Epub 2013 Dec 24.

198. Maksimow M, Kyhälä L, Nieminen A, Kylänpää L, Aalto K, Elima K, Mentula P, Lehti M, Puolakkainen P, Yegutkin GC, Jalkanen S, Repo H, Salmi M. Early prediction of persistent organ failure by soluble CD73 in patients with acute pancreatitis. Crit Care Med 2014 42(12):2556-64

2015

199. Wittel UA, Schmidt AL, Poxleitner PJ, Seifert GJ, Chikhladze S, Puolakkainen P, Hopt UT, Kylänpää L. The chemokine ligand CXCL16 is an indicator of bacterial infection in necrotizing pancreatitis. Pancreatology 2015Jan 23 pii:S14124

200. Shen Z, yan Y, Ye C, Wand B, Jiang K, Ye Y, Mustonen H, Puolakkainen P, Wang S. The effect of vasohibin-1 expression and tumor associated macrophages on the angiogenesis in vitro and in vivo. Tumor Biol Dec 14, 2015 (Epub ahead of print)

201. Nukarinen E, Lindstrom O, Kuuliala K, Kylanpaa L, Pettila V, Puolakkainen P, Kuuliala A, Hamalainen M, Moilanen E, Repo H. Hastbacka J. MMPs-7,-8,-9 and TIMP-1 in Acute Pancreatitis Pancreas. 44, 8, s. 1404-1404  2015

 

2016  

 

202.Salmiheimo AN,Mustonen H,Vainionpää S, Shen Z, Kemppainen E,Seppänen H, Puolakkainen P. Increasing the inflammatory competence of macrophages with IL-6 or with combination of IL-4 and LPS restrains the invasiveness of pancreatic cancer cells. J Cancer 7(1):42-9, 2016

203.Kyhälä L, Lindström O, Kylänpää L, Mustonen H, Puolakkainen P, Kemppainen E, Tallgren M.Pettilä V, Repo H, Petäjä J. Activated protein C retards recovery from coagulopathy in severe acute pancreatitis. Scand J Clin Lab Invest 76(1):10-16, 2016

204. Armengol G, Sarhadi V, Ansarir A, Malekzadeh R, Kokkola A, Puolakkainen P, Knuutila S. Driver gene mutations in stools of colorectal carcinoma patients detected by targeted next generation sequencing. J Molecular Diagnostics in press 2016

205. Rouhiainen A J, Penttilä A, Kylänpää M-L, Mustonen H K, Puolakkainen P, Rauvala H, Repo, H. Circulating nucleosomes as predictive markers of severe acute pancreatitis. Journal of Intensive Care. 2016, 4, s. 14 8 2016

 

206. Shen Z, Puolakkainen P & et al, The effect of Vasohibin 1 expression and tumor-associated macrophages on the angiogenesis in vitro and in vivo. PMID: 26666821  (epub ahead of print) Tumor Biology, 2016

 

207. Salmiheimo A, Mustonen H, Stenman UH, Puolakkainen P, Kemppainen E, Seppänen H, Haglund C. Systemic Inflammatory Response and Elevated Tumour Markers Predict Worse Survival in Resectable Pancreatic Ductal Adenocarcinoma. PLoS One. 2016 Sep 15;11(9):e0163064. doi: 10.1371/journal.pone.0163064. eCollection 2016

 

208. Shen Z, Wang B, Luo J, Jiang K, Zhang H, Mustonen H, Puolakkainen P, Zhu J, Ye Y, Wang S.Global-scale profiling of differential expressed lysine acetylated proteins in colorectal cancer tumors and paired liver metastases. J Proteomics. 2016 Jun 16;142:24-32. doi: 10.1016/j.jprot.2016.05.002. Epub 2016

 

209. Penttilä AK, Rouhiainen A, Kylänpää L, Mustonen H, Puolakkainen P, Rauvala H, Repo H. Circulating nucleosomes as predictive markers of severe acute pancreatitis. J Intensive Care. 2016 Feb 17;4:14. doi: 10.1186/s40560-016-0135-6. eCollection 2016

 

 

2017

 

210. Youssef O, Sarhadi V, Böhling T, Puolakkainen P, Carpelan-Homstrom M, Koskensalo S, Kokkola A, Knuutila S. Gene mutations in stool from gastric and colorectal neoplasia patients by next generation sequencing. World j Gastroent, in press 2017

 

211. Salmiheimo A, Mustonen H, Vainionpää S, Shen Z, Kemppainen E, Puolakkainen P, Seppänen H. Tumour-associated macrophages activate migration and STAT3 in pancreatic ductal adenocarcinoma cells in co-cultures. Pancreatology. 2017 Jul - Aug;17(4):635-641. doi: 10.1016/j.pan.2017.04.013.

 

212. Kauttu T, Mustonen H, Vainionpää S, Krogerus L, Ilonen I, Räsänen J, Salo J, Puolakkainen P. Disintegrin and metalloproteinases (ADAMs) expression in gastroesophageal reflux disease and in esophageal adenocarcinoma. Clin Transl Oncol. 2017 Jan;19(1):58-66. doi: 10.1007/s12094-016-1503-3.

 

213. Kuuliala K, Penttilä AK, Kaukonen KM, Mustonen H, Kuuliala A, Oiva J, Hämäläinen M, Moilanen E, Petilä V, Puolakkainen P, Kylänpää L, Repo H. Signalling profiels of blood leucocytes in sepsis and in acute pancreatitis in relation to disease severity. Cand J Immunol. Nov 2017, in press

 

214. Penttilä A, Kylänpää L, Lindströn O, Hastbacka J, Kuuliala K, Kuuliala A, Mustonen H, Moilanen E, Hamalainen M, Puolakkainen P, Repo H. Interleukin 8 and Hepatocyte Growth Factor in Predicting Development of Severe Acute Pancreatitis COGENT in press 2017

 

2018              215. Youssef O, Lahti L, Kokkola A, Karla T, Tikkanen M, Rautelin H, Puolakkainen P, Knuutila S, Sarhadi V. Stool microbiota conposition differs in patients with stomach, colon and rectal neoplasms. Dig Dis Sci, in press, 2018

                     

                      216. Vonlanthen R, Lodge P, Barkun J, Puolakkainen P, Clavien P-A et al . Toward a consensus on centralization in surgery. Ann Surg, in press, 2018

 

 

 

Manuscripts: submitted / in preparation :

 

- Husu H, Mentula P, Lehtonen T, Puolakkainen P, Leppäniemi A. Treatment results of acute severe pancreatitis – 17 year experience from single institution. Ann Surg Subitted 2017

- Kyhälä L, Aalto K, Kylänpää L, Maksimov M, Mentula P, Puolakkainen P, Yegutkin G, Jalkanen S, Repo H, Salmi M. The level of soluble CD73 in serum on admission correlates with the severity of acute pancreatitis. In preparation.

 

- Ezer S, Söderhäll C, Känkänen R, Puolakkainen P, Kere J. Neuropeptide S-NPSR1 signalling in neurobalstoma cells. In preparation.

 

-Arkkila P, Kokkola A, Puolakkainen P, Ristimäki A, Sipponen P. The cancer preventive effect of H.pylori eradication with special emphasis on different types of gastric cancer. In preparation.

 

- Shen Zhanlong, Seppänen Hanna, Mustonen Harri, Ye Yingjiang, Wnag Shan, Vainionpää Sanna, Repo Heikki, Kemppainen Esko, Puolakkainen Pauli. Both macrophages and hypoxia play critical role in regulating invasion and metastasis of gastric cancer. In preparation.

 

- Lappalainen M, Mustonen H, Vainionpää S, Puolakkainen P, Repo H. Phosphorylation levels of NF-κB and p38 in response to MDP in sixteen Chron’s Disease patients with the common and rare mutations of the CARD15 gene. In preparation.

 

 

 

b)        Reviews and editorials, LETTERS

1987  

 

1. Schröder T, Puolakkainen P: Laserin käyttö kirurgiassa. (The Use of Lasers in Surgery; A Review in Finnish) Duodecim 1987;103:803-9.

1988

 

2. Puolakkainen P, Rämö J, Schröder T: Fotodynaaminen terapia. (Photodynamic Therapy; A Review in Finnish) Duodecim 1988;104:762-7.

 

3. Schröder T, Jumpponen A, Nuutinen P, Puolakkainen P, Rämö OJ (eds.): Pancreas in focus IV. Helsinki, Finland, 1988.

1990

 

4. Puolakkainen P, Rämö J, Schröder T: Photodynamic therapy (PDT) in gastroenterology; A review. Scand J Gastroenterol 1990;25:417-21.

 

5. Puolakkainen P, Schröder T. New trends in the diagnosis and treatment of severe acute pancreatitis. Editorial. Ann Med 1990;22: 375-6.

 

6. Puolakkainen P, Schröder T: Photodynamic therapy; a review. Ann Chir Gyn 1990:79:240-3.

 

1992

 

7. Puolakkainen P, Schröder T: Akuutin haimatulehduksen hoito. Käypä hoito. (New Trends in the Treatment of Acute Pancreatitis; A Review in Finnish) Duodecim 1992;108:1891-5.

 

8. Puolakkainen P, Schröder T: Akuutin haimatulehduksen hoitolinjat. (The Current Treatment of Acute Pancreatitis; A Review in Finnish) Suomen Lääkärilehti 1990;45:1992.

 

9. Puolakkainen P, Schröder T: Photodynamic therapy (PDT) of gastrointestinal tumors ; A review. Dig Dis 1992:10:53-60.

 

10. Puolakkainen P, Twardzik D: Transforming growth factors alpha and beta, a review. In: Neurotrophic factors. Laughlin S, Fallon J (eds.). Academic Press, San Diego, 1992.

1994

 

11. Haapiainen R, Puolakkainen P, Valtonen V. Fulminantti haimatulehdus. (Fulminant Pancreatitis, A Review in Finnish Duodecim 1994;110:1913-7.

 

12. Puolakkainen P. Proktiitit. Kirjassa: Sukupuolitaudit. Duodecim, (Proctitis ; A Review in the textbook of sexually transmitted diseases in Finnish), Helsinki, 1994.

1995

 

13. Sainio V, Kemppainen E, Haapiainen R, Schröder T, Kivilaakso E, Valtonen V, Puolakkainen P. Early antibiotic treatment in acute necrotising pancreatitis. Lancet (letter) 1995;346:1374-5.

 

1997

 

14. Kemppainen E, Puolakkainen P, Stenman UH. Measurement of Urinary trypsinogen-2 as a screening test for acute pancreatitis. N Engl J Med 1997;1394 (letter).

 

1998

 

15. Kemppainen E, Hedström J, Puolakkainen P, Haapiainen R, Stenman U-H. Advances in laboratory diagnostics of acute pancreatitis. A review. Ann Med, 1998;30:169-75.

 

16. Kemppainen E, Puolakkainen P, Leppäniemi A, Hietaranta A, Grönroos J, Haapiainen R. Diagnosis of acute pancreatitis, current review. Ann Chir Gyn 1998;87:191-4.

 

17. Leppäniemi A, Kemppainen E, Puolakkainen P, Takkunen O, Pettilä V, Haapiainen R. Vaikean haimatulehduksen hoito. (Treatment of severe pancreatitis, a review in Finnish). Suomen Lääkärilehti 1998; 53:3501-7.

