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Publications 2004 2019

2019

Accumulation of progerin affects the symmetry of cell division and is associated with impaired Wnt signaling and the mislocalization of nuclear envelope proteins

Sola-Carvajal, A., Revêchon, G., Helgadottir, H. T., Whisenant, D., Hagblom, R., Döhla, J., Katajisto, P., Brodin, D., Fagerström-Billai, F., Viceconte, N. & Eriksson, M., 23 Apr 2019, In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticleScientificpeer-review

Suoliston kantasolut

Andersson, S., Luopajärvi, K., Pentinmikko, N. & Katajisto, P., 2019, In : Duodecim. 135, 7, p. 647-653 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2018

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

Mihaylova, M. M., Cheng, C-W., Cao, A. Q., Tripathi, S., Mana, M. D., Bauer-Rowe, K. E., Abu-Remaileh, M., Clavain, L., Erdemir, A., Lewis, C. A., Freinkman, E., Dickey, A. S., La Spada, A. R., Huang, Y., Bell, G. W., Deshpande, V., Carmeliet, P., Katajisto, P., Sabatini, D. M. & Yilmaz, Ö. H., 3 May 2018, In : Cell Stem Cell. 22, 5, p. 769

Research output: Contribution to journalArticleScientificpeer-review

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway

Ollila, S., Domenech-Moreno, E., Laajanen, K., Wong, I. P. L., Tripathi, S., Pentinmikko, N., Gao, Y., Yan, Y., Niemelä, E. H., Wang, T. C., Viollet, B., Leone, G., Katajisto, P., Vaahtomeri, K. & Mäkelä, T. P., 2 Jan 2018, In : Journal of Clinical Investigation. 128, 1, p. 402-414 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2017

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma

Tammela, T., Sanchez-Rivera, F. J., Cetinbas, N. M., Wu, K., Joshi, N. S., Helenius, K., Park, Y., Azimi, R., Kerper, N. R., Wesselhoeft, R. A., Gu, X., Schmidt, L., Cornwall-Brady, M., Yilmaz, Ö. H., Xue, W., Katajisto, P., Bhutkar, A. & Jacks, T., 18 May 2017, In : Nature. 545, 7654, p. 355-+ 24 p.

Research output: Contribution to journalArticleScientificpeer-review

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

Roper, J., Tammela, T., Cetinbas, N. M., Akkad, A., Roghanian, A., Rickelt, S., Almeqdadi, M., Wu, K., Oberli, M. A., Sanchez-Rivera, F., Park, Y. K., Liang, X., Eng, G., Taylor, M. S., Azimi, R., Kedrin, D., Neupane, R., Beyaz, S., Sicinska, E. T., Suarez, Y. & 14 othersYoo, J., Chen, L., Zukerberg, L., Katajisto, P., Deshpande, V., Bass, A. J., Tsichlis, P. N., Lees, J., Langer, R., Hynes, R. O., Chen, J., Bhutkar, A., Jacks, T. & Yilmaz, O. H., Jun 2017, In : Nature Biotechnology. 35, 6, p. 569-579 11 p.

Research output: Contribution to journalLetterScientificpeer-review

2015

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

Katajisto, P., Doehla, J., Chaffer, C. L., Pentinmikko, N., Marjanovic, N., Iqbal, M. S., Zoncu, R., Chen, W., Weinberg, R. A. & Sabatini, D. M., 17 Apr 2015, In : Science. 348, 6232, p. 340-343 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2014

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan.

Lamming, DW., Mihaylova, MM., Katajisto, P., Baar, EL., Yilmaz, OH., Hutchins, A., Gultekin, Y., Gaither, R. & Sabatini, DM., 2014, In : Aging Cell. 13, 5, p. 911-917 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2012

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

Katajisto, P., Yilmaz, O. H., Lamming, D. W., Gueltekin, Y., Bauer-Rowe, K. E., Sengupta, S., Birsoy, K., Dursun, A., Yilmaz, V. O., Selig, M., Nielsen, G. P., Mino-Kenudson, M., Zukerberg, L. R., Bhan, A. K., Deshpande, V. & Sabatini, D. M., 28 Jun 2012, In : Nature. 486, 7404, p. 490-U87 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

Lamming, D. W., Ye, L., Katajisto, P., Goncalves, M. D., Saitoh, M., Stevens, D. M., Davis, J. G., Salmon, A. B., Richardson, A., Ahima, R. S., Guertin, D. A., Sabatini, D. M. & Baur, J. A., 30 Mar 2012, In : Science. 335, 6076, p. 1638-1643 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity

