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Publications 2010 2019

2019

Immunological monitoring of newly diagnosed CML patients treated with bosutinib or imatinib first-line

Kreutzman, A., Yadav, B., Brummendorf, T. H., Gjertsen, B. T., Hee, M. L., Janssen, J., Kasanen, T., Koskenvesa, P., Lotfi, K., Markevärn, B., Olsson-Stromberg, U., Stentoft, J., Stenke, L., Söderlund, S., Udby, L., Richter, J., Hjörth-Hansen, H. & Mustjoki, S., 2 Sep 2019, In : OncoImmunology. 8, 9, 13 p., e1638210.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Discontinuation of tyrosine kinase inhibitor therapy in chronic myeloid leukaemia (EURO-SKI): a prespecified interim analysis of a prospective, multicentre, non-randomised, trial

EURO-SKI Investigators, Jun 2018, In : Lancet Oncology. 19, 6, p. 747-757 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML

Bruck, O., Blom, S., Dufva, O., Turkki, R., Chheda, H., Ribeiro, A., Kovanen, P., Aittokallio, T., Koskenvesa, P., Kallioniemi, O., Porkka, K., Pellinen, T. & Mustjoki, S., Jul 2018, In : Leukemia. 32, 7, p. 1643-1656 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

CHRONIC MYELOID LEUKEMIA PATIENTS WERE NOT DIFFERENT IN MOLECULAR RELAPSE AFTER STOPPING IMATINIB IN MR4 WHETHER RESIDUAL DISEASE WAS DETECTED OR NOT - WHEN ADJUSTING FOR NUMBER OF CONTROL TRANSCRIPTS

Pfirrmann, M., Mahon, F-X., Guilhot, J., Richter, J., Almeida, A., Janssen, J. J., Mayer, J., Koskenvesa, P., Panayiotidis, P., Olsson-Stromberg, U., Berger, M. G., Diamond, J., Ehrencrona, H., Kairisto, V., Polakova, K. M., Mueller, M. C., Mustjoki, S., Hochhaus, A., Saussele, S. & Hjorth-Hansen, H., 26 Jun 2017, In : Haematologica. 102, p. 153-153 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Impact of age on efficacy and toxicity of nilotinib in patients with chronic myeloid leukemia in chronic phase: ENEST1st subanalysis

Giles, F. J., Rea, D., Rosti, G., Cross, N. C. P., Luis Steegmann, J., Griskevicius, L., le Coutre, P., Coriu, D., Petrov, L., Ossenkoppele, G. J., Mahon, F-X., Saussele, S., Hellmann, A., Koskenvesa, P., Bruemmendorf, T. H., Gastl, G., Castagnetti, F., Vincenzi, B., Haenig, J. & Hochhaus, A., Aug 2017, In : Journal of Cancer Research and Clinical Oncology. 143, 8, p. 1585-1596 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia

Ilander, M., Olsson-Stromberg, U., Schlums, H., Guilhot, J., Bruck, O., Lahteenmaki, H., Kasanen, T., Koskenvesa, P., Soderlund, S., Hoglund, M., Markevarn, B., Sjalander, A., Lotfi, K., Dreimane, A., Lubking, A., Holm, E., Bjoreman, M., Lehmann, S., Stenke, L., Ohm, L. & 11 othersGedde-Dahl, T., Majeed, W., Ehrencrona, H., Koskela, S., Saussele, S., Mahon, F-X., Porkka, K., Hjorth-Hansen, H., Bryceson, Y. T., Richter, J. & Mustjoki, S., May 2017, In : Leukemia. 31, 5, p. 1108-1116 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Krooninen myelooinen leukemia (KML)

Koskenvesa, P., 2017, Lääkärin käsikirja. Jousimaa, J., Alenius, H., Atula, S., Berghem, N., Kattainen, A., Kunnamo, I., Pelttari, H. & Teikari, M. (eds.). 12. uud. p. ed. Helsinki: Duodecim, p. 691-692 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Treatment and outcome of 2904 CML patients from the EUTOS population-based registry

Hoffmann, V. S., Baccarani, M., Hasford, J., Castagnetti, F., Di Raimondo, F., Casado, L. F., Turkina, A., Zackova, D., Ossenkoppele, G., Zaritskey, A., Hoglund, M., Simonsson, B., Indrak, K., Sninska, Z., Sacha, T., Clark, R., Bogdanovic, A., Hellmann, A., Griskevicius, L., Schubert-Fritschle, G. & 13 othersSertic, D., Guilhot, J., Lejniece, S., Zupan, I., Burgstaller, S., Koskenvesa, P. M., Everaus, H., Costeas, P., Lindoerfer, D., Rosti, G., Saussele, S., Hochhaus, A. & Hehlmann, R., Mar 2017, In : Leukemia. 31, 3, p. 593-601 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Tyrosine kinase inhibitor therapy-induced changes in humoral immunity in patients with chronic myeloid leukemia