 

18. Puolakkainen P, Hietaranta A, Kemppainen E, Kivilaakso E. The role of antibiotic therapy in the prevention and treatment of MOF in severe acute pancreatitis. J Phys Pharm, 1998;49, suppl 2:123-9.

 

19. Puolakkainen P, Kemppainen E, Leppäniemi A, Sainio V, Hietaranta A, Haapiainen R. Current principles of treatment in acute pancreatitis, current review. Ann Chir Gyn 1998;87:200-3.

 

20. Stenman UH, Kemppainen E, Hedström J, Puolakkainen P. A Better test for acute pancreatitis? (Selected summaries) Gastroenterology 1998;114:411-2.

 

21. Tielinen L, Manninen M, Puolakkainen P, Pätiälä H, Pohjonen T, Rautvuori J, Rokkanen P: Biohajoavan polylaktidisauvasta vapautuvan transformoivan kasvutekijän beta 1 (TGF-b1) vaikutus kokeellisen osteotomian paranemiseen (The effect of TGF-beta released from biodegradable polyactide pin on experimental osteotomy in rats). SOT 1998;4: 325-8.

 

22. Tielinen L, Manninen M, Rokkanen P, Puolakkainen P, Kellomäki M, Törmälä P, Rich J, Seppälä J: Biohajoavaan polypeerimassaan yhdistetty transformoiva kasvutekijä beta 1 ei edistä luudefektin paranemista distaalisessa reidessä (TGF-beta combined to biodegradable polymeric mass does not enhance bone healing in rats).  SOT 1998;21:393-5.

1999

 

23. Sainio V, Puolakkainen P, Kemppainen E, Valtonen V, Kivilaakso E. Antibiotic prophylaxis in infected pancreatic necrosis. Pp 330-334. In: Acute pancreatitis - Novel concepts in biology and therapy, Buchler, Uhl, Friess, Malfertheiner (eds.). Blackwell Wissenschaft, 1999.

 

2000

 

24. Kemppainen E, Puolakkainen P, Leppäniemi A, Kivisaari L, Haapiainen R. Akuutin haimatulehduksen diagnostiikka. (Diagnosis of acute pancreatitis) A Review in Finnish. Suomen Lääk l 2000:3439-42.

 

2002

 

25. Puolakkainen P: Akuutti haimatulehdus (Acute Pancreatitis). Kirjassa: Kunnamo I (päätoim.) Lääkärin käsikirja 2002. Helsinki: Kustannus Oy Duodecim, 2002; s. 355-6, ISBN 951-656-079-2. A book chapter in Finnish

 

2003

 

26. Reed MJ, Koike T, Puolakkainen P. Wound repair in aging. In: Wound healing: methods and protocols (Methods in molecular medicine; 78), eds Eds. LA DiPietro and AL Burns, Humana Press Inc., Totowa, NJ, USA, pp 217-237, 2003

 

2004

 

27. Puolakkainen P: Akuutti haimatulehdus. (Acute Pancreatitis).  Kirjassa: Kunnamo I (päätoim.) Lääkärin käsikirja 2004. Helsinki: Kustannus Oy Duodecim, 2004; s. 374-5. 951-656-144-6. A book chapter in Finnish

 

28. Puolakkainen P. Selecting severe cases of acute pancreatitis for trials and for treatment: enzymes and activation peptides. In: Pancreatic Disease: Basic Science and Clinical Management. Eds. Johnson CD, Imrie CW, Springer Berlin, Heidelberg, New York, ISBN 1-85233-711-7, pp. 358-365, 2004

 

2005

 

29. Kokkola A, Kiviluoto T, Sirén J, Halttunen J, Puolakkainen P: Mahasyövän kehittyvä kirurginen hoito. (The development in the operative treatment of gastric cancer).Suomen Lääk l 60(23): 2583-88, 2005. A review in Finnish.

2006

 

27. Kylänpää L, Mentula P, Kemppainen E, Repo H, Haapiainen R, Puolakkainen P:  Vaikea akuutti haimatulehdus systeemisairautena – onko monielinvaurio ennustettavissa ja estettävissä? (Severe acute pancreatitis –is MOF predictable? (A review in Finnish). Duodecim 2006;122:563-3

 

28. Puolakkainen P: Acute pancreatitis. In: Evidence-Based Medicine Guidelines. Ed. Kunnamo I, John Wiley & Sons, Ltd, England, ISBN 0-470-01184-X, pp. 338-39, 2005. A book chapter

 

29. Puolakkainen P: Akuutti haimatulehdus (Acute Pancreatitis). Kirjassa: Kunnamo I (päätoim.) Lääkärin käsikirja 2006. Helsinki: Kustannus Oy Duodecim, 2006; s. 382-3. 951-656-213-2. A book chapter in Finnish

 

30. Puolakkainen P: Krooninen haimatulehdus (Chronic Pancreatitis). Kirjassa: Kunnamo I (päätoim.) Lääkärin käsikirja 2006. Helsinki: Kustannus Oy Duodecim, 2006; s. 383-5. 951-656-213-2. A book chapter in Finnish

 

31. Puolakkainen P. Akuutti haimatulehdus (Acute Pancreatitis). Ajankohtaista Lääkärin käsikirjasta. Duodecim 2006;122:1997-8

2007

 

32. Kemppainen E, Puolakkainen P: Non-alcoholic etiologies of acute pancreatitis – exclusion of other etiologic factors besides alcohol and gallstones. A review. Pancreatology  2007; 7: 142-6

 

2008

 

33. Mentula P, Kemppainen E, Puolakkainen P. Sappikitaudin hoito sappikivien aiheuttamassa akuutissa haimatulehduksessa. Duodecim 2008: 123: 2449-53. A review in Finnish

 

34. Puolakkainen P, Haapiainen R, Kemppainen E. Haimatulehdusta voidaan hoitaa.(The Treatment of Acute Pancreatitis.  Kirjassa: Sairaanhoidon ytimessä. Toim. Joutsivuo, Laakso. Edita 2008 (A book chapter in Finnish)

2010

 

35. Kylänpää ML, Repo H, Puolakkainen PA. Inflammation and immunosuppression in severe acute pancreatitis. World J Gastroenterol. 2010 Jun 21;16(23):2867-72. A review.

 

2011

 

36. Puolakkainen P: Akuutti haimatulehdus (Acute Pancreatitis). Kirjassa: Jousimaa JP (päätoim.) Lääkärin käsikirja 2011. Helsinki: Kustannus Oy Duodecim; s. 380-81 (Textbook Chapter in Finnish)

 

37. Puolakkainen P: Krooninen haimatulehdus (Chronic Pancreatitis). Kirjassa: Jousimaa JP (päätoim.) Lääkärin käsikirja 2011. Helsinki: Kustannus Oy Duodecim s. 381-3. (Textbook Chapter in Finnish)

 

38. Puolakkainen P: Haimasyöpä (Pancreatic Cancer). Kirjassa: Jousimaa JP (päätoim.) Lääkärin käsikirja 2011. Helsinki: Kustannus Oy Duodecim s. 384-5. (Textbook Chapter in Finnish)

 

2016

39. Puolakkainen, P. Umpilisäketulehduksen hoidosta tarvitaan lisää tutkimustietoa. (Further data is needed on the treatment of acute appendicitis (Editorial) Suomen lääkärilehti. 71, 7, p.461, 2016

 

2018

40. Färkkilä M, Isoniemi H, Heikkinen M, Puolakkainen P (Editors) Gastroenterology and hepatology(textbook in Finnish) Gastroenterologia ja hepatologia, Duodecim 2018

 

41. Räihä M, Puolakkainen P. Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer – A review. Chronic Diseases and Translational Medicine. In press, 2018

 

 

c)        Abstracts and other publications

1984

 

1. Lehtola A, Schröder T, Kivilaakso E, Lempinen M, Puolakkainen P, Karonen S-L. Alterations in blood flow during experimental pancreatitis in the pig. Fourth Meeting of the Experimental Research Section of the Nordic Surgical Association. Hanasaari, Espoo, Finland, 1984.

 

2. Parkkinen E, Nordling S, Puolakkainen P, Kiviluoto T, Schröder T, Schröder J. Monoclonal antibodies to exocrine cells of pancreas. XIV Annual Meeting of the Scandinavian Society for Immunology. Oslo, Norway, 1984.

 

3. Puolakkainen P, Schröder T, Paananen A, Kaarne M, Kuusi T, Lempinen M. Aprotinin and Na2CaEDTA in experimental hemorrhagic pancreatitis. Fourth Meeting of the Experimental Research Section of the Nordic Surgical Association. Hanasaari, Espoo, Finland, 1984.

 

4. Rämö J, Schröder T, Kuusi T, Puolakkainen P, Paananen A, Jalovaara P. Chronic ethanol ingestion causes an increase of phospholipase A2 in acute experimental pancreatitis. Fourth Meeting of the Experimental Research Section of the Nordic Surgical Association. Hanasaari, Espoo, Finland, 1984.

 

5. Schröder T, Kivisaari L, Lehtola A, Kivilaakso E, Lempinen M, Standertskjöld-Nordenstam C-G, Somer K, Puolakkainen P, Karonen S-L. Contrast enhancement in computed tomography (CT) and pancreatic blood flow in experimental acute pancreatitis. XIXth Congress of the European Society for Surgical Research. Eur Surg Res 16:24, 1984.

                       

1985

 

6. Lehtola A, Schröder T, Kivilaakso E, Lempinen M, Puolakkainen P, Karonen S-L. Alterations in organ blood flow during experimental pancreatitis in the pig. Sixth Tripartite Meeting, Boston, USA, 1985.

1986

 

7. Schröder T, Puolakkainen P, Brackett K, Sankar MY, Joffe SN. Effects of electrocautery, CO2-laser and contact Nd:YAG laser scalpel on the healing of intestinal anastomoses. Third Congress of the European Laser Association, Amsterdam, Netherlands, 1986.

 

 

1987

 

8. Puolakkainen P, Brackett K, Sankar MY, Schröder T, Joffe SN. Effects of electrocautery, CO2-laser and contact Nd:YAG laser scalpel on the healing of intestinal anastomoses. The Seventh Annual Meeting of the American Society for Laser Medicine and Surgery. San Francisco, USA, Lasers Surg Med 1987;7:90.

 

9. Puolakkainen P, Schröder T. Fotodynaaminen terapia. Suomen Gastroenterologiayhdistyksen syyskokous. (Photodynamic Therapy; The Annual Meeting of the Finnish Society for Gastroenterology) Lahti, Finland, 24.-25.9.1987.

1988

 

10. Puolakkainen P, Schröder T. Computed tomography and laboratory tests  in the early diagnosis of acute pancreatitis. 21st Scandinavian Conference on Gastroenterology. Turku, Finland, 2.-4.6.1988. Scand J Gastroent 1988;23, Suppl 145: 100.

 

11. Rämö OJ, Lehtonen E, Puolakkainen P, Schröder T. The effect of laser-induced hyperthermia on tumor cells. Eight Annual Meeting of the American Society for Laser Medicine and Surgery. Dallas, USA, 25.-27.4.1988,Lasers Surg Med 1988;8:203.

