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Petri T Kovanen

1987 …2019
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Publications 1987 2019

1987

Detection of two apolipoprotein B species (apoB(c) and apoB(g)) by a monoclonal antibody

TIKKANEN, M. J., EHNHOLM, C., KOVANEN, P. T., Bütler, R., YOUNG, S. G., CURTISS, L. K. & WITZTUM, J. L., 1987, In : Atherosclerosis. 65, p. 247-256 10 p.

Research output: Contribution to journalArticleScientificpeer-review

1992

Familiaalinen hyperkolesterolemia: hoidettava reseptoritauti

Translated title of the contribution: (Review: Familial hypercholesterolemia: a receptor disease that can be treated)Kovanen, P. T., Tikkanen, M. & Pyörälä, K., 1992, In : Duodecim. 108, p. 1305-1317

Research output: Contribution to journalReview ArticleScientificpeer-review

1993

A LEUKOCYTE INTEGRIN BINDING PEPTIDE FROM INTERCELLULAR-ADHESION MOLECULE-2 STIMULATES T-CELL ADHESION AND NATURAL-KILLER-CELL ACTIVITY

LI, R., NORTAMO, P., KANTOR, C., KOVANEN, P., TIMONEN, T. & GAHMBERG, CG., 15 Oct 1993, In : Journal of Biological Chemistry. 268, 29, p. 21474-21477 4 p.

Research output: Contribution to journalComment/debateScientificpeer-review

Hyperkolesterolemian ja muiden hyperlipidemioiden diagnostiikan ja hoidon suuntaviivat aikuisilla 1992

Frick, M. H., Huttunen, J., Huvinen, M., Katila, A., Kesäniemi, A., Kovanen, P., Miettinen, T., Olkinuora, J., Pyörälä, K., Salmi, J., Savolainen, M., Taskinen, M-R., Tikkanen, M., Uusitupa, M., Viikari, J. & Winell, K., 1993, In : Duodecim. 109, p. 205-225

Research output: Contribution to journalArticleScientificpeer-review

1994
1995

Proteolysis and fusion of low density lipoprotein particles strengthen their binding to human aortic proteoglycans

Paananen, K., Saarinen, J., Annila, A. & Kovanen, P. T., 1995, In : Journal of Biological Chemistry. 270, 20, p. 12257-12262 6 p.

Research output: Contribution to journalArticleScientificpeer-review

1997

Human arterial proteoglycans increase the rate of proteolytic fusion of low density lipoprotein particles

Pentikäinen, M. O., Lehtonen, E. M. P., Öörni, K., Lusa, S., Somerharju, P., Jauhiainen, M. & Kovanen, P. T., 1997, In : Journal of Biological Chemistry. 272, 40, p. 25283-25288 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Oxidation of low density lipoprotein particles decreases their ability to bind to human aortic proteoglycans. Dependence on oxidative modification of the lysine residues

Öörni, K., Pentikäinen, M. O., Annila, A. & Kovanen, P. T., 1997, In : Journal of Biological Chemistry. 272, 34, p. 21303-21311 9 p.

Research output: Contribution to journalArticleScientificpeer-review

The proteoglycan decorin links low density lipoproteins with collagen type I

Pentikäinen, M. O., Öörni, K., Lassila, R. & Kovanen, P. T., 1997, In : Journal of Biological Chemistry. 272, 12, p. 7633-7638 6 p.

Research output: Contribution to journalArticleScientificpeer-review

1999

Lipolytic modification of LDL by phospholipase A2 induces particle aggregation in the absence and fusion in the presence of heparin

Hakala, J. K., Öörni, K., Ala-Korpela, M. & Kovanen, P. T., 1999, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 19, 5, p. 1276-1283 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2000

Aggregation, fusion, and vesicle formation of modified low density lipoprotein particles: Molecular mechanisms and effects on matrix interactions

Oorni, K., Pentikainen, M. O., Ala-Korpela, M. & Kovanen, P. T., 2000, In : Journal of Lipid Research. 41, 11, p. 1703-1714 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Modified LDL - Trigger of atherosclerosis and inflammation in the arterial intima

Pentikäinen, M. O., Öörni, K., Ala-Korpela, M. & Kovanen, P. T., 2000, In : Journal of internal medicine. 247, 3, p. 359-370 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2001

Altered phospholipid-apoB-100 interactions and generation of extra membrane material in proteolysis-induced fusion of LDL particles

Pentikäinen, M. O., Hyvönen, M. T., Öörni, K., Hevonoja, T., Korhonen, A., Lehtonen-Smeds, E. M. P., Ala-Korpela, M. & Kovanen, P. T., 2001, In : Journal of Lipid Research. 42, 6, p. 916-922 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Changes in a phospholipid bilayer induced by the hydrolysis of a phospholipase A2enzyme: A molecular dynamics simulation study