Koskela, H. L. M., El Missiry, M., Ruusila, A., Koskenvesa, P., Bruemmendorf, T. H., Gjertsen, B. T., Janssen, J., Lotfi, K., Markevarn, B., Olsson-Stromberg, U., Stenke, L., Stentoft, J., Richter, J., Hjorth-Hansen, H., Kreutzman, A. & Mustjoki, S., Aug 2017, In : Journal of Cancer Research and Clinical Oncology. 143, 8, p. 1543-1554 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

CML Patients with Primary Resistance or Suboptimal Response to TKI Therapy Have Variants in Genes Affecting Drug Absorption and Metabolism

Pietarinen, P., Koskenvesa, P., Klievink, J., Porkka, K., Niemi, M. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 4 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Early MRD-Negativity May Predict for Favorable Outcome Irrespective of Allotransplantation in TKI-Treated Patients with Ph-Positive Acute Lymphoblastic Leukemia

Hohtari, H., Sinisalo, M., Nousiainen, T., Koskenvesa, P., Wartiovaara-Kautto, U., Mustjoki, S., Koistinen, P., Saeily, M., Itaelae-Remes, M., Elonen, E., Remes, K. & Porkka, K., 2 Dec 2016, In : Blood. 128, 22, 5 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Effects of Dasatinib and Interferon-alpha Combination Treatment on the Immune System in CML

Ilander, M., Lahteenmaki, H., Olsson-Stromberg, U., Stentoft, J., Richter, J., Koskenvesa, P., Hoglund, M., Dreimane, A., Porkka, K., Gedde-Dahl, T., Gjertsen, B. T., Gruber, F. X., Stenke, L., Myhr-Eriksson, K., Markevarn, B., Lubking, A., Vestergaard, H., Udby, L., Bjerrum, O. W., Hjorth-Hansen, H. & 1 othersMustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 5 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Immunological Monitoring of CML Patients during First-Line Bosutinib and Imatinib Treatment

Kreutzman, A., Koskenvesa, P., Tiina, K., Olsson-Stromberg, U., Stentoft, J., Stenke, L., Udby, L., Gjertsen, B. T., Lotfi, K., Markevan, B., Janssen, J., Brummendorf, T., Richter, J., Hjorth-Hansen, H. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 5 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Safety and efficacy of the combination of pegylated interferon-alpha 2b and dasatinib in newly diagnosed chronic-phase chronic myeloid leukemia patients

Hjorth-Hansen, H., Stentoft, J., Richter, J., Koskenvesa, P., Hoeglund, M., Dreimane, A., Porkka, K., Gedde-Dahl, T., Gjertsen, B. T., Gruber, F. X., Stenke, L., Eriksson, K. M., Markevarn, B., Lubking, A., Vestergaard, H., Udby, L., Bjerrum, O. W., Persson, I., Mustjoki, S., Olsson-Stromberg, U. & 1 othersNCMLSG, Sep 2016, In : Leukemia. 30, 9, p. 1853-1860 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: clinical results from a randomised phase-2 study (NordCML006)

Hjorth-Hansen, H., Stenke, L., Soderlund, S., Dreimane, A., Ehrencrona, H., Gedde-Dahl, T., Gjertsen, B. T., Hoglund, M., Koskenvesa, P., Lotfi, K., Majeed, W., Markevarn, B., Ohm, L., Olsson-Stromberg, U., Remes, K., Suominen, M., Simonsson, B., Porkka, K., Mustjoki, S., Richter, J. & 1 othersNCMLSG, Mar 2015, In : European Journal of Haematology. 94, 3, p. 243-250 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Kamalan kallista on vain huono hoito

Koskenvesa, P., 2015, In : Sic! Lääketietoa Fimeasta. 5, 3, p. 24-26 3 p.

Research output: Contribution to journalArticleProfessional

Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing

Pietarinen, P. O., Pemovska, T., Kontro, M., Yadav, B., Mpindi, J. P., Andersson, E. I., Majumder, M. M., Kuusanmaki, H., Koskenvesa, P., Kallioniemi, O., Wennerberg, K., Heckman, C. A., Mustjoki, S. & Porkka, K., May 2015, In : Blood cancer journal. 5, 6 p., 309.

