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Petri T Kovanen

1987 …2019
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Publications 1987 2019

190 MAST CELL ACTIVATION IN VIVO IMPAIRS THE MACROPHAGE REVERSE CHOLESTEROL TRANSPORT PATHWAY IN THE MOUSE

Silvennoinen, R., Lee-Rueckert, M., Rotllan, N., Judstrom, I., Blanco-Vaca, F., Jauhiainen, M., Metso, J., Escola-Gil, J. C. & Kovanen, P. T., 1 Jun 2011, In : Atherosclerosis. Supplements. 12, 1, p. 42 1 p.

Research output: Contribution to journalArticleScientificpeer-review

1H NMR at 800 MHz facilitates detailed phospholipid follow-up during atherogenic modifications in low density lipoproteins

Soininen, P., Öörni, K., Maaheimo, H., Laatikainen, R., Kovanen, P. T., Kaski, K. & Ala-Korpela, M., 2007, In : Biochemical and Biophysical Research Communications. 360, 1, p. 290-294 5 p.

Research output: Contribution to journalArticleScientificpeer-review

ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model

Simolin, M. A., Pedersen, T. X., Bro, S., Mayranpaa, M. I., Helske, S., Nielsen, L. B. & Kovanen, P. T., 3 Mar 2009, In : BMC Cardiovascular Disorders. 9, 10 p., 10.

Research output: Contribution to journalArticleScientificpeer-review

Acidic Extracellular Environments Strongly Impair ABCA1-Mediated Cholesterol Efflux From Human Macrophage Foam Cells

Lee-Rueckert, M., Lappalainen, J., Leinonen, H., Pihlajamaa, T., Jauhiainen, M. & Kovanen, P. T., 2010, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 30, p. 1766-1772 23 p.

Research output: Contribution to journalArticleScientificpeer-review

Acidity and lipolysis by group V secreted phospholipase A(2) strongly increase the binding of apoB-100-containing lipoproteins to human aortic proteoglycans

Lahdesmaki, K., Öörni, K., Alanne-Kinnunen, M., Jauhiainen, M., Hurt-Camejo, E. & Kovanen, P. T., Feb 2012, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1821, 2, p. 257-267 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Acidity increases the uptake of native LDL by human monocyte-derived macrophages

Plihtari, R., Kovanen, P. T. & Öörni, K., 2011, In : Atherosclerosis. 217, 2, p. 401-406 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Activated Human Mast Cells Induce LOX-1-Specific Scavenger Receptor Expression in Human Monocyte-Derived Macrophages

Alanne-Kinnunen, M., Lappalainen, J., Öörni, K. & Kovanen, P. T., 24 Sep 2014, In : PLoS One. 9, 9, 9 p., 108352.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Activated mast cells increase the level of endothelin-1 mRNA in cocultured endothelial cells and degrade the secreted peptide

Metsarinne, K. P., Vehmaan-Kreula, P., Kovanen, P. T., Saijonmaa, O., Baumann, M., Wang, Y. F., Nyman, T., Fyhrquist, F. Y. & Eklund, K. K., 2002, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 22, p. 268-273 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha

Heikkilä, H. M., Lätti, S., Leskinen, M. J., Hakala, J. K., Kovanen, P. T. & Lindstedt, K. A., 2008, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 2, p. 309-314 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Aggregation, fusion, and vesicle formation of modified low density lipoprotein particles: Molecular mechanisms and effects on matrix interactions

Oorni, K., Pentikainen, M. O., Ala-Korpela, M. & Kovanen, P. T., 2000, In : Journal of Lipid Research. 41, 11, p. 1703-1714 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

A LEUKOCYTE INTEGRIN BINDING PEPTIDE FROM INTERCELLULAR-ADHESION MOLECULE-2 STIMULATES T-CELL ADHESION AND NATURAL-KILLER-CELL ACTIVITY

LI, R., NORTAMO, P., KANTOR, C., KOVANEN, P., TIMONEN, T. & GAHMBERG, CG., 15 Oct 1993, In : Journal of Biological Chemistry. 268, 29, p. 21474-21477 4 p.

