Pekka Rauhala

Publications

Research output per year 1984 1988 1995 1996 1998 2003 2020 2024

• 73 Article
• 1 Chapter
• 1 Meeting Abstract
• 1 Comment/debate
• 2 More
  • 1 Review Article
  • 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2024

  Gene expression in the dorsal root ganglion and the cerebrospinal fluid metabolome in polyneuropathy and opioid tolerance in rats

  Ahlström, F. H. G., Viisanen, H., Karhinen, L., Velagapudi, V., Blomqvist, K. J., Lilius, T. O., Rauhala, P. V. & Kalso, E. A., 2024, In: Ibro Neuroscience Reports. 17, p. 38-51 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2023

  The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord

  Ahlström, F. H. G., Viisanen, H., Karhinen, L., Mätlik, K., Blomqvist, K. J., Lilius, T. O., Sidorova, Y. A., Palada, V., Rauhala, P. V. & Kalso, E. A., 9 Jun 2023, In: Molecular pain. 19, 17 p., 17448069231183902.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2022

  Antagonism of peripheral opioid receptors by methylnaltrexone does not prevent morphine tolerance in rats

  Blomqvist, K. J., Dudek, K., Viisanen, H., Mätlik, K., Ahlström, F. H. G., Laitila, J., Kalso, E. A., Rauhala, P. V. & Lilius, T. O., Jan 2022, In: Journal of Neuroscience Research. 100, 1, p. 329-338 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Glymfaattinen järjestelmä saattaa intratekaalisen lääkkeen selkäytimeen

  Blomqvist, K. J., Skogster, M. O. B., Kurkela, M. J., Rosenholm, M. P., Ahlström, F. H. G., Airavaara, M. T., Backman, J. T., Rauhala, P. V., Kalso, E. A. & Lilius, T. O., 2022, In: Duodecim. 138, 10, p. 949 1 p.

  Research output: Contribution to journal › Comment/debate › Professional

  Open Access

  File

• Systemic hypertonic saline enhances glymphatic spinal cord delivery of lumbar intrathecal morphine

  Blomqvist, K. J., Skogster, M. O. B., Kurkela, M. J., Rosenholm, M. P., Ahlström, F. H. G., Airavaara, M. T., Backman, J. T., Rauhala, P. V., Kalso, E. A. & Lilius, T. O., Apr 2022, In: Journal of Controlled Release. 344, p. 214–224 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2021

  Spared Nerve Injury Causes Sexually Dimorphic Mechanical Allodynia and Differential Gene Expression in Spinal Cords and Dorsal Root Ganglia in Rats

  Ahlström, F. H. G., Mätlik, K., Viisanen, H., Blomqvist, K. J., Liu, X., Lilius, T. O., Sidorova, Y., Kalso, E. A. & Rauhala, P. V., Oct 2021, In: Molecular Neurobiology. 58, 10, p. 5396-5419 24 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Uusien kipulääkkeiden kehitys on haastavaa

  Rauhala, P., Lilius, T. & Kalso, E., 2021, In: Finnanest. 54, 1, p. 20-25 6 p.

  Research output: Contribution to journal › Article › Professional

  Open Access

  File
• 2020

  Kielletyt aineet ja menetelmät urheilussa ja erivapaus urheilijan lääkityksessä

  Rauhala, P., Mjøsund, K., Miettinen, P. J., Simula, A., Helajärvi, H., Karjalainen, J. & Heinonen, O. J., 2020, In: Duodecim. 136, 22, p. 2461-2469 9 p.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File

• Morphine-3-glucuronide causes antinociceptive cross-tolerance to morphine and increases spinal substance P expression

  Blomqvist, K., Viisanen, H., Ahlström, F. H. G., Jokinen, V., Sidorova, Y. A., Suleymanova, I., Rauhala, P. V., Kalso, E. A. & Lilius, T. O., 15 May 2020, In: European Journal of Pharmacology. 875, 9 p., 173021.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Neurophysiological response properties of medullary pain-control neurons following chronic treatment with morphine or oxycodone: modulation by acute ketamine

  Viisanen, H., Lilius, T. O., Sagalajev, B., Rauhala, P., Kalso, E. & Pertovaara, A., Sept 2020, In: Journal of Neurophysiology. 124, 3, p. 790-801 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Novel RET agonist for the treatment of experimental neuropathies