Research output: Contribution to journalArticleScientificpeer-review

The EUTOS population-based registry: incidence and clinical characteristics of 2904 CML patients in 20 European Countries

Hoffmann, V. S., Baccarani, M., Hasford, J., Lindoerfer, D., Burgstaller, S., Sertic, D., Costeas, P., Mayer, J., Indrak, K., Everaus, H., Koskenvesa, P., Guilhot, J., Schubert-Fritschle, G., Castagnetti, F., Di Raimondo, F., Lejniece, S., Griskevicius, L., Thielen, N., Sacha, T., Hellmann, A. & 11 othersTurkina, A. G., Zaritskey, A., Bogdanovic, A., Sninska, Z., Zupan, I., Steegmann, J-L., Simonsson, B., Clark, R. E., Covelli, A., Guidi, G. & Hehlmann, R., Jun 2015, In : Leukemia. 29, 6, p. 1336-1343 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Chronic myeloid leukemia patients' adherence to peroral tyrosine kinase inhibitors compared with adherence as estimated by their physicians

Kekale, M., Talvensaari, K., Koskenvesa, P., Porkka, K. & Airaksinen, M., 2014, In : Patient preference and adherence. 8, p. 1619-1627 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Imatinib and pegylated IFN-alpha 2b discontinuation in first-line chronic myeloid leukemia patients following a major molecular response

Koskenvesa, P., Kreutzman, A., Rohon, P., Pihlman, M., Vakkila, E., Rasanen, A., Vapaatalo, M., Remes, K., Lundan, T., Hjorth-Hansen, H., Vakkila, J., Simonsson, B., Mustjoki, S. & Porkka, K., May 2014, In : European Journal of Haematology. 92, 5, p. 413-420 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients

Mustjoki, S., Richter, J., Barbany, G., Ehrencrona, H., Fioretos, T., Gedde-Dahl, T., Gjertsen, B. T., Hovland, R., Hernesniemi, S., Josefsen, D., Koskenvesa, P., Dybedal, I., Markevarn, B., Olofsson, T., Olsson-Stromberg, U., Rapakko, K., Thunberg, S., Stenke, L., Simonsson, B., Porkka, K. & 2 othersHjorth-Hansen, H. & Nordic CML Study Grp, Jul 2013, In : Leukemia. 27, 7, p. 1520-1526 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Kroonisen myelooisen leukemian nykyhoito

Koskela, H., Koskenvesa, P., Mustjoki, S. & Porkka, K., 2012, In : Duodecim. 128, 6, p. 579-588 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2011

Combination of pegylated IFN-alpha 2b with imatinib increases molecular response rates in patients with low- or intermediate-risk chronic myeloid leukemia

Simonsson, B., Gedde-Dahl, T., Markevarn, B., Remes, K., Stentoft, J., Almqvist, A., Bjoreman, M., Flogegard, M., Koskenvesa, P., Lindblom, A., Malm, C., Mustjoki, S., Myhr-Eriksson, K., Ohm, L., Rasanen, A., Sinisalo, M., Sjalander, A., Stromberg, U., Bjerrum, O. W., Ehrencrona, H. & 9 othersGruber, F., Kairisto, V., Olsson, K., Sandin, F., Nagler, A., Nielsen, J. L., Hjorth-Hansen, H., Porkka, K. & Nordic CML Study Grp, 2011, In : Blood. 118, 12, p. 3228-3235 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

The Proportion of Ph+CD34(+)CD38(neg) Leukemic Stem Cells In the Bone Marrow of Newly Diagnosed Patients with Chronic Myeloid Leukemia (CML) In Chronic Phase (CP) Is Variable and Correlates with High Sokal Risk, High Leukocyte Count, Low Hemoglobin Concentration, Splenomegaly and Increased Hematological Toxicity During Initial TKI-Therapy. Data From a Randomized Phase II NordCML006 Study

Mustjoki, S., Richter, J., Barbany, G., Dybedal, I., Fioretos, T., Gedde-Dahl, T., Gjertsen, B. T., Hovland, R., Jalkanen, S., Josefsen, D., Koskenvesa, P., Lassen, C., Latvala, K., Majeed, W., Malm, C., Markevarn, B., Moshfegh, A., Ohm, L., Olofsson, T., Olsson-Stromberg, U. & 10 othersRapakko, K., Remes, K., Stentoft, J., Stenke, L., Suominen, M., Thunberg, S., Bjerrum, O. W., Simonsson, B., Porkka, K. & Hjorth-Hansen, H., 2010, In : Blood. 116, p. 291-292 2 p.

Research output: Contribution to journalConference articleScientificpeer-review