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Publications 1982 2019

2019

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

Ahluwalia, T. S., Schulz, C-A., Waage, J., Skaaby, T., Sandholm, N., van Zuydam, N., Charmet, R., Bork-Jensen, J., Almgren, P., Thuesen, B. H., Bedin, M., Brandslund, I., Christensen, C. K., Linneberg, A., Ahlqvist, E., Groop, P-H., Hadjadj, S., Tregouet, D-A., Jorgensen, M. E., Grarup, N. & 9 othersPedersen, O., Simons, M., Groop, L., Orho-Melander, M., McCarthy, M. I., Melander, O., Rossing, P., Kilpeläinen, T. O. & Hansen, T., Feb 2019, In : Diabetologia. 62, 2, p. 292-305 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes

Thorn, L. M., Shams, S., Gordin, D., Liebkind, R., Forsblom, C., Summanen, P., Hägg-Holmberg, S., Tatlisumak, T., Salonen, O., Putaala, J., Martola, J. & Groop, P-H., 1 Feb 2019, In : Diabetes Care. 42, 2, p. 327-330 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Cumulative Risk of End-Stage Renal Disease Among Patients With Type 2 Diabetes: A Nationwide Inception Cohort Study

Finne, P., Groop, P-H., Arffman, M., Kervinen, M., Helve, J., Gronhagen-Riska, C. & Sund, R., Apr 2019, In : Diabetes Care. 42, 4, p. 539-544 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Dietary intake in type 1 diabetes at different stages of diabetic kidney disease

Ahola, A. J., Forsblom, C., Harjutsalo, V. & Groop, P-H., 1 Jul 2019, In : Diabetes Research and Clinical Practice.

Research output: Contribution to journalArticleScientificpeer-review

Genetic Determinants of Glycated Hemoglobin in Type 1 Diabetes

DCCT EDIC Res Grp, Finndiane Study Grp, Syreeni, A., Sandholm, N., Cao, J., Toppila, I., Maahs, D. M., Rewers, M. J., Snell-Bergeon, J. K., Costacou, T., Orchard, T. J., Caramori, M. L., Mauer, M., Klein, B. E. K., Klein, R., Valo, E., Parkkonen, M., Forsblom, C., Harjutsalo, V., Paterson, A. D. & 1 othersGroop, P-H., 1 Apr 2019, In : Diabetes. 68, 4, p. 858-867 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Long-term Mortality After Kidney Transplantation in a Nationwide Cohort of Patients With Type 1 Diabetes in Finland

Ortiz, F., Harjutsalo, V., Helanterä, I., Lempinen, M., Forsblom, C. & Groop, P-H., 1 Jan 2019, In : Diabetes Care. 42, 1, p. 55-61 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

Polianskyte-Prause, Z., Tolvanen, T. A., Lindfors, S., Dumont, V., Van, M., Wang, H., Dash, S. N., Berg, M., Naams, J-B., Hautala, L. C., Nisen, H., Mirtti, T., Groop, P-H., Wähälä, K., Tienari, J. & Lehtonen, S., Feb 2019, In : FASEB Journal. 33, 2, p. 2858-2869 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

Family Invest Nephropathy Diabet-E, DCCT EDIC Res Grp, Pollack, S., Groop, L., Toppila, I., Sandholm, N., Groop, P-H. & Sobrin, L., 1 Feb 2019, In : Diabetes. 68, 2, p. 441-456 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Physical Activity in the Prevention of Development and Progression of Kidney Disease in Type 1 Diabetes

Barlovic, D. P., Tikkanen-Dolenc, H. & Groop, P-H., Jul 2019, In : Current diabetes reports.. 19, 7, 8 p., 41.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Soluble receptor for AGE in diabetic nephropathy and its progression in Finnish individuals with type 1 diabetes

Finndiane Study Grp, Waden, J. M., Dahlström, E. H., Elonen, N., Thorn, L. M., Waden, J., Sandholm, N., Forsblom, C. & Groop, P-H., Jul 2019, In : Diabetologia. 62, 7, p. 1268-1274 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The role of blood pressure in risk of ischemic and hemorrhagic stroke in type 1 diabetes

Hägg-Holmberg, S., Dahlström, E. H., Forsblom, C., Harjutsalo, V., Liebkind, R., Putaala, J., Tatlisumak, T., Groop, P-H. & Thorn, L., 2019, In : Cardiovascular Diabetology. 18, 88

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Variations in Risk of End-Stage Renal Disease and Risk of Mortality in an International Study of Patients With Type 1 Diabetes and Advanced Nephropathy