Research output: Contribution to journalComment/debateScientificpeer-review

Altered phospholipid-apoB-100 interactions and generation of extra membrane material in proteolysis-induced fusion of LDL particles

Pentikäinen, M. O., Hyvönen, M. T., Öörni, K., Hevonoja, T., Korhonen, A., Lehtonen-Smeds, E. M. P., Ala-Korpela, M. & Kovanen, P. T., 2001, In : Journal of Lipid Research. 42, 6, p. 916-922 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: An angiotensin II type 2 receptor-mediated effect

Kaakinen, R., Lindstedt, K. A., Sneck, M., Kovanen, P. T. & Öörni, K., 2007, In : Atherosclerosis. 192, 2, p. 323-327 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Aorttaläpän ahtauman lääkehoito - onko se edes mahdollista?

Syväranta, S., Suihko, S. & Kovanen, P. T., 2015, In : Suomen lääkärilehti. 70, 38, p. 2405-2411 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Apolipoprotein A-I mimetic peptide 4F blocks sphingomyelinase-induced LDL aggregation

Nguyen, S. D., Javanainen, M., Rissanen, S., Zhao, H., Huusko, J., Kivelä, A. M., Ylä-Herttuala, S., Navab, M., Fogelman, A. M., Vattulainen, I., Kovanen, P. T. & Öörni, K., 2015, In : Journal of Lipid Research. 56, 6, p. 1206-1221 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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A role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves

Helske, S., Aalto, S., Kupari, M., Lappalainen, J., Laine, M., Lommi, J., Kovanen, P. T. & Lindstedt, K. A., 2005, In : European Heart Journal. 26, p. 383-383 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

Arterial endothelial denudation by intraluminal use of papaverine-NaCl solution in coronary bypass surgery

Mayranpaa, M., Simpanen, J., Hess, MW., Werkkala, K. & Kovanen, P. T., Apr 2004, In : European Journal of Cardio-Thoracic Surgery. 25, 4, p. 560-566 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties

Duy Nguyen, S., Maaninka, K., Lappalainen, J., Nurmi, K., Metso, J., Oorni, K., Navab, M., Fogelman, A. M., Jauhiainen, M., Lee-Rueckert, M. & Kovanen, P. T., Feb 2016, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 2, p. 274-284 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

Wang, J., Tang, T-T., Öörni, K., Wu, W., Liu, C., Secco, B., Tia, V., Sukhova, G. K., Fernandes, C., Lesner, A., Kovanen, P. T., Libby, P., Cheng, X. & Shi, G-P., 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 11, p. 2174-2183 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Cathepsins F and S block HDL3-induced cholesterol efflux from macrophage foam cells

Lindstedt, L., Lee, M., Öörni, K., Brömme, D. & Kovanen, P. T., 2003, In : Biochemical and Biophysical Research Communications. 312, 4, p. 1019-1024 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Changes in a phospholipid bilayer induced by the hydrolysis of a phospholipase A2enzyme: A molecular dynamics simulation study

Hyvönen, M. T., Öörni, K., Kovanen, P. T. & Ala-Korpela, M., 2001, In : Biophysical Journal. 80, 2, p. 565-578 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Chlamydia pneumoniae proteins induce secretion of the 92-kDa gelatinase by human monocyte-derived macrophages

Vehmaan-Kreula, P., Puolakkainen, M., Sarvas, M., Welgus, H. G. & Kovanen, P. T., 2001, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 21, p. E1-E8 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

Rajamaki, K., Lappalainen, J., Öörni, K., Valimaki, E., Matikainen, S., Kovanen, P. T. & Eklund, K. K., 23 Jul 2010, In : PLoS One. 5, 7, 9 p., 11765.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Chronic intermittent psychological stress promotes macrophage reverse cholesterol transport by impairing bile acid absorption in mice

Silvennoinen, R., Quesada, H., Kareinen, I., Julve, J., Kaipiainen, L., Gylling, H., Blanco-Vaca, F., Escola-Gil, J. C., Kovanen, P. T. & Lee-Rueckert, M., 1 May 2015, In : Physiological Reports. 3, 5, 15 p., 12402.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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C-reactive protein binds to the 3 beta-OH group of cholesterol in LDL particles