Partanen, J. I., Tervonen, T. A., Myllynen, M., Lind, E., Imai, M., Katajisto, P., Dijkgraaf, G. J. P., Kovanen, P. E., Makela, T. P., Werb, Z. & Klefstrom, J., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, p. E388-E397 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

DEPLETION OF MTOR AND MLST8 UNCOUPLES LONGEVITY FROM RAPAMYCIN-INDUCED CHANGES IN GLUCOSE HOMEOSTASIS

Lamming, D., Ye, L., Katajisto, P., Ahima, R., Guertin, D., Sabatini, D. & Baur, J., Nov 2011, In : Gerontologist. 51, p. 505-506 2 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Impaired Gastric Gland Differentiation in Peutz-Jeghers Syndrome

Udd, L., Katajisto, P., Kyyrönen, M., Ristimaki, A. P. & Makela, T. P., 2010, In : The American Journal of Pathology. 176, 5, p. 2467-2476 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

LKB1 in endothelial cells is required for angiogenesis and TGF beta-mediated vascular smooth muscle cell recruitment

Londesborough, A., Vaahtomeri, K., Tiainen, M., Katajisto, P., Ekman, N., Vallenius, T. & Makela, T. P., 2008, In : Development. 135, p. 2331-2338 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Lkb1 is required for TGF beta-mediated myofibroblast differentiation

Vaahtomeri, K., Ventelae, E., Laajanen, K., Katajisto, P., Wipff, P-J., Hinz, B., Vallenius, T., Tiainen, M. & Mäkelä, T. P., 2008, In : Journal of Cell Science. 121, p. 3531-3540 10 p.

Research output: Contribution to journalArticleScientificpeer-review

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis

Katajisto, P., Vaahtomeri, K., Ekman, N., Ventelä, E., Ristimäki, A., Bardeesy, N., Feil, R., DePinho, R. & Mäkelä, T., 2008, In : Nature Genetics. 40, 4, p. 455-459 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutaatiot kasvaimen tukisoluissa polyyppien aiheuttajina: [referaatti Nature Genetics -lehden artikkelista]

Katajisto, P., Vaahtomeri, K., Ekman, N., Ventelä, E., Ristimäki, A., Bardeesy, N., Feil, R., DePinho, R. & Mäkelä, T., 2008, In : Duodecim. 124, p. 600-601 2 p.

Research output: Contribution to journalArticleScientific

2007

The LKB1 tumor suppressor kinase in human disease

Katajisto, P., Vallenius, T., Vaahtomeri, K., Ekman, N., Udd, L., Tiainen, M. & Makela, T. P., 2007, In : Biochimica et Biophysica Acta. Reviews on Cancer. 1775, 1, p. 63-75 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome

Alhopuro, P., Katajisto, P., Lehtonen, R. J., Ylisaukko-oja, S., Näätäsaari, L., Karhu, A., Westerman, A. M., Wilson, J. H. P., de Rooij, F. W. M., Vogel, T., Moeslein, G., Tomlinson, I. P. M., Aaltonen, L. A., Mäkelä, T. P. & Launonen, V., 2005, In : British Journal of Cancer. 92, 6, p. 1126-1129 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRAD alpha, and MO25 alpha, in Peutz-Jeghers syndrome

Alhopuro, P., Katajisto, P., Lehtonen, R., Ylisaukko-oja, S. K., Näätsaari, L., Karhu, A., Westerman, A. M., Wilson, J. H. P., de Rooij, F. W. M., Vogel, T., Moeslein, G., Tomlinson, I. P., Aaltonen, L. A., Mäkelä, T. P. & Launonen, V., 2005, In : British Journal of Cancer. 92, p. 1126-1129 4 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

Eläinmallista hoitokokeisiin Peutz–Jeghersin syndroomassa

Udd, L. V., Katajisto, P., Rossi, D., Lepistö, A., Lahesmaa-Korpinen, A-M. K., Ylikorkala, A., Järvinen, H., Ristimäki, A. & Mäkelä, T., 2004, In : Duodecim. 120, 19, p. 2353 2354 p.

Research output: Contribution to journalArticleScientific

Suppression of Peutz—Jeghers polyposis by inhibition of cyclooxygenase-2

Udd, L. V., Katajisto, P., Rossi, D., Lepistö, A. H., Lahesmaa-Korpinen, A-M. K., Ylikorkala, A., Järvinen, H., Ristimäki, A. & Mäkelä, T., 2004, In : Gastroenterology. 127, 4, p. 1030-1037

Research output: Contribution to journalArticleScientificpeer-review