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Petri T Kovanen

1987 …2019
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Publications 1987 2019

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2018

Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties

Lehti, S., Nguyen, S. D., Belevich, I., Vihinen, H., Heikkilä, H. M., Soliymani, R., Käkelä, R., Saksi, J., Jauhiainen, M., Grabowski, G. A., Kummu, O., Hörkkö, S., Baumann, M., Lindsberg, P. J., Jokitalo, E., Kovanen, P. T. & Öörni, K., Feb 2018, In : The American Journal of Pathology. 188, 2, p. 525-538 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Macrophage Infiltration in the Saccular Intracranial Aneurysm Wall as a Response to Locally Lysed Erythrocytes That Promote Degeneration

Ollikainen, E., Tulamo, R., Kaitainen, S., Honkanen, P., Lehti, S., Liimatainen, T., Hernesniemi, J., Niemelä, M., Kovanen, P. T. & Frösen, J., Oct 2018, In : Journal of Neuropathology and Experimental Neurology. 77, 10, p. 890-903 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Morphology and histology of silent and symptom-causing atherosclerotic carotid plaques - Rationale and design of the Helsinki Carotid Endarterectomy Study 2 (the HeCES2)

Nuotio, K., Ijäs, P., Heikkilä, H. M., Koskinen, S. M., Saksi, J., Vikatmaa, P., Sorto, P., Mäkitie, L., Eriksson, H., Kasari, S., Silvennoinen, H., Valanne, L., Mäyränpää, M. I., Kovanen, P. T., Soinne, L. & Lindsberg, P. J., 2018, In : Annals of Medicine. 50, 6, p. 501-510 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Myeloperoxidase Associates With Degenerative Remodeling and Rupture of the Saccular Intracranial Aneurysm Wall

Ollikainen, E., Tulamo, R., Lehti, S., Hernesniemi, J., Niemelä, M., Kovanen, P. T. & Frösen, J., Jun 2018, In : Journal of Neuropathology and Experimental Neurology. 77, 6, p. 461-468 8 p.

Research output: Contribution to journalArticleScientificpeer-review

USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages

Ruuth, M., Soronen, J., Kaiharju, E., Merikanto, K., Perttilä, J., Metso, J., Lee-Rueckert, M., Taskinen, M-R., Kovanen, P. T., Öörni, K., Olkkonen, V. M., Jauhiainen, M. S. & Laurila, P-P., 13 Dec 2018, In : Lipids in Health and Disease. 17, 11 p., 285.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties

Duy Nguyen, S., Maaninka, K., Lappalainen, J., Nurmi, K., Metso, J., Oorni, K., Navab, M., Fogelman, A. M., Jauhiainen, M., Lee-Rueckert, M. & Kovanen, P. T., Feb 2016, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 2, p. 274-284 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Novel 6p21.3 Risk Haplotype Predisposes to Acute Coronary Syndrome

Sinisalo, J., Vlachopoulou, E., Marchesani, M., Nokelainen, J., Mayranpaa, M. I., Lappalainen, J., Paakkanen, R., Wennerstrom, A., Salli, K., Niemi, H. J., Mannisto, S., Salo, P., Junttila, J., Eskola, M., Nikus, K., Arstila, T. P., Perola, M., Huikuri, H., Karhunen, P. J., Kovanen, P. T. & 8 others, Palotie, A., Havulinna, A. S., Lluis-Ganella, C., Marrugat, J., Elosua, R., Salomaa, V., Nieminen, M. S. & Lokki, M-L., Feb 2016, In : Circulation. Cardiovascular genetics. 9, 1, p. 55-63 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Smooth Muscle Cell Foam Cell Formation, Apolipoproteins, and ABCA1 in Intracranial Aneurysms: Implications for Lipid Accumulation as a Promoter of Aneurysm Wall Rupture

Ollikainen, E., Tulamo, R., Lehti, S., Lee-Rueckert, M., Hernesniemi, J., Niemela, M., Yla-Herttuala, S., Kovanen, P. T. & Frosen, J., Jul 2016, In : Journal of Neuropathology and Experimental Neurology. 75, 7, p. 689-699 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Apolipoprotein A-I mimetic peptide 4F blocks sphingomyelinase-induced LDL aggregation

Nguyen, S. D., Javanainen, M., Rissanen, S., Zhao, H., Huusko, J., Kivelä, A. M., Ylä-Herttuala, S., Navab, M., Fogelman, A. M., Vattulainen, I., Kovanen, P. T. & Öörni, K., 2015, In : Journal of Lipid Research. 56, 6, p. 1206-1221 16 p.