Taskinen, S., Hyvönen, M., Kovanen, PT., Meri, S. & Pentikäinen, MO., 2005, In : Biochemical and Biophysical Research Communications. 329, 4, p. 1208-1216 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro

Öörni, K., Sneck, M., Bromme, D., Pentikäinen, M. O., Lindstedt, K. A., Mäyränpää, M., Aitio, H. & Kovanen, P. T., 13 Aug 2004, In : Journal of Biological Chemistry. 279, 33, p. 34776-34784 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Decreasing the Cholesterol Burden in Heterozygous Familial Hypercholesterolemia Children by Dietary Plant Stanol Esters

Vuorio, A. & Kovanen, P. T., Dec 2018, In : Nutrients. 10, 12, 10 p., 1842.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Desquamation of human coronary artery endothelium by human mast cell proteases: implications for plaque erosion

Mäyränpää, M. I., Heikkilä, H. A., Lindstedt, K. A., Walls, A. F. & Kovanen, P. T., 2006, In : Coronary Artery Disease. 17, 7, p. 611-621 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Detection of two apolipoprotein B species (apoB(c) and apoB(g)) by a monoclonal antibody

TIKKANEN, M. J., EHNHOLM, C., KOVANEN, P. T., Bütler, R., YOUNG, S. G., CURTISS, L. K. & WITZTUM, J. L., 1987, In : Atherosclerosis. 65, p. 247-256 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Dietary plant stanols or sterols neither accumulate in stenotic aortic valves nor influence their structure or inflammatory status

Simonen, P., Lommi, J., Hallikainen, M., Helske-Suihko, S., Werkkala, K., Kupari, M., Kovanen, P. T. & Gylling, H., Dec 2015, In : Clinical Nutrition. 34, 6, p. 1251-1257 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Dilated cardiomyopathy alters the expression patterns of CAR and other adenoviral receptors in human heart

Toivonen, R., Mayranpaa, M. I., Kovanen, P. T. & Savontaus, M., Mar 2010, In : Histochemistry and Cell Biology. 133, 3, p. 349-357 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of milk casein-derived tripeptides Ile-Pro-Pro, Val-Pro-Pro, and Leu-Pro-Pro on enzymes processing vaso active precursors in vitro

Lehtinen, R., Jauhiainen, T., Kankuri, E., Lindstedt, K., Kovanen, P. T., Kerojoki, O., Korpela, R. & Vapaatalo, H., 2010, In : Arzneimittel-Forschung. 60, p. 182-185 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Electronegative LDL induces priming and inflammasome activation leading to IL-1 beta release in human monocytes and macrophages

Estruch, M., Rajamaki, K., Sanchez-Quesada, J. L., Kovanen, P. T., Öörni, K., Benitez, S. & Ordonez-Llanos, J., Nov 2015, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1851, 11, p. 1442-1449 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Endothelial apoptosis does not determine symptom status in carotid artery disease

Nuotio, K., Mäyränpää, M., Saksi, J., Ijäs, P., Sairanen, T., Carpen, O., Soinne, L., Saimanen, E., Salonen, O., Lepäntalo, M., Kovanen, P. T., Kaste, M. & Lindsberg, P. J., 2007, In : Cerebrovascular Diseases. 23, 1, p. 27-34 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Enhanced extracellular lipid accumulation in acidic environments

Öörni, K. & Kovanen, P. T., 2006, In : Current Opinion in Lipidology. 17, 5, p. 534-540 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Enhanced vascular permeability facilitates entry of plasma HDL and promotes macrophage-reverse cholesterol transport from skin in mice

Kareinen, I., Cedó, L., Silvennoinen, R., Laurila, P-P., Jauhiainen, M., Julve, J., Blanco-Vaca, F., Escola-Gil, J. C., Kovanen, P. T. & Lee-Rueckert, M., 1 Dec 2014, In : Journal of Lipid Research. 56, 2, p. 241-253 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Ethanol Inhibits Activation of NLRP3 and AIM2 Inflammasomes in Human Macrophages- A Novel Anti-Inflammatory Action of Alcohol