  Viisanen, H., Nuotio, U., Kambur, O., Mahato, A. K., Jokinen, V., Lilius, T., Li, W., Santos, H. A., Karelson, M., Rauhala, P., Kalso, E. & Sidorova, Y. A., 18 Aug 2020, In: Molecular pain. 16, 19 p., 1744806920950866.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2019

  Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs

  Lilius, T. O., Blomqvist, K., Hauglund, N., Liu, G., Stæger, F. F., Bærentzen, S., Du, T., Ahlström, F., Backman, J. T., Kalso, E., Rauhala, P. V. & Nedergaard, M., 28 Jun 2019, In: Journal of Controlled Release. 304, p. 29-38 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2018

  Differential Spinal and Supraspinal Activation of Glia in a Rat Model of Morphine Tolerance

  Jokinen, V., Sidorova, Y., Viisanen, H., Suleymanova, I., Tiilikainen, H., Li, Z., Lilius, T. O., Matlik, K., Anttila, J. E., Airavaara, M., Tian, L., Rauhala, P. V. & Kalso, E. A., 1 Apr 2018, In: Neuroscience. 375, p. 10-24 15 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Interactions of (2S,6S;2R,6R)-Hydroxynorketamine, a Secondary Metabolite of (R,S)-Ketamine, with Morphine

  Lilius, T. O., Viisanen, H., Jokinen, V., Niemi, M., Kalso, E. A. & Rauhala, P. V., May 2018, In: Basic & Clinical Pharmacology & Toxicology. 122, 5, p. 481-488 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Ketamine and norketamine attenuate oxycodone tolerance markedly less than that of morphine: from behaviour to drug availability

  Lilius, T., Kangas, E., Niemi, M., Rauhala, P. & Kalso, E., Apr 2018, In: British Journal of Anaesthesia. 120, 4, p. 818-826 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2017

  A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat

  Sidorova, Y. A., Bespalov, M. M., Wong, A. W., Kambur, O., Jokinen, V., Lilius, T. O., Suleymanova, I., Karelson, G., Rauhala, P. V., Karelson, M., Osborne, P. B., Keast, J. R., Kalso, E. A. & Saarma, M., 21 Jun 2017, In: Frontiers in Pharmacology. 8, 18 p., 365.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Do Diuretics have Antinociceptive Actions: Studies of Spironolactone, Eplerenone, Furosemide and Chlorothiazide, Individually and with Oxycodone and Morphine

  Jokinen, V., Lilius, T., Laitila, J., Niemi, M., Kambur, O., Kalso, E. & Rauhala, P., Jan 2017, In: Basic & Clinical Pharmacology & Toxicology. 120, 1, p. 38-45 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access
• 2016

  Novel agonist of GDNF family ligand receptor RET for the treatment of experimental neuropathy

  Bespalov, M., Sidorova, Y., Suleymanova, I., Thompson, J., Kambur, O., Jokinen, V., Lilius, T. O., Karelson, G., Puusepp, L., Rauhala, P. V., Kalso, E. A., Karelson, M. & Saarma, M., 4 Jul 2016, In: BioRxiv beta : the preprint server for biology.

  Research output: Contribution to journal › Article › Professional

  Open Access

• Pregabalin enhances the antinociceptive effect of oxycodone and morphine in thermal models of nociception in the rat without any pharmacokinetic interactions

  Jokinen, V., Lilius, T., Laitila, J., Niemi, M., Rauhala, P. V. & Kalso, E. A., Feb 2016, In: European Journal of Pain. 20, 2, p. 297-306 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2015

  Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat

  Lilius, T., Jokinen, V., Neuvonen, M. S., Niemi, M., Kalso, E. A. & Rauhala, P. V., Jun 2015, In: British Journal of Pharmacology. 172, 11, p. 2799-2813 15 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2014

  The mineralocorticoid receptor antagonist spironolactone enhances morphine antinociception

  Lilius, T., Jokinen, V., Neuvonen, M. S., Vaananen, A. J., Niemi, M., Rauhala, P. V. & Kalso, E. A., Mar 2014, In: European Journal of Pain. 18, 3, p. 386-395 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2013

  Lääke elimistössä : farmakologian perusteita ensihoitajille

  Rauhala, P. & Lilius, T., 2013, In: Systole : ensihoidon erikoislehti. 6, p. 34-36 3 p.

