No photo of Pertti Neuvonen
  • Finland

  • PL 20 (Tukholmankatu 8 C)

    HELSINGIN YLIOPISTO

    Finland

1984 …2019
If you made any changes in Pure these will be visible here soon.

Publications 1984 2019

Filter
Article
2019
Open Access
File
Open Access
File

CYP3A4*22 Impairs the Elimination of Ticagrelor, But Has No Significant Effect on the Bioactivation of Clopidogrel or Prasugrel

Holmberg, M. T., Tornio, A., Paile-Hyvärinen, M., Tarkiainen, E. K., Neuvonen, M., Neuvonen, P. J., Backman, J. T. & Niemi, M., Feb 2019, In : Clinical Pharmacology and Therapeutics. 105, 2, p. 448-457 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Withdrawal from long-term use of zopiclone, zolpidem and temazepam may improve perceived sleep and quality of life in older adults with primary insomnia

Lähteenmäki, R., Neuvonen, P. J., Puustinen, J., Vahlberg, T., Partinen, M., Räihä, I. & Kivelä, S-L., Mar 2019, In : Basic & Clinical Pharmacology & Toxicology. 124, 3, p. 330-340 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

Analgesic Plasma Concentrations of Oxycodone After Surgery for Breast CancerWhich Factors Matter?

Cajanus, K., Neuvonen, M., Koskela, O., Kaunisto, M. A., Neuvonen, P. J., Niemi, M. & Kalso, E., Apr 2018, In : Clinical Pharmacology and Therapeutics. 103, 4, p. 653-662 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans.

Itkonen, M. K., Tornio, A., Filppula, A. M., Neuvonen, M., Neuvonen, P. J., Niemi, M. & Backman, J. T., Sep 2018, In : Clinical Pharmacology and Therapeutics. 104, 3, p. 495-504 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions

Kahma, H., Filppula, A. M., Neuvonen, M., Tarkiainen, E. K., Tornio, A., Holmberg, M. T., Itkonen, M. K., Finel, M., Neuvonen, P. J., Niemi, M. & Backman, J. T., 1 Feb 2018, In : Drug Metabolism and Disposition. 46, 2, p. 141-150 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects

Neuvonen, M., Tarkiainen, E. K., Tornio, A., Hirvensalo, P., Tapaninen, T., Paile-Hyvärinen, M., Itkonen, M. K., Holmberg, M. T., Karja, V., Männistö, V. T., Neuvonen, P. J., Pihlajamäki, J., Backman, J. T. & Niemi, M., Mar 2018, In : Basic & Clinical Pharmacology & Toxicology. 122, 3, p. 341-345 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Long-term persistence of withdrawal of temazepam, zopiclone, and zolpidem in older adults: a 3-year follow-up study

Puustinen, J., Lähteenmäki, R., Nurminen, J., Vahlberg, T., Aarnio, P., Partinen, M., Räihä, I., Neuvonen, P. J. & Kivelä, S-L., 15 Jun 2018, In : BMC Geriatrics. 18, 9 p., 142.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Semimechanistic Population Pharmacokinetic Model to Predict the Drug-Drug Interaction Between S-ketamine and Ticlopidine in Healthy Human Volunteers

Ashraf, M. W., Peltoniemi, M. A., Olkkola, K. T., Neuvonen, P. J. & Saari, T. I., Oct 2018, In : CPT : Pharmacometrics & Systems Pharmacology. 7, 10, p. 687-697 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Voriconazole greatly increases the exposure to oral buprenorphine

Fihlman, M., Hemmilä, T., Hagelberg, N. M., Backman, J. T., Laitila, J., Laine, K., Neuvonen, P. J., Olkkola, K. T. & Saari, T. I., Dec 2018, In : European Journal of Clinical Pharmacology. 74, 12, p. 1615-1622 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2017

Kuinka kliinisen farmakologian tutkimus ja edistysaskeleet ovat jalkautuneet käytäntöön ja mitä haasteita on ratkaistavana lähitulevaisuudessa?

Neuvonen, P. J., 2017, In : Dosis. 33, 4, p. 232-247 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Open Access
File
2016

Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone

Itkonen, M. K., Tornio, A., Neuvonen, M., Neuvonen, P. J., Niemi, M. & Backman, J. T., Aug 2016, In : Drug Metabolism and Disposition. 44, 8, p. 1364-1371 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Lääkkeiden aiheuttamat kuolemantapaukset ovat vähentyneet yliopistosairaalassa

Lapatto-Reiniluoto, O., Niemi, M., Backman, J. & Neuvonen, P. J., 2016, In : Suomen lääkärilehti. 71, 5, p. 295-301 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipid Rescue - Efficacy and Safety Still Unproven

Hojer, J., Jacobsen, D., Neuvonen, P. J. & Rosenberg, P. H., Oct 2016, In : Basic & Clinical Pharmacology & Toxicology. 119, 4, p. 345-348 4 p.

