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Petri T Kovanen

1987 …2019
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Publications 1987 2019

2019

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

Back, M., Yurdagul, A., Tabas, I., Oorni, K. & Kovanen, P. T., Jul 2019, In : Nature reviews. Cardiology. 16, 7, p. 389-406 18 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Lipoprotein(a) as a risk factor for calcific aortic valvulopathy in heterozygous familial hypercholesterolemia

Vuorio, A., Watts, G. F. & Kovanen, P. T., Feb 2019, In : Atherosclerosis. 281, p. 25-30 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2018

Decreasing the Cholesterol Burden in Heterozygous Familial Hypercholesterolemia Children by Dietary Plant Stanol Esters

Vuorio, A. & Kovanen, P. T., Dec 2018, In : Nutrients. 10, 12, 10 p., 1842.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties

Lehti, S., Nguyen, S. D., Belevich, I., Vihinen, H., Heikkilä, H. M., Soliymani, R., Käkelä, R., Saksi, J., Jauhiainen, M., Grabowski, G. A., Kummu, O., Hörkkö, S., Baumann, M., Lindsberg, P. J., Jokitalo, E., Kovanen, P. T. & Öörni, K., Feb 2018, In : The American Journal of Pathology. 188, 2, p. 525-538 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Ilmailija terveydenhuollon tuulissa : Hoitavan lääkärin ja ilmailulääkärin yhteistyö parantaa lentoturvallisuutta

Vuorio, A., Laukkala, T., Hartikainen, J., Kovanen, P., Leino, T., Moilanen, J., Mäkelä, J. P., Skyttä, J. & Mäntysaari, M., 2018, In : Duodecim. 134, 2, p. 133-141 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Keramidit ja sepelvaltimotauti

Laaksonen, R., Öörni, K., Hilvo, M., Kovanen, P. T. & Sinisalo, J., 2018, In : Duodecim. 134, 5, p. 456-464 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Macrophage Infiltration in the Saccular Intracranial Aneurysm Wall as a Response to Locally Lysed Erythrocytes That Promote Degeneration

Ollikainen, E., Tulamo, R., Kaitainen, S., Honkanen, P., Lehti, S., Liimatainen, T., Hernesniemi, J., Niemelä, M., Kovanen, P. T. & Frösen, J., Oct 2018, In : Journal of Neuropathology and Experimental Neurology. 77, 10, p. 890-903 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Morphology and histology of silent and symptom-causing atherosclerotic carotid plaques - Rationale and design of the Helsinki Carotid Endarterectomy Study 2 (the HeCES2)

Nuotio, K., Ijäs, P., Heikkilä, H. M., Koskinen, S. M., Saksi, J., Vikatmaa, P., Sorto, P., Mäkitie, L., Eriksson, H., Kasari, S., Silvennoinen, H., Valanne, L., Mäyränpää, M. I., Kovanen, P. T., Soinne, L. & Lindsberg, P. J., 2018, In : Annals of Medicine. 50, 6, p. 501-510 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Myeloperoxidase Associates With Degenerative Remodeling and Rupture of the Saccular Intracranial Aneurysm Wall

Ollikainen, E., Tulamo, R., Lehti, S., Hernesniemi, J., Niemelä, M., Kovanen, P. T. & Frösen, J., Jun 2018, In : Journal of Neuropathology and Experimental Neurology. 77, 6, p. 461-468 8 p.

Research output: Contribution to journalArticleScientificpeer-review

USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages

Ruuth, M., Soronen, J., Kaiharju, E., Merikanto, K., Perttilä, J., Metso, J., Lee-Rueckert, M., Taskinen, M-R., Kovanen, P. T., Öörni, K., Olkkonen, V. M., Jauhiainen, M. S. & Laurila, P-P., 13 Dec 2018, In : Lipids in Health and Disease. 17, 11 p., 285.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017
Open Access
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2016

Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties

Duy Nguyen, S., Maaninka, K., Lappalainen, J., Nurmi, K., Metso, J., Oorni, K., Navab, M., Fogelman, A. M., Jauhiainen, M., Lee-Rueckert, M. & Kovanen, P. T., Feb 2016, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 2, p. 274-284 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Lipid droplets in activated mast cells - a significant source of triglyceride-derived arachidonic acid for eicosanoid production

Dichlberger, A., Schlager, S., Kovanen, P. T. & Schneider, W. J., 15 Aug 2016, In : European Journal of Pharmacology. 785, p. 59-69 11 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Novel 6p21.3 Risk Haplotype Predisposes to Acute Coronary Syndrome