Nurmi, K., Virkanen, J., Rajamaki, K., Niemi, K., Kovanen, P. T. & Eklund, K. K., 11 Nov 2013, In : PLoS One. 8, 11, 12 p., 78537.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Expression of antizyme inhibitor 2 in mast cells and role of polyamines as selective regulators of serotonin secretion

Kanerva, K., Lappalainen, J., Makitie, L. T., Virolainen, S., Kovanen, P. T. & Andersson, L. C., 2009, In : PLoS One. 4, 8, p. e6858

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome

Rajamäki, K., Nordström, T., Nurmi, K., Åkerman, K. E. O., Kovanen, P. T., Öörni, K. & Eklund, K. K., 10 May 2013, In : Journal of Biological Chemistry. 288, 19, p. 13410-13419 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties

Lehti, S., Nguyen, S. D., Belevich, I., Vihinen, H., Heikkilä, H. M., Soliymani, R., Käkelä, R., Saksi, J., Jauhiainen, M., Grabowski, G. A., Kummu, O., Hörkkö, S., Baumann, M., Lindsberg, P. J., Jokitalo, E., Kovanen, P. T. & Öörni, K., Feb 2018, In : The American Journal of Pathology. 188, 2, p. 525-538 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Familiaalinen hyperkolesterolemia: hoidettava reseptoritauti

Translated title of the contribution: (Review: Familial hypercholesterolemia: a receptor disease that can be treated)Kovanen, P. T., Tikkanen, M. & Pyörälä, K., 1992, In : Duodecim. 108, p. 1305-1317

Research output: Contribution to journalReview ArticleScientificpeer-review

Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment

Wiegman, A., Gidding, S. S., Watts, G. F., Chapman, M. J., Ginsberg, H. N., Cuchel, M., Ose, L., Averna, M., Boileau, C., Boren, J., Bruckert, E., Catapano, A. L., Defesche, J. C., Descamps, O. S., Hegele, R. A., Hovingh, G. K., Humphries, S. E., Kovanen, P. T., Kuivenhoven, J. A., Masana, L. & 13 others, Nordestgaard, B. G., Pajukanta, P., Parhofer, K. G., Raal, F. J., Ray, K. K., Santos, R. D., Stalenhoef, A. F. H., Steinhagen-Thiessen, E., Stroes, E. S., Taskinen, M-R., Tybjaerg-Hansen, A., Wiklund, O. & European Atherosclerosis Soc Conse, 21 Sep 2015, In : European Heart Journal. 36, 36, p. 2425-U34 17 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease

Nordestgaard, B. G., Chapman, M. J., Humphries, S. E., Ginsberg, H. N., Masana, L., Descamps, O. S., Wiklund, O., Hegele, R. A., Raal, F. J., Defesche, J. C., Wiegman, A., Santos, R. D., Watts, G. F., Parhofer, K. G., Hovingh, G. K., Kovanen, P. T., Boileau, C., Averna, M., Boren, J., Bruckert, E. & 9 others, Catapano, A. L., Kuivenhoven, J. A., Pajukanta, P., Ray, K., Stalenhoef, A. F. H., Stroes, E., Taskinen, M-R., Tybjaerg-Hansen, A. & European Atherosclerosis Soc Conse, Dec 2013, In : European Heart Journal. 34, 45, p. 3478-+ 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Haptoglobin 2 allele associates with unstable carotid plaque and major cardiovascular events

Ijäs, P., Saksi, J., Soinne, L., Tuimala, J., Jauhiainen, M., Jula, A., Kahonen, M., Kesaniemi, Y. A., Kovanen, P. T., Kaste, M. & Lindsberg, P. J., Oct 2013, In : Atherosclerosis. 230, 2, p. 228-234 7 p.

Research output: Contribution to journalArticleScientificpeer-review

High binding affinity of electronegative LDL to human aortic proteoglycans depends on its aggregation level

Bancells, C., Benítez, S., Jauhiainen, M., Ordóñez-Llanos, J., Kovanen, P. T., Villegas, S., Sánchez-Quesada, J. L. & Öörni, K., 2009, In : Journal of Lipid Research. 50, 3, p. 446-455 10 p.

Research output: Contribution to journalArticleScientificpeer-review