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Petri T Kovanen

1987 …2019
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Publications 1987 2019

2011

High-density lipoproteins (HDL) are present in stenotic aortic valves and may interfere with the mechanisms of valvular calcification

Lommi, J. I., Kovanen, P. T., Jauhiainen, M., Lee-Rueckert, M., Kupari, M. & Helske, S., Dec 2011, In : Atherosclerosis. 219, 2, p. 538-544 7 p.

Research output: Contribution to journalArticleScientificpeer-review

IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe(-/-) mice

Wang, J., Cheng, X., Xiang, M-X., Alanne-Kinnunen, M., Wang, J-A., Chen, H., He, A., Sun, X., Lin, Y., Tang, T-T., Tu, X., Sjoeberg, S., Sukhova, G. K., Liao, Y-H., Conrad, D. H., Yu, L., Kawakami, T., Kovanen, P. T., Libby, P. & Shi, G-P., Sep 2011, In : Journal of Clinical Investigation. 121, 9, p. 3564-3577 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Immunochemical analysis of the electronegative LDL subfraction shows that abnormal N-terminal apolipoprotein B conformation is involved in increased binding to proteoglycans

Bancells, C., Benítez, S., Ordóñez-Llanos, J., Öörni, K., Kovanen, P. T., Milne, R. W. & Sánchez-Quesada, J. L., 2011, In : Journal of Biological Chemistry. 286, 2, p. 1125-1133 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Is the "lipid paradox" in rheumatoid arthritis really a paradox? Comment on the article by Bartels et al

Strandberg, T., Kovanen, P. T. & Eklund, K. K., Nov 2011, In : Arthritis & Rheumatism. 63, 11, p. 3644-3645 2 p.

Research output: Contribution to journalArticleScientific

Lipid body formation during maturation of human mast cells

Dichlberger, A., Schlager, S., Lappalainen, J., Käkelä, R., Hattula, K., Butcher, S. J., Schneider, W. J. & Kovanen, P. T., 2011, In : Journal of Lipid Research. 52, 12, p. 2198-2208 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Mast Cell Activation In Vivo Impairs the Macrophage Reverse Cholesterol Transport Pathway in the Mouse

Lee-Rueckert, M., Silvennoinen, R., Rotllan, N., Judstrom, I., Blanco-Vaca, F., Metso, J., Jauhiainen, M., Kovanen, P. T. & Carles Escola-Gil, J., Mar 2011, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 3, p. 520-527 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Mast Cells Important Players in the Orchestrated Pathogenesis of Abdominal Aortic Aneurysms

Swedenborg, J., Mayranpaa, M. I. & Kovanen, P. T., Apr 2011, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 4, p. 734-740 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Three-Dimensional cryoEM Reconstruction of Native LDL Particles to 16 angstrom Resolution at Physiological Body Temperature

Kumar, V., Butcher, S. J., Öörni, K., Engelhardt, P., Heikkonen, J., Kaski, K., Ala-Korpela, M. & Kovanen, P. T., 2011, In : PLoS One. 6, 5, p. e18841 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management

Chapman, M. J., Ginsberg, H. N., Amarenco, P., Andreotti, F., Boren, J., Catapano, A. L., Descamps, O. S., Fisher, E., Kovanen, P. T., Kuivenhoven, J. A., Lesnik, P., Masana, L., Nordestgaard, B. G., Ray, K. K., Reiner, Z., Taskinen, M-R., Tokgozoglu, L., Tybjaerg-Hansen, A., Watts, G. F. & European Atherosclerosis Soc, 2011, In : European Heart Journal. 32, 11, p. 1345-1361 24 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Acidic Extracellular Environments Strongly Impair ABCA1-Mediated Cholesterol Efflux From Human Macrophage Foam Cells

Lee-Rueckert, M., Lappalainen, J., Leinonen, H., Pihlajamaa, T., Jauhiainen, M. & Kovanen, P. T., 2010, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 30, p. 1766-1772 23 p.