  Research output: Contribution to journal › Article › Professional

• 2012

  Intrathecal Atipamezole Augments the Antinociceptive Effect of Morphine in Rats

  Lilius, T., Rauhala, P. V., Kambur, O., Rossi, S. M., Vaananen, A. J. & Kalso, E. A., 2012, In: Anesthesia & Analgesia. 114, 6, p. 1353-1358 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2010

  Simultaneous analysis of catechol-O-methyl transferase activity, S-adenosylhomocysteine and adenosine

  Reenilä, I. & Rauhala, P., 2010, In: Biomedical Chromatography. 24, p. 294-300 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2009

  EFFECTS OF IBUDILAST ON MORPHINE TOLERANCE

  Kalso, E., Lilius, T. & Rauhala, P., Oct 2009, In: Glia. 57, 13, p. S125-S125 1 p.

  Research output: Contribution to journal › Meeting Abstract

• Modulation of morphine-induced antinociception in acute and chronic opioid treatment by ibudilast

  Lilius, T. O., Rauhala, P., Kambur, O. & Kalso, E., 2009, In: Anesthesiology. 111, 6, p. 1356-1364 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• 2008

  Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide

  Väänänen, A., Salmenperä, P., Hukkanen, M., Miranda, K., Harjula, A., Rauhala, P. & Kankuri, E., 2008, In: Free Radical Biology & Medicine. 45, 6, p. 749-755 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2007

  Increased catechol-O-methyltransferase activity and protein expression in OX-42-positive cells in the substantia nigra after lipopolysaccharide microinfusion

  Helkamaa, T., Reenilä, I., Tuominen, R. K., Soinila, S., Väänänen, A., Tilgmann, C. & Rauhala, P., 2007, In: Neurochemistry International. 51, 6-7, p. 412-423 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2006

  Cathepsin B is a differentiation-resistant target for nitroxyl (HNO) in THP-1 monocyte/macrophages

  Väänänen, A., Salmenperä, P., Hukkanen, M., Rauhala, P. & Kankuri, E., 2006, In: Free Radical Biology & Medicine. 41, p. 120-131 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• KDI tripeptide of 1 laminin protects rat dopaminergic neurons from 6-OHDA induced toxicity

  Väänänen, A., Rauhala, P., Tuominen, R. K. & Liesi, P., 2006, In: Journal of Neuroscience Research. 84, 3, p. 655-65 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Sauna ja urheilu

  Rauhala, P., 2006, In: Sauna.. 4, p. 10-11

  Research output: Contribution to journal › Article › General public

• 2005

  Neuroprotective properties of nitric oxide and S-nitrosoglutathione

  Rauhala, P., Chiueh, C. C. & Andoh, T., 2005, In: Toxicology and Applied Pharmacology. 207, 2, p. 91-95

  Research output: Contribution to journal › Article › Scientific › peer-review

• Nitric oxide-related species-induced protein oxidation: reversible, irreversible, and protective effects on enzyme function of papain

  Väänänen, A., Kankuri, E. & Rauhala, P., 2005, In: Free Radical Biology & Medicine. 38, p. 1102-1111 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• The COMT inhibitor, entacapone, reduces levodopa-induced elevations in plasma homocysteine in healthy adult rats

  Nissinen, E., Nissinen, H., Larjonmaa, H., Väänänen, A., Helkamaa, T., Reenilä, I. & Rauhala, P., 2005, In: Journal of Neural Transmission. 112, 9, p. 1213-1221 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2004

  Angeli's salt and spinal motor neuron injury

  Vaananen, A. J., Liebkind, R., Kankuri, E., Liesi, P. & Rauhala, P., 2004, In: Free Radical Research. 38, p. 271-282 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Soluble KDI domain of gamma 1 laminin protects adult hippocampus from excitotoxicity of kainic acid

  Wiksten, M., Vaananen, A., Liebkind, R., Rauhala, P. & Liesi, P., 2004, In: Journal of Neuroscience Research. 78, p. 411-419 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2003