Skupien, J., Smiles, A. M., Valo, E., Ahluwalia, T. S., Gyorgy, B., Sandholm, N., Croall, S., Lajer, M., McDonnell, K., Forsblom, C., Harjutsalo, V., Marre, M., Galecki, A. T., Tregouet, D-A., Wu, C. Y., Mychaleckyj, J. C., Nickerson, H., Pragnell, M., Rich, S. S., Pezzolesi, M. G. & 4 othersHadjadj, S., Rossing, P., Groop, P-H. & Krolewski, A. S., 1 Jan 2019, In : Diabetes Care. 42, 1, p. 93-101 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Adherence to special diets and its association with meeting the nutrient recommendations in individuals with type 1 diabetes

Ahola, A. J., Forsblom, C. & Groop, P-H., Aug 2018, In : Acta Diabetologica. 55, 8, p. 843-851 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

van Zuydam, N. R., Ahlqvist, E., Sandholm, N., Deshmukh, H., Rayner, N. W., Abdalla, M., Ladenvall, C., Ziemek, D., Fauman, E., Robertson, N. R., McKeigue, P. M., Valo, E., Forsblom, C., Harjutsalo, V., Perna, A., Rurali, E., Marcovecchio, M. L., Igo, R. P., Salem, R. M., Perico, N. & 30 othersLajer, M., Karajamak, A., Imamura, M., Kubo, M., Takahashi, A., Sim, X., Liu, J., van Dam, R. M., Jiang, G., Tam, C. H. T., Luk, A. O. Y., Lee, H. M., Lim, C. K. P., Szeto, C. C., So, W. Y., Chan, J. C. N., Ang, S. F., Dorajoo, R., Wang, L., Clara, T. S. H., McKnight, A-J., Duffy, S., Pezzolesi, M. G., Marre, M., Gyorgy, B., Hadjadj, S., Hiraki, L. T., Tuomi, T., Groop, P-H. & Groop, L. C., Jul 2018, In : Diabetes. 67, 7, p. 1414-1427 14 p.

Research output: Contribution to journalArticleScientificpeer-review

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A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes

Surrogate Markers Micro-Macro-Vasc, Nov 2018, In : Acta Ophthalmologica. 96, 7, p. E811-E819 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Ambulatory blood pressure and arterial stiffness in individuals with type 1 diabetes

Finndiane Study Grp, Sep 2018, In : Diabetologia. 61, 9, p. 1935-1945 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Association between depressive symptoms and dietary intake in patients with type 1 diabetes

Ahola, A. J., Forsblom, C. & Groop, P-H., May 2018, In : Diabetes Research and Clinical Practice. 139, p. 91-99 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Association between diet and measures of arterial stiffness in type 1 diabetes - Focus on dietary patterns and macronutrient substitutions

Finndiane Study Grp, Nov 2018, In : Nutrition, Metabolism and Cardiovascular Diseases. 28, 11, p. 1166-1172 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Association between habitual coffee consumption and metabolic syndrome in type 1 diabetes

Finndiane Study Grp, May 2018, In : Nutrition, Metabolism and Cardiovascular Diseases. 28, 5, p. 470-476 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Cardiovascular autonomic function after simultaneous pancreas-kidney and kidney-alone transplantation in patients with diabetes

Paajanen, H., Bordino, M., Sandelin, A., Ekstrand, A., Lempinen, M., Forsblom, C., Bernardi, L. & Groop, P-H., 2018, (Accepted/In press) In : Diabetes Care. 1 p.

Research output: Contribution to journalMeeting AbstractResearch

Confirmation of GLRA3 as a susceptibility locus for albuminuria in Finnish patients with type 1 diabetes

Sandholm, N., Haukka, J. K., Toppila, I., Valo, E., Harjutsalo, V., Forsblom, C. & Groop, P-H., 17 Aug 2018, In : Scientific Reports. 8, 8 p., 12408.

Research output: Contribution to journalArticleScientificpeer-review

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Diabetes and intracerebral hemorrhage: Baseline characteristics and mortality

Liebkind, R., Gordin, D., Strbian, D., Meretoja, A., Thorn, L. M., Hägg-Holmberg, S., Forsblom, C., Tatlisumak, T., Groop, P-H. & Putaala, J., 2018, In : European Journal of Neurology. 25, 6, p. 825-832 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Differential Association of Microvascular Attributions With Cardiovascular Disease in Patients With Long Duration of Type 1 Diabetes

Gordin, D., Harjutsalo, V., Tinsley, L., Fickweiler, W., Sun, J. K., Forsblom, C., Amenta, P. S., Pober, D., D'Eon, S., Khatri, M., Stillman, I. E., Groop, P-H., Keenan, H. A. & King, G. L., 1 Apr 2018, In : Diabetes Care. 41, 4, p. 815-822 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Dose-dependent effect of smoking on risk of coronary heart disease, heart failure and stroke in individuals with type 1 diabetes

Finndiane Study Grp, Dec 2018, In : Diabetologia. 61, 12, p. 2580-2589 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Electrocardiographic changes before and after successful kidney transplantation and associations with cardiovascular and mortality outcomes

Paajanen, H., Helanterä, I., Kaartinen, K., Nikus, K., Eskola, M., Groop, P-H. & Koskinen, P., May 2018, In : Clinical Transplantation. 32, 5, 9 p., 13242.