Research output: Contribution to journalArticleScientificpeer-review

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

Rajamaki, K., Lappalainen, J., Öörni, K., Valimaki, E., Matikainen, S., Kovanen, P. T. & Eklund, K. K., 23 Jul 2010, In : PLoS One. 5, 7, 9 p., 11765.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Dilated cardiomyopathy alters the expression patterns of CAR and other adenoviral receptors in human heart

Toivonen, R., Mayranpaa, M. I., Kovanen, P. T. & Savontaus, M., Mar 2010, In : Histochemistry and Cell Biology. 133, 3, p. 349-357 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of milk casein-derived tripeptides Ile-Pro-Pro, Val-Pro-Pro, and Leu-Pro-Pro on enzymes processing vaso active precursors in vitro

Lehtinen, R., Jauhiainen, T., Kankuri, E., Lindstedt, K., Kovanen, P. T., Kerojoki, O., Korpela, R. & Vapaatalo, H., 2010, In : Arzneimittel-Forschung. 60, p. 182-185 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Mast cell-dependent proteolytic modification of HDL particles during anaphylactic shock in the mouse reduces their ability to induce cholesterol efflux from macrophage foam cells ex vivo

Judström, I., Jukkola, H., Metso, J., Jauhiainen, M., Kovanen, P. T. & Lee-Rueckert, M., Jan 2010, In : Atherosclerosis. 208, 1, p. 148-154 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Mast cells promote atherosclerosis by inducing both an atherogenic lipid profile and vascular inflammation

Heikkilä, H-M. A., Trosien, J., Metso, J., Jauhiainen, M., Pentikäinen, M. O., Kovanen, P. T. & Lindstedt, K. A., 2010, In : Journal of Cellular Biochemistry. 109, 3, p. 615-623 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Proteolysis sensitizes LDL particles to phospholipolysis by secretory phospholipase A(2) group V and secretory sphingomyelinase

Plihtari, R., Hurt-Camejo, E., Öörni, K. & Kovanen, P. T., Jul 2010, In : Journal of Lipid Research. 51, 7, p. 1801-1809 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Transcardiac gradients of circulating apelin: extraction by normal hearts vs. release by hearts failing due to pressure overload

Helske, S., Kovanen, P. T., Lommi, J., Turto, H. & Kupari, M., 2010, In : Journal of Applied Physiology. 109, p. 1744-1748 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Vascular Endothelial Growth Factor-Secreting Mast Cells and Myofibroblasts A Novel Self-Perpetuating Angiogenic Pathway in Aortic Valve Stenosis

Syvaranta, S., Helske, S., Laine, M., Lappalainen, J., Kupari, M., Mayranpaa, M. I., Lindstedt, K. A. & Kovanen, P. T., 2010, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 30, p. 1220-U329 23 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model

Simolin, M. A., Pedersen, T. X., Bro, S., Mayranpaa, M. I., Helske, S., Nielsen, L. B. & Kovanen, P. T., 3 Mar 2009, In : BMC Cardiovascular Disorders. 9, 10 p., 10.

Research output: Contribution to journalArticleScientificpeer-review

Expression of antizyme inhibitor 2 in mast cells and role of polyamines as selective regulators of serotonin secretion

Kanerva, K., Lappalainen, J., Makitie, L. T., Virolainen, S., Kovanen, P. T. & Andersson, L. C., 2009, In : PLoS One. 4, 8, p. e6858

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

High binding affinity of electronegative LDL to human aortic proteoglycans depends on its aggregation level

Bancells, C., Benítez, S., Jauhiainen, M., Ordóñez-Llanos, J., Kovanen, P. T., Villegas, S., Sánchez-Quesada, J. L. & Öörni, K., 2009, In : Journal of Lipid Research. 50, 3, p. 446-455 10 p.