Hyvönen, M. T., Öörni, K., Kovanen, P. T. & Ala-Korpela, M., 2001, In : Biophysical Journal. 80, 2, p. 565-578 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Chlamydia pneumoniae proteins induce secretion of the 92-kDa gelatinase by human monocyte-derived macrophages

Vehmaan-Kreula, P., Puolakkainen, M., Sarvas, M., Welgus, H. G. & Kovanen, P. T., 2001, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 21, p. E1-E8 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipolysis of LDL by human secretory phospholipase A2 induces particle fusion and enhances the retention of LDL to human aortic proteoglycans

Hakala, J. K., Öörni, K., Pentiköinen, M. O., Hurt-Camejo, E. & Kovanen, P. T., 2001, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 21, 6, p. 1053-1058 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Mast cells in acute and chronic rejection of rat cardiac allografts - A major source of basic fibroblast growth factor

Koskinen, P. K., Kovanen, P. T., Lindstedt, K. A. & Lemstrom, K. B., 2001, In : Transplantation. 71, p. 1741-1747 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Myeloperoxidase and hypochlorite, but not copper ions, oxidize heparin-bound LDL particles and release them from heparin

Pentikäinen, M. O., Öörni, K. & Kovanen, P. T., 2001, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 21, 12, p. 1902-1908 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Phospholipase A2 in vascular disease

Hurt-Camejo, E., Camejo, G., Peilot, H., Öörni, K. & Kovanen, P., 2001, In : Circulation Research. 89, 4, p. 298-304 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2002

Activated mast cells increase the level of endothelin-1 mRNA in cocultured endothelial cells and degrade the secreted peptide

Metsarinne, K. P., Vehmaan-Kreula, P., Kovanen, P. T., Saijonmaa, O., Baumann, M., Wang, Y. F., Nyman, T., Fyhrquist, F. Y. & Eklund, K. K., 2002, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 22, p. 268-273 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipoprotein lipase in the arterial wall: Linking LDL to the arterial extracellular matrix and much more

Pentikäinen, M. O., Oksjoki, R., Öörni, K. & Kovanen, P. T., 2002, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 22, 2, p. 211-217 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2003

Cathepsins F and S block HDL3-induced cholesterol efflux from macrophage foam cells

Lindstedt, L., Lee, M., Öörni, K., Brömme, D. & Kovanen, P. T., 2003, In : Biochemical and Biophysical Research Communications. 312, 4, p. 1019-1024 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

Arterial endothelial denudation by intraluminal use of papaverine-NaCl solution in coronary bypass surgery

Mayranpaa, M., Simpanen, J., Hess, MW., Werkkala, K. & Kovanen, P. T., Apr 2004, In : European Journal of Cardio-Thoracic Surgery. 25, 4, p. 560-566 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro

Öörni, K., Sneck, M., Bromme, D., Pentikäinen, M. O., Lindstedt, K. A., Mäyränpää, M., Aitio, H. & Kovanen, P. T., 13 Aug 2004, In : Journal of Biological Chemistry. 279, 33, p. 34776-34784 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Induction of local angiotensin II-producing systems in stenotic aortic valves

Helske, S., Lindstedt, K. A., Laine, M., Mayranpaa, M., Werkkala, K., Lommi, J., Turto, H., Kupari, M. & Kovanen, P. T., 2004, In : Journal of the American College of Cardiology. 44, p. 1859-1866 8 p.

Research output: Contribution to journalArticleScientificpeer-review

The mast cell, a rich source of neutral proteases in atherosclerotic plaques: International Congress Series

Kovanen, P. T., Lee, M., Leskinen, M. J., Öörni, K. & Lindstedt, K. A., 2004, 4 p.

Research output: Book/ReportBook

2005

A role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves

Helske, S., Aalto, S., Kupari, M., Lappalainen, J., Laine, M., Lommi, J., Kovanen, P. T. & Lindstedt, K. A., 2005, In : European Heart Journal. 26, p. 383-383 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

C-reactive protein binds to the 3 beta-OH group of cholesterol in LDL particles

Taskinen, S., Hyvönen, M., Kovanen, PT., Meri, S. & Pentikäinen, MO., 2005, In : Biochemical and Biophysical Research Communications. 329, 4, p. 1208-1216 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Increased expression of bradykinin type-1 receptors in endothelium of intramyocardial coronary vessels in human failing hearts

Liesmaa, I., Kuoppala, A., Shiota, N., Kokkonen, J. O., Kostner, K., Mayranpaa, M., Kovanen, P. T. & Lindstedt, K. A., May 2005, In : American Journal of Physiology: Heart and Circulatory Physiology. 288, 5, p. H2317-H2322 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Desquamation of human coronary artery endothelium by human mast cell proteases: implications for plaque erosion