Research output: Contribution to journalArticleScientific

Open Access

Rifampicin decreases exposure to sublingual buprenorphine in healthy subjects

Hagelberg, N. M., Fihlman, M., Hemmilä, T., Backman, J. T., Laitila, J., Neuvonen, P., Laine, K., Olkkola, K. & Saari, T., 2016, In : Pharmacology Research & Perspectives. 4, 6, 10 p., e00271.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Unilääkevieroituksesta saatiin hyviä tuloksia Satauni-projektissa

Puustinen, J., Lähteenmäki, R., Neuvonen, P. J. & Kivelä, S-L., 2016, In : Suomen lääkärilehti. 71, 18, p. 1324-1325 2 p.

Research output: Contribution to journalArticleProfessional

Open Access
File

Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction

Fihlman, M., Hemmila, T., Hagelberg, N. M., Kuusniemi, K., Backman, J. T., Laitila, J., Laine, K., Neuvonen, P. J., Olkkola, K. T. & Saari, T. I., Nov 2016, In : European Journal of Clinical Pharmacology. 72, 11, p. 1363-1371 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2015

Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans

Tarkiainen, E. K., Holmberg, M. T., Tornio, A., Neuvonen, M., Neuvonen, P. J., Backman, J. T. & Niemi, M., Jun 2015, In : Clinical Pharmacology and Therapeutics. 97, 6, p. 650-658 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Drug-related inadvertent deaths in a university hospital - a declining trend

Lapatto-Reiniluoto, O., Patinen, L., Niemi, M., Backman, J. T. & Neuvonen, P. J., 2015, In : Basic & Clinical Pharmacology & Toxicology. 117, 6, p. 421-426 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril

Tarkiainen, E. K., Tornio, A., Holmberg, M. T., Launiainen, T., Neuvonen, P. J., Backman, J. T. & Niemi, M., Nov 2015, In : British Journal of Clinical Pharmacology. 80, 5, p. 1131-1138 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of grapefruit juice on the bioactivation of prasugrel

Holmberg, M. T., Tornio, A., Hyvarinen, H., Neuvonen, M., Neuvonen, P. J., Backman, J. T. & Niemi, M., Jul 2015, In : British Journal of Clinical Pharmacology. 80, 1, p. 139-145 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol

Saarikoski, T., Saari, T. I., Hagelberg, N. M., Backman, J. T., Neuvonen, P. J., Scheinin, M., Olkkola, K. T. & Laine, K., Mar 2015, In : European Journal of Clinical Pharmacology. 71, 3, p. 321-327 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Karboksyyliesteraasin geenimuutos tehostaa klopidogreelin vaikutuksia

Tarkiainen, E. K., Holmberg, M. T., Tornio, A., Neuvonen, M., Neuvonen, P., Backman, J. & Niemi, M., 4 May 2015, In : Duodecim. 131, 9, p. 881 1 p.

Research output: Contribution to journalArticleScientific

SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid

Tornio, A., Vakkilainen, J., Neuvonen, M., Backman, J. T., Neuvonen, P. J. & Niemi, M., Aug 2015, In : Pharmacogenetics and Genomics. 25, 8, p. 382-387 6 p.

Research output: Contribution to journalArticleScientificpeer-review

The role of concentration-effect relationships in the QT(c) interval prolongation: case sotalol

Neuvonen, P. J. & Elonen, E., Jun 2015, In : British Journal of Clinical Pharmacology. 79, 6, p. 1040-1041 2 p.

Research output: Contribution to journalArticleScientific

2014

Effect of timing and route of methylprednisolone administration during pediatric cardiac surgical procedures

Keski-Nisula, J., Suominen, P. K., Olkkola, K., Peltola, K., Neuvonen, P., Tynkkynen, P., Salminen, J., Andersson, S. & Pesonen, E., 18 Nov 2014, In : Annals of Thoracic Surgery. 2015 / 99, 1, p. 180-185 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults

Puustinen, J., Lahteenmaki, R., Polo-Kantola, P., Salo, P., Vahlberg, T., Lyles, C. A., Neuvonen, P. J., Partinen, M., Raiha, I. & Kivelä, S-L., Mar 2014, In : European Journal of Clinical Pharmacology. 70, 3, p. 319-329 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug-Drug Interactions

Tornio, A., Filppula, A. M., Kailari, O., Neuvonen, M., Nyrönen, T. H., Tapaninen, T., Neuvonen, P. J., Niemi, M. & Backman, J. T., Oct 2014, In : Clinical Pharmacology and Therapeutics. 96, 4, p. 498-507 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Grapefruit Juice Inhibits the Metabolic Activation of Clopidogrel

Holmberg, M. T., Tornio, A., Neuvonen, M. S., Neuvonen, P. J., Backman, J. T. & Niemi, M., Mar 2014, In : Clinical Pharmacology and Therapeutics. 95, 3, p. 307-313 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Handgrip strength and balance in older adults following withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotics

Nurminen, J., Puustinen, J., Lahteenmaki, R., Vahlberg, T., Lyles, A., Partinen, M., Raiha, I., Neuvonen, P. J. & Kivelä, S-L., 21 Nov 2014, In : BMC Geriatrics. 14, 10 p., 121.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Infections and possible vaccine-drug interactions

Raaska, K. & Neuvonen, P. J., Jul 2014, In : European Journal of Clinical Pharmacology. 70, 7, p. 889-890 2 p.