 

12. Rämö OJ, Schröder T, Puolakkainen P, Jalovaara P. The behaviour of plasma phospholipase A2 activity in experimental pancreatitis is dependent on diet. 20th Meeting of European Pancreatic Club, Budapest, Hungary, 29.-31.8.1988.

 

1989

 

13. Hahl J, Haapiainen R, Puolakkainen P, Schröder T. Laserthermia in the treatment of liver tumors. The Second Meeting of the Scandinavian Society for Laser Therapy. Espoo, Finland, 15.-17.10.1989

 

14. Hahl J, Ovaska J, Puolakkainen P, Schröder T. Nd:YAG laser in mastectomy. The Second Meeting of the Scandinavian Society for Laser Therapy. Espoo, Finland, 15.-17.10.1989.

 

15. Hukki J, Castren M, Puolakkainen P, Lipasti J, Rämö OJ, Schröder T. Comparison of the effects of scalpel, electrocautery and various lasers on pig skin. 9th Annual Meeting of the American Society for Laser Medicine and Surgery, Arlington, Virginia, USA, 15.-17.4.1989. Lasers Surg Med 1989; Suppl. 1:7.

 

16. Hukki J, Puolakkainen P, Lipasti J, Castren M, Schröder T. Comparison of surgical lasers and conventional methods in skin incisions. The Second Meeting of the Scandinavian Society for Laser Therapy. Espoo, Finland, 15.-17.10.1989.

 

17. Puolakkainen P, Hukki J, Erkko P, Karvonen P. CO2-laser treatment of male genital and perianal condylomata. The Second Meeting of the Scandinavian Society for Laser Therapy, Espoo, Finland, 15.-17.10.1989.

 

18. Puolakkainen P, Kivisaari L, Nuutinen P, Schröder T. Varjoainetehosteinen tietokonetomografia akuutin pankreatiitin diagnostiikassa ja luokituksessa. (Contrast enhanced computed tomography in the diagnosis and classification of acute pancreatitis). The Eight Meeting of the Finnish Surgical Society, Helsinki, Finland, 9.-10.11.1989.

 

 

1990

 

19. Nuutinen P, Sainio V, Puolakkainen P, Kivisaari L, Schröder T. Contrast enhanced CT in the diagnosis and classification of acute pancreatitis - a 7-year experience. XXIII Nordic Congress of Gastroenterology and XIV Nordic Endoscopy Meeting, Reykjavik, Iceland, 14.-16.6.1990. Scand J Gastroent 1990;25, Suppl 176: 78.

 

20. Puolakkainen P, Schröder T. Akuutin haimatulehduksen hoitolinjat. (The current treatment of acute pancreatitis). The Meeting of Lääketiede 90 Medicin, Helsinki, Finland, 1990.

 

21. Puolakkainen P. Early assessment of acute pancreatitis: A comparative study of computed tomography and laboratory tests. Curr Surg 1990;47:307.

 

22. Saarinen P, Lipasti J, Hukki J, Puolakkainen P, Schröder T. New observations on healing of laser wounds. 2nd International         Gastro-Surgical Club Joint Meeting of Surgeons and Gastroenterologists, Athens, Greece, 14.-17.11.1990.

 

23. Schröder T, Sainio V, Nuutinen P, Puolakkainen P, Kivisaari L. Contrast enhanced CT in the diagnosis and classification of acute pancreatitis - a 7-year experience. American Gastroenterologic Association (AGA) and American Association for the Study of Liver Diseases, San Antonio, Texas, USA, 13.-16.5.1990.

 

1991

 

24. Twardzik D, Paciucci P, Ranchalis J, Oleksowicz L, Puolakkainen P. Interleukin-2 augments the expression of transforming growth factor beta (TGFß) and its proform in patients with disseminated cancer. Second Annual Scientific Poster Session, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ, USA, Nov 21-22, 1991. Current Science Highlights, Bristol-Myers Squibb Pharmaceutical Research Institute, 1991:S9.

 

1992

 

25. Gombotz W, Pankey S, Braatz J, Ranchalis J, Puolakkainen P. The controlled release of TGF-ß1 from different formulations for wound healing. 19th International Symposium on Controlled Release of Bioactive Materials, Orlando, FL, 26-31.7. 1992. Proceed Intern Symp Control Res Bioact Mater 1992;19:108-109.

 

26. Puolakkainen P, Paciucci P, Ranchalis J, Oleksowicz L, Twardzik D. Interleukin-2 augments the expression of transforming growth factor beta in patients with disseminated cancer. Growth Factors, Peptides and Receptors '92. XIIth Washington International Spring Symposium, Washington D.C., June 1-5, 1992.

 

27. Puolakkainen P, Ranchalis J, Reed M, Pankey S, Gombotz W. TGF-ß1's wound healing effect depends on the carrier. Second Annual Meeting of The Wound Healing Society, Richmond VA, 23.-26.4.1992.

 

28. Puolakkainen P, Reed M, Iruela-Arispe L, Lane T, Bornstein P, Sage H. Distribution of ECM proteins in wound repair. Second Annual Meeting of The Wound Healing Society, Richmond VA, 23.-26.4.1992.

 

 

1993

 

29. Bouchard LS, Mumper RJ, Puolakkainen P, Gombotz W. Controlled release of TGF-ß1 to the small intestine using an alginate based delivery system. Bristol-Myers Squibb PRI Second Annual Scientific Poster Session, Seattle, WA, 1993.

 

30. Gombotz W, Bouchard L, Pankey S, Hawkins M, Puolakkainen P. Osteogenic implants containing TGF-ß1. 20th International Symposium of Controlled Release Society, Washington DC, 1993.

 

31. Puolakkainen P, Pankey S, Bouchard L, Ranchalis J, Gombotz W. Controlled release of TGF-ß1 from a biodegradable matrix for bone regeneration. XXVIII Congress of The European Society for Surgical Research, Turku, Finland, 23.-26.5.1993.

 

32. Puolakkainen P, Ranchalis JE, Saarinen P, Twardzik DR. Activation of latent TGF-ß1 by human wound exudates. First Joint Meeting of The Wound Healing Society and the European Tissue Repair Society. Amsterdam 1993. Wound Repair and Regeneration 1993;1:119.

 

33. Puolakkainen P, Ranchalis JE, Strong DM, Twardzik DR. The effect of sterilization on TGF-beta isolated from demineralized human bone. 16th Annual Meeting of American Association of Tissue Banks. San Diego, California, USA, Aug 24-26, 1992, Transfusion 1993;33:612.

 

34. Puolakkainen P, Reed M, Lane T, Dickerson D, Bornstein P, Sage H. Expression of SPARC and thrombospondin 1 in wound repair: immunolocalization and in situ hybridization. Keystone Symposia on Molecular and Cellular Biology, Breckenridge, CO, 1993. J Cell Biochem 1993; Suppl 17E: 117.

 

35. Reed M, Puolakkainen P, Abbrass I, Sage EH. Transforming Growth Factor Beta 1 reverses the impaired wound healing in aged rats. Annual Scientific Meeting of the American Geriatrics Society, New Orleans, LA, 1993.

 

36. Sainio V, Kemppainen E, Puolakkainen P, Taavitsainen M, Kivisaari L, Valtonen V, Schröder T, Lempinen M, Haapiainen R, Kivilaakso E. Prophylactic antibiotic treatment in acute necrotizing pancreatitis. Digestive Disease Week and 94th Annual Meeting of the American Gastroenterologic Association, Boston, MA, 1993. Gastroenterology 1993;104:A332.

 

37. Sainio V, Kemppainen E, Puolakkainen P, Taavitsainen M, Kivisaari L, Valtonen V, Haapiainen R, Schröder T, Lempinen M, Kivilaakso E. Early antibiotic treatment in acute necrotizing  pancreatitis. XXVIII Congress of The European Society for Surgical Research, Turku, Finland, 23.-26.5.1993.

 

1994

 

38. Puolakkainen P, Ranchalis J, Gombotz I, Mumper R, Twardzik D. A novel delivery system for inducing quiescence in intestinal stem cells in rats by TGF-ß1. The Meeting of the American Gastroenterological Association, 15.-18.5.1994, New Orleans, USA.

 

39. Puolakkainen P, Reed M, Abrass I, Gombotz W, Sage H. TGF-ß1 reverses the impaired wound healing in aged rats. Fourth annual meeting of the Wound Healing Society. 18.-21.5.1994, San Francisco, USA.

 

40. Sainio V, Kemppainen E, Puolakkainen P, Taavitsainen M, Kivisaari L, Valtonen V, Haapiainen R, Schröder T, Lempinen M, Kivilaakso E. Profylaktinen antibioottihoito nekrotisoivassa pankreatiitissa. (Prophylactic Antibiotic Therapy in Acute Pancreatitis; the Meeting of the Finnish Surgical Association) 13. Kirurgipäivät, Helsinki, 10.-11.11.1994.

 

41. Sainio V, Kemppainen E, Puolakkainen P, Taavitsainen M, Kivisaari L, Valtonen V, Haapiainen R, Schröder T, Kivilaakso E. Early antibiotic treatment in acute necrotizing pancreatitis. The Meeting of the American Gastroenterological Association, 15.-18.5.1994, New Orleans, USA.

 

1995

 

42. Hedström J, Korvuo A, Kenkimäki P, Tikanoja S, Haapiainen R, Kivilaakso E, Sainio V, Kemppainen E, Puolakkainen P, Stenman UH. Virtsan trypsinogeeni-2-testiliuska, uusi pikatesti akuutin haimatulehduksen diagnostiikassa. The Meeting of The Finnish Surgical Association, Helsinki, 23.-24.11.1995.

 

43. Kemppainen E, Sainio V, Haapiainen R, Kivisaari L, Kivilaakso E, Puolakkainen P. Early localization of necrotic areas by contrast enhanced computed tomography is important in predicting outcome in severe acute pancreatitis. The Meeting of The Finnish Surgical Association, Helsinki, 23.-24.11.1995.