Research output: Contribution to journalArticleScientificpeer-review

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Chronic intermittent psychological stress promotes macrophage reverse cholesterol transport by impairing bile acid absorption in mice

Silvennoinen, R., Quesada, H., Kareinen, I., Julve, J., Kaipiainen, L., Gylling, H., Blanco-Vaca, F., Escola-Gil, J. C., Kovanen, P. T. & Lee-Rueckert, M., 1 May 2015, In : Physiological Reports. 3, 5, 15 p., 12402.

Research output: Contribution to journalArticleScientificpeer-review

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Dietary plant stanols or sterols neither accumulate in stenotic aortic valves nor influence their structure or inflammatory status

Simonen, P., Lommi, J., Hallikainen, M., Helske-Suihko, S., Werkkala, K., Kupari, M., Kovanen, P. T. & Gylling, H., Dec 2015, In : Clinical Nutrition. 34, 6, p. 1251-1257 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Electronegative LDL induces priming and inflammasome activation leading to IL-1 beta release in human monocytes and macrophages

Estruch, M., Rajamaki, K., Sanchez-Quesada, J. L., Kovanen, P. T., Öörni, K., Benitez, S. & Ordonez-Llanos, J., Nov 2015, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1851, 11, p. 1442-1449 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Life-threatening coronary disease is prevalent in patients with stenosing carotid artery disease

Nuotio, K., Soinne, L., Hänninen, H., Saksi, J., Tuimala, J., Jula, A., Kovanen, P. T., Kaste, M., Ijas, P. & Lindsberg, P. J., Dec 2015, In : International Journal of Stroke. 10, 8, p. 1217-1223 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Activated Human Mast Cells Induce LOX-1-Specific Scavenger Receptor Expression in Human Monocyte-Derived Macrophages

Alanne-Kinnunen, M., Lappalainen, J., Öörni, K. & Kovanen, P. T., 24 Sep 2014, In : PLoS One. 9, 9, 9 p., 108352.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

Wang, J., Tang, T-T., Öörni, K., Wu, W., Liu, C., Secco, B., Tia, V., Sukhova, G. K., Fernandes, C., Lesner, A., Kovanen, P. T., Libby, P., Cheng, X. & Shi, G-P., 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 11, p. 2174-2183 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Enhanced vascular permeability facilitates entry of plasma HDL and promotes macrophage-reverse cholesterol transport from skin in mice

Kareinen, I., Cedó, L., Silvennoinen, R., Laurila, P-P., Jauhiainen, M., Julve, J., Blanco-Vaca, F., Escola-Gil, J. C., Kovanen, P. T. & Lee-Rueckert, M., 1 Dec 2014, In : Journal of Lipid Research. 56, 2, p. 241-253 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Low-Expression Variant of Fatty Acid-Binding Protein 4 Favors Reduced Manifestations of Atherosclerotic Disease and Increased Plaque Stability

Saksi, J., Ijas, P., Mayranpaa, M. I., Nuotio, K., Isoviita, P. M., Tuimala, J., Lehtonen-Smeds, E., Kaste, M., Jula, A., Nieminen, M. S., Lokki, M-L., Perola, M., Havulinna, A. S., Salomaa, V., Kettunen, J., Jauhiainen, M., Kovanen, P. T. & Lindsberg, P. J., Oct 2014, In : Circulation. Cardiovascular genetics. 7, 5, p. 588-598 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Mast Cells, Neovascularization, and Microhemorrhages are Associated With Saccular Intracranial Artery Aneurysm Wall Remodeling

Ollikainen, E., Tulamo, R., Frosen, J., Lehti, S., Honkanen, P., Hernesniemi, J., Niemela, M. & Kovanen, P. T., Sep 2014, In : Journal of Neuropathology and Experimental Neurology. 73, 9, p. 855-864 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Potential pathological roles for oxidized low-density lipoprotein and scavenger receptors SR-AI CD36, and LOX-1 in aortic valve stenosis

Syvaranta, S., Kinnunen, M., Öörni, K., Oksjoki, R., Kupari, M., Kovanen, P. T. & Helske-Suihko, S., Aug 2014, In : Atherosclerosis. 235, 2, p. 398-407 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Ethanol Inhibits Activation of NLRP3 and AIM2 Inflammasomes in Human Macrophages- A Novel Anti-Inflammatory Action of Alcohol

Nurmi, K., Virkanen, J., Rajamaki, K., Niemi, K., Kovanen, P. T. & Eklund, K. K., 11 Nov 2013, In : PLoS One. 8, 11, 12 p., 78537.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome

Rajamäki, K., Nordström, T., Nurmi, K., Åkerman, K. E. O., Kovanen, P. T., Öörni, K. & Eklund, K. K., 10 May 2013, In : Journal of Biological Chemistry. 288, 19, p. 13410-13419 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease

Nordestgaard, B. G., Chapman, M. J., Humphries, S. E., Ginsberg, H. N., Masana, L., Descamps, O. S., Wiklund, O., Hegele, R. A., Raal, F. J., Defesche, J. C., Wiegman, A., Santos, R. D., Watts, G. F., Parhofer, K. G., Hovingh, G. K., Kovanen, P. T., Boileau, C., Averna, M., Boren, J., Bruckert, E. & 9 others, Catapano, A. L., Kuivenhoven, J. A., Pajukanta, P., Ray, K., Stalenhoef, A. F. H., Stroes, E., Taskinen, M-R., Tybjaerg-Hansen, A. & European Atherosclerosis Soc Conse, Dec 2013, In : European Heart Journal. 34, 45, p. 3478-+ 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Haptoglobin 2 allele associates with unstable carotid plaque and major cardiovascular events

Ijäs, P., Saksi, J., Soinne, L., Tuimala, J., Jauhiainen, M., Jula, A., Kahonen, M., Kesaniemi, Y. A., Kovanen, P. T., Kaste, M. & Lindsberg, P. J., Oct 2013, In : Atherosclerosis. 230, 2, p. 228-234 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Human mast cells arise from a common circulating progenitor

Maaninka, K., Lappalainen, J. & Kovanen, P. T., Aug 2013, In : Journal of Allergy and Clinical Immunology. p. 463-469 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Miksi nivelreumaa sairastavien sydäntautiriski on suurentunut?

Eklund, K. K. & Kovanen, P. T., 2013, In : Suomen lääkärilehti. 68, 44, p. 2811 1 p.

Research output: Contribution to journalArticleProfessional

The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice

Hyvärinen, K., Tuomainen, A. M., Laitinen, S., Alfthan, G., Salminen, I., Leinonen, M., Saikku, P., Kovanen, P. T., Jauhiainen, M. & Pussinen, P. J., 17 Oct 2013, In : BMC Genomics. 14, 14 p., 709 .

Research output: Contribution to journalArticleScientificpeer-review

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The impact of gender and serum estradiol levels on HDL-mediated reverse cholesterol transport

Badeau, R. M., Metso, J., Kovanen, P. T., Lee-Rueckert, M., Tikkanen, M. J. & Jauhiainen, M., Apr 2013, In : European Journal of Clinical Investigation. 43, 4, p. 317-323 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Acidity and lipolysis by group V secreted phospholipase A(2) strongly increase the binding of apoB-100-containing lipoproteins to human aortic proteoglycans

Lahdesmaki, K., Öörni, K., Alanne-Kinnunen, M., Jauhiainen, M., Hurt-Camejo, E. & Kovanen, P. T., Feb 2012, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1821, 2, p. 257-267 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Imatinib mesylate alleviates diarrhea in a mouse model of intestinal allergy

Vaali, K., Lappalainen, J., Lin, A. H., Mäyränpää, M., Kovanen, P. T., Berstad, A. & Eklund, K. K., 2012, In : Neurogastroenterology and Motility. 24, 7, p. e325-e335 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cells

Nguyen, S. D., Öörni, K., Lee-Rueckert, M., Pihlajamaa, T., Metso, J., Jauhiainen, M. & Kovanen, P. T., 2012, In : Journal of Lipid Research. 53, 10, p. 2115-2125 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2011

190 MAST CELL ACTIVATION IN VIVO IMPAIRS THE MACROPHAGE REVERSE CHOLESTEROL TRANSPORT PATHWAY IN THE MOUSE

Silvennoinen, R., Lee-Rueckert, M., Rotllan, N., Judstrom, I., Blanco-Vaca, F., Jauhiainen, M., Metso, J., Escola-Gil, J. C. & Kovanen, P. T., 1 Jun 2011, In : Atherosclerosis. Supplements. 12, 1, p. 42 1 p.

Research output: Contribution to journalArticleScientificpeer-review

Acidity increases the uptake of native LDL by human monocyte-derived macrophages

Plihtari, R., Kovanen, P. T. & Öörni, K., 2011, In : Atherosclerosis. 217, 2, p. 401-406 6 p.

Research output: Contribution to journalArticleScientificpeer-review

High-density lipoproteins (HDL) are present in stenotic aortic valves and may interfere with the mechanisms of valvular calcification

Lommi, J. I., Kovanen, P. T., Jauhiainen, M., Lee-Rueckert, M., Kupari, M. & Helske, S., Dec 2011, In : Atherosclerosis. 219, 2, p. 538-544 7 p.