Sinisalo, J., Vlachopoulou, E., Marchesani, M., Nokelainen, J., Mayranpaa, M. I., Lappalainen, J., Paakkanen, R., Wennerstrom, A., Salli, K., Niemi, H. J., Mannisto, S., Salo, P., Junttila, J., Eskola, M., Nikus, K., Arstila, T. P., Perola, M., Huikuri, H., Karhunen, P. J., Kovanen, P. T. & 8 others, Palotie, A., Havulinna, A. S., Lluis-Ganella, C., Marrugat, J., Elosua, R., Salomaa, V., Nieminen, M. S. & Lokki, M-L., Feb 2016, In : Circulation. Cardiovascular genetics. 9, 1, p. 55-63 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Smooth Muscle Cell Foam Cell Formation, Apolipoproteins, and ABCA1 in Intracranial Aneurysms: Implications for Lipid Accumulation as a Promoter of Aneurysm Wall Rupture

Ollikainen, E., Tulamo, R., Lehti, S., Lee-Rueckert, M., Hernesniemi, J., Niemela, M., Yla-Herttuala, S., Kovanen, P. T. & Frosen, J., Jul 2016, In : Journal of Neuropathology and Experimental Neurology. 75, 7, p. 689-699 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Aorttaläpän ahtauman lääkehoito - onko se edes mahdollista?

Syväranta, S., Suihko, S. & Kovanen, P. T., 2015, In : Suomen lääkärilehti. 70, 38, p. 2405-2411 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Apolipoprotein A-I mimetic peptide 4F blocks sphingomyelinase-induced LDL aggregation

Nguyen, S. D., Javanainen, M., Rissanen, S., Zhao, H., Huusko, J., Kivelä, A. M., Ylä-Herttuala, S., Navab, M., Fogelman, A. M., Vattulainen, I., Kovanen, P. T. & Öörni, K., 2015, In : Journal of Lipid Research. 56, 6, p. 1206-1221 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Chronic intermittent psychological stress promotes macrophage reverse cholesterol transport by impairing bile acid absorption in mice

Silvennoinen, R., Quesada, H., Kareinen, I., Julve, J., Kaipiainen, L., Gylling, H., Blanco-Vaca, F., Escola-Gil, J. C., Kovanen, P. T. & Lee-Rueckert, M., 1 May 2015, In : Physiological Reports. 3, 5, 15 p., 12402.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Dietary plant stanols or sterols neither accumulate in stenotic aortic valves nor influence their structure or inflammatory status

Simonen, P., Lommi, J., Hallikainen, M., Helske-Suihko, S., Werkkala, K., Kupari, M., Kovanen, P. T. & Gylling, H., Dec 2015, In : Clinical Nutrition. 34, 6, p. 1251-1257 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Electronegative LDL induces priming and inflammasome activation leading to IL-1 beta release in human monocytes and macrophages

Estruch, M., Rajamaki, K., Sanchez-Quesada, J. L., Kovanen, P. T., Öörni, K., Benitez, S. & Ordonez-Llanos, J., Nov 2015, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1851, 11, p. 1442-1449 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment

Wiegman, A., Gidding, S. S., Watts, G. F., Chapman, M. J., Ginsberg, H. N., Cuchel, M., Ose, L., Averna, M., Boileau, C., Boren, J., Bruckert, E., Catapano, A. L., Defesche, J. C., Descamps, O. S., Hegele, R. A., Hovingh, G. K., Humphries, S. E., Kovanen, P. T., Kuivenhoven, J. A., Masana, L. & 13 others, Nordestgaard, B. G., Pajukanta, P., Parhofer, K. G., Raal, F. J., Ray, K. K., Santos, R. D., Stalenhoef, A. F. H., Steinhagen-Thiessen, E., Stroes, E. S., Taskinen, M-R., Tybjaerg-Hansen, A., Wiklund, O. & European Atherosclerosis Soc Conse, 21 Sep 2015, In : European Heart Journal. 36, 36, p. 2425-U34 17 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Life-threatening coronary disease is prevalent in patients with stenosing carotid artery disease

Nuotio, K., Soinne, L., Hänninen, H., Saksi, J., Tuimala, J., Jula, A., Kovanen, P. T., Kaste, M., Ijas, P. & Lindsberg, P. J., Dec 2015, In : International Journal of Stroke. 10, 8, p. 1217-1223 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Mitä PCSK9:n estäjät tuovat familiaalisen hyperkolesterolemian hoitoon?