 

44. Puolakkainen P, Karjalainen-Lindsberg ML, Vaalamo A, Airola T, Kivilaakso E, Saarialho-Kere U. Expression of matrix metalloproteinases (MMPs) in peptic ulcers and in inflammatory bowel disease. The Meeting of the American Gastroenterological Association, San Diego, USA, 13.-19.5.1995

 

45. Sainio V, Kemppainen E, Puolakkainen P, Taavitsainen M, Kivisaari L, Valtonen V, Haapiainen R, Schröder T, Kivilaakso E. Early antibiotic treatment reduces mortality in acute necrotizing pancreatitis. The Meeting of The Finnish Surgical Association, Turku, 18.-19.5.1995

 

46. Sainio V, Puolakkainen P, Kemppainen E, Hedström J, Haapiainen R, Kivisaari L, Stenman U, Schröder T, Kivilaakso E. Serum trypsinogen-2, a new reliable assay for the early diagnosis and prediction of outcome in acute necrotizing pancreatitis. The Meeting of the American Gastroenterological Association, San Diego, USA, 13.-19.5.1995

 

47. Vento P, Kiviluoto T, Kivilaakso E, Reed M, Lehtonen E, Sage EH, Puolakkainen P. Expression of TGFß1 and SPARC in the healing of intestinal anastomoses and in short bowel syndrome.The Meeting of the American Gastroenterological Association, San Diego, USA, 13.-19.5.1995

 

1996

 

48. Hedström J, Puolakkainen P, Sainio V, Kemppainen E, Haapiainen R, Kivilaakso E, Stenman UH. Urinary trypsinogen-2 test strip: new rapid test for the early diagnosis of acute pancreatitis. The Meeting of the American Gastroenterological Association, San Francisco, USA, 19.-22.5.1996

 

49. Kemppainen E, Hedström J, Puolakkainen P, Sainio V, Haapiainen R, Perhoniemi V, Kivilaakso E, Stenman UH. Urinary trypsinogen-2 test strip for screening acute pancreatitis. The Meeting of the Finnish Surgical Association, Helsinki 21.-22.11. 1996

 

50.  Kemppainen E, Sand J, Puolakkainen P, Laine S, Hedström J, Sainio V, Haapiainen R, Nordback I. Pancreatitis associated protein as a marker of acute pancreatitis. The Meeting of the American Gastroenterological Association, San Francisco, USA, 19.-22.5.1996

 

51. Kokkola A, Laxen F, Puolakkainen P, Haapiainen R, Kivilaakso E, Virtamo J, Sipponen P. Mahasyövän riski atrofiseen gastriittiin liittyvässä dysplasiassa. The Meeting of The Finnish Surgical Association. Helsinki 21.-22.11. 1996

 

52. Kokkola A, Monni O, Puolakkainen P, Haapiainen R, Kivilaakso E, Knuutila S. DNA copy number changes in gastric carcinoma (GC) as evaluated by comparative genomic hybridization (CGH). The Meeting of the American Gastroenterological Association, San Francisco, USA, 19.-22.5.1996 / Gastroenterology suppl. 110:A544, 1996

 

53. Puolakkainen P, Kiviluoto T, Lehtonen E, Paimela H, Watanabe S, Sato N, Kivilaakso E. The intracellular signaling pathway for gastric epithelial cell restitution in monolayer cell culture includes activation of tyrosine kinase and Na+/H+ antiport. The Meeting of the American Gastroenterological Association, San Francisco, USA, 19.-22.5.1996

 

54 Puolakkainen P, Kokkola A, Valle J, Haapiainen R, Sipponen P, Kivilaakso E. Helicobacter pylori infection in young patients with gastric carcinoma. Gastroenterology 1996;110: A579.

 

1997

 

55. Heinonen P, Blomqvist K, Jousela I, Puolakkainen P, Nordin A, Takkunen O. Comparison of the Tonocap to the saline tonometry in anesthetized pigs with high gastric PCO2 values. Meeting of the European Society of Intensive Care Medicine. Brussels, 1997.

 

56. Hietaranta A, Kemppainen E, Peuravuori H, Puolakkainen P, Sainio V, Haapiainen R, Kivilaakso E, Nevalainen T. Bactericidical / permeability-increasing protein (BPI), group II phospholipase A2 and pancreatic PLA2 in acute pancreatitis. The Meeting of the American Gastroenterological Association, Washington DC, 1997.

 

57. Kemppainen E, Hedström J, Puolakkainen P, Sainio V, Haapiainen R, Perhoniemi V, Kivilaakso E, Stenman UH. Simple urinary trypsinogen-2 test strip for screening acute pancreatitis. The Meeting of the American Gastroenterological Association, Washington DC, 1997.

 

58. Kiviluoto T, Watanabe S, Hirose M, Sato N, Ranta-Knuuttila T, Puolakkainen P, Lehtonen E, Kivilaakso E. Direct effects of endogenous and exogenous nitric oxide on wound repair in a cultured gastric epithelial cell model. The Meeting of the American Gastroenterological Association, Washington DC, 1997.

 

59. Kokkola A, Monni O, Puolakkainen P, Nordling S, Haapiainen R, Kivilaakso E, Knuutila S. DNA copy number changes in gastric adenomas as evaluated by comparative genomic hybridization. Gastroenterology suppl. 112:A593, 1997.

 

60. Latvala T, Uusitalo M, Puolakkainen P, Kivelä T, Tervo T. Transforming growth factor-b1 (TGF-b1), tenascin, and sparc in secondary cataract. Joint European Research Meeting in Ophthalmology and Vision, October 15-19, 1997, Montpellier, France, p.40

 

61. Nevalainen T, Hietaranta A, Kemppainen E, Peuravuori H, Puolakkainen P, Sainio V, Haapiainen R, Kivilaakso E. Phospholipases A2 and bactericidical/permeability increasing protein in acute pancreatitis. Abstract for European Pancreatic Club. Digestion 58(suppl.2):166, 1997.

 

62. Puolakkainen P, Kemppainen E, Hedström J, Halttunen j, Sainio V, Haapiainen R, Kivilaakso E, Stenman UH. Increased serum trypsinogen-2 and trypsin-2-alpha1-antirtypsin complex values identify ERCP-induced pancreatitis with high accuracy. Gastroenterology suppl. 112:A474, 1997.

 

63. Puolakkainen P, Lax M, Lehtonen E, Kiviluoto T, Ranta-Knuuttila T, Watanabe S, Kivilaakso E. Distribution of microfilaments, adhesion plaques and intermediate filaments in isolated gastric cell culture, a confocal microscopic study. The Meeting of the American Gastroenterological Association, Washington DC, 1997.

 

64. Puolakkainen P, Rautelin H, Sipponen P, Färkkilä M, Kosunen T, Haapiainen R, Kivilaakso E, Kokkola A. Comparison of histology, 13Curea breath test and serology for detecting H. Pylori infection in patients with atrophic gastritis. The Meeting of the American Gastroenterological Association, Washington DC, 1997.

 

65. Sainio V, Puolakkainen P, Kemppainen E, Kivisaari L, Haapiainen R, Schröder T, Lehtonen E, Kivilaakso E. Incorrect estimation of severity in acute pancreatitis by contrast-enhanced computed tomography. Gastroenterology suppl. 112:A478, 1997.

 

1998

 

66. Aarnio M, Kokkola A, Puolakkainen P, Larramendy M, El-Rifail, W, Monni O, Kivilaakso E, Knuutila S. Amplification of 17q12-21 in sporadic gastric carcinomas but not in gastric carcinoma from patients with HNPCC. Digestive Disease Week, Meeting of American Gastroenterologic Association, New Orleans, LA, May, 1998.

 

67. Halonen K, Puolakkainen P, Leppäniemi A, Kemppainen E, Haapiainen R. Ennustetekijät vaikeassa haimatulehduksessa - 270 potilaan kliininen tutkimus. 17. Kirurgipäivät , 12.-13.11.1998, Tampere (Meeting of the Finnish Surgical Association).

 

68. Hietaranta A, Kemppainen E, Puolakkainen P, Sainio V, Haapiainen R, Kivilaakso E. Extracellular phospholipases A2 in severe acute pancreatitis associated systemic inflammatory response syndrome (SIRS). Digestive Disease Week, Meeting of American Gastroenterologic Association, New Orleans, LA, May, 1998.

 

69. Kemppainen E, Hietaranta A, Puolakkainen P, Hedström J, Haapiainen R, Stenman UH. Seerumin trypsinogeeni-2:n ja trypsin-2-alfa1- antitrypsiinin ns. time course profile akuutissa pankreatiitissa. Suomen kirurgiyhdistyksen kokous 23.-24.4.1998 Oulu (Meeting of the Finnish Surgical Association).

 

70. Kemppainen E, Hietaranta A, Puolakkainen P, Sainio V, Halttunen J, Haapiainen R, Kivilaakso E, Nevalainen T. Bactericidal/permeability increasing protein and group I and II phopsholipases A2 during the induction phase of human acute pancreatitis. Digestive Disease Week, Meeting of American Gastroenterologic Association, New Orleans, LA, May, 1998.

 

71. Kiviluoto T, Lax M, Lehtonen E, Ranta-Knuuttila T, Watanabe S, Sato N, Kivilaakso E. Puolakkainen P. Early phase of epithelial cell migration; Distribution of microfilaments and focal adhesions in calcium-depleted gastric cell culture. Digestive Disease Week, Meeting of American Gastroenterologic Association, New Orleans, LA, May 1998.

 

72. Kiviluoto T, Watanabe S, Hirose M, Sato N, Mustonen H, Puolakkainen P, Ranta-Knuuttila T, Kivilaakso E. Exogenous nitric oxide impairs healing of wounded rabbit epithelial cell monolayer culture. World Congresses of Gastroenterology, Sep 6-11.1998, Vienna, Austria. Digestion 1998;59 Suppl 3:247.

 

73. Kokkola A, Puolakkainen P, Rautelin H, Sipponen P, Färkkilä M, Haapiainen R, Kivilaakso E, Kosunen TU. Positive serology indicates an active H.pylori infection in patients with atrophic gastritis in spite of negative histology and 13C-urea breath test (13C-UBT). World Congresses of Gastroenterology, Sep 6-11.1998, Vienna, Austria. Digestion 1998;59 Suppl 3:466.

 

74. Kokkola A, Savolainen H, Färkkilä M, Haapiainen R, Kiviluoto T, Kivilaakso E, Puolakkainen P. Endoskooppinen UÄ-tutkimus mahasyövän preoperatiivisessa selvittelyssä. 17. Kirurgipäivät, 12.-13.11.1998, Tampere (Meeting of the Finnish Surgical Association).

 

75. Lonka K, Pitkälä K, Puolakkainen P, Sauri P, Vanhanen H. A problem -based tutorial laboratory - a method of mentoring medical teachers. Meeting of the European Society for Medical Teachers. Gothenburg, Sweden, 1998.

 

76. Nevalainen T, Kemppainen E, Hietaranta A, Puolakkainen P, Haapiainen R, Kivilaakso E. Bactericidal/permeability increasing protein and group I and II phopsholipases A2 in ERCP-induced acute pancreatitis. Digestion 1998;59;95

 

77. Puolakkainen P Kiviluoto T, Lax M, Lehtonen E, Ranta-Knuuttila T, Watanabe S, Sato N, Kivilaakso E. Early phase of gastric epithelial cell migration: distribution of microfilaments and focal adhesions in calcium-depleted gastric cell culture; A confocal microscopic study. World Congresses of Gastroenterology, Sep 6-11. 1998, Vienna, Austria. Digestion 1998;59 Suppl 3:96.

 

78. Puolakkainen P, Kiviluoto T, Ranta-Knuuttila T, Watanabe S, Kivilaakso E. Calcium/Calmodulin dependent pathway plays a second messenger role in signal transduction of migrating cultured gastric epithelial cells. World Congresses of Gastroenterology, Sep 6-11. 1998, Vienna, Austria. Digestion 1998;59 Suppl 3:672.

 

79. Puolakkainen P, Kokkola A, Haapiainen R, Laxen F, Kivilaakso E, Sipponen P. Natural course of atrophic gastritis: A prospective 6-year follow-up study. Gastroenterology 1998;114:A263.

 

80. Puolakkainen P, Kokkola A, Rautelin H, Sipponen P, Färkkilä M, Haapiainen R, Kivilaakso E, Kosunen TU. Positive serology indicates an active H.pylori infection in patients with atrophic gastritis in spite of negative histology and ¹³C-urea breath test (¹³C-UBT).Scand J Gastroent 1998:33 Suppl. 227:F4.