Research output: Contribution to journalArticleScientificpeer-review

High negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease

Muhl, L., Galuska, S. P., Öörni, K., Hernández-Ruiz, L., Andrei-Selmer, L-C., Geyer, R., Preissner, K. T., Ruiz, F. A., Kovanen, P. T. & Kanse, S. M., 2009, In : The FEBS Journal. 276, 17, p. 4828-4839 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipoprotein modification by secretory phospholipase A2 enzymes contributes to the initiation and progression of atherosclerosis

Öörni, K. & Kovanen, P. T., 2009, In : Current Opinion in Lipidology. 20, 5, p. 421-427 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Phospholipase A2-modified LDL particles retain the generated hydrolytic products and are more atherogenic at acidic pH

Lähdesmäki, K., Plihtari, R., Soininen, P., Hurt-Camejo, E., Ala-Korpela, M., Öörni, K. & Kovanen, P. T., 2009, In : Atherosclerosis. 207, 2, p. 352-359 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha

Heikkilä, H. M., Lätti, S., Leskinen, M. J., Hakala, J. K., Kovanen, P. T. & Lindstedt, K. A., 2008, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 2, p. 309-314 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Mast cells associate with T cells and neointimal microvessels in giant cell arteritis

Mayranpaa, M. I., Trosien, J. A., Nikkari, S. T. & Kovanen, P. T., 2008, In : Clinical and Experimental Rheumatology. 26, 3, Suppl. 49, p. S63-S66 4 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

1H NMR at 800 MHz facilitates detailed phospholipid follow-up during atherogenic modifications in low density lipoproteins

Soininen, P., Öörni, K., Maaheimo, H., Laatikainen, R., Kovanen, P. T., Kaski, K. & Ala-Korpela, M., 2007, In : Biochemical and Biophysical Research Communications. 360, 1, p. 290-294 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: An angiotensin II type 2 receptor-mediated effect

Kaakinen, R., Lindstedt, K. A., Sneck, M., Kovanen, P. T. & Öörni, K., 2007, In : Atherosclerosis. 192, 2, p. 323-327 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Endothelial apoptosis does not determine symptom status in carotid artery disease

Nuotio, K., Mäyränpää, M., Saksi, J., Ijäs, P., Sairanen, T., Carpen, O., Soinne, L., Saimanen, E., Salonen, O., Lepäntalo, M., Kovanen, P. T., Kaste, M. & Lindsberg, P. J., 2007, In : Cerebrovascular Diseases. 23, 1, p. 27-34 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Improved identification of endothelial erosion by simultaneous detection of endothelial cells (CD31/CD34) and platelets (CD42b)

Mayranpaa, M. I., Resendiz, J. C., Heikkila, H. M., Lindstedt, K. A. & Kovanen, P. T., 2007, In : Endothelium. 14, 2, p. 81-87 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Mast cells in vulnerable atherosclerotic plaques - a view to a kill

Lindstedt, K. A., Mayranpaa, M. I. & Kovanen, P. T., 2007, In : Journal of Cellular and Molecular Medicine. 11, 4, p. 739-758 20 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Microarray analysis reveals overexpression of CD163 and HO-1 in symptomatic carotid plaques

Ijäs, P., Nuotio, K., Saksi, J., Soinne, L., Saimanen, E., Karjalainen-Lindsberg, M-L., Salonen, O., Sarna, S., Tuimala, J., Kovanen, P. T., Kaste, M. & Lindsberg, P. J., 2007, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 27, 1, p. 154-160 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Mikroverenvuodot ja CD163-HO1-signalointi oireilevassa kaukavaltimon ateroskleroosissa: [Arterioscler Thromb Vasc Biol in press]

Ijäs, P., Nuotio, K., Saksi, J., Soinne, L., Saimanen, E., Karjalainen-Lindsberg, M-L., Salonen, O., Sarna, S., Tuimala, J., Kovanen, P. T., Kaste, M. & Lindsberg, P. J., 2007, In : Duodecim. 123, p. 141-142 2 p.