Tikkanen, M. J. & Kovanen, P. T., 2015, In : Suomen lääkärilehti. 70, 48, p. 3291-3296 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Statiinihoito ja diabetesriski : mekanismeja ja kliininen merkitys

Vuorio, A., Kovanen, P. T. & Strandberg, T., 2015, In : Suomen lääkärilehti. 70, 44, p. 2935-2938 4 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2014

Activated Human Mast Cells Induce LOX-1-Specific Scavenger Receptor Expression in Human Monocyte-Derived Macrophages

Alanne-Kinnunen, M., Lappalainen, J., Öörni, K. & Kovanen, P. T., 24 Sep 2014, In : PLoS One. 9, 9, 9 p., 108352.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

Wang, J., Tang, T-T., Öörni, K., Wu, W., Liu, C., Secco, B., Tia, V., Sukhova, G. K., Fernandes, C., Lesner, A., Kovanen, P. T., Libby, P., Cheng, X. & Shi, G-P., 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 11, p. 2174-2183 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Enhanced vascular permeability facilitates entry of plasma HDL and promotes macrophage-reverse cholesterol transport from skin in mice

Kareinen, I., Cedó, L., Silvennoinen, R., Laurila, P-P., Jauhiainen, M., Julve, J., Blanco-Vaca, F., Escola-Gil, J. C., Kovanen, P. T. & Lee-Rueckert, M., 1 Dec 2014, In : Journal of Lipid Research. 56, 2, p. 241-253 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society

Cuchel, M., Bruckert, E., Ginsberg, H. N., Raal, F. J., Santos, R. D., Hegele, R. A., Kuivenhoven, J. A., Nordestgaard, B. G., Descamps, O. S., Steinhagen-Thiessen, E., Tybjrg-Hansen, A., Watts, G. F., Averna, M., Boileau, C., Boren, J., Catapano, A. L., Defesche, J. C., Hovingh, G. K., Humphries, S. E., Kovanen, P. T. & 11 others, Masana, L., Pajukanta, P., Parhofer, K. G., Ray, K. K., Stalenhoef, A. F. H., Stroes, E., Taskinen, M-R., Wiegman, A., Wiklund, O., Chapman, M. J. & European Atherosclerosis Soc Conse, 21 Aug 2014, In : European Heart Journal. 35, 32, p. 2146-U100 14 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Low-Expression Variant of Fatty Acid-Binding Protein 4 Favors Reduced Manifestations of Atherosclerotic Disease and Increased Plaque Stability

Saksi, J., Ijas, P., Mayranpaa, M. I., Nuotio, K., Isoviita, P. M., Tuimala, J., Lehtonen-Smeds, E., Kaste, M., Jula, A., Nieminen, M. S., Lokki, M-L., Perola, M., Havulinna, A. S., Salomaa, V., Kettunen, J., Jauhiainen, M., Kovanen, P. T. & Lindsberg, P. J., Oct 2014, In : Circulation. Cardiovascular genetics. 7, 5, p. 588-598 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Mast Cells, Neovascularization, and Microhemorrhages are Associated With Saccular Intracranial Artery Aneurysm Wall Remodeling

Ollikainen, E., Tulamo, R., Frosen, J., Lehti, S., Honkanen, P., Hernesniemi, J., Niemela, M. & Kovanen, P. T., Sep 2014, In : Journal of Neuropathology and Experimental Neurology. 73, 9, p. 855-864 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Potential pathological roles for oxidized low-density lipoprotein and scavenger receptors SR-AI CD36, and LOX-1 in aortic valve stenosis

Syvaranta, S., Kinnunen, M., Öörni, K., Oksjoki, R., Kupari, M., Kovanen, P. T. & Helske-Suihko, S., Aug 2014, In : Atherosclerosis. 235, 2, p. 398-407 10 p.

Research output: Contribution to journalArticleScientificpeer-review

The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management

Hegele, R. A., Ginsberg, H. N., Chapman, M. J., Nordestgaard, B. G., Kuivenhoven, J. A., Averna, M., Boren, J., Bruckert, E., Catapano, A. L., Descamps, O. S., Hovingh, G. K., Humphries, S. E., Kovanen, P. T., Masana, L., Pajukanta, P., Parhofer, K. G., Raal, F. J., Ray, K. K., Santos, R. D., Stalenhoef, A. F. H. & 5 others, Stroes, E., Taskinen, M-R., Tybjrg-Hansen, A., Watts, G. F. & Wiklund, O., Aug 2014, In : The Lancet diabetes & endocrinology. 2, 8, p. 655-666 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2013

Ethanol Inhibits Activation of NLRP3 and AIM2 Inflammasomes in Human Macrophages- A Novel Anti-Inflammatory Action of Alcohol

Nurmi, K., Virkanen, J., Rajamaki, K., Niemi, K., Kovanen, P. T. & Eklund, K. K., 11 Nov 2013, In : PLoS One. 8, 11, 12 p., 78537.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome

Rajamäki, K., Nordström, T., Nurmi, K., Åkerman, K. E. O., Kovanen, P. T., Öörni, K. & Eklund, K. K., 10 May 2013, In : Journal of Biological Chemistry. 288, 19, p. 13410-13419 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease

Nordestgaard, B. G., Chapman, M. J., Humphries, S. E., Ginsberg, H. N., Masana, L., Descamps, O. S., Wiklund, O., Hegele, R. A., Raal, F. J., Defesche, J. C., Wiegman, A., Santos, R. D., Watts, G. F., Parhofer, K. G., Hovingh, G. K., Kovanen, P. T., Boileau, C., Averna, M., Boren, J., Bruckert, E. & 9 others, Catapano, A. L., Kuivenhoven, J. A., Pajukanta, P., Ray, K., Stalenhoef, A. F. H., Stroes, E., Taskinen, M-R., Tybjaerg-Hansen, A. & European Atherosclerosis Soc Conse, Dec 2013, In : European Heart Journal. 34, 45, p. 3478-+ 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Haptoglobin 2 allele associates with unstable carotid plaque and major cardiovascular events

Ijäs, P., Saksi, J., Soinne, L., Tuimala, J., Jauhiainen, M., Jula, A., Kahonen, M., Kesaniemi, Y. A., Kovanen, P. T., Kaste, M. & Lindsberg, P. J., Oct 2013, In : Atherosclerosis. 230, 2, p. 228-234 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Human mast cells arise from a common circulating progenitor

Maaninka, K., Lappalainen, J. & Kovanen, P. T., Aug 2013, In : Journal of Allergy and Clinical Immunology. p. 463-469 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Miksi nivelreumaa sairastavien sydäntautiriski on suurentunut?

Eklund, K. K. & Kovanen, P. T., 2013, In : Suomen lääkärilehti. 68, 44, p. 2811 1 p.

Research output: Contribution to journalArticleProfessional

Ravinto ja kolesteroli : käännetään suomalaisten kolesterolitaso taas laskuun

Tikkanen, M. J., Gylling, H., Juonala, M. & Kovanen, P. T., 2013, In : Suomen lääkärilehti. 68, 47, p. 3069-3072 4 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice

Hyvärinen, K., Tuomainen, A. M., Laitinen, S., Alfthan, G., Salminen, I., Leinonen, M., Saikku, P., Kovanen, P. T., Jauhiainen, M. & Pussinen, P. J., 17 Oct 2013, In : BMC Genomics. 14, 14 p., 709 .

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The impact of gender and serum estradiol levels on HDL-mediated reverse cholesterol transport

Badeau, R. M., Metso, J., Kovanen, P. T., Lee-Rueckert, M., Tikkanen, M. J. & Jauhiainen, M., Apr 2013, In : European Journal of Clinical Investigation. 43, 4, p. 317-323 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Acidity and lipolysis by group V secreted phospholipase A(2) strongly increase the binding of apoB-100-containing lipoproteins to human aortic proteoglycans

Lahdesmaki, K., Öörni, K., Alanne-Kinnunen, M., Jauhiainen, M., Hurt-Camejo, E. & Kovanen, P. T., Feb 2012, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1821, 2, p. 257-267 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Imatinib mesylate alleviates diarrhea in a mouse model of intestinal allergy

Vaali, K., Lappalainen, J., Lin, A. H., Mäyränpää, M., Kovanen, P. T., Berstad, A. & Eklund, K. K., 2012, In : Neurogastroenterology and Motility. 24, 7, p. e325-e335 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cells

Nguyen, S. D., Öörni, K., Lee-Rueckert, M., Pihlajamaa, T., Metso, J., Jauhiainen, M. & Kovanen, P. T., 2012, In : Journal of Lipid Research. 53, 10, p. 2115-2125 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2011

190 MAST CELL ACTIVATION IN VIVO IMPAIRS THE MACROPHAGE REVERSE CHOLESTEROL TRANSPORT PATHWAY IN THE MOUSE

Silvennoinen, R., Lee-Rueckert, M., Rotllan, N., Judstrom, I., Blanco-Vaca, F., Jauhiainen, M., Metso, J., Escola-Gil, J. C. & Kovanen, P. T., 1 Jun 2011, In : Atherosclerosis. Supplements. 12, 1, p. 42 1 p.

Research output: Contribution to journalArticleScientificpeer-review

Acidity increases the uptake of native LDL by human monocyte-derived macrophages

Plihtari, R., Kovanen, P. T. & Öörni, K., 2011, In : Atherosclerosis. 217, 2, p. 401-406 6 p.

Research output: Contribution to journalArticleScientificpeer-review