 

81. Puolakkainen P, Vaalamo M, Karjalainen-Lindsberg ML, Kere J, Kivilaakso E, Saarialho-Kere U. Distinct expression profiles of stromelysin 2, collagenase-3, macrophage metalloelastase and TIMP-3 in intestinal ulcerations. Gastroenterology 1998;114:A1064

 

82. Ranta-Knuuttila T, Puolakkainen P, Kiviluoto T, Mustonen H, Kivilaakso E. Calcium/calmodulin toimii toisiolähettinä mahalaukun pintaepiteelisolujen migraation signaalinvälityksessä. 17. Kirurgipäivät , 12.-13.11.1998, Tampere (Meeting of the Finnish Surgical Association).

 

83. Ranta-Knuuttila T, Puolakkainen P, Kiviluoto T, Watanabe S, Sato N, Kivilaakso E. Calcium/calmodulin dependent pathway plays a second messenger role in signal transduction of migration in cultured gastric epithelial cells. Digestive Disease Week, Meeting of American Gastroenterologic Association, New Orleans, LA, May, 1998.

 

84. Tielinen L, Manninen M, Puolakkainen P, Pätiälä H, Pohjonen T, Rautavuori J, Rokkanen P. Biohajoavasta polylaktidisauvasta vapautuvan TGF-Beta1:n vaikutus kokeellisen osteotomian paranemiseen rotalla. Lääkäripäivät, 1998, Helsinki.

 

85. Tielinen L, Manninen M, Puolakkainen P, Pätiälä H, Pohjonen T, Rautavuori J, Rokkanen P. Combining TGF-Beta1 to a bioabsorbable self-reinforced polylactide pin for bone healing. 8th Annual Meeting, European Orthopaedic Research Society, May 7-10. 1998, Amsterdam.

 

86. Tielinen L, Puolakkainen P, Pohjonen T, Rautavuori J, Törmälä P, Rokkanen P. The effect TGF-beta released from a bioabsorbable self-reinforced polylactide pin, on a bone defect. Acta Orthop Scand 1998;69 Suppl 280, 24.

 

87. Vanhanen H, Puolakkainen P, Pitkälä K, Strandberg T, Lonka K. The problem based learning tutorial laboratory - a method of teaching medical teachers. Meeting for Medical Teachers, Prague, 1998.

 

1999

 

88. Halonen K, Puolakkainen P, Leppäniemi A, Lundin J, Kemppainen E, Hietaranta A, Kivilaakso E, Haapiainen R: Severe acute pancreatitis – prognostic factors in 270 consecutive patients. Gastroenterology 116: A1130, 1999

 

89. Kemppainen E, Kylänpää-Bäck L, Hedström J, Haapianen R, Perhoniemi V, Kivilaakso E, Stenman U-H, Puolakkainen P. Reliable screening for acute pancreatitis with rapid trypsinogen-2 test strip. Ann Chir Gynaecol Vol 88 (2):155, 1999

 

90. Kemppainen E, Puolakkainen P, Hietaranta A, Hedström J, Haapiainen R, Kivilaakso E: Time course profile of serum trypsinogen-2 and trypsin-2-alpha1-antitrypsin with acute pancreatitis. Gastroenterology 116: G4929, 1999

 

91. Kemppainen E, Takala A, Kylänpää-Bäck M-L, Puolakkainen P,Haapianen R, Repo H. Procalcitonin, E-selectin and IL-2R as early markers of severity in acute pancreatitis. Pancreas, vol 19(4):427, 1999

 

92. Kokkola A, Puolakkainen P, Rautelin H, Sipponen P, Haapiainen R, Kivilaakso E, Kosunen T: Time-course of H.pylori antibody titres in patients with atrophic corpus gastritis. European Helicobacter Pylori Study Group, 2-4 September, Helsinki, 1999, Gut Vol 45(111): A54, 1999

 

93. Kokkola A, Puolakkainen P, Rautelin H, Sipponen P, Haapiainen R, Kivilaakso E: Spontaneous decline of H.pylori antibody titres in patients with advanced atrophic gastritis. Gastroenterology 116: A218, 1999

 

94. Kylänpää-Bäck M-L, Takala A, Kemppainen E, Puolakkainen P,Leppäniemi A, Haapiainen R, Repo H. Plasma level of procalcitonin determined on admission to hospital predicts the severity of acute pancreatitis. 12th Annual Congress, European Society of Intensive Care Medicine, Berlin, Germany 3-6 October, 1999, Vol 25(1), 77, 1999

 

95. Neoptolemos JP, Raraty MGT, Slavin J, Kemppainen E, Hietaranta A, Puolakkainen P, Fizpatrick J, Mayer J, beger H-G. Urinary trypsinogen activation peptide is a reliable early redictor of severity in acute pancreatitis. Pancreas Vol.19(4):432, 1999

 

96. Puolakkainen P,Kylänpää-Bäck M-L, Kemppainen E, Hedström J, Haapiainen R, Perhoniemi V, Kivilaakso E, Stenman U-H: Rapid urine trypsinogen-2 test strip provides reliable screening for acute pancreatitis. 38th World Congress of Surgery, International Surgical Week ISW99, August 15-20, 1999

 

97. Puolakkainen P, Neoptolemos J, Mayer J, Raraty M, Slavin J, Fizpatrick J, Hietaranta A, Sainio V, Beger H, Kemppainen: Urinary trypsinogen activation peptide (TAP) for the assessment of severity in acute pancreatitis – a prospective multicenter study. Gut 1999; 45 (Suppl V): A316.

 

98. Puolakkainen P, Neoptolemos J, Mayer J, Raraty M, Slavin J, Fizpatrick J, Hietaranta A, Sainio V, Beger H, Kemppainen: Urinary trypsinogen activation peptide (TAP) for the assessment of severity in acute pancreatitis – a prospective multicenter study. Ann Chir Gynaecol Vol 88 (2):164, 1999

 

99. Puolakkainen P, Vakkari M-L, Kokkola A, Varis A, Haapiainen R, Kivilaakso E, Knuutila S: DNA copy number changes in gastric adenocarcinoma (GC) cell lines evaluated by comparative genomic hybridization (CGH). 3^rd International Gastric Cancer Congress, Seoul, April 27-30, 1999, p. 272

 

100. Rautemaa R, Meri S, Puolakkainen P, Kokkola A, Kärkkäinen P, Rautelin H. Acquired resistance of helicobacter pylori to complement lysis by incorporation of GPI-anchored protectin (CD59). European Helicobacter Pylori Study Group, 2-4 September, Helsinki, 1999, Gut Vol 45(111): A26, 1999

 

101. Tielinen L, Manninen M, Puolakkainen P, Rokkanen P, Kellomäki M, Törmälä P, Rich J, Seppälä j. Inability of local application of transforming growth factor-β1, combined to bioabsorbable polymers mass, to promote healing of bone defects in the distal femur. 9th Transactions of the European Orthopedic Research Society (EORS), Brussels, June 3-4, 1999, p. 135

 

2000

 

102. Halonen K, Leppäniemi A, Lundin J, Puolakkainen P, Kemppainen E, Haapiainen R. Predicting fatal outcome in early phase of severe acute pancreatitis. Gastroenterology Vol 118(4): A421, 2000 (AGA Abstracts 2175)

 

103. Halonen K, Pettilä V, Leppäniemi A, Kemppainen E, Puolakkainen P, Haapiainen R. Elinvaurioiden ja monielinvauriopisteiden (SOFA, MODS ja LODS) hyödyllisyys sairaalakuolleisuuden ennustamisessa vaikeassa haimatulehduksessa. Suomen Kirurgiyhdistys, Helsingin Messukeskus, 8-10.11.2000. The Meeting of The Finnish Surgical Association

 

104. Kemppainen E, Mayer J, Puolakkainen P, Raraty M, Slavin J, Fitzpatrick J, Hietaranta A, Beger H-G, Neoptolemos J. Trypsinogen activation peptide (TAP) in plasma of patients with acute pancreatitis. Gastroenterology Vol 118(4): A161, 2000 (AGA Abstracts 918)

 

105. Kokkola A, Puolakkainen P, Haapiainen R, Rautelin H, Kosunen T,Kivilaakso E, Sipponen P: The effect of H.pylori eradication on atrophic corpus gastritis. Gastroenterology 118: A1259, 2000

 

106. Kylänpää-Bäck ML, Kemppainen E, Puolakkainen P,Hedström J, Haapiainen R, Stenman UH. Comparison of urine trypsinogen-2 test strip with serum lipase in the diagnosis of acute pancreatitis. Gastroenterology Vol 118(4): A162, 2000 (AGA Abstracts 919) 

 

107. Puolakkainen P.Antibioottiproylaksian käyttö akuutissa pankreatiitissa. Lääkäripäivät, Helsingin Messukeskus, p. 242, 2000. The Finnish Medical Convention

 

108. Puolakkainen P.Current concepts in acute pancreatitis. Harvard Medical School, 28.5.2000

 

109. Puolakkainen P, Kemppainen E, Mayer JM, Fitzpatrick JM, Raraty M, Slavin J, Beger H, hietaranta A, Neoptolemos J. A multicentre study of early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide. Gastroenterology 118(4): 929, 2000

 

110. Salmela M, Saarialho-Kere U, Karjalainen-Lindsberg M-L, Salo J, Puolakkainen P.Upregulation and differential expression of matrisylin, metalloelastase and timp-3 in barrets’ carcinoma. Gastroenterology Vol 118(4): A37, 2000 (AGA Abstracts 415)

2001

 

111. Halonen KI, Pettilä V, Leppäniemi AK, Kemppainen EA, Puolakkainen P,Haapiainen R.Multiple organ dysfunction associated with severe acute pancreatitis (SAP). Gastroenterology 120(5): A644-5, 2001

 

112. Kylänpää-Bäck M-L, Takala A, Kemppainen EA,Puolakkainen PA, Haapiainen RK, Repo H: The strip test of procalcitonin in early detection of severe acute pancreatits. Gastroenterology 120(5): A469, 2001

 

113. Puolakkainen P, Bradshaw A, Kyriakides T, Lehman A, Brekken R, Bornstein P, Sage EH:Reduced foreign body response to implanted biomaterials in sparc-null mice. Reparative Medicine: Growing Tissues and Organs, June 25-26, 2001, Natcher Conference Center, National Institutes of Health, Maryland, p. 37

 

114. Puolakkainen P,Bradshaw A, Kyriakides T, Lehman A, Brekken R, Bornstein P, Sage EH:Reduced foreign body response to implanted biomaterials in sparc-null mice. Frontiers in Cardiovascular Research, Bell Harbor International Conference Center, Seattle, Washington, October 29-30, 2001, p. 15

 

115. Puolakkainen P, Bradshaw A, Kyriakides TR, Lehman A, Brekken R, Bornstein P, Sage EH. Reduced foreign body response in sparc-null mice.(11^th Annual Educational Symposium of the Wound Healing Society, May 17, 2001) Wound Repair and Regeneration 2001;9(2):162

 

116. Puolakkainen P:  The dermal fibrotic response to implanted biomaterials in mice. Invited lecture in Vascular Biology Lab Seminars, 14.2.2001

 