Research output: Contribution to journalArticleScientific

PLA2-V: A real player in atherogenesis

Öörni, K. & Kovanen, P. T., 2007, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 27, 3, p. 445-447 3 p.

Research output: Contribution to journalArticleScientific

2006

Desquamation of human coronary artery endothelium by human mast cell proteases: implications for plaque erosion

Mäyränpää, M. I., Heikkilä, H. A., Lindstedt, K. A., Walls, A. F. & Kovanen, P. T., 2006, In : Coronary Artery Disease. 17, 7, p. 611-621 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Enhanced extracellular lipid accumulation in acidic environments

Öörni, K. & Kovanen, P. T., 2006, In : Current Opinion in Lipidology. 17, 5, p. 534-540 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Increased expression of elastolytic cathepsins S, K, and V and their inhibitor cystatin C in stenotic aortic valves

Helske, S., Syväranta, S., Lindstedt, K. A., Lappalainen, J., Öörni, K., Mäyränpää, M., Lommi, J., Turto, H., Werkkala, K., Kupari, M. & Kovanen, P. T., 2006, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 26, 8, p. 1791-1798 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Increased expression of profibrotic neutral endopeptidase and bradykinin type 1 receptors in stenotic aortic valves

Helske, S., Laine, M., Kupari, M., Lommi, J., Tikkanen, I., Werkkala, K., Lindstedt, K. & Kovanen, P., 2006, In : Circulation Research. 114, p. 657-657 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-kappaB-mediated survival signaling

Leskinen, M. J., Heikkilä, H. M., Speer, M. Y., Hakala, J. K., Laine, M., Kovanen, P. T. & Lindstedt, K. A., 2006, In : Experimental Cell Research. 312, 8, p. 1289-1298 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

A role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves

Helske, S., Aalto, S., Kupari, M., Lappalainen, J., Laine, M., Lommi, J., Kovanen, P. T. & Lindstedt, K. A., 2005, In : European Heart Journal. 26, p. 383-383 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

C-reactive protein binds to the 3 beta-OH group of cholesterol in LDL particles

Taskinen, S., Hyvönen, M., Kovanen, PT., Meri, S. & Pentikäinen, MO., 2005, In : Biochemical and Biophysical Research Communications. 329, 4, p. 1208-1216 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Increased expression of bradykinin type-1 receptors in endothelium of intramyocardial coronary vessels in human failing hearts

Liesmaa, I., Kuoppala, A., Shiota, N., Kokkonen, J. O., Kostner, K., Mayranpaa, M., Kovanen, P. T. & Lindstedt, K. A., May 2005, In : American Journal of Physiology: Heart and Circulatory Physiology. 288, 5, p. H2317-H2322 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

Arterial endothelial denudation by intraluminal use of papaverine-NaCl solution in coronary bypass surgery

Mayranpaa, M., Simpanen, J., Hess, MW., Werkkala, K. & Kovanen, P. T., Apr 2004, In : European Journal of Cardio-Thoracic Surgery. 25, 4, p. 560-566 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro

Öörni, K., Sneck, M., Bromme, D., Pentikäinen, M. O., Lindstedt, K. A., Mäyränpää, M., Aitio, H. & Kovanen, P. T., 13 Aug 2004, In : Journal of Biological Chemistry. 279, 33, p. 34776-34784 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Induction of local angiotensin II-producing systems in stenotic aortic valves

Helske, S., Lindstedt, K. A., Laine, M., Mayranpaa, M., Werkkala, K., Lommi, J., Turto, H., Kupari, M. & Kovanen, P. T., 2004, In : Journal of the American College of Cardiology. 44, p. 1859-1866 8 p.

Research output: Contribution to journalArticleScientificpeer-review

The mast cell, a rich source of neutral proteases in atherosclerotic plaques: International Congress Series

Kovanen, P. T., Lee, M., Leskinen, M. J., Öörni, K. & Lindstedt, K. A., 2004, 4 p.

Research output: Book/ReportBook