Research output: Contribution to journalArticleScientificpeer-review

IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe(-/-) mice

Wang, J., Cheng, X., Xiang, M-X., Alanne-Kinnunen, M., Wang, J-A., Chen, H., He, A., Sun, X., Lin, Y., Tang, T-T., Tu, X., Sjoeberg, S., Sukhova, G. K., Liao, Y-H., Conrad, D. H., Yu, L., Kawakami, T., Kovanen, P. T., Libby, P. & Shi, G-P., Sep 2011, In : Journal of Clinical Investigation. 121, 9, p. 3564-3577 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Immunochemical analysis of the electronegative LDL subfraction shows that abnormal N-terminal apolipoprotein B conformation is involved in increased binding to proteoglycans

Bancells, C., Benítez, S., Ordóñez-Llanos, J., Öörni, K., Kovanen, P. T., Milne, R. W. & Sánchez-Quesada, J. L., 2011, In : Journal of Biological Chemistry. 286, 2, p. 1125-1133 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Is the "lipid paradox" in rheumatoid arthritis really a paradox? Comment on the article by Bartels et al

Strandberg, T., Kovanen, P. T. & Eklund, K. K., Nov 2011, In : Arthritis & Rheumatism. 63, 11, p. 3644-3645 2 p.

Research output: Contribution to journalArticleScientific

Lipid body formation during maturation of human mast cells

Dichlberger, A., Schlager, S., Lappalainen, J., Käkelä, R., Hattula, K., Butcher, S. J., Schneider, W. J. & Kovanen, P. T., 2011, In : Journal of Lipid Research. 52, 12, p. 2198-2208 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Mast Cell Activation In Vivo Impairs the Macrophage Reverse Cholesterol Transport Pathway in the Mouse

Lee-Rueckert, M., Silvennoinen, R., Rotllan, N., Judstrom, I., Blanco-Vaca, F., Metso, J., Jauhiainen, M., Kovanen, P. T. & Carles Escola-Gil, J., Mar 2011, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 3, p. 520-527 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Three-Dimensional cryoEM Reconstruction of Native LDL Particles to 16 angstrom Resolution at Physiological Body Temperature

Kumar, V., Butcher, S. J., Öörni, K., Engelhardt, P., Heikkonen, J., Kaski, K., Ala-Korpela, M. & Kovanen, P. T., 2011, In : PLoS One. 6, 5, p. e18841 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management

Chapman, M. J., Ginsberg, H. N., Amarenco, P., Andreotti, F., Boren, J., Catapano, A. L., Descamps, O. S., Fisher, E., Kovanen, P. T., Kuivenhoven, J. A., Lesnik, P., Masana, L., Nordestgaard, B. G., Ray, K. K., Reiner, Z., Taskinen, M-R., Tokgozoglu, L., Tybjaerg-Hansen, A., Watts, G. F. & European Atherosclerosis Soc, 2011, In : European Heart Journal. 32, 11, p. 1345-1361 24 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Acidic Extracellular Environments Strongly Impair ABCA1-Mediated Cholesterol Efflux From Human Macrophage Foam Cells

Lee-Rueckert, M., Lappalainen, J., Leinonen, H., Pihlajamaa, T., Jauhiainen, M. & Kovanen, P. T., 2010, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 30, p. 1766-1772 23 p.

Research output: Contribution to journalArticleScientificpeer-review

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

Rajamaki, K., Lappalainen, J., Öörni, K., Valimaki, E., Matikainen, S., Kovanen, P. T. & Eklund, K. K., 23 Jul 2010, In : PLoS One. 5, 7, 9 p., 11765.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Dilated cardiomyopathy alters the expression patterns of CAR and other adenoviral receptors in human heart

Toivonen, R., Mayranpaa, M. I., Kovanen, P. T. & Savontaus, M., Mar 2010, In : Histochemistry and Cell Biology. 133, 3, p. 349-357 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of milk casein-derived tripeptides Ile-Pro-Pro, Val-Pro-Pro, and Leu-Pro-Pro on enzymes processing vaso active precursors in vitro

Lehtinen, R., Jauhiainen, T., Kankuri, E., Lindstedt, K., Kovanen, P. T., Kerojoki, O., Korpela, R. & Vapaatalo, H., 2010, In : Arzneimittel-Forschung. 60, p. 182-185 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Mast cell-dependent proteolytic modification of HDL particles during anaphylactic shock in the mouse reduces their ability to induce cholesterol efflux from macrophage foam cells ex vivo

Judström, I., Jukkola, H., Metso, J., Jauhiainen, M., Kovanen, P. T. & Lee-Rueckert, M., Jan 2010, In : Atherosclerosis. 208, 1, p. 148-154 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Mast cells promote atherosclerosis by inducing both an atherogenic lipid profile and vascular inflammation

Heikkilä, H-M. A., Trosien, J., Metso, J., Jauhiainen, M., Pentikäinen, M. O., Kovanen, P. T. & Lindstedt, K. A., 2010, In : Journal of Cellular Biochemistry. 109, 3, p. 615-623 9 p.

Research output: Contribution to journalArticleScientificpeer-review