117. Raraty M, Slavin J, Kemppainen E, Fitzpatrick J, Beger HG, Hietaranta A,Puolakkainen P,Neoptolemos JP.Serum amyloid A is an early prognostic marker in human acute pancreatitis – results from a prospective multicenter trial. Gastroenterology 120(5): A468, 2001

 

118. Reed MJ, Koike T, Sadoun E, Sage EH, Puolakkainen P: Inhibition of TIMP1 enhances angiogenesis in vivo. Frontiers in Cardiovascular Research, Bell Harbor International Conference Center, Seattle, Washington, October 29-30, 2001, p. 8

 

2002

 

119. Bradshaw AD, Puolakkainen P,Dasgupta J, Davidson JM , Wight TN, Sage EH. SPARC influences the structure and composition of the dermal ECM. Basement Membrane Gordon Conference, Holderness School, Plymouth, NH, June 9-14, 2002

 

120. Brekken RA,Puolakkainen P,Graves DC, Workman G, Bradshaw D, Sage H. Enhanced growth of implanted tumors in SPARC-null mice. Keystone Symposia, Banff Centre, Banff Alberta, Canada, February 8-13, 2002, abs. 239, p. 135

 

121. Järveläinen H, Puolakkainen P,Brown EL, Höök M, Iozzo RV, Sage H, Wight TN. Decorin-deficient mice exhibit delayed cutaneous wound healing and increased fibrovascular invasion in polyvinyl alcohol sponges. 10^th Gordon Research Conference on Proteoglycans, Proctor Academy Andover, New Hampshire, July 7-12, 2002, p. 5

 

122. Puolakkainen P,Bradshaw A, Kyriakides T, Reed M, Brekken R, Bornstein P, Sage EH. Reduced foreign body response to implanted biomaterials in sparc-null mice. Keystone Symposia, Banff Centre, Banff Alberta, Canada, February 8-13, 2002, abs. 301.

 

123. Puolakkainen PA,Brekken RA, Sage H. Enhanced growth of implanted pancreatic tumors in SPARC-null mice. Gastroenterology122(4): A-489, 2002

 

2003

 

124. Kivilaakso E, Lepistö A, Mustonen H, Lehtonen S, Lehtonen E, Puolakkainen P, Kiviluoto T. CD2-associated protein (CD2AP) interacts with E-cadherin in a cell culture model simulating gastric restitution. 11^th European Gastroenterology Week, November 1-5, 2003

 

125. Kokkola A, Louhimo J, Haglund C, Alfthan O, Rautelin H, Puolakkainen P. H.pylori infection and low serum pepsinogen I as risk factors for gastric cancer. 11^th European Gastroenterology Week, November 1-5, 2003

 

126. Lepistö A, Mustonen H, Lehtonen S, Puolakkainen P, Kivilaakso E: CD2- associated protein (CD2AP) interacts with E-cadherin in a cell culture model simulating gastric restitution.  Gastroenterology 124 (4)(Suppl 1): T908, 2003

 

127. Mentula P, Kylänpää ML, Kemppainen E, Jansson SE, Sarna S, Puolakkainen P, Haapiainen R, Repo H. Elinvaurion varhainen ennustaminen akuutissa pankreatiitissa. Operatiiviset päivät, Helsingin Messukeskus, 19.-21.11.2003, Vol. 24 (4): 92, 2003. The Meeting of The Finnish Surgical Association

 

128. Puolakkaien P, Bradshaw  A, Brekken R, Reed M, Kyriakides T, Bornstein P, Sage H. Sparc-thrombospondin-2 double-null mice exhibit enhanced epidermal closure and dermal wound healing. Wound Repair and Regeneration Vol. 11, no. 2, A23, 2003.

 

129. Puolakkainen PA, Brekken RA, Sage H. Enhanced growth and decreased levels of apoptosis of pancreatic tumors in sparc-null mice is associated with altered extracellular matrix. Gut 52 (Suppl VI): A48, 2003

 

2004

 

130. Kivilaakso E, Mustonen H, Kiviluoto T, Lepistö A, Paimela H, Puolakkainen P. Ethanol induces cell volume decrease and ingibits gap junctional traffic via culcium signaling pathway in cultured rat gastric mucosal cells. Gut 2004;53(Suppl V):A96

 

131. Kokkola A, Louhimo J, Puolakkainen P, Alfthan H, Haglung C, Rautelin H: Helicobakter pylori infection, low serum pepsinogen I level and parietal cell antibodies as risk factors for gastric carcinoma. The XXXII Meeting of the International Society for Oncodevelopment Biology and Medicine, ISOMB 2004, June 19-23, 2004, Helsinki, Finland

 

132. Kokkola A, Sipponen P, Puolakkainen P. Pylori eradication therapy without endoscopy may delay the diagnosis of gastric cancer. Gut 53 (Suppl VI): A126, 2004

 

133. Lepistö A, Mustonen H, Kiviluoto T, Lehtonen S, Lehtonen E, Puolakkainen P, Kivilaakso E. CD-2associated protein contributes to cell membrane-cytoskeleton interaction and cell migration in a cell culture model simulating gastric restitution. Gut 2004;53(Suppl VI):A97

 

134. Mustonen H, Kiviluoto T, Paimela H, Puolakkainen P, Kivilaakso E: Ethanol induced volume decrease and inhibition of gap junctional traffic is mediated by calcium signalling in cultured gastric epithelial cells.  Gastroenterology 126 (Suppl 2): A537-8, 2004

 

135. Mustonen H, Lepistö A, Lehtonen S, Lehtonen E, Puolakkainen P: CD2-associated protein contributes to cell membrane-cytoskeleton and cell migration in cultured gastric epithelial cells. Gastroenterology 126 (Suppl 2): A538-9, 2004

 

136. Puolakkainen P, Salmela MT, Pender SL, Karjalainen-Lindsberg M, MacDonald TT, Saarialho-Kere U. Collagenase-1 (MMP.1), matrilysin-1 (MMP-7), and stryomelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing. Gut 53 (Suppl VI): A127, 2004

 

2005

 

137. Halttunen J, Weckman L, Kylänpää ML, Puolakkainen P. Haiman pseudokystien endoskooppinen hoito. Operatiiviset päivät, Helsingin Messukeskus 23-25.11.2005, Vol. 26(4): 99, 2005. The Meeting of The Finnish Surgical Association

 

138. Kiviluoto T, Kokkola A, Danielson H, Kivilaakso E, Puolakkainen P,: Complications and survival following curative D1 vs. D2-3 gastrectomy for gastric cancer.  6^th International Gastric Cancer Congress, Yokohama, May 4-7, 2005

 

139. Kylänpää L, Puolakkainen P, Weckman L, Halttunen J. Endoscopic treatment of pancreatic pseudocysts. Pancreas 31(4), 450, 2005 (36th Annual Meeting of the American Pancreatic Association, November 3-4, 2005)

 

140. Lawrence I, Lloyd F, Puolakkainen P, Sage EH, Raye W: SPARC protects against chronic murine inflamamtion-induced intensinal fibrosis. Gastroenterology 128(4): S1395, 2005

 

141. Mentula P, Kylänpää ML, Kemppainen E, Jansson SE, Puolakkainen P, Haapiainen R, Repo H: Elinvaurion varhainen ennustaminen akuutissa haimatulehduksessa. Duodecim 2005;121:1331

 

142. Mentula P, Lindström O, Kylänpää L, Kemppainen E, Puolakkainen P, Haapiainen R, Fernandez JA, Griffin JH, Repo H, Petajä J. Up-regulated but insufficient generation of activated protein C is associated with development of multi-organ failure in severe acute pancreatitis. Pancreas 31(4), 456, 2005 (36th Annual Meeting of the American Pancreatic Association, November 3-4, 2005)

 

143. Mustonen H, Kiviluoto T, Puolakkainen P, Kivilaakso E. Heat shock pretreatment inhibitis ethanol induced, calcium mediated Nfkb activation in cultured rat castric mucosal cells. Gastroenterology 128(4): W1367, 2005

 

144. Myllykangas S, Junnila S, Kokkola A, Autio R, Saharinen J, Karjalainen-Lindsberg ML, Puolakkainen P, Monni O, Knuutila S. Associations between fragile sites, genen copy number aberrations and gene expression changes in gastric cancer. Fragilome, Chromosomal instability, fragile sites, and cancer. Heidelberg, German Cancer Research Center, DKFZ February 17-19, 2005

 

145. Puolakkainen P, Sipponen P, Kiviluoto T, Kivilaakso E, Kokkola A: H. pyloriEradication may delay the diagnosis of gastric cancer. 6^th International Gastric Cancer Congress, Yokohama, Japan, May 4-7, 2005, p. 163

 

146. Tukiainen E, Kylänpää M-L, Puolakkainen P, Kemppainen E, Halonen K, Methuen T, Salaspuro M, Haapiainen R, Repo H. TNF-α, HSP70-2 and CD14 polymorphisms in acute pancreatitis. Pancreas 31(4), 456, 2005 (36th Annual Meeting of the American Pancreatic Association, November 3-4, 2005)

 

2006

 

147. Junnila S, Myllykangas S, Kokkola A, Autio R, Saharinen J, Karjalainen-Lindsberg M-L, Puolakkainen P, Knuutila S, Monni O. Characterization of primary gastric tumors with CGH and expression microarray analyses. Lääkäripäivät, Helsingin Messukeskus 8.-12.1.2006, p. 227, The Finnish Medical Convention.

 

148. Lindström O, Kylänpää L, Jarva H, Puolakkainen P, Kemppainen E, Haapiainen R, Repo H, Meri S. Elevated serum level of the complement regulator protein CD59 is a predictor of organ failure in acute pancreatitis. Pancreatology 2006;6:377-8 (38th European Pancreatic Club, Tampere, Finland, June 7-10, 2006)

 

149. Lindström O, Kylänpää L, Jarva H, Puolakkainen P, Kemppainen E, Haapiainen R, Repo H, Meri S. Elevated serum level of the complement regulator protein CD59 is a predictor of organ failure in acute pancreatitis. The 38th Meeting of the European Pancreatic Club, Tampere, Finland, June 7-10, 2006, p. 42

 

150. Lindström O, Kylänpää L, Jarva H, Puolakkainen P, Kemppainen E, Haapiainen R, Repo H, Meri S. Elevated serum level of the complement regulator protein CD59 is a predictor of organ failure in acute pancreatitis. Pancreas 2006; 33(4); 478.

 

151. Mentula P, Kylänpää L, Puolakkainen P, Kemppainen E. Obesity correlates with early hyperglycaemia in patients with acute pancreatittis who developed organ failure. The 38th Meeting of the European Pancreatic Club, Tampere, Finland, June 7-10, 2006, p. 46

 

152. Mentula P, Kylänpää L, Puolakkainen P, Kemppainen E. Obesity correlates with early hyperglycaemia in patients with acute pancreatittis who developed organ failure. Pancreatology 2006;6:387 (38th European Pancreatic Club, Tampere, Finland, June 7-10, 2006)

 

153. Mentula P, Kylänpää L, Kemppainen E,Puolakkainen P. Obesity correlates with early hyperglycaemia in patients with acute pancreatittis who developed organ failure. Pancreas 33(4); 483-4.