Research output: Contribution to journalArticleScientific

Melatonin for sedative withdrawal in older patients with primary insomnia: a randomized double-blind placebo-controlled trial

Lahteenmaki, R., Puustinen, J., Vahlberg, T., Lyles, A., Neuvonen, P. J., Partinen, M., Raiha, I. & Kivelä, S-L., Jun 2014, In : British Journal of Clinical Pharmacology. 77, 6, p. 975-985 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Paroxetine Markedly Increases Plasma Concentrations of Ophthalmic Timolol; CYP2D6 Inhibitors May Increase the Risk of Cardiovascular Adverse Effects of 0.5% Timolol Eye Drops

Maenpaa, J., Volotinen-Maja, M., Kautiainen, H., Neuvonen, M., Niemi, M., Neuvonen, P. J. & Backman, J. T., Dec 2014, In : Drug Metabolism and Disposition. 42, 12, p. 2068-2076 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Tietämys lääkeyhteisvaikutuksista on lisääntynyt huikeasti

Neuvonen, P. J., 2014, In : Sic! Lääketietoa Fimeasta. 4, 2

Research output: Contribution to journalArticleProfessional

2013

A randomized clinical trial of histamine 2 receptor antagonism in treatment-resistant schizophrenia

Meskanen, K., Ekelund, H., Laitinen, J., Neuvonen, P., Haukka, J., Panula, P. & Ekelund, J., 2013, In : Journal of Clinical Psychopharmacology. 33, 4, p. 472-478 7 p.

Research output: Contribution to journalArticleScientificpeer-review

A Semiphysiological Population Pharmacokinetic Model for Dynamic Inhibition of Liver and Gut Wall Cytochrome P450 3A by Voriconazole

Frechen, S., Junge, L., Saari, T. I., Suleiman, A. A., Rokitta, D., Neuvonen, P. J., Olkkola, K. T. & Fuhr, U., Sep 2013, In : Clinical Pharmacokinetics. 52, 9, p. 763-781 19 p.

Research output: Contribution to journalArticleScientificpeer-review

Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects

Holmberg, M. T., Tornio, A., Joutsi-Korhonen, L., Neuvonen, M., Neuvonen, P. J., Lassila, R., Niemi, M. & Backman, J. T., Jun 2013, In : British Journal of Clinical Pharmacology. 75, 6, p. 1488-1496 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Intravenous Lipid Emulsion Entraps Amitriptyline into Plasma and Can Lower its Brain Concentration - An Experimental Intoxication Study in Pigs

Heinonen, J. A., Litonius, E., Backman, J. T., Neuvonen, P. J. & Rosenberg, P. H., Sep 2013, In : Basic & Clinical Pharmacology & Toxicology. 113, 3, p. 193-200 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Methylprednisolone in Neonatal Cardiac Surgery: Reduced Inflammation Without Improved Clinical Outcome

Keski-Nisula, J., Pesonen, E., Olkkola, K. T., Peltola, K., Neuvonen, P. J., Tuominen, N., Sairanen, H., Andersson, S. & Suominen, P. K., Jun 2013, In : Annals of Thoracic Surgery. 95, 6, p. 2126-2132 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Rifampicin markedly decreases the exposure to oral and intravenous tramadol

Saarikoski, T., Saari, T. I., Hagelberg, N. M., Neuvonen, M., Neuvonen, P. J., Scheinin, M., Olkkola, K. T. & Laine, K., Jun 2013, In : European Journal of Clinical Pharmacology. 69, 6, p. 1293-1301 9 p.

Research output: Contribution to journalArticleScientificpeer-review

SLCO2B1 c.935G > A single nucleotide polymorphism has no effect on the pharmacokinetics of montelukast and aliskiren

Tapaninen, T., Karonen, T., Backman, J. T., Neuvonen, P. J. & Niemi, M., Jan 2013, In : Pharmacogenetics and Genomics. 23, 1, p. 19-24 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction

Hagelberg, N. M., Saarikoski, T., Saari, T. I., Neuvonen, M., Neuvonen, P. J., Turpeinen, M., Scheinin, M., Laine, K. & Olkkola, K. T., Apr 2013, In : European Journal of Clinical Pharmacology. 69, 4, p. 867-875 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification

Krauss, M., Burghaus, R., Lippert, J., Niemi, M., Neuvonen, P., Schuppert, A., Willmann, S., Kuepfer, L. & Görlitz, L., 16 Apr 2013, In : In Silico Pharmacology. 1, 6, 11 p.

Research output: Contribution to journalArticleScientificpeer-review