  Angeli's salt induces neurotoxicity in dopaminergic neurons in vivo and in vitro

  Vaananen, A. J., Moed, M., Tuominen, R. K., Helkamaa, T. H., Wiksten, M., Liesi, P., Chiueh, C. C. & Rauhala, P., 2003, In: Free Radical Research. 37, 4, p. 381-389 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Entacapone protects from angiotensin II-induced inflammation and renal injury

  Helkamaa, T., Finckenberg, P., Louhelainen, M., Merasto, S., Rauhala, P., Lapatto, R., Cheng, Z. J., Reenila, I., Mannisto, P., Muller, D. N., Luft, F. C. & Mervaala, E. M. A., 2003, In: Journal of Hypertension. 21, p. 2353-2363 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Farmakologian ja kliinisen farmakologian opetus Helsingin yliopiston lääketieteellisessä tiedekunnassa

  Paakkari, I., Rauhala, P., Backman, J. T. & Neuvonen, P. J., 2003, In: Suomen lääkärilehti. 58, 9, p. 1048-1050

  Research output: Contribution to journal › Article › Scientific

• Resistance to salt-induced hypertension in catechol-O-methyltransferase-gene-disrupted mice

  Helkamaa, T., Mannisto, P. T., Rauhala, P., Cheng, Z. J., Finckenberg, P., Huotari, M., Gogos, J. A., Karayiorgou, M. & Mervaala, E. M. A., 2003, In: Journal of Hypertension. 21, p. 2365-2374 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2002

  Contradictory effects of sodium nitroprusside and S-nitroso-N-acetylpenicillamine on oxidative stress in brain dopamine neurons in vivo

  Rauhala, P., Andoh, T., Yeh, K. & Chiueh, C. C., 2002, In: Annals of the New York Academy of Sciences. 962, p. 60-72 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• 2000

  Dietary potassium and magnesium supplementation in cyclosporine-induced hypertension and nephrotoxicity

  Pere, A. K., Lingren, L., Tuomainen, P., Krogerus, L., Rauhala, P., Laakso, J., Karppanen, H., Vapaatalo, H., Ahonen, J. & Mervaala, E. M. A., 2000, In: Kidney International. 58, p. 2462-2472 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Effects of atypical antioxidative agents, S-nitrosoglutathione and manganese, on brain lipid peroxidation induced by iron leaking from tissue disruption

  Rauhala, P. & Chiueh, C. C., 2000, In: Annals of the New York Academy of Sciences. 899, p. 238-254 17 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• 1999

  Hemoglobin and iron-evoked oxidative stress in the brain: Protection by bile pigments, manganese and S-nitrosoglutathione

  Van Bergen, P., Rauhala, P., Spooner, C. M. & Chiueh, C. C., 1999, In: Free Radical Research. 31, p. 631-640 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Implications for atypical antioxidative properties of manganese in iron-induced brain lipid peroxidation and copper-dependent low density lipoprotein conjugation

  Sziraki, I., Rauhala, P., Koh, K. K., van Bergen, P. & Chiueh, C. C., 1999, In: NeuroToxicology. 20, p. 455-466 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• The redox pathway of S-nitrosoglutathione, glutathione and nitric oxide in cell to neuron communications

  Chiueh, C. C. & Rauhala, P., 1999, In: Free Radical Research. 31, p. 641-650 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• 1998

  Apparent role of hydroxyl radicals in oxidative brain injury induced by sodium nitroprusside

  Rauhala, P., Khaldi, A., Mohanakumar, K. P. & Chiueh, C. C., 1998, In: Free Radical Biology & Medicine. 24, p. 1065-1073 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Free radicals and MPTP-induced selective destruction of substantia nigra compacta neurons

  Chiueh, C. & Rauhala, P., 1998, In: Advances in Pharmacology. p. 796-800

  Research output: Contribution to journal › Article › Scientific › peer-review

• Manganese: a transition metal protects nigrostriatal neurons from oxidative stress in the iron-induced animal model of parkinsonism

  Sziraki, I., Mohanakumar, K., Rauhala, P., Kim, H., Yeh, K. & Chiueh, C., 1998, In: Neuroscience. 85, p. 1101-1111

  Research output: Contribution to journal › Article › Scientific › peer-review

• Neuroprotection by S-nitrosoglutathione of brain dopamine neurons from oxidative stress

  Rauhala, P., Lin, A. M. Y. & Chiueh, C. C., 1998, In: FASEB Journal. 12, p. 165-173 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review