 

154. Methuen T, Kylänpää M-L, Kekäläinen O, Halonen T, Tukiainen E, Sarna S, Puolakkainen P, Kemppainen e, Haapiainen R, Salaspuro M. Disialotransferrin, determined by capillary electophoresis, is an accurate and rapid test for detecting alcoholic cause of acute pancreatitis. The 38th Meeting of the European Pancreatic Club, Tampere, Finland, June 7-10, 2006, p. 33

 

155. Methuen T, Kylänpää M-L, Kekäläinen O, Halonen T, Tukiainen E, Sarna S, Puolakkainen P, Kemppainen E, Haapiainen R, Salaspuro M. Disialotransferrin, determined by capillary electophoresis, is an accurate and rapid test for detecting alcoholic cause of acute pancreatitis. Pancreatology 2006;6:358 (38th European Pancreatic Club, Tampere, Finland, June 7-10, 2006)

 

156. Mustonen H, Kiviluoto T, Puolakkainen P, Kivilaakso E. Taurocholate potentiates ethanol induced NfκB Activation an inhibits caspase-3 activity in cultured rat gastric epithelium. – Gastroenterology 130(4): W1720, 2006 (Digestive Disease Week^® and the 107^th Annual Meeting of the American Gastroenterological Association Institute, May 20-205, 2006, Los Angeles, CA)

 

157. Nylander-Koski O, Mustonen H, Kiviluoto T, Puolakkainen P, Kivilaakso E. Simultaneous effects of nitric oxide and growth factors on wound healing in cultured gastric mucosal epithelium. Gastroenterology 130(4): W1713, 2006 (Digestive Disease Week^® and the 107^th Annual Meeting of the American Gastroenterological Association Institute, May 20-205, 2006, Los Angeles, CA)

 

158. Puolakkainen P.Akuutti haimatulehdus. Suomen Gastroenterologiayhdistys RY:n 50-vuotisjuhlakokous, 7.-.8.9.2006 Turun Messu- ja kongressikeskus, pp. 22-23.

 

159. Puolakkainen P,Junnila S, Myllykangas S, Kokkola A, Autio R, Karjalainen-Lindsberg M, Scheinin I, Knuutila S, Monni O. Integrated gene copy number and expression microarray analysis of primary gastric tumors highlights potential gastric cancer target genes. – Gut 2006; 55 (Suppl V) A30: OP-G-130

2007

 

160. Mustonen H, Kiviluoto T, Puolakkainen P, Kivilaakso E. Ethanol induced NF-κΒ activation protects against cell injury in cultured rat gastric mucosal epithelium. Poster 316389 (Digestive Disease Week^® Washington Convention Center in Washington, DC, May 19-24, 2007)

 

161. Mustonen H, Kiviluoto T, Puolakkainen P, Kivilaakso E. Taurocholate inhibits caspase-3 activity in ethanol exposed cultured rat gastric epithelium. Poster S1888 (Digestive Disease Week^® Washington Convention Center in Washington, DC, May 19-24, 2007)

 

162. Petrova TV, Nykänen A, Norrmén Camilla, Andersson L, Haglund C, Puolakkainen P, Vanharanta S, Aaltonen L, Taipale J, Alitalo K. Novel role for PROX1 in the control of colon tumor growth and differentiation. – Helsinki Biomedical Graduate School, Transcription: for molecular mechanisms to disease, February 9-10, 2007, Biomedicum Helsinki, Finland

 

163. Tukiainen E, Kyläpää M-L, Puolakkainen P, Kemppainen E, Halonen K, Methuen T, Salaspuro M, Haapiainen R, Repo H. Sytokiinigeenien TNF, CD14 ja HSPA1B polymorfismien merkitys alkoholin aiheuttamassa akuutissa haimatulehduksessa. – 9. Gastropäivät, Suomen Gastroenterologiyhdistys ry, Helsinki, Marina Congress Center, 15.-16.2.2007. Meeting of The Finnish Gastroenterological Association.

 

164. Rau B, Matt S, Kemppainen E, Bassi C, Buchler M, Beger H, Puolakkainen P. Defining early organ failure in acute pancreatitis: a prospective international multicenter evaluation of the SOFA- versus the Marshall system. Pancreas 2007, 35:424,

 

2008

 

165. Puolakkainen P. Alcohol as the cause of acute and chronic pancreatitis. Annual Meeting of The Finnish Digestive Surgeons, Helsinki

 

166. Puolakkainen P, Kiviluoto T, Lehtonen E, Lehtonen S, Mustonen H. CD2 associated protein expression at plasma membrane is increased and associates with cell junction disruption after extracellular Caa – depleteion in rat gastric epithelia. Digestive Disease Week, San Diego, USA

 

167. Kauhanen SP, Komar G, Seppänen MP, Dean KI, Minn HR, Kajander SA, Rinta-Kiikka I, Alanen K, Borra RJ, Puolakkainen P, Nuuttila P, Ovaska JT. A prospective diagnostic accuracy study of 18F-fluoreoxyglucose positron emission tomography/computed tomography, multidetector row computed tomography, and magnetic resonance imaging in primary diagnosis and staging of pancreatic cancer. United European Gastroenterology Week, Vienna

 

168. Nieminen A, Kokkola A, Ylä_liedenpohja J, Louhimo J, Mustonen H, Puolakkainen P. Varhaisvaiheen mahasyöpä (Early gastric cancer). Annual Meeting of The Finnish Surgical Society. Helsinki

 

 

 

2009

 

169. Surgeon’s view; is it an abdominal tumor? The Finnish Medical Convention, 2009

 

170. Kauttu T, Rantanen T, Sihvo E, Räsänen J, Puolakkainen P, Salo J. Esophageal adenocarcinoma arising after fundoplication: a population based analysis. Digestive Disease Week, USA, 2009.

 

171. Kauttu T, Rantanen T, Sihvo E, Räsänen J, Puolakkainen P, Salo J.Fundoplikaation jälkeinen ruokatorven adenokarsinooma: väestötason analyysi. The Annual Meeting of the Finnish Surgical Society, Operatiiviset päivät , 2009

 

172. Puolakkainen P, Repo H, Vainionpää S, Kylänpää L, Oiva J, Kemppainen E, Mustonen H. Defects in monocyte signalling in patients with acute pancreatitis. American Pancreatic Association Annual Meeting, Honolulu, USA

 

173. Kauhanen S, Komar G, Seppänen M, Dean K, Borra R,Puolakkainen P, Nuutila P. A prospective diagnostic accuracy study of 18F-fluoreoxyglucose positron emission tomography/computed tomography, multidetector row computed tomography, and magnetic resonance imaging in primary diagnosis and staging of pancreatic cancer. American Pancreatic Association Annual Meeting, Honolulu, USA

 

174. Kylänpää O, Lindström O, Tukiainen E, Mentula P, Puolakkainen P, Repo H. Circulating levels of SRAGE and HMGB1 in patients with acute pancreatitis. American Pancreatic Association Annual Meeting, Honolulu, USA

 

175. Lindström O, Tukiainen E, Kylänpää L, Mentula P, Puolakkainen P, Wartiovaara-Kautto U, Repo H, Petäjä J. Disturbed tissue factor regulation associates with organ failure and predicts death in acute pancreatitis. American Pancreatic Association Annual Meeting, Honolulu, USA

 

176. Kemppainen E, Pettilä V, Kyhälä L, Kylänpää L, Tallgren M, Repo H, Puolakkainen P. Activated protein C in acute pancreatitis. A double-blinded randomized human pilot study. American Pancreatic Association Annual Meeting, Honolulu, USA

 

177. Pelli H, Mustonen H, Vainionpää S, Repo H, Kemppainen E, Puolakkainen P. Invasion of the pancreatic cancer – dependence on the cancer cell-macrophage interaction. American Pancreatic Association Annual Meeting, Honolulu, USA

 

178. Puolakkainen P, Kauhanen SP, Komar G, Seppänen MP, Dean KI, Minn HR, Kajander SA, Rinta-Kiikka I, Alanen K, Borra RJ, Nuuttila P, Ovaska JT. A prospective diagnostic accuracy study of 18F-fluoreoxyglucose positron emission tomography/computed tomography, multidetector row computed tomography, and magnetic resonance imaging in primary diagnosis and staging of pancreatic cancer. International Surgical Week, Adelaide, Australia.

 

2010

 

179. Kokkola A, Louhimo J, Puolakkainen P. Does non-curative operation improve the outcome of patients with metastatic gastric cancer. Annual Meeting of the Finnish Surgical Society, Helsinki

 

180. Oiva J, Muston H, Kylänpää L, Kyhälä L, Siitonen S, Kemppainen E, Repo H, Puolakkainen P.  Abnormal lymphocyte signalling in severe acute pancreatitis. Annual Meeting of the Finnish Surgical Society, Helsinki

 

181. Puolakkainen P, Oiva J, Kylänpää ML, Kyhälä L, Siitonen S, Kemppainen E, Repo H, Mustonen H. Patients with severe acute pancreatitis show abnormal lymphocyte signalling profile assessed by phospho-specific flow cytometry. United European Gastroenterology Week, Barcelona, Spain.

 

182. Oiva J, Mustonen H, kylänpää ML, Kyhälä L, Siitonen S, Kemappainen E, Repo H, Puolakkainen P. Patients with acute pancreatitis complicated by organ dysfunction show abnormal lymphocyte signalling. American Pancreatic Association, Chicago, 2010.

 

183. Puolakkainen P, Mustonen H, Vainionpää S, Kemppainen E, Repo H, Pelli H. Pancreatic canver cell invasion is increased in hypoxia induced MMP9 mRNA expression. American Pancreatic Association, Chicago, 2010

 

etc.

Others PUBLICATIONS

 

1. Puolakkainen P, Schröder T: Laseri parantaa (Lasers in Medicine; A Review) (in Finnish) Tiede 2000, 1990; 52-55.

 

2. Puolakkainen P. Somatostatiini ja oktreotidi abdominaali-kirurgiassa.(Somatostatin and octreotide in abdominal surgery; review in Finnish.) Sandoreport 3:5-8, 1996.

 

3. Puolakkainen P, Turunen JP, Kivisaari L, Kekki P: Kurssimuotoisen koulutuksen laatu ja vaikuttavuus ja niiiden arviointi erikoislääkärikoulutuksessa. Suomen Lääk L 2001;56(51-52):5295-300.