Research output: Contribution to journalArticleScientificpeer-review

Empagliflozin and Kidney Function Decline in Patients with Type 2 Diabetes: A Slope Analysis from the EMPA-REG OUTCOME Trial

EMPA-REG OUTCOME Investigators, Nov 2018, In : Journal of the American Society of Nephrology. 29, 11, p. 2755-2769 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Excess Mortality in Patients With Type 1 Diabetes Without Albuminuria-Separating the Contribution of Early and Late Risks

Finndiane Study Grp, 1 Apr 2018, In : Diabetes Care. 41, 4, p. 748-754 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic basis of diabetic kidney disease and other diabetic complications

Sandholm, N. & Groop, P-H., 2018, In : Current Opinion in Genetics & Development. 50, p. 17-24 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Metabolomic Profile Predicts Development of Microalbuminuria in Individuals with Type 1 Diabetes

Haukka, J. K., Sandholm, N., Forsblom, C., Cobb, J. E., Groop, P-H. & Ferrannini, E., 14 Sep 2018, In : Scientific Reports. 8, 10 p., 13853.

Research output: Contribution to journalArticleScientificpeer-review

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Miten diabeteksen kokonaisvaltainen hoito huomioidaan avoterveydenhuollon vastaanotolla?

Thorn, L. & Groop, P-H., 2018, In : Duodecim. 134, 22, p. 2237-2239 3 p.

Research output: Contribution to journalEditorialProfessional

Prevalence and progression of subclinical atherosclerosis in patients with chronic kidney disease and diabetes

Palanca, A., Castelblanco, E., Perpinan, H., Betriu, A., Soldevila, B., Manuel Valdivielso, J., Bermudez, M., Duran, X., Fernandez, E., Puig-Domingo, M., Groop, P-H., Alonso, N. & Mauricio, D., Sep 2018, In : Atherosclerosis. 276, p. 50-57 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Regression of albuminuria and its association with incident cardiovascular outcomes and mortality in type 1 diabetes: the FinnDiane Study

Jansson, F. J., Forsblom, C., Harjutsalo, V., Thorn, L. M., Wadén, J., Elonen, N., Ahola, A. J., Saraheimo, M., Groop, P-H. & Group, O. B. O. T. F. S., 2018, In : Diabetologia. 61, 5, p. 1203-1211 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Risk of coronary artery disease and stroke according to sex and presence of diabetic nephropathy in type 1 diabetes

Finndiane Study Grp, Dec 2018, In : Diabetes, obesity and metabolism. 20, 12, p. 2759-2767 9 p.

Research output: Contribution to journalArticleScientificpeer-review

The Association of Severe Diabetic Retinopathy With Cardiovascular Outcomes in Long-standing Type 1 Diabetes: A Longitudinal Follow-up

Finndiane Study Grp, 1 Dec 2018, In : Diabetes Care. 41, 12, p. 2487-2494 8 p.

Research output: Contribution to journalArticleScientificpeer-review

The Gut-Kidney Axis: Putative Interconnections Between Gastrointestinal and Renal Disorders

Lehto, M. & Groop, P-H., 19 Sep 2018, In : Frontiers in Endocrinology. 9, 11 p., 553.

Research output: Contribution to journalReview ArticleScientificpeer-review

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Association between adherence to dietary recommendations and high-sensitivity C-reactive protein level in type 1 diabetes

Ahola, A. J., Saraheimo, M., Freese, R., Forsblom, C., Mäkimattila, S., Groop, P-H. & FinnDiane Study Grp, Apr 2017, In : Diabetes Research and Clinical Practice. 126, p. 122-128 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Considerations on glycaemic control in older and/or frail individuals with diabetes and advanced kidney disease

Panduru, N. M., Nistor, I., Groop, P-H., Van Biesen, W., Farrington, K. & Covic, A., Apr 2017, In : Nephrology, Dialysis, Transplantation. 32, 4, p. 591-597 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Data-driven metabolic subtypes predict future adverse events in individuals with type 1 diabetes

Lithovius, R., Toppila, I., Harjutsalo, V., Forsblom, C., Groop, P-H., Makinen, V-P. & FinnDiane Study Grp, Jul 2017, In : Diabetologia. 60, 7, p. 1234-1243 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity

Ahola, A. J., Lassenius, M. I., Forsblom, C., Harjutsalo, V., Lehto, M. & Groop, P-H., 26 Jul 2017, In : Scientific Reports. 7, 9 p., 6511.