Mäyränpää, M. I., Heikkilä, H. A., Lindstedt, K. A., Walls, A. F. & Kovanen, P. T., 2006, In : Coronary Artery Disease. 17, 7, p. 611-621 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Enhanced extracellular lipid accumulation in acidic environments

Öörni, K. & Kovanen, P. T., 2006, In : Current Opinion in Lipidology. 17, 5, p. 534-540 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Increased expression of elastolytic cathepsins S, K, and V and their inhibitor cystatin C in stenotic aortic valves

Helske, S., Syväranta, S., Lindstedt, K. A., Lappalainen, J., Öörni, K., Mäyränpää, M., Lommi, J., Turto, H., Werkkala, K., Kupari, M. & Kovanen, P. T., 2006, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 26, 8, p. 1791-1798 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Increased expression of profibrotic neutral endopeptidase and bradykinin type 1 receptors in stenotic aortic valves

Helske, S., Laine, M., Kupari, M., Lommi, J., Tikkanen, I., Werkkala, K., Lindstedt, K. & Kovanen, P., 2006, In : Circulation Research. 114, p. 657-657 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-kappaB-mediated survival signaling

Leskinen, M. J., Heikkilä, H. M., Speer, M. Y., Hakala, J. K., Laine, M., Kovanen, P. T. & Lindstedt, K. A., 2006, In : Experimental Cell Research. 312, 8, p. 1289-1298 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

1H NMR at 800 MHz facilitates detailed phospholipid follow-up during atherogenic modifications in low density lipoproteins

Soininen, P., Öörni, K., Maaheimo, H., Laatikainen, R., Kovanen, P. T., Kaski, K. & Ala-Korpela, M., 2007, In : Biochemical and Biophysical Research Communications. 360, 1, p. 290-294 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: An angiotensin II type 2 receptor-mediated effect

Kaakinen, R., Lindstedt, K. A., Sneck, M., Kovanen, P. T. & Öörni, K., 2007, In : Atherosclerosis. 192, 2, p. 323-327 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Endothelial apoptosis does not determine symptom status in carotid artery disease

Nuotio, K., Mäyränpää, M., Saksi, J., Ijäs, P., Sairanen, T., Carpen, O., Soinne, L., Saimanen, E., Salonen, O., Lepäntalo, M., Kovanen, P. T., Kaste, M. & Lindsberg, P. J., 2007, In : Cerebrovascular Diseases. 23, 1, p. 27-34 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Improved identification of endothelial erosion by simultaneous detection of endothelial cells (CD31/CD34) and platelets (CD42b)

Mayranpaa, M. I., Resendiz, J. C., Heikkila, H. M., Lindstedt, K. A. & Kovanen, P. T., 2007, In : Endothelium. 14, 2, p. 81-87 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Mast cells in vulnerable atherosclerotic plaques - a view to a kill

Lindstedt, K. A., Mayranpaa, M. I. & Kovanen, P. T., 2007, In : Journal of Cellular and Molecular Medicine. 11, 4, p. 739-758 20 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Microarray analysis reveals overexpression of CD163 and HO-1 in symptomatic carotid plaques

Ijäs, P., Nuotio, K., Saksi, J., Soinne, L., Saimanen, E., Karjalainen-Lindsberg, M-L., Salonen, O., Sarna, S., Tuimala, J., Kovanen, P. T., Kaste, M. & Lindsberg, P. J., 2007, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 27, 1, p. 154-160 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Mikroverenvuodot ja CD163-HO1-signalointi oireilevassa kaukavaltimon ateroskleroosissa: [Arterioscler Thromb Vasc Biol in press]

Ijäs, P., Nuotio, K., Saksi, J., Soinne, L., Saimanen, E., Karjalainen-Lindsberg, M-L., Salonen, O., Sarna, S., Tuimala, J., Kovanen, P. T., Kaste, M. & Lindsberg, P. J., 2007, In : Duodecim. 123, p. 141-142 2 p.

Research output: Contribution to journalArticleScientific

PLA2-V: A real player in atherogenesis

Öörni, K. & Kovanen, P. T., 2007, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 27, 3, p. 445-447 3 p.

Research output: Contribution to journalArticleScientific

2008

Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha

Heikkilä, H. M., Lätti, S., Leskinen, M. J., Hakala, J. K., Kovanen, P. T. & Lindstedt, K. A., 2008, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 2, p. 309-314 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Mast cells associate with T cells and neointimal microvessels in giant cell arteritis

Mayranpaa, M. I., Trosien, J. A., Nikkari, S. T. & Kovanen, P. T., 2008, In : Clinical and Experimental Rheumatology. 26, 3, Suppl. 49, p. S63-S66 4 p.

Research output: Contribution to journalArticleScientificpeer-review