 

4. Rau BM, Kemppainen EA, Gumbs AA, Uhl W, Büchler MW, Wegscheider K, Bassi C, PA Puolakkainen, Beger HG, Schilling MK: Prokalsitoniini haiman infektioiden ja kokonaisennusteen arvioinnissa vaikeaa akuuttia haimatulehdusta sairastavilla potilailla: prospektiivinen, kansainvälinen monikeskustutkimus. Early assessment of pancreatic infections and overall prognosis in severe acute pancreatitis by procalcitonin (PCT). a prospesctive international multicenter study. Duodecim 2007;123:1256-1257

 

5. Mentula P, Kemppainen E, Puolakkainen P. Sappikivitaudin hoito akuutin sappikivien aiheuttamahaimatulehduksen yhteydessä. Duodecim 2007; 123: 2449-53

 

            6. Järvinen M, Höckerstedt K, Alhava E, Juvonen T, Puolakkainen P et al. Kirurgian professorit: selvtyshenkilöiltä varsin radikaaleja ehdotuksia erikoislääkärikoulutuksesta. Suomen Lääkärilehti 2007; 41: 3777-9

 

7. Rau BM, Kemppainen EA, Gumbs AA, Uhl W, Büchler MW, Wegscheider K, Bassi C, PA Puolakkainen, Beger HG: Prokalsitoniini haiman infektioiden ja kokonaisennusteen arvioinnissa vaikeaa akuuttia haimatulehdusta sairastavilla. In press, Duodecim 2007;123:1256-7

 

8. Puolakkainen P, Aaltonen L, Alitalo K. Äyräpään palkinto 2011 Juha Kerelle. Duodecim 2011;127:107-8

 

 

APPENDIX

 

 

Pedagogical training (University of Helsinki unless other vice marked)

 

- Tutor teaching course (1 day)1996/ Teaching EBM-course (1-day)1996/ “Simulated patients” (1-day)1996 / A course of University pedagogy (Korkeakoulupedagogiikan kurssi)(6 sw) accepted with distinction and special honours (Professor Lonka,1997-8)/ The course “Portfolio”, (2-days)1997-1998/ Information technology in medical education (1-day) 2004/ Electronic library services (1-day)2004/ The OSCE examination training (1-day)2005/ Train the Trainers international pedagogical workshop (4-day course), World Gastroenterology Organization, Uruguay, 2005/ MD Profession – Medical teaching (1-day)2007/ The AMEE Meeting, Prague 2008, Lyon 2012, Milan 2014/ The day of learning in the Faculty of Medicine – Comparing educational practices between Helsinki and Lindköping 2009/ IT-Medi seminar, (1-day)2010/ Blended-learning –symposium 2010/ Moodle- basic course(1-day) 2010/ Several iPAD courses 2014

 

Practical teaching experience

 

I have been teaching medicine /surgery for 20 years

- Lecturer, School for Dental Technicians and Schools of  Nursing, 1983-2000 Helsinki/ Teaching some medical students (as Visiting Professor) at Benaroya Research Institute  and at University of Washington, Seattle, USA, 2000-2002/ Intensive programme in surgery co-ordinating meeting, Göttingen, Germany, 1999/ Lecturer: Harvard Digestive Disease Center, Boston USA 1999/ Teaching medical (and dental) students and surgical residents (as Assistant Professor / Senior Lecturer) at University of Helsinki, 1994-2000, 2002-2007, 2010-  (as Professor, ongoing) / Teaching medical students and surgical residents (Professor of Surgery) at University of Turku, 2007-2010/Supervising several “Extended studies” –programs for medical students 1994-ongoing/ Teaching abdominal surgery in English to international medical students, University of Helsinki, 2002- ongoing / Annual educational site visit (surgery) with medical students to Stockholm, 1994-/

- Supervisor of 8 completed PhD theses, 5 ongoing, managing own Puolakkainen laboratory in Biomedicum Helsinki since 2002.

- Planning, lecturing, arranging, organizing and participating educational annual symposia: Finnish Digestive Surgeons (board member), The Finnish Gastroenterological Association (Vice President 2009-11, President 2011-2013), The Finnish Surgical Society (board member, Vice President 2010-2012, President 2012-2014,), Joint Education Committee: The Finnish Digestive Surgeons and The Finnish Gastroenterological Association; Program Committee, The Annual Finnish Medical Convention

 

- Planning, lecturing, arranging, organizing and participating in educational and scientific international symposia : European Pancreatic Club 2006, Nordic Meeting of Gastroenterology 2008, International Surgical Week (World Congress in Surgery) 2013 (Vice President)

 

- Annual Hanasaari -symposium for residents: Gastroenterological diseases, (2 days), 2007-

- Experimental animal hands-on courses (Lap-simulator, endo-simulator, experimental animals) for residents and specialists on techniques in abdominal surgery, 2005- (mean of 8-10 one-day courses/year)

- Courses on surgery and emergency surgery, Department of General Medicine, University of Helsinki, 2002-

- Lecture series “Abdominal complaints – how should I treat ? ” in over 20 health care centres in Finland, 2005-6

- “Every man’s surgery” – annual symposium during Finnish Medical Convention, 2006-

- “Acute abdomen in the elderly”, Annual Lecture series, Lahti / University of Helsinki, 2005-

- “To be a certified MD in Finland” – lecture series for foreigners, University of Helsinki, 2008, 2011-

- In addition, tens of educational talks over the years in different levels of medical profession in conferences and meetings in Finland and abroad (Sapporo, Tallin, Dallas)

Contribution in the Development of teaching

- I was actively involved in the development of Helsinki 2000 teaching curriculum at Faculty of Medicine, University of Helsinki (1996-2000). Curriculum represent a hybrid including both conventional teaching methods and problem based learning (PBL). Curriculum includes mentor teaching, a technique in developing of which I was actively involved. In 2005 we updated the program according to Bologna process. During the last 3 years I have been heavily involved in the development of our curriculum to Helsinki 2020.

-As coordinator of surgical teaching in the Faculty of Medicine, University of Helsinki, I have been responsible for applying modern pedagogical techniques in teaching. I have been involved in planning the “Learning laboratory / Taitopaja” for hands-on practicing for medical students. Recently, I have started to apply a simulator in teaching surgical residents (operating a “virtual patient”). I have also been organizing courses of operative techniques using experimental animals. Teaching videos and virtual patient concept have also been implemented as part of the development process.

-For our residents I have started to organize courses including theoretical lectures, experimental animal training on operative techniques, simulators and finally, teaching operations. Titles include surgery on: Hernias, Thyroid, Gallbladder, Liver, and GERD.

- I have actively participated in the development of teaching in various other projects as a member of the Council of the basic medical teaching (perustutkinnon suunnittelutoimikunta) 2002-.

- In University of Turku (as a Professor 2007-2010) I up-dated the teaching methods and practices of both C7 (Basics and introduction to surgery) and C12 (Surgery) courses to meet both national and international modern standards.

- Other teaching planning projects include:

- “Abdominal diseases” – block as part of Helsinki 2000 curriculum

- Development of the assessment of OSCE examination

- “Organization, quality and validation of postgraduate theoretical courses / Teoreettisen kurssimuotoisen koulutuksen organisointi, laatu ja validointi erikoislääkärikoulutuksessa” -, 2000.

 

- Vice Chair (educational issues), Institute of Clinical Medicine; University of Helsinki, 2010-

- Member, Council of medical professionals, Ministry of Social Affairs and Health, Finland 2010-

 

Related pedagogical publications

- Lonka K, Pitkälä K, Puolakkainen P, Sauri P, Vanhanen H. A problem -based tutorial laboratory - a method of mentoring medical teachers. Meeting of the European Society for Medical Teachers. Gothenburg, Sweden, 1998. Abstract.

- Vanhanen H, Puolakkainen P, Pitkälä K, Strandberg T, Lonka K. The problem based learning tutorial laboratory - a method of teaching medical teachers. Meeting for Medical Teachers, Prague, 1998. Abstract

- Vanhanen H, Pitkälä K, Puolakkainen P, Strandberg TE, Lonka K. The problem-based learning tutorial laboratory – a method for training medical teachers. Med Teach 2001;23:99-101. Original paper

- Puolakkainen P, Turunen JP, Kivisaari L, Kekki P: Kurssimuotoisen koulutuksen laatu ja vaikuttavuus ja niiden arviointi erikoislääkärikoulutuksessa. Suomen Lääk L 2001;56(51-52):5295-300. Original report and review.

- Several articles and reviews in Finnish (Duodecim, Suomen Lääkärilehti)

- Editor: Gastroenterology and Hepatology, 2013, (Gastroenterologia ja hepatologia; The Finnish Textbook).

- Puolakkainen P. Proktiitit. Kirjassa: Sukupuolitaudit. Duodecim, (Proctitis ; A Review in the textbook of sexually transmitted diseases) (in Finnish), Helsinki,            1994.

-Puolakkainen P: Akuutti haimatulehdus. Kirjassa: Kunnamo I (päätoim.) Lääkärin käsikirja 2004. Helsinki: Kustannus Oy Duodecim, 2004; s. 374-5. 951-656-144-6

-Puolakkainen P: Krooninen haimatulehdus. Kirjassa: Kunnamo I (päätoim.) Lääkärin käsikirja 2006. Helsinki: Kustannus Oy Duodecim, 2006; s. 383-5. 951-656-213-2

-Puolakkainen P: Krooninen haimatulehdus [online]. Lääkärin tietokannat/Lääkärin käsikirja. Helsinki: Kustannus Oy Duodecim, 2005. [päivitetty 5.3.2005]. Saatavilla Internetissä (vaatii käyttäjätunnuksen): http://www.terveysportti.fi

- Puolakkainen P: Acute pancreatitis. In: Evidence-Based Medicine Guidelines. Ed. Kunnamo I, John Wiley & Sons, Ltd, England, ISBN 0-470-01184-X, pp. 338-39, 2005. A book chapter

- Puolakkainen P: Akuutti haimatulehdus [online]. Lääkärin tietokannat/Lääkärin käsikirja. Helsinki: Kustannus Oy Duodecim, 2006. [päivitetty 24.5.2005]. Saatavilla Internetissä (vaatii käyttäjätunnuksen): http://www.terveysportti.fi

-Puolakkainen P: Akuutti haimatulehdus. Kirjassa: Jousimaa JP (päätoim.) Lääkärin käsikirja 2011. Helsinki: Kustannus Oy Duodecim; s. 380-81

-Puolakkainen P: Krooninen haimatulehdus. Kirjassa: Jousimaa JP (päätoim.) Lääkärin käsikirja 2011. Helsinki: Kustannus Oy Duodecim s. 381-3.

- Puolakkainen P: Haimasyöpä. Kirjassa: Jousimaa JP (päätoim.) Lääkärin käsikirja 2011. Helsinki: Kustannus Oy Duodecim s. 384-5.

 

Teaching merits, feedback, awards and recognition

-Supervised thesis (Esko Kemppainen) was accepted with special honours, and was awarded as the best surgical dissertation of the year in Finland, 1997

- Numerous very positive feed-back reports over the years: applying to both lectures and group teaching  (both medical students and residents and doctors undergoing CME training).

- The group teacher of the year, 1999, Faculty of Medicine, University of Helsinki (chosen by the medical students)

- Speciality in medical teaching /education, 2008 (The Finnish Medical Association)

- Teaching person of the year, 2012, University of Helsinki (chosen by the medical students)

- dedicated song in the song book of medical students (“Kultainen uvula”, song 136)

- I have received annual grant from the Helsinki University Central Hospital Research Funds (EVO) for the development of teaching techniques, personnel and related purposes (over 100 000 E during the last 5 years)

Teaching demonstration of teaching skills

Formal lectures assessing teaching skills (both graded as excellent):

- 1994 Docent in experimental surgery, University of Helsinki

- 1999 Docent in gastrointestinal surgery, University of Helsinki

- Site visit /evaluation of centres of excellence in university education: Observation of teaching activities; tutorial at the clinical stage of studies (2008), University of Helsinki

-Teaching skillswere demonstrated in all during the process that led to the Speciality in Medical Education and Professorship in Surgery first in Turku and 2011 in Helsinki