Research output: Contribution to journalArticleScientificpeer-review

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Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis

Skyler, J. S., Bakris, G. L., Bonifacio, E., Darsow, T., Eckel, R. H., Groop, L., Groop, P-H., Handelsman, Y., Insel, R. A., Mathieu, C., McElvaine, A. T., Palmer, J. P., Pugliese, A., Schatz, D. A., Sosenko, J. M., Wilding, J. P. H. & Ratner, R. E., Feb 2017, In : Diabetes. 66, 2, p. 241-255 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Frequent and intensive physical activity reduces risk of cardiovascular events in type 1 diabetes

Tikkanen-Dolenc, H., Waden, J., Forsblom, C., Harjutsalo, V., Thorn, L. M., Saraheimo, M., Elonen, N., Rosengård-Bärlund, M., Gordin, D., Tikkanen, H. O., Groop, P-H. & FinnDiane Study Grp, Mar 2017, In : Diabetologia. 60, 3, p. 574-580 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Incidence of End-Stage Renal Disease in Patients With Type 1 Diabetes

Helve, J., Sund, R., Arffman, M., Harjutsalo, V., Groop, P. H., Grönhagen-Riska, C. & Finne, P., 20 Dec 2017, In : Diabetes Care. 41, 3, 6 p., dc172364.

Research output: Contribution to journalArticleScientificpeer-review

Intestinal alkaline phosphatase at the crossroad of intestinal health and disease - a putative role in type 1 diabetes

Lassenius, M. I., Fogarty, C., Blaut, M., Haimila, K., Riittinen, L., Paju, A., Kirveskari, J., Järvelä, J., Ahola, A., Gordin, D., Härmä, M-A., Kumar, A., Hamarneh, S. R., Hodin, R. A., Sorsa, T., Tervahartiala, T., Hoerkkoe, S., Pussinen, P. J., Forsblom, C., Jauhiainen, M. & 4 othersTaskinen, M-R., Groop, P-H., Lehto, M. & FinnDiane Study Grp, Jun 2017, In : Journal of internal medicine. 281, 6, p. 586-600 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Linagliptin and its effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: the randomized MARLINA-T2D trial

Groop, P-H., Cooper, M. E., Perkovic, V., Hocher, B., Kanasaki, K., Haneda, M., Schernthaner, G., Sharma, K., Stanton, R. C., Toto, R., Cescutti, J., Gordat, M., Meinicke, T., Koitka-Weber, A., Thiemann, S. & von Eynatten, M., Nov 2017, In : Diabetes, obesity and metabolism. 19, 11, p. 1610-1619 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Oxygen-induced impairment in arterial function is corrected by slow breathing in patients with type 1 diabetes

Bernardi, L., Gordin, D., Bordino, M., Rosengard-Barlund, M., Sandelin, A., Forsblom, C. & Groop, P-H., 20 Jul 2017, In : Scientific Reports. 7, 8 p., 6001.

Research output: Contribution to journalArticleScientificpeer-review

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Physical Activity Reduces Risk of Premature Mortality in Patients With Type 1 Diabetes With and Without Kidney Disease

Tikkanen-Dolenc, H., Waden, J., Forsblom, C., Harjutsalo, V., Thorn, L. M., Saraheimo, M., Elonen, N., Tikkanen, H. O., Groop, P-H. & FinnDiane Study Grp, 1 Dec 2017, In : Diabetes Care. 40, 12, p. 1727-1732 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease

Mardinoglu, A., Stancakova, A., Lotta, L. A., Kuusisto, J., Boren, J., Bluher, M., Wareham, N. J., Ferrannini, E., Groop, P. H., Laakso, M., Langenberg, C. & Smith, U., 1 Aug 2017, In : Cell Metabolism. 26, 2, p. 281-283 3 p.

Research output: Contribution to journalArticleScientific

Open Access
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Prognosis and Its Predictors After Incident Stroke in Patients With Type 1 Diabetes

Hagg-Holmberg, S., Thorn, L. M., Forsblom, C. M., Gordin, D., Elonen, N., Harjutsalo, V., Liebkind, R., Putaala, J., Tatlisumak, T., Groop, P-H. & FinnDiane Study Grp, 1 Oct 2017, In : Diabetes Care. 40, 10, p. 1